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  1. Article ; Online: A Therapeutic Conundrum: Should a Physician Serve Simultaneously as Caregiver and Researcher?

    Hutchinson, Raymond J

    The American journal of bioethics : AJOB

    2020  Volume 20, Issue 10, Page(s) 96–98

    MeSH term(s) Caregivers ; Conflict of Interest ; Humans ; Physician-Patient Relations ; Physicians ; Research Personnel
    Language English
    Publishing date 2020-09-18
    Publishing country United States
    Document type Journal Article ; Comment
    ZDB-ID 2060433-6
    ISSN 1536-0075 ; 1526-5161
    ISSN (online) 1536-0075
    ISSN 1526-5161
    DOI 10.1080/15265161.2020.1806378
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  2. Article ; Online: Scleral ectasia stabilization following intra-arterial chemotherapy in an eye with recurrent retinoblastoma.

    Pan, Warren / Chaudhary, Neeraj / Sedig, Laura / Edmonds, Amy / Hutchinson, Raymond / Demirci, Hakan

    American journal of ophthalmology case reports

    2023  Volume 32, Page(s) 101941

    Abstract: Purpose: To report a case of recurrent retinoblastoma following transpupillary thermotherapy (TTT) with development of scleral ectasia, as well as their successful treatment with intra-arterial chemotherapy.: Observations: A 15-month-old girl with ... ...

    Abstract Purpose: To report a case of recurrent retinoblastoma following transpupillary thermotherapy (TTT) with development of scleral ectasia, as well as their successful treatment with intra-arterial chemotherapy.
    Observations: A 15-month-old girl with bilateral retinoblastoma presented with recurrent retinoblastoma and associated scleral ectasia with concern for extraocular extension after receiving multiple round of systemic chemotherapy and TTT. Given her negative systemic evaluation, decision was made to pursue intra-arterial chemotherapy. After completion of six rounds of 3-agent intra-arterial chemotherapy, the recurrent retinoblastoma had completely regressed and the scleral ectasia had improved and fibrosed.
    Conclusions and importance: The sclera is classically viewed as hyperthermy-resistant to TTT. Here, we describe scleral ectasia due to aggressive TTT with recurrence of the retinoblastoma. Our treatment with intra-arterial chemotherapy not only caused complete regression of the recurrent retinoblastoma, but it also contributed to the stabilization and improvement of the weakened scleral.
    Language English
    Publishing date 2023-10-13
    Publishing country United States
    Document type Case Reports
    ISSN 2451-9936
    ISSN (online) 2451-9936
    DOI 10.1016/j.ajoc.2023.101941
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  3. Article ; Online: Redefining Informed Consent as Part of Consent Training in Pediatrics-Reply.

    Tait, Alan R / Hutchinson, Raymond J

    JAMA pediatrics

    2018  Volume 172, Issue 7, Page(s) 702–703

    MeSH term(s) Child ; Humans ; Informed Consent ; Parents ; Pediatrics
    Language English
    Publishing date 2018-07-18
    Publishing country United States
    Document type Letter ; Comment
    ZDB-ID 2701223-2
    ISSN 2168-6211 ; 2168-6203
    ISSN (online) 2168-6211
    ISSN 2168-6203
    DOI 10.1001/jamapediatrics.2018.0925
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  4. Article ; Online: Informed Consent Training in Pediatrics-Are We Doing Enough?

    Tait, Alan R / Hutchinson, Raymond J

    JAMA pediatrics

    2018  Volume 172, Issue 3, Page(s) 211–212

    MeSH term(s) Child ; Clinical Competence ; Curriculum ; Education, Medical/standards ; Ethics, Medical/education ; Humans ; Informed Consent ; Parents/education ; Pediatrics/education ; Physician's Role ; Professional-Family Relations ; Societies, Medical ; United States
    Language English
    Publishing date 2018-01-22
    Publishing country United States
    Document type Journal Article
    ZDB-ID 2701223-2
    ISSN 2168-6211 ; 2168-6203
    ISSN (online) 2168-6211
    ISSN 2168-6203
    DOI 10.1001/jamapediatrics.2017.4088
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  5. Article: Primary care for adult survivors of childhood cancer: medical needs and required strategies.

    Hutchinson, Raymond J

    Adolescent medicine: state of the art reviews

    2013  Volume 24, Issue 3, Page(s) 643–658

    Abstract: Provision of targeted care to the adult survivors of childhood cancer is a current need, likely to only increase in the future. The definition of the long-term effects of cancer, the magnitude of the treatment delivered, and the care required as a ... ...

