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  1. Book ; Online ; E-Book: Traumatic brain injury

    Whitfield, Peter C. / Welbourne, Jessie / Thomas, Elfyn / Summers, Fiona / Whyte, Maggie / Hutchinson, Peter J.

    a multidisciplinary approach

    2020  

    Author's details edited by Peter C. Whitfield, Jessie Welbourne, Elfyn Thomas, Fiona Summers, Maggie Whyte, Peter J. Hutchinson
    Keywords Brain / Wounds and injuries
    Language English
    Size 1 Online-Ressource (xii, 400 Seiten), Illustrationen, Diagramme
    Edition Second edition
    Publisher Cambridge University Press
    Publishing place Cambridge
    Publishing country Great Britain
    Document type Book ; Online ; E-Book
    Remark Zugriff für angemeldete ZB MED-Nutzerinnen und -Nutzer
    HBZ-ID HT020451461
    ISBN 978-1-108-35524-7 ; 9781108430869 ; 1-108-35524-2 ; 1108430864
    Database ZB MED Catalogue: Medicine, Health, Nutrition, Environment, Agriculture

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  2. Book: Oxford textbook of neurological surgery

    Kirollos, Ramez / Helmy, Adel / Thomson, Simon / Hutchinson, Peter J. A.

    (Oxford textbooks in surgery)

    2019  

    Title variant Textbook of neurological surgery ; Neurological surgery
    Author's details [edited by] Ramez W. Kirollos, Adel Helmy, Simon Thomson, Peter Hutchinson
    Series title Oxford textbooks in surgery
    Keywords Nervous system/Surgery
    Subject code 617.48
    Language English
    Size xxvi, 1148 Seiten, Illustrationen, 28 cm
    Publisher Oxford University Press
    Publishing place Oxford
    Publishing country Great Britain
    Document type Book
    HBZ-ID HT020240143
    ISBN 978-0-19-874670-6 ; 9780192519535 ; 0-19-874670-9 ; 0192519530
    Database Catalogue ZB MED Medicine, Health

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    Shelf markLoan statusLocation
    2019 A 1452 available for loan (reading room) Lesesaal EG

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  3. Article ; Online: Is Pre-Injury Socioeconomic Status Associated With Outcomes in Patients With Traumatic Brain Injury? A Systematic Review.

    Venturini, Sara / Still, Megan E H / Hutchinson, Peter J / Gwinnutt, James M

    Journal of neurotrauma

    2024  Volume 41, Issue 7-8, Page(s) 789–806

    Abstract: While socioeconomic status (SES) is associated with a variety of health outcomes, the literature on the association between SES and traumatic brain injury (TBI) outcomes has not been formally summarized. This study aims to review existing literature to ... ...

    Abstract While socioeconomic status (SES) is associated with a variety of health outcomes, the literature on the association between SES and traumatic brain injury (TBI) outcomes has not been formally summarized. This study aims to review existing literature to ascertain whether patients with low SES pre-injury have worse clinical outcomes after TBI compared with those with high SES, in high-income countries. A systematic search was conducted using the MEDLINE, Embase, and PsychINFO databases. Observational studies addressing the association between SES and TBI outcomes (mortality, functional, cognitive, and vocational outcomes) were included (published from 2000, written in English). Both pediatric and adult TBI groups were included. Thirty-two studies met the inclusion criteria. Measures of SES varied across studies. Mortality was assessed in seven studies; five reported an association between low SES and higher mortality. Five of eight studies showed an association between low SES and worse functional outcomes; results for cognitive (
    MeSH term(s) Adult ; Humans ; Child ; Brain Injuries, Traumatic/complications ; Social Class ; Hospitalization
    Language English
    Publishing date 2024-02-16
    Publishing country United States
    Document type Systematic Review ; Journal Article ; Review
    ZDB-ID 645092-1
    ISSN 1557-9042 ; 0897-7151
    ISSN (online) 1557-9042
    ISSN 0897-7151
    DOI 10.1089/neu.2022.0341
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  4. Article ; Online: Early neuro-rehabilitation in traumatic brain injury: the need for an African perspective.

