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Book ; Online ; E-Book: Traumatic brain injury

Whitfield, Peter C. / Welbourne, Jessie / Thomas, Elfyn / Summers, Fiona / Whyte, Maggie / Hutchinson, Peter J.

a multidisciplinary approach

2020

Author's details	edited by Peter C. Whitfield, Jessie Welbourne, Elfyn Thomas, Fiona Summers, Maggie Whyte, Peter J. Hutchinson
Keywords	Brain / Wounds and injuries
Language	English
Size	1 Online-Ressource (xii, 400 Seiten), Illustrationen, Diagramme
Edition	Second edition
Publisher	Cambridge University Press
Publishing place	Cambridge
Publishing country	Great Britain
Document type	Book ; Online ; E-Book
Remark	Zugriff für angemeldete ZB MED-Nutzerinnen und -Nutzer
HBZ-ID	HT020451461
ISBN	978-1-108-35524-7 ; 9781108430869 ; 1-108-35524-2 ; 1108430864
Database	ZB MED Catalogue: Medicine, Health, Nutrition, Environment, Agriculture

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Book: Oxford textbook of neurological surgery

Kirollos, Ramez / Helmy, Adel / Thomson, Simon / Hutchinson, Peter J. A.

(Oxford textbooks in surgery)

2019

Title variant	Textbook of neurological surgery ; Neurological surgery
Author's details	[edited by] Ramez W. Kirollos, Adel Helmy, Simon Thomson, Peter Hutchinson
Series title	Oxford textbooks in surgery
Keywords	Nervous system/Surgery
Subject code	617.48
Language	English
Size	xxvi, 1148 Seiten, Illustrationen, 28 cm
Publisher	Oxford University Press
Publishing place	Oxford
Publishing country	Great Britain
Document type	Book
HBZ-ID	HT020240143
ISBN	978-0-19-874670-6 ; 9780192519535 ; 0-19-874670-9 ; 0192519530
Database	Catalogue ZB MED Medicine, Health

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2019 A 1452	available for loan (reading room)	Lesesaal EG

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Article ; Online: Consideration of possible effects of vitamin D on established cancer, with reference to malignant melanoma.

Hutchinson, Peter E / Pringle, James H

Pigment cell & melanoma research

2022 Volume 35, Issue 4, Page(s) 408–424

Abstract: Epidemiological studies indicate that Vitamin D has a beneficial, inhibitory effect on cancer development and subsequent progression, including melanoma (MM), and favourable MM outcome has been reported as directly related to vitamin ... ...

Abstract	Epidemiological studies indicate that Vitamin D has a beneficial, inhibitory effect on cancer development and subsequent progression, including melanoma (MM), and favourable MM outcome has been reported as directly related to vitamin D
MeSH term(s)	Animals ; Humans ; Melanoma/drug therapy ; Melanoma/pathology ; Receptors, Calcitriol ; Skin Neoplasms/drug therapy ; Skin Neoplasms/pathology ; Vitamin D/pharmacology ; Vitamin D/therapeutic use ; Melanoma, Cutaneous Malignant
Chemical Substances	Receptors, Calcitriol ; Vitamin D (1406-16-2)
Language	English
Publishing date	2022-05-11
Publishing country	England
Document type	Journal Article ; Review
ZDB-ID	2409570-9
ISSN	1755-148X ; 1600-0749 ; 0893-5785 ; 1755-1471
ISSN (online)	1755-148X ; 1600-0749
ISSN	0893-5785 ; 1755-1471
DOI	10.1111/pcmr.13040
Database	MEDical Literature Analysis and Retrieval System OnLINE

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Zs.A 2444: Show issues

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Article ; Online: Is Pre-Injury Socioeconomic Status Associated With Outcomes in Patients With Traumatic Brain Injury? A Systematic Review.

Venturini, Sara / Still, Megan E H / Hutchinson, Peter J / Gwinnutt, James M

Journal of neurotrauma

2024 Volume 41, Issue 7-8, Page(s) 789–806

Abstract: While socioeconomic status (SES) is associated with a variety of health outcomes, the literature on the association between SES and traumatic brain injury (TBI) outcomes has not been formally summarized. This study aims to review existing literature to ... ...