    Abstract Provision of targeted care to the adult survivors of childhood cancer is a current need, likely to only increase in the future. The definition of the long-term effects of cancer, the magnitude of the treatment delivered, and the care required as a consequence fall within the domain of pediatric oncologists. The actual delivery of care including targeted follow-up and interventions, require the combined dedication and talents of pediatric oncologists working with adolescent medicine, internal medicine, medical-pediatrics, and family practice physicians to contribute by making this domain of care a priority and a collaborative goal, developing both an educational approach to and a structured care delivery model for the special needs of adult survivors of childhood cancer.
    MeSH term(s) Chronic Disease/epidemiology ; Comorbidity ; Humans ; Needs Assessment ; Neoplasms/physiopathology ; Neoplasms/psychology ; Neoplasms/therapy ; Primary Health Care/organization & administration ; Risk Factors ; Survivors/psychology ; Time Factors ; Transition to Adult Care/organization & administration ; Young Adult
    Language English
    Publishing date 2013-12
    Publishing country United States
    Document type Journal Article ; Review
    ZDB-ID 2398471-5
    ISSN 1934-4287
    ISSN 1934-4287
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  6. Article ; Online: Hematology: Improved outcome for young adult patients with ALL.

    Hutchinson, Raymond

    Nature reviews. Clinical oncology

    2010  Volume 7, Issue 3, Page(s) 132–134

    MeSH term(s) Adult ; Antineoplastic Combined Chemotherapy Protocols/therapeutic use ; Humans ; Leukemia-Lymphoma, Adult T-Cell/drug therapy ; Treatment Outcome ; Young Adult
    Language English
    Publishing date 2010-03-01
    Publishing country England
    Document type News
    ZDB-ID 2491410-1
    ISSN 1759-4782 ; 1759-4774
    ISSN (online) 1759-4782
    ISSN 1759-4774
    DOI 10.1038/nrclinonc.2010.14
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  7. Article ; Online: Comparing internal versus external carotid artery branch delivery of intraarterial chemotherapy for the treatment of retinoblastoma.

    Chang, Emily / Zhou, Yunshu / Musch, David / Edmonds, Amy / Sedig, Laura / Hutchinson, Raymond / Chaudhary, Neeraj / Demirci, Hakan

    Graefe's archive for clinical and experimental ophthalmology = Albrecht von Graefes Archiv fur klinische und experimentelle Ophthalmologie

    2023  Volume 261, Issue 9, Page(s) 2679–2687

    Abstract: Purpose: The goal of this study was to compare the efficacy of intraarterial chemotherapy (IAC) for retinoblastoma delivered via the ophthalmic artery (OA) division of the internal carotid artery (ICA) versus alternative branches of the external carotid ...

    Abstract Purpose: The goal of this study was to compare the efficacy of intraarterial chemotherapy (IAC) for retinoblastoma delivered via the ophthalmic artery (OA) division of the internal carotid artery (ICA) versus alternative branches of the external carotid artery (ECA).
    Methods: We performed a retrospective chart review of patients receiving IAC for retinoblastoma at a single institution. Subjects were divided into three groups: those that received IAC solely through the OA branch of the ICA, those that initially received IAC through the OA branch of the ICA but were later switched to the ECA, and those that only received IAC through the ECA. The main outcomes compared included globe salvage rate and reduction in tumor thickness and size.
    Results: A total of 30 eyes from 26 patients were included. A total of 91 (58%) sessions of IAC were performed through the OA division of the ICA and 65 (42%) were performed through branches of the ECA. Eleven eyes (37%) solely received IAC through the OA branch of the ICA, 16 eyes (53%) were converted to ECA treatment, and 3 eyes solely received IAC through branches of the ECA. Statistical analysis did not show any significant difference in globe salvage rate or reduction in tumor thickness and size.
    Conclusion: The use of alternative approaches for IAC when the OA branch of the ICA catheterization is not feasible allows for safe continued delivery of highly effective IAC, leading to similar outcomes in terms of globe salvage and reduction in tumor size.
    MeSH term(s) Humans ; Retinoblastoma/diagnosis ; Retinoblastoma/drug therapy ; Retinal Neoplasms/diagnosis ; Retinal Neoplasms/drug therapy ; Carotid Artery, External ; Retrospective Studies ; Infusions, Intra-Arterial ; Treatment Outcome ; Carotid Artery, Internal
    Language English
    Publishing date 2023-04-03
    Publishing country Germany
    Document type Journal Article
    ZDB-ID 8435-9
    ISSN 1435-702X ; 0721-832X
    ISSN (online) 1435-702X
    ISSN 0721-832X
    DOI 10.1007/s00417-023-06037-w
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  8. Article ; Online: Ethical Perspectives of Chinese and United States Physicians at Initiation of a Research Collaborative.