    Buh, Franklin Chu / Hutchinson, Peter J A / Anwar, Fahim

    BMC medicine

    2023  Volume 21, Issue 1, Page(s) 290

    Abstract: Background: Traumatic brain injury (TBI) is a global public health challenge, affecting about 69 million individuals annually and being one of the leading causes of mortality. It has adverse consequences in terms of cognitive and physical functioning, ... ...

    Abstract Background: Traumatic brain injury (TBI) is a global public health challenge, affecting about 69 million individuals annually and being one of the leading causes of mortality. It has adverse consequences in terms of cognitive and physical functioning, which makes rehabilitation interventions an integral part of its management. Early neuro-rehabilitation guidelines for traumatic brain injury have not yet been developed and implemented in most of Africa especially Sub-Saharan Africa. BODY: We aimed with this Opinion to propose a collective reflection on the development and implementation of early neuro-rehabilitation guidelines as an integral part of the care in traumatic brain injury. The different aspects to be considered for reflection have been highlighted: Traumatic brain injury severity to be considered in early neuro-rehabilitation; who should be assessed and receive early neurorehabilitation, barriers to be considered for early neurorehabilitation; what early neurorehabilitation to be considered; the different phases involved in rehabilitation after mild, moderate, and severe TBI; and lastly, what perspective for the creation of neurorehabilitation teams. In conclusion, neuro-rehabilitation should start at the time of admission and should continue from the intensive care unit through the community for the moderate-to-severe traumatic brain injury population. However, mild TBI should also be considered for long-term follow-up in the community due to the fact that some mild traumatic brain injury patients might develop chronic cognitive problems or fatigue with time.
    Conclusion: Neurorehabilitation should start at the time of admission and continue from the intensive care unit through the community for the moderate-to-severe traumatic brain injury population. There is a need to develop, agree on, and implement guidelines on early neuro-rehabilitation interventions for patients with moderate to severe traumatic brain injury in the African region, where disparities in care are common reality.
    MeSH term(s) Humans ; Brain Injuries, Traumatic ; Brain Injuries ; Neurological Rehabilitation ; Hospitalization ; Neurology
    Language English
    Publishing date 2023-08-04
    Publishing country England
    Document type Journal Article
    ZDB-ID 2131669-7
    ISSN 1741-7015 ; 1741-7015
    ISSN (online) 1741-7015
    ISSN 1741-7015
    DOI 10.1186/s12916-023-03009-z
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  5. Article ; Online: Craniectomy or Craniotomy for Acute Subdural Hematoma. Reply.

    Hutchinson, Peter J / Devi, Bhagavatula I / Kolias, Angelos G

    The New England journal of medicine

    2023  Volume 389, Issue 9, Page(s) 863–864

    MeSH term(s) Humans ; Hematoma, Subdural, Acute/diagnostic imaging ; Hematoma, Subdural, Acute/surgery ; Decompressive Craniectomy
    Language English
    Publishing date 2023-08-31
    Publishing country United States
    Document type Letter ; Comment
    ZDB-ID 207154-x
    ISSN 1533-4406 ; 0028-4793
    ISSN (online) 1533-4406
    ISSN 0028-4793
    DOI 10.1056/NEJMc2308428
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    In stock of ZB MED Cologne/Königswinter

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  6. Article ; Online: A proposed novel traumatic brain injury classification system - an overview and inter-rater reliability validation on behalf of the Society of British Neurological Surgeons.

    Wilson, Mark H / Ashworth, Emily / Hutchinson, Peter J

    British journal of neurosurgery

    2022  Volume 36, Issue 5, Page(s) 633–638

    Abstract: Introduction: The measurement of traumatic brain injury (TBI) 'severity' has traditionally been based on the earliest Glasgow Coma Score (GCS) recorded, however, the underlying parenchymal pathology is highly heterogonous. This heterogeneity renders ... ...