Abstract	While socioeconomic status (SES) is associated with a variety of health outcomes, the literature on the association between SES and traumatic brain injury (TBI) outcomes has not been formally summarized. This study aims to review existing literature to ascertain whether patients with low SES pre-injury have worse clinical outcomes after TBI compared with those with high SES, in high-income countries. A systematic search was conducted using the MEDLINE, Embase, and PsychINFO databases. Observational studies addressing the association between SES and TBI outcomes (mortality, functional, cognitive, and vocational outcomes) were included (published from 2000, written in English). Both pediatric and adult TBI groups were included. Thirty-two studies met the inclusion criteria. Measures of SES varied across studies. Mortality was assessed in seven studies; five reported an association between low SES and higher mortality. Five of eight studies showed an association between low SES and worse functional outcomes; results for cognitive (
MeSH term(s)	Adult ; Humans ; Child ; Brain Injuries, Traumatic/complications ; Social Class ; Hospitalization
Language	English
Publishing date	2024-02-16
Publishing country	United States
Document type	Systematic Review ; Journal Article ; Review
ZDB-ID	645092-1
ISSN	1557-9042 ; 0897-7151
ISSN (online)	1557-9042
ISSN	0897-7151
DOI	10.1089/neu.2022.0341
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Zs.A 2016: Show issues

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Article ; Online: Early neuro-rehabilitation in traumatic brain injury: the need for an African perspective.

Buh, Franklin Chu / Hutchinson, Peter J A / Anwar, Fahim

BMC medicine

2023 Volume 21, Issue 1, Page(s) 290

Abstract: Background: Traumatic brain injury (TBI) is a global public health challenge, affecting about 69 million individuals annually and being one of the leading causes of mortality. It has adverse consequences in terms of cognitive and physical functioning, ... ...

Abstract	Background: Traumatic brain injury (TBI) is a global public health challenge, affecting about 69 million individuals annually and being one of the leading causes of mortality. It has adverse consequences in terms of cognitive and physical functioning, which makes rehabilitation interventions an integral part of its management. Early neuro-rehabilitation guidelines for traumatic brain injury have not yet been developed and implemented in most of Africa especially Sub-Saharan Africa. BODY: We aimed with this Opinion to propose a collective reflection on the development and implementation of early neuro-rehabilitation guidelines as an integral part of the care in traumatic brain injury. The different aspects to be considered for reflection have been highlighted: Traumatic brain injury severity to be considered in early neuro-rehabilitation; who should be assessed and receive early neurorehabilitation, barriers to be considered for early neurorehabilitation; what early neurorehabilitation to be considered; the different phases involved in rehabilitation after mild, moderate, and severe TBI; and lastly, what perspective for the creation of neurorehabilitation teams. In conclusion, neuro-rehabilitation should start at the time of admission and should continue from the intensive care unit through the community for the moderate-to-severe traumatic brain injury population. However, mild TBI should also be considered for long-term follow-up in the community due to the fact that some mild traumatic brain injury patients might develop chronic cognitive problems or fatigue with time. Conclusion: Neurorehabilitation should start at the time of admission and continue from the intensive care unit through the community for the moderate-to-severe traumatic brain injury population. There is a need to develop, agree on, and implement guidelines on early neuro-rehabilitation interventions for patients with moderate to severe traumatic brain injury in the African region, where disparities in care are common reality.
MeSH term(s)	Humans ; Brain Injuries, Traumatic ; Brain Injuries ; Neurological Rehabilitation ; Hospitalization ; Neurology
Language	English
Publishing date	2023-08-04
Publishing country	England
Document type	Journal Article
ZDB-ID	2131669-7
ISSN	1741-7015 ; 1741-7015
ISSN (online)	1741-7015
ISSN	1741-7015
DOI	10.1186/s12916-023-03009-z
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Article ; Online: Craniectomy or Craniotomy for Acute Subdural Hematoma. Reply.

Hutchinson, Peter J / Devi, Bhagavatula I / Kolias, Angelos G

The New England journal of medicine

2023 Volume 389, Issue 9, Page(s) 863–864

MeSH term(s)	Humans ; Hematoma, Subdural, Acute/diagnostic imaging ; Hematoma, Subdural, Acute/surgery ; Decompressive Craniectomy
Language	English
Publishing date	2023-08-31
Publishing country	United States
Document type	Letter ; Comment
ZDB-ID	207154-x
ISSN	1533-4406 ; 0028-4793
ISSN (online)	1533-4406
ISSN	0028-4793
DOI	10.1056/NEJMc2308428
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Article ; Online: Customised pre-operative cranioplasty to achieve maximal surgical resection of tumours with osseous involvement-a case series.