    Grondin, Christopher / Cong, Yali / Keshavarzi, Nahid / Geisser, Michael E / Kolars, Joseph C / Hutchinson, Raymond J

    Accountability in research

    2021  Volume 29, Issue 5, Page(s) 294–308

    Abstract: Variances in perceived standards regarding research integrity appear to exist between China and the U.S. An established joint institute for translational and clinical research between one Chinese and one U.S. health system provides a valuable venue in ... ...

    Abstract Variances in perceived standards regarding research integrity appear to exist between China and the U.S. An established joint institute for translational and clinical research between one Chinese and one U.S. health system provides a valuable venue in which to evaluate these perceptions better. We therefore undertook a survey of 209 physicians at the two institutions in 2013-14. The vast majority of physicians from both institutions understood the necessity of obtaining informed consent from research participants, the need to provide a description of the risks of participation, and the voluntary nature of research participation. However, there were differences in responses between the two sites in willingness to report plagiarism (U.S. 95.65% vs. Chinese 40.21%; p < .0001) and data falsification (U.S. 100% vs. Chinese 81.25%; p < .0001) and in willingness to attend biomedical industry-funded promotional events (U.S. 11.0% vs. Chinese 74.0%; p < .0001). When planning to conduct collaborative clinical research across cultures, particularly when uncertainty regarding the similarity of research cultures exists, exploration of cultural and ethical norms in research may be informative regarding educational needs and the risks of research and academic misconduct.
    MeSH term(s) Biomedical Research ; China ; Humans ; Physicians ; Plagiarism ; Scientific Misconduct ; United States
    Language English
    Publishing date 2021-05-04
    Publishing country United States
    Document type Journal Article ; Research Support, N.I.H., Intramural
    ZDB-ID 2069334-5
    ISSN 1545-5815 ; 0898-9621
    ISSN (online) 1545-5815
    ISSN 0898-9621
    DOI 10.1080/08989621.2021.1920014
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  9. Article ; Online: Perspectives from a Predominantly African American Community about Biobank Research and a Biobank Consent Form.

    Sedig, Laura K / De Loney, E Hill / Bailey, Sarah B / Spector-Bagdady, Kayte / Ghita, Bianca / Krienke, Lydia Koh / Hutchinson, Raymond

    Ethics & human research

    2022  Volume 44, Issue 4, Page(s) 26–33

    Abstract: Minority populations have been underrepresented in clinical trials, as well as in research biobanks that are created to conduct research with participants' biospecimens and related medical and research data. Biobank research raises issues about informed ... ...

    Abstract Minority populations have been underrepresented in clinical trials, as well as in research biobanks that are created to conduct research with participants' biospecimens and related medical and research data. Biobank research raises issues about informed consent and privacy and the confidentiality of participants' personal data. Our study involved three focus groups of 10 adults each that were conducted in a medically underserved, predominantly African American community to elucidate questions and concerns regarding an institutional biobank. Transcripts from the discussion were qualitatively analyzed. Three main themes that arose from the focus groups included the importance of trust, the importance of the community in research, and suggestions to improve trust. The concerns identified in this study provide a starting point for future research to help research institutions become more trustworthy to the communities they serve.
    MeSH term(s) Adult ; Black or African American ; Biological Specimen Banks ; Consent Forms ; Humans ; Informed Consent ; Privacy
    Language English
    Publishing date 2022-05-06
    Publishing country United States
    Document type Journal Article
    ISSN 2578-2363
    ISSN (online) 2578-2363
    DOI 10.1002/eahr.500134
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  10. Article ; Online: Adolescents and Young Adults With Sickle Cell Disease: Nociplastic Pain and Pain Catastrophizing as Predictors of Pain Interference and Opioid Consumption.

    Kuisell, Clare / Ploutz-Snyder, Robert / Williams, David A / Voepel-Lