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  1. Book ; Thesis: Messungen der intrazellulären Natriumkonzentration bei Patienten mit essentieller Hypertonie und bei der spontanhypertonen Ratte

    Husseini, Samir

    1994  

    Author's details vorgelegt von Samir Husseini
    Language German
    Size II, 49 Bl. : Ill., graph. Darst.
    Edition [Mikrofiche-Ausg.]
    Document type Book ; Thesis
    Thesis / German Habilitation thesis Münster (Westfalen), Univ., Diss., 1994
    Note 1 Mikrofiche
    HBZ-ID HT006460510
    Database Catalogue ZB MED Medicine, Health

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    Shelf markLoan statusLocation
    1994 MB 1552 order for loan Magazin

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  2. Article ; Online: Review of Israel's action and response during the COVID-19 pandemic and tabletop exercise for the evaluation of readiness and resilience-lessons learned 2020-2021.

    Muhsen, Khitam / Cohen, Dani / Glatman-Freedman, Aharona / Husseini, Sari / Perlman, Saritte / McNeil, Carrie

    Frontiers in public health

    2024  Volume 11, Page(s) 1308267

    Abstract: Background: Reevaluating response plans is essential to ensuring consistent readiness and resilience to the COVID-19 pandemic. The "During Action Review" and Tabletop (DART) methodology provides a retrospective and prospective assessment to inform the ... ...

    Abstract Background: Reevaluating response plans is essential to ensuring consistent readiness and resilience to the COVID-19 pandemic. The "During Action Review" and Tabletop (DART) methodology provides a retrospective and prospective assessment to inform the adaptive response. Israel introduced COVID-19 vaccinations in December 2020 and was the first country to implement booster vaccination to address waning immunity and surges caused by new variants. We assessed Israel's readiness and resilience related to COVID-19 response while capturing the pre-vaccination and vaccination periods.
    Methods: A DART analysis was conducted between December 2020 and August 2021 among experts involved in the management of the COVID-19 pandemic in Israel. During the retrospective stage, a role-based questionnaire and discussions were undertaken in a participant-led review of the response, focusing on epidemiology and surveillance, risk communication, and vaccines. The prospective stage included tabletop exercises to evaluate short to long-term simulated scenarios.
    Results: Participants emphasized the pivotal role of Israel globally by sharing experiences with the pandemic, and vaccination. Perceived strengths included multi-sectoral collaboration between the Ministry of Health, healthcare providers, academia, military, and others, stretching capacities, expanding laboratory workload, and establishing/maintaining surveillance. The vaccine prioritization plan and strong infrastructure, including computerized databases, enabled real-life assessment of vaccine uptake and impact. Challenges included the need to change case definitions early on and insufficient staffing. Quarantine of patients and contacts was particularly challenging among underprivileged communities. Risk communication approaches need to focus more on creating norms in behavior. Trust issues and limited cooperation were noted, especially among ethnic and religious minorities. To ensure readiness and resiliency, participants recommended establishing a nationally deployed system for bringing in and acting upon feedback from the field, especially concerning risk communication and vaccines.
    Conclusion: Our study appraised strengths and weaknesses of the COVID-19 pandemic response in Israel and led to concrete recommendations for adjusting responses and future similar events. An efficient response comprised multi-sectoral collaboration, policy design, infrastructure, care delivery, and mitigation measures, including vaccines, while risk communication, trust issues, and limited cooperation with minority groups were perceived as areas for action and intervention.
    MeSH term(s) Humans ; COVID-19/epidemiology ; COVID-19/prevention & control ; Israel/epidemiology ; Pandemics/prevention & control ; Prospective Studies ; Resilience, Psychological ; Retrospective Studies ; Vaccines
    Chemical Substances Vaccines
    Language English
    Publishing date 2024-01-24
    Publishing country Switzerland
    Document type Journal Article ; Review ; Research Support, Non-U.S. Gov't
    ZDB-ID 2711781-9
    ISSN 2296-2565 ; 2296-2565
    ISSN (online) 2296-2565
    ISSN 2296-2565
    DOI 10.3389/fpubh.2023.1308267
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  3. Article: A bi-level multi-follower optimization model for R&D project portfolio: an application to a pharmaceutical holding company.