Jain, Swati / Helmy, Adel / Santarius, Thomas / Owen, Nicola / Grieve, Kirsty / Hutchinson, Peter / Timofeev, Ivan

Acta neurochirurgica

2024 Volume 166, Issue 1, Page(s) 152

Abstract: Purpose: Surgical resection with bony margins would be the treatment of choice for tumours with osseous involvement such as meningiomas and metastasis. By developing and designing pre-operative customised 3D modelled implants, the patient can undergo ... ...

Abstract	Purpose: Surgical resection with bony margins would be the treatment of choice for tumours with osseous involvement such as meningiomas and metastasis. By developing and designing pre-operative customised 3D modelled implants, the patient can undergo resection of meningioma and repair of bone defect in the same operation. We present a generalisable method for designing pre-operative cranioplasty in patients to repair the bone defect after the resection of tumours. Materials and methods: We included six patients who presented with a tumour that was associated with overlying bone involvement. They underwent placement of customised cranioplasty in the same setting. A customised implant using a pre-operative imaging was designed with a 2-cm margin to allow for any intra-operative requirements for extending the craniectomy. Results: Six patients were evaluated in this case series. Four patients had meningiomas, 1 patient had metastatic breast cancer on final histology, and 1 patient was found to have an intra-osseous arteriovenous malformation. Craniectomy based on margins provided by a cutting guide was fashioned. After tumour removal and haemostasis, the cranioplasty was then placed. All patients recovered well post-operatively with satisfactory cosmetic results. No wound infection was reported in our series. Conclusion: Our series demonstrate the feasibility of utilising pre-designed cranioplasty for meningiomas and other tumours with osseous involvement. Following strict infection protocols, minimal intra-operative handling/modification of the implant, and close follow-up has resulted in good cosmetic outcomes with no implant-related infections.
MeSH term(s)	Humans ; Plastic Surgery Procedures ; Meningioma/surgery ; Decompressive Craniectomy/methods ; Skull/surgery ; Postoperative Complications/surgery ; Meningeal Neoplasms/surgery ; Retrospective Studies
Language	English
Publishing date	2024-03-27
Publishing country	Austria
Document type	Journal Article
ZDB-ID	80010-7
ISSN	0942-0940 ; 0001-6268
ISSN (online)	0942-0940
ISSN	0001-6268
DOI	10.1007/s00701-024-06055-5
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Article ; Online: Blood biomarkers for traumatic brain injury: A narrative review of current evidence.

Hossain, Iftakher / Marklund, Niklas / Czeiter, Endre / Hutchinson, Peter / Buki, Andras

Brain & spine

2023 Volume 4, Page(s) 102735

Abstract: Introduction: A blood-based biomarker (BBBM) test could help to better stratify patients with traumatic brain injury (TBI), reduce unnecessary imaging, to detect and treat secondary insults, predict outcomes, and monitor treatment effects and quality of ...

Abstract	Introduction: A blood-based biomarker (BBBM) test could help to better stratify patients with traumatic brain injury (TBI), reduce unnecessary imaging, to detect and treat secondary insults, predict outcomes, and monitor treatment effects and quality of care. Research question: What evidence is available for clinical applications of BBBMs in TBI and how to advance this field? Material and methods: This narrative review discusses the potential clinical applications of core BBBMs in TBI. A literature search in PubMed, Scopus, and ISI Web of Knowledge focused on articles in English with the words "traumatic brain injury" together with the words "blood biomarkers", "diagnostics", "outcome prediction", "extracranial injury" and "assay method" alone-, or in combination. Results: Glial fibrillary acidic protein (GFAP) combined with Ubiquitin C-terminal hydrolase-L1(UCH-L1) has received FDA clearance to aid computed tomography (CT)-detection of brain lesions in mild (m) TBI. Application of S100B led to reduction of head CT scans. GFAP may also predict magnetic resonance imaging (MRI) abnormalities in CT-negative cases of TBI. Further, UCH-L1, S100B, Neurofilament light (NF-L), and total tau showed value for predicting mortality or unfavourable outcome. Nevertheless, biomarkers have less role in outcome prediction in mTBI. S100B could serve as a tool in the multimodality monitoring of patients in the neurointensive care unit. Discussion and conclusion: Largescale systematic studies are required to explore the kinetics of BBBMs and their use in multiple clinical groups. Assay development/cross validation should advance the generalizability of those results which implicated GFAP, S100B and NF-L as most promising biomarkers in the diagnostics of TBI.
Language	English
Publishing date	2023-12-14
Publishing country	Netherlands
Document type	Journal Article ; Review
ISSN	2772-5294
ISSN (online)	2772-5294
DOI	10.1016/j.bas.2023.102735
Database	MEDical Literature Analysis and Retrieval System OnLINE