    Abstract Introduction: The measurement of traumatic brain injury (TBI) 'severity' has traditionally been based on the earliest Glasgow Coma Score (GCS) recorded, however, the underlying parenchymal pathology is highly heterogonous. This heterogeneity renders prediction of outcome on an individual patient level inaccurate and makes comparison between patients both in clinical practice and research difficult. The complexity of this heterogeneity has resulted in generic all encompassing 'traumatic brain injury protocols'. Early management and studies of neuro-protectants are often done irrespective of TBI type, yet it may well be that a specific treatment may be beneficial in a subset of TBI pathologies.
    Methods: A simple CT-based classification system rating the recognised types of blunt TBI (extradural, subdural, subarachnoid haemorrhage, contusions/intracerebral haematoma and diffuse axonal injury) as mild (1), moderate (2) or severe (3) is proposed. Hypoxic brain injury, a common secondary injury following TBI, is also included. Scores can be combined to reflect concomitant types of TBI and predominant location of injury is also recorded. To assess interrater reliability, 50 patient CT images were assessed by 5 independent clinicians of varying experience. Interrater reliability was calculated using overall agreement through Cronbach's alpha including confidence intervals for intra-class coefficients.
    Results: Interrater reliability scores showed strong agreement for same score and same injury for TBIs with blood on CT and Cronbach's alpha co-efficient (range 0.87-0.93) demonstrated excellent correlation between raters. Cronbach's alpha was not affected when individual raters were removed.
    Conclusions: The proposed simple CT classification system has good inter-rater reliability and hence potentially could enable better individual prognostication and targeted treatments to be compared while also accounting for multiple intracranial injury types. Further studies are proposed and underway.
    MeSH term(s) Humans ; Glasgow Coma Scale ; Neurosurgeons ; Reproducibility of Results ; Brain Injuries, Traumatic/diagnostic imaging ; Brain Injuries, Traumatic/surgery ; Brain Injuries, Traumatic/complications ; Hematoma, Epidural, Cranial/complications
    Language English
    Publishing date 2022-06-30
    Publishing country England
    Document type Journal Article
    ZDB-ID 639029-8
    ISSN 1360-046X ; 0268-8697
    ISSN (online) 1360-046X
    ISSN 0268-8697
    DOI 10.1080/02688697.2022.2090509
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  7. Article ; Online: Intensive care for neurotrauma patients during the COVID-19 pandemic.

    Hutchinson, Peter J A / Kolias, Angelos G

    British journal of neurosurgery

    2022  Volume 36, Issue 5, Page(s) 545

    MeSH term(s) Humans ; COVID-19 ; Pandemics/prevention & control ; SARS-CoV-2 ; Critical Care
    Language English
    Publishing date 2022-02-17
    Publishing country England
    Document type Editorial
    ZDB-ID 639029-8
    ISSN 1360-046X ; 0268-8697
    ISSN (online) 1360-046X
    ISSN 0268-8697
    DOI 10.1080/02688697.2022.2040949
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    In stock of ZB MED Cologne/Königswinter

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  8. Article: Research Evaluating Sports ConcUssion Events-Rapid Assessment of Concussion and Evidence for Return (RESCUE-RACER): a two-year longitudinal observational study of concussion in motorsport.

    Deakin, Naomi D / Suckling, John / Hutchinson, Peter J

    BMJ open sport & exercise medicine

    2021  Volume 7, Issue 1, Page(s) e000879

    Abstract: Introduction: Concussion is a clinical diagnosis, based on self-reported patient symptoms supported by clinical assessments across many domains including postural control, ocular/vestibular dysfunction, and neurocognition. Concussion incidence may be ... ...

    Abstract Introduction: Concussion is a clinical diagnosis, based on self-reported patient symptoms supported by clinical assessments across many domains including postural control, ocular/vestibular dysfunction, and neurocognition. Concussion incidence may be rising in motorsport which, combined with unresolved challenges to accurate diagnosis and lack of guidance on the optimal return-to-race timeframe, creates a difficult environment for healthcare practitioners.
    Methods and analysis: Research Evaluating Sports ConcUssion Events-Rapid Assessment of Concussion and Evidence for Return (RESCUE-RACER) evaluates motorsports competitors at baseline (Competitor Assessment at Baseline; Ocular, Neuroscientific (CArBON) study) and post-injury (Concussion Assessment and Return to motorSport (CARS) study), including longitudinal data. CArBON collects pre-injury neuroscientific data; CARS repeats the CArBON battery sequentially during recovery for competitors involved in a potentially concussive event. As its primary outcome, RESCUE-RACER will develop the evidence base for an accurate trackside diagnostic tool. Baseline objective clinical scoring (Sport Concussion Assessment Tool-5th edition (SCAT5)) and neurocognitive data (Immediate Post-Concussion Assessment and Cognitive Testing (ImPACT)) will be assessed for specificity to motorsport and relationship to existing examinations. Changes to SCAT5 and ocular, vestibular, and reaction time function (Dx 100) will be estimated by the reliability change index as a practical tool for trackside diagnosis. Neuropsychological (Cambridge Neuropsychological Test Automated Battery (CANTAB)) assessments, brain MRI (7 Tesla) and salivary biomarkers will be compared with the new tool to establish utility in diagnosing and monitoring concussive injuries.
    Ethics and dissemination: Ethical approval was received from East of England-Cambridge Central Research Ethics Committee (18/EE/0141). Participants will be notified of study outcomes via publications (to administrators) and summary reports (funder communications). Ideally, all publications will be open access.
    Trial registration number: February 2019 nationally (Central Portfolio Management System 38259) and internationally (ClinicalTrials.gov NCT03844282).
    Language English
    Publishing date 2021-01-13
    Publishing country England
    Document type Journal Article
    ZDB-ID 2817580-3
    ISSN 2055-7647
    ISSN 2055-7647
    DOI 10.1136/bmjsem-2020-000879
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  9. Article ; Online: Quantification of pyruvate in-vitro using mid-infrared spectroscopy: Developing a system for microdialysis monitoring in traumatic brain injury patients.

    Zimphango, Chisomo / Alimagham, Farah C / Hutter, Tanya / Hutchinson, Peter J / Carpenter, Keri L H

    Brain & spine

    2023  Volume 3, Page(s) 102686

    Abstract: Introduction: Complex metabolic disruption is a major aspect of the pathophysiology of traumatic brain injury (TBI). Pyruvate is an intermediate in glucose metabolism and considered one of the most clinically informative metabolites during neurocritical ...

    Abstract Introduction: Complex metabolic disruption is a major aspect of the pathophysiology of traumatic brain injury (TBI). Pyruvate is an intermediate in glucose metabolism and considered one of the most clinically informative metabolites during neurocritical care of TBI patients, especially in deducing the lactate/pyruvate ratio (LPR) - a widely-used metric for probing the brain's metabolic redox state. LPR is conventionally measured offline on a bedside analyzer, on hourly accumulations of brain microdialysate. However, there is increasing interest within the field to quantify microdialysate pyruvate and LPR continuously in near-real-time within its pathophysiological range. We have previously measured pure standard pyruvate in-vitro using mid-infrared transmission, employing a commercially available external cavity-quantum cascade laser (EC-QCL) and a microfluidic flow cell and reported a limit of detection (LOD) of 0.1 mM.
    Research question: The present study was to test whether the current commercially available state-of-the-art mid-infrared transmission system, can detect pyruvate levels lower than previously reported.
    Materials and methods: We measured pyruvate in perfusion fluid on the mid-infrared transmission system also equipped with an EC-QCL and microfluidic flow cells, tested at three pathlengths.
    Results: We characterised the system to extract its relevant figures-of-merit and report the LOD of 0.07 mM.
    Discussion and conclusion: The reported LOD of 0.07 mM represents a clinically recognised threshold and is the lowest value reported in the field for a sensor that can be coupled to microdialysis. While work is ongoing for a definitive evaluation of the system to measuring pyruvate, these preliminary results set a good benchmark and reference against which future developments can be examined.
    Language English
    Publishing date 2023-10-11
    Publishing country Netherlands
    Document type Journal Article
    ISSN 2772-5294
    ISSN (online) 2772-5294
    DOI 10.1016/j.bas.2023.102686
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  10. Article ; Online: The EyeVu Consortium for global neurosurgery.

    Smith, Brandon G / Rambabu, Lekaashree / Kolias, Angelos G / Hutchinson, Peter J / Bashford, Tom

    The Lancet. Neurology

    2023  Volume 22, Issue 10, Page(s) 883–884

    MeSH term(s) Humans ; Neurosurgery ; Neurosurgical Procedures
    Language English
    Publishing date 2023-09-20
    Publishing country England
    Document type Letter ; Research Support, Non-U.S. Gov't
    ZDB-ID 2081241-3
    ISSN 1474-4465 ; 1474-4422
    ISSN (online) 1474-4465
    ISSN 1474-4422
    DOI 10.1016/S1474-4422(23)00328-9
    Database MEDical Literature Analysis and Retrieval System OnLINE

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