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Article ; Online: Correlation of Neuroendocrine Differentiation with Neuroendocrine Cell Hyperplasia and Vascular Endothelial Growth Factor in Colorectal Adenocarcinoma

Khesar Hussein Khalil / Bashar Al-Hassawi / Jasim Abdo

Baghdad Science Journal, Vol 18, Iss

2021 Volume 1

Abstract: Neuroendocrine differentiation has been mentioned in many cancers of non-neuroendocrinal organs, involving the gastrointestinal tract. In contrast, the correlation of focally diffused neuroendocrine differentiation in colorectal adenocarcinoma with ... ...

Abstract	Neuroendocrine differentiation has been mentioned in many cancers of non-neuroendocrinal organs, involving the gastrointestinal tract. In contrast, the correlation of focally diffused neuroendocrine differentiation in colorectal adenocarcinoma with neuroendocrine cell hyperplasia has not been somewhat reported. The objective of this research is to study the relationship between neuroendocrine cell hyperplasia and neuroendocrine differentiation in colorectal adenocarcinoma and to find the correlation of neuroendocrine differentiation and VEGF expression with clinicopathological parameters of colorectal adenocarcinoma. Methods employed in the current study were including eighty-one patients with colorectal cancer. Formalin fixed paraffin embedded blocks were sectioned and stained with immunohistochemical markers; Chromogranin A and VEGF; and processed automatically according to protocols supplied by the antibody manufacturer. Results show that neuroendocrine cell hyperplasia in the mucosa nearby tumor comprised (42%) and it was associated with neuroendocrine differentiation. Neuroendocrine differentiation and vascular endothelial growth factor were positive in 48.1% and 63% respectively. Neuroendocrine differentiation did not show a relation with clinicopathological parameters with the exception of tumor that metastasizes to other tissues and organs. The association of VEGF with the same factors had significant impact with tumor stage, degree of local invasion and lymph node metastasis. Other histological changes revealed that only desmoplastic reaction had significant difference in relation to neuroendocrine differentiation. This study reached the conclusion that neuroendocrine cell hyperplasia is positively correlated with neuroendocrine differentiation and it has strong linkage in pathogenesis of colorectal adenocarcinoma. Neuroendocrine differentiation and VEGF expression are greatly correlated with progression and invasion of tumor to other tissues and organs, and this can be represented as an important ...
Keywords	Science ; Q
Subject code	616
Language	Arabic
Publishing date	2021-03-01T00:00:00Z
Publisher	College of Science for Women, University of Baghdad
Document type	Article ; Online
Database	BASE - Bielefeld Academic Search Engine (life sciences selection)

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Article: Hypertriglyceridemia-induced pancreatitis after egg retrieval for in vitro fertilization and fenofibrate cessation.

Shrimanker, Tushaar V / Retalis, Zachary / Hussein, Khalil Ian

Clinical case reports

2022 Volume 10, Issue 5, Page(s) e05874

Abstract: A 36-year-old woman with prior hypertriglyceridemia-induced pancreatitis presented with a recurrence of pancreatitis after beginning in vitro fertilization (IVF). Her primary care physician had discontinued fenofibrate due to concerns for teratogenicity. ...

Abstract	A 36-year-old woman with prior hypertriglyceridemia-induced pancreatitis presented with a recurrence of pancreatitis after beginning in vitro fertilization (IVF). Her primary care physician had discontinued fenofibrate due to concerns for teratogenicity. This case illustrates the importance of fibrate therapy for high-risk women undergoing IVF, despite limited evidence regarding its teratogenicity.
Language	English
Publishing date	2022-05-12
Publishing country	England
Document type	Case Reports
ZDB-ID	2740234-4
ISSN	2050-0904
ISSN	2050-0904
DOI	10.1002/ccr3.5874
Database	MEDical Literature Analysis and Retrieval System OnLINE

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Article ; Online: Effects of Deposition Time And PH on The Characterization of Chemically Synthesized Composite Nano-Wires of Cu2S Thin Films

Honar S. Ahmed / Raghad Y. Mohammed / Mohammed Hussein Khalil

Science Journal of University of Zakho, Vol 9, Iss

2021 Volume 4

Abstract: The chemical bath deposition technique (CBD) had used for depositing Cu2S thin films on the glass substrates. It found that thickness and deposition rate were significantly dependent on deposition parameters (deposition time and pH value). XRD data ... ...

Abstract	The chemical bath deposition technique (CBD) had used for depositing Cu2S thin films on the glass substrates. It found that thickness and deposition rate were significantly dependent on deposition parameters (deposition time and pH value). XRD data indicates that at different deposition times and pH values are given amorphous structure except for the deposited thin film of (8hours) and, pH of (10.4) the structure was crystalline. The morphology of the deposited thin films remarkably changed as the deposition time increased. Optical transmittance measurements illustrate that transmission of the thin films decreases from 93.27% for a deposition time of 4 hours to 81.73 for deposition time of 10 hours and, the maximum transmission rate of the films is 95.21 % with pH=8.4 and decreases to 28.39 % with pH=11.4. Also, optical studies revealed that Cu2S thin film with direct energy bandgap decreased from 3.04 to 2.78 eV as deposition time increased and from 3.09 to 2.32 eV as pH increased.
Keywords	Cu2S thin film ; CBD ; Bandgap ; thin-film ; optical properties ; XRD ; Science ; Q
Subject code	620
Language	English
Publishing date	2021-12-01T00:00:00Z
Publisher	University of Zakho
Document type	Article ; Online
Database	BASE - Bielefeld Academic Search Engine (life sciences selection)

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Article: Recurrent severe neutropenia following doxycycline use in a young healthy woman.

Foti, Michael / Shrimanker, Tushaar V / Hasan, Umar N / Hussein, Khalil I

Clinical case reports

2022 Volume 10, Issue 3, Page(s) e05524

Abstract: A 29-year-old woman was hospitalized for fever, pharyngitis, and severe neutropenia after recent use of doxycycline and other antimicrobials. Three years later, she again presented with severe neutropenia after recent doxycycline use. Diagnostic workups ... ...

Abstract	A 29-year-old woman was hospitalized for fever, pharyngitis, and severe neutropenia after recent use of doxycycline and other antimicrobials. Three years later, she again presented with severe neutropenia after recent doxycycline use. Diagnostic workups were unyielding. This is only the second published case of severe neutropenia associated with doxycycline use.
Language	English
Publishing date	2022-03-01
Publishing country	England
Document type	Case Reports
ZDB-ID	2740234-4
ISSN	2050-0904
ISSN	2050-0904
DOI	10.1002/ccr3.5524
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Article ; Online: Management of low-risk chest pain in ambulatory medical assessment area and the role of the heart scoring system in identifying risk.

Hussein, Khalil / Khairy, Amged / Clare, Sarbjit

Clinical medicine (London, England)

2020 Volume 20, Issue Suppl 2, Page(s) s89

MeSH term(s)	Chest Pain/diagnosis ; Chest Pain/etiology ; Emergency Service, Hospital ; Humans ; Risk ; Risk Assessment
Language	English
Publishing date	2020-05-13
Publishing country	England
Document type	Journal Article
ZDB-ID	2048646-7
ISSN	1473-4893 ; 1470-2118
ISSN (online)	1473-4893
ISSN	1470-2118
DOI	10.7861/clinmed.20-2-s89
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Article ; Online: Seronegative Goodpasture's syndrome associated with organising pneumonia.

Bae, Ju Young / Hussein, Khalil Ian / Leibert, Eric / Archer, Herbert M

BMJ case reports

2021 Volume 14, Issue 2

Abstract: Goodpasture's syndrome is a rare vasculitis associated with anti-glomerular basement membrane (anti-GBM) autoantibodies that target type IV collagen found in the basement membranes of glomeruli and alveoli. We present a case of a 79-year-old man with ... ...