    Salehi, Faraz / Mirzapour Al-E-Hashem, S Mohammad J / Moattar Husseini, S Mohammad / Ghodsypour, S Hassan

    Annals of operations research

    2022  Volume 323, Issue 1-2, Page(s) 331–360

    Abstract: The need for a study of project portfolio optimization in pharmaceutical R&D has become all the more urgent with the outbreak of COVID-19. This study examines a new model for optimizing R&D project portfolios under a decentralized decision-making ... ...

    Abstract The need for a study of project portfolio optimization in pharmaceutical R&D has become all the more urgent with the outbreak of COVID-19. This study examines a new model for optimizing R&D project portfolios under a decentralized decision-making structure in a pharmaceutical holding company. Specifically, two levels of decision makers hierarchically decide on budget allocation and project portfolio selection-scheduling to maximize their profit, and we formulate the problem as a bi-level multi-follower mixed-integer optimization model. At the upper level, the investment company has complete knowledge of the subsidiaries' response, acts first, and decides on the best budget allocation. At the lower level, each subsidiary responds to the allocated budget and decides on its portfolio scheduling. Since the lower level represents several mixed-integer programming problems, solving the resulting bi-level model is challenging. Therefore, we propose an efficient hybrid solution approach based on parametric optimization and convert the bi-level model into a single-level mixed-integer model. To validate it, we solve a case and discuss the optimal strategy of each actor. The experimental results show that the planned project portfolio for each subsidiary of the holding company is drastically affected by the allocated budget and its decisions.
    Supplementary information: The online version contains supplementary material available at 10.1007/s10479-022-05052-0.
    Language English
    Publishing date 2022-11-08
    Publishing country United States
    Document type Journal Article
    ISSN 0254-5330
    ISSN 0254-5330
    DOI 10.1007/s10479-022-05052-0
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  4. Article: Diagnostic Usefulness of p16 Immunohistochemistry for some Epithelial Lesions in the Pathology Service of Sultan Qaboos University Hospital.

    Al-Ghafri, Iman / Al-Husseini, Samia / Al-Rashdi, Afrah / Arafa, Mohammad

    Maedica

    2021  Volume 16, Issue 4, Page(s) 634–641

    Abstract: Objectives: ...

    Abstract Objectives:
    Language English
    Publishing date 2021-12-09
    Publishing country Romania
    Document type Editorial
    ZDB-ID 2399972-X
    ISSN 2069-6116 ; 1841-9038
    ISSN (online) 2069-6116
    ISSN 1841-9038
    DOI 10.26574/maedica.2021.16.4.634
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  5. Book ; Online: EDLP versus Hi-Lo Pricing Strategies in Retailing

    El Husseini, Sabine

    Literature Review and Empirical Examinations in the German Retail Market

    2014  

    Abstract: Retail pricing strategy is seen as one of the priorities in retail management. There exist two main pricing strategies in retailing: the Every Day Low Price (EDLP) strategy and the High-Low (Hi-Lo) pricing strategy. Despite the importance of this topic, ... ...

    Abstract Retail pricing strategy is seen as one of the priorities in retail management. There exist two main pricing strategies in retailing: the Every Day Low Price (EDLP) strategy and the High-Low (Hi-Lo) pricing strategy. Despite the importance of this topic, it has been given little attention in academic research. The author fills this gap in academic literature and examines the topic both from a theoretical and an empirical perspective. Based on a comprehensive conceptual examination of pricing strategies in retailing, the author conducted two large-scale empirical studies about the impact of the
    Language English
    Size Online-Ressource (0 p)
    Publisher Peter Lang GmbH, Internationaler Verlag der Wissenschaften
    Publishing place Frankfurt
    Document type Book ; Online
    Note Description based upon print version of record
    ISBN 9783631643570 ; 3631643578
    Database Library catalogue of the German National Library of Science and Technology (TIB), Hannover

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  6. Article: La redistribution territoriale des chretiens au Liban.