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Article ; Online: A proposed novel traumatic brain injury classification system - an overview and inter-rater reliability validation on behalf of the Society of British Neurological Surgeons.

Wilson, Mark H / Ashworth, Emily / Hutchinson, Peter J

British journal of neurosurgery

2022 Volume 36, Issue 5, Page(s) 633–638

Abstract: Introduction: The measurement of traumatic brain injury (TBI) 'severity' has traditionally been based on the earliest Glasgow Coma Score (GCS) recorded, however, the underlying parenchymal pathology is highly heterogonous. This heterogeneity renders ... ...

Abstract	Introduction: The measurement of traumatic brain injury (TBI) 'severity' has traditionally been based on the earliest Glasgow Coma Score (GCS) recorded, however, the underlying parenchymal pathology is highly heterogonous. This heterogeneity renders prediction of outcome on an individual patient level inaccurate and makes comparison between patients both in clinical practice and research difficult. The complexity of this heterogeneity has resulted in generic all encompassing 'traumatic brain injury protocols'. Early management and studies of neuro-protectants are often done irrespective of TBI type, yet it may well be that a specific treatment may be beneficial in a subset of TBI pathologies. Methods: A simple CT-based classification system rating the recognised types of blunt TBI (extradural, subdural, subarachnoid haemorrhage, contusions/intracerebral haematoma and diffuse axonal injury) as mild (1), moderate (2) or severe (3) is proposed. Hypoxic brain injury, a common secondary injury following TBI, is also included. Scores can be combined to reflect concomitant types of TBI and predominant location of injury is also recorded. To assess interrater reliability, 50 patient CT images were assessed by 5 independent clinicians of varying experience. Interrater reliability was calculated using overall agreement through Cronbach's alpha including confidence intervals for intra-class coefficients. Results: Interrater reliability scores showed strong agreement for same score and same injury for TBIs with blood on CT and Cronbach's alpha co-efficient (range 0.87-0.93) demonstrated excellent correlation between raters. Cronbach's alpha was not affected when individual raters were removed. Conclusions: The proposed simple CT classification system has good inter-rater reliability and hence potentially could enable better individual prognostication and targeted treatments to be compared while also accounting for multiple intracranial injury types. Further studies are proposed and underway.
MeSH term(s)	Humans ; Glasgow Coma Scale ; Neurosurgeons ; Reproducibility of Results ; Brain Injuries, Traumatic/diagnostic imaging ; Brain Injuries, Traumatic/surgery ; Brain Injuries, Traumatic/complications ; Hematoma, Epidural, Cranial/complications
Language	English
Publishing date	2022-06-30
Publishing country	England
Document type	Journal Article
ZDB-ID	639029-8
ISSN	1360-046X ; 0268-8697
ISSN (online)	1360-046X
ISSN	0268-8697
DOI	10.1080/02688697.2022.2090509
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Zs.A 2210: Show issues

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Article ; Online: Intensive care for neurotrauma patients during the COVID-19 pandemic.

Hutchinson, Peter J A / Kolias, Angelos G

British journal of neurosurgery

2022 Volume 36, Issue 5, Page(s) 545

MeSH term(s)	Humans ; COVID-19 ; Pandemics/prevention & control ; SARS-CoV-2 ; Critical Care
Language	English
Publishing date	2022-02-17
Publishing country	England
Document type	Editorial
ZDB-ID	639029-8
ISSN	1360-046X ; 0268-8697
ISSN (online)	1360-046X
ISSN	0268-8697
DOI	10.1080/02688697.2022.2040949
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