Abstract	Goodpasture's syndrome is a rare vasculitis associated with anti-glomerular basement membrane (anti-GBM) autoantibodies that target type IV collagen found in the basement membranes of glomeruli and alveoli. We present a case of a 79-year-old man with seronegative Goodpasture's syndrome with predominant respiratory symptoms and mild acute kidney injury that initially improved. Final diagnosis was made by immunofluorescent staining on open lung biopsy which also revealed concomitant organising pneumonia. The patient underwent treatment with corticosteroids, cyclophosphamide, haemodialysis and plasmapheresis. This was an atypical presentation wherein the patient only exhibited pulmonary symptoms early in the course of illness in the setting of negative anti-GBM antibody serum testing, which made diagnosis challenging. With this case, we emphasise that clinicians should have a high suspicion for Goodpasture's syndrome in the setting of unexplained severe pulmonary or renal disease despite negative anti-GBM antibody testing.
MeSH term(s)	Acute Kidney Injury/diagnosis ; Acute Kidney Injury/therapy ; Aged ; Anti-Glomerular Basement Membrane Disease/diagnosis ; Anti-Glomerular Basement Membrane Disease/therapy ; Anti-Infective Agents/therapeutic use ; Biomarkers/analysis ; Bronchoscopy ; Diagnosis, Differential ; Fatal Outcome ; Humans ; Intubation, Intratracheal ; Male ; Plasmapheresis ; Pneumonia/diagnosis ; Pneumonia/therapy ; Renal Dialysis ; Steroids/therapeutic use
Chemical Substances	Anti-Infective Agents ; Biomarkers ; Steroids
Language	English
Publishing date	2021-02-09
Publishing country	England
Document type	Case Reports ; Journal Article
ISSN	1757-790X
ISSN (online)	1757-790X
DOI	10.1136/bcr-2020-239390
Database	MEDical Literature Analysis and Retrieval System OnLINE

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Article: Coombs-negative hemolytic anemia in a male with COVID-19.

Bae, Ju Young / Jeon, June Evelyn / Hussein, Khalil Ian / Lee, Merlin Sung

Clinical case reports

2021 Volume 9, Issue 7, Page(s) e04503

Abstract: This case illustrates the need to consider SARS-CoV-2 infection as a catalyst for Coombs-negative hemolytic anemia as well as the potential for IVIG to serve as an effective treatment for the condition. ...

Abstract	This case illustrates the need to consider SARS-CoV-2 infection as a catalyst for Coombs-negative hemolytic anemia as well as the potential for IVIG to serve as an effective treatment for the condition.
Language	English
Publishing date	2021-07-06
Publishing country	England
Document type	Case Reports
ZDB-ID	2740234-4
ISSN	2050-0904
ISSN	2050-0904
DOI	10.1002/ccr3.4503
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Article: The Challenges of ST-Elevation Myocardial Infarction in COVID-19 Patients.

Bae, Ju Young / Hussein, Khalil Ian / Howes, Christopher John / Setaro, John Francis

Case reports in cardiology

2021 Volume 2021, Page(s) 9915650

Abstract: By July 2021, the United States had over 34.4 million confirmed COVID-19 cases. Various cardiovascular manifestations of COVID-19 have been reported including ST-elevation myocardial infarction (STEMI), and there is concern that SARS-CoV-2 may be ... ...

Abstract	By July 2021, the United States had over 34.4 million confirmed COVID-19 cases. Various cardiovascular manifestations of COVID-19 have been reported including ST-elevation myocardial infarction (STEMI), and there is concern that SARS-CoV-2 may be associated with a higher thrombus burden. We performed a retrospective chart review of 535 adult patients with COVID-19 admitted at Yale-New Haven Health Greenwich Hospital from February 1, 2020, to May 13, 2020. All admitted patients had undergone testing for serum troponin I and various inflammatory markers, and we identified three patients who were diagnosed with acute STEMI. Data was collected via manual chart review and included patient demographics, comorbidities, laboratory tests, electrocardiogram (ECG) results, echocardiography results, diagnoses during hospitalization, inpatient therapies, and outcomes including length of hospital stay, revascularization results, and mortality. Three of our patients had obstructive coronary artery disease confirmed via angiography. One subject was noted to display vasospasm in addition to coronary atherosclerotic obstruction and refractory thrombus formation. Among our patients with COVID-19 and STEMI, presentations were variable in terms of timing of onset of ECG changes, age, gender, race, comorbidities, symptomology, and outcomes.
Language	English
Publishing date	2021-08-21
Publishing country	United States
Document type	Case Reports
ZDB-ID	2627627-6
ISSN	2090-6412 ; 2090-6404
ISSN (online)	2090-6412
ISSN	2090-6404
DOI	10.1155/2021/9915650
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Article: Human Borrelia miyamotoi infection: A cause of persistent fever and severe hyperthermia in New England.