    Husseini, S

    Les Cahiers de l'Orient

    1993  , Issue 32-33, Page(s) 145–174

    Title translation The spatial redistribution of Christians in Lebanon.
    MeSH term(s) Asia ; Asia, Western ; Christianity ; Demography ; Developing Countries ; Geography ; Lebanon ; Middle East ; Politics ; Population ; Religion ; Warfare
    Language French
    Publishing date 1993
    Publishing country France
    Document type English Abstract ; Journal Article
    ISSN 0767-6468
    ISSN 0767-6468
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  7. Article: Investigating replenishment policies for centralised and decentralised supply chains using stochastic programming approach

    Alborzi, F / Fattahi, M / Husseini, S. M. Moattar / Keyvanshokooh, E / Mahootchi, M

    International journal of production research Vol. 53, No. 1 , p. 41-69

    2015  Volume 53, Issue 1, Page(s) 41–69

    Author's details M. Fattahi, M. Mahootchi, S. M. Moattar Husseini, E. Keyvanshokooh and F. Alborzi
    Keywords inventory management ; centralised and decentralised supply chains ; stochastic programming ; evolutionary strategies ; Imperialist competitive algorithm ; simulation
    Language English
    Size graph. Darst.
    Publisher Taylor & Francis
    Publishing place London
    Document type Article
    ZDB-ID 160477-6 ; 1485085-0
    ISSN 1366-588X ; 0020-7543
    ISSN (online) 1366-588X
    ISSN 0020-7543
    Database ECONomics Information System

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  8. Article ; Online: Inhibition of HDAC Enzymes Contributes to Differential Expression of Pro-Inflammatory Proteins in the TLR-4 Signaling Cascade

    Weiss, U. / Möller, M. / Husseini, S.A. / Manderscheid, C. / Häusler, J. / Geisslinger, G. / Niederberger, E.

    2020  

    Abstract: Art. 8943, 17 S. ... Class I and II histone deacetylases (HDAC) are considered important regulators of immunity and inflammation. Modulation of HDAC expression and activity is associated with altered inflammatory responses but reports are controversial and ...

    Abstract Art. 8943, 17 S.

    Class I and II histone deacetylases (HDAC) are considered important regulators of immunity and inflammation. Modulation of HDAC expression and activity is associated with altered inflammatory responses but reports are controversial and the specific impact of single HDACs is not clear. We examined class I and II HDACs in TLR-4 signaling pathways in murine macrophages with a focus on IkB kinase epsilon (IKKe) which has not been investigated in this context before. Therefore, we applied the pan-HDAC inhibitors (HDACi) trichostatin A (TSA) and suberoylanilide hydroxamic acid (SAHA) as well as HDAC-specific siRNA. Administration of HDACi reduced HDAC activity and decreased expression of IKKe although its acetylation was increased. Other pro-inflammatory genes (IL-1v, iNOS, TNFa) also decreased while COX-2 expression increased. HDAC 2, 3 and 4, respectively, might be involved in IKKe and iNOS downregulation with potential participation of NF-kB transcription factor inhibition. Suppression of HDAC 1-3, activation of NF-kB and RNA stabilization mechanisms might contribute to increased COX-2 expression. In conclusion, our results indicate that TSA and SAHA exert a number of histone- and HDAC-independent functions. Furthermore, the data show that different HDAC enzymes fulfill different functions in macrophages and might lead to both pro- and anti-inflammatory effects which have to be considered in therapeutic approaches.

    21

    Nr.23
    Keywords 540 ; 547 ; 571 ; 572
    Subject code 572
    Language English
    Publishing country de
    Document type Article ; Online
    Database BASE - Bielefeld Academic Search Engine (life sciences selection)

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  9. Article ; Online: Laryngeal findings and acoustic changes in light cigar smokers.

    Hamdan, Abdul-Latif / Al-Barazi, Randa / Ashkar, Jihad / Husseini, Sami / Dowli, Alexander / Fuleihan, Nabil

    Ear, nose, & throat journal

    2015  Volume 94, Issue 6, Page(s) 231–235

    Abstract: Unlabelled: The aim of this prospective study was to look at the laryngeal findings and acoustic changes in light cigar smokers in comparison to nonsmokers, in the setting of a voice clinic. A total of 22 cigar smokers and 19 nonsmokers used as controls ...

    Abstract Unlabelled: The aim of this prospective study was to look at the laryngeal findings and acoustic changes in light cigar smokers in comparison to nonsmokers, in the setting of a voice clinic. A total of 22 cigar smokers and 19 nonsmokers used as controls were enrolled in the study. Demographic data included age, number of years smoking, number of cigars per week, history of allergy, and history of reflux. The confounding effects of allergy and reflux were accounted for in the control group. Subjects underwent laryngeal endoscopy and acoustic analysis. On laryngeal endoscopy, the most common laryngeal finding was thick mucus. There was no significant difference in the prevalence of any of the laryngeal findings in cigar smokers vs.
    Controls: In comparison with the control group, both the fundamental frequency and habitual pitch were significantly lower in cigar smokers (p value = 0.034 and 0.004, respectively). We conclude that cigar smokers have lower fundamental frequency and habitual pitch compared to nonsmokers.
    MeSH term(s) Adult ; Humans ; Laryngeal Mucosa/pathology ; Male ; Prospective Studies ; Smoking/pathology ; Smoking/physiopathology ; Speech Acoustics ; Vocal Cords/pathology
    Language English
    Publishing date 2015-06-05
    Publishing country United States
    Document type Journal Article
    ZDB-ID 750153-5
    ISSN 1942-7522 ; 0145-5613
    ISSN (online) 1942-7522
    ISSN 0145-5613
    DOI 10.1177/014556131509400609
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    bis Jg. 2021: Bestellungen von Artikeln über das Online-Bestellformular
    ab Jg. 2022: Lesesaal (EG)

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  10. Article: Influence of Eysenckian Personality Traits in Choice of Specialization by Young Omani Doctors.

    Al-Alawi, Mohammed / Al-Sinawi, Hamed / Al-Husseini, Salim / Al-Adawi, Samir / Panchatcharam, Sathiya Murthi / Khan, Sahar / Jeyaseelan, Lakshmanan

    Oman medical journal

    2017  Volume 32, Issue 4, Page(s) 291–296

    Abstract: Objectives: The role of personality in occupational specialty choices has been explored in many parts of the world. To our knowledge, there is a dearth of such studies in the Arab/Islamic population and Oman is no exception. This study aimed to explore ... ...

    Abstract Objectives: The role of personality in occupational specialty choices has been explored in many parts of the world. To our knowledge, there is a dearth of such studies in the Arab/Islamic population and Oman is no exception. This study aimed to explore the relationship between personality traits and specialty choice among residents of Oman Medical Specialty Board (OMSB).
    Methods: A cross-sectional study was carried out among Omani resident physicians working under OMSB. The Eysenck Personality Questionnaire-Revised was employed to quantify personality subtypes (e.g., psychoticism, extraversion, and neuroticism). Specialties were categorized as surgical, medical, and diagnostics as per standard of North American medical specialties. A total of 255 residents in 17 medical specialties participated in the study (m = 40.4%; f = 59.6%) of 300 eligible subjects giving a response rate of 85.0%.
    Results: Respondents who had chosen surgical specialties scored significantly higher on the psychoticism subscale than those who had opted for medical and diagnostic specialties. As for individual specialties, orthopedic respondents had statistically significant higher mean scores on psychoticism and neuroticism compared to radiologists and psychiatrists who scored the lowest in the two personality traits, respectively.
    Conclusions: This study found statistically significant associations between personality traits and choices of specialty by young Omani doctors. We recommend more detailed studies that examine further psychological and cultural variables that are likely to affect the choices of specializations by young Omani professionals in both medical and non-medical fields.
    Language English
    Publishing date 2017-06-19
    Publishing country Oman
    Document type Journal Article
    ZDB-ID 2571431-4
    ISSN 2070-5204 ; 1999-768X
    ISSN (online) 2070-5204
    ISSN 1999-768X
    DOI 10.5001/omj.2017.57
    Database MEDical Literature Analysis and Retrieval System OnLINE

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