Bobojama, Sotonye B / Bae, Ju Young / McLeod, Gavin X / Hussein, Khalil I

IDCases

2022 Volume 30, Page(s) e01614

Abstract: An adult male presented to a hospital in southwestern Connecticut with tachypnea, generalized weakness, altered mental status, and relapsing fever with maximum recorded temperature of 106 °F. He required active cooling, antipyretic therapy, broad ... ...

Abstract	An adult male presented to a hospital in southwestern Connecticut with tachypnea, generalized weakness, altered mental status, and relapsing fever with maximum recorded temperature of 106 °F. He required active cooling, antipyretic therapy, broad spectrum antibiotics, and intubation for airway protection after an episode of emesis. Initial laboratory and imaging workup were remarkable for elevated inflammatory markers, acute kidney injury, and bilateral lower lobe infiltrates. Further workup with lumbar puncture and electroencephalography were unrevealing. Extensive testing for causes of relapsing fever including tickborne diseases revealed that the patient was seropositive for Borrelia miyamotoi. Notably, he had no rash, and workup found no evidence of coinfection by other Borrelia, Ehrlichia or Anaplasma species. This case illustrates the need for clinicians to test for tick-borne diseases when evaluating for cases of relapsing fever in New England and is among the first case reports to demonstrate Borrelia miyamotoi as a cause of severe pyrexia.
Language	English
Publishing date	2022-09-06
Publishing country	Netherlands
Document type	Case Reports
ZDB-ID	2745454-X
ISSN	2214-2509
ISSN	2214-2509
DOI	10.1016/j.idcr.2022.e01614
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Article ; Online: The Effect of Aqueous Extractof Anise Seeds. Pimpinella Anisum L.Effect on Body Weight , Weight Gain , Feed Consumption and Feed Conversion Ratio of Japanese Quail

Ali Hussein Khalil al-Hilali / Zahra Muhammad Najm

Al-Qadisiyah Journal For Agriculture Sciences, Vol 7, Iss

2018 Volume 2

Abstract: An Experiment has been conducted in research station (the first) of the college of Agriculture / University of Al-Muthanna for the period from 07/22/2015 until 09/5/2015 in order to study the effect of adding aqueous extract of anise seeds recipes on the ...

Abstract	An Experiment has been conducted in research station (the first) of the college of Agriculture / University of Al-Muthanna for the period from 07/22/2015 until 09/5/2015 in order to study the effect of adding aqueous extract of anise seeds recipes on the body weight and feed conversion of Japanese quail.Atotalof 256 of day old quail chicks which are randomly distributed into four treatment groups,64 chicks are per treatment . Chicks in each treatment group have been subdivided into four replicates (16 chicks for each) the aqueous extract of anise seeds has been added to the drinking water at the rate of 25,50,75,0 ml per liter of drinking water for the four treatment groups respectively . The data show that water treatment is significantly (p<0.05) improved live body weight gain, feed intake and feed conversion of Japanese quail chicks.
Keywords	Agriculture ; S ; Plant culture ; SB1-1110 ; Botany ; QK1-989
Subject code	630
Language	Arabic
Publishing date	2018-04-01T00:00:00Z
Publisher	University of Al-Qadisiya
Document type	Article ; Online
Database	BASE - Bielefeld Academic Search Engine (life sciences selection)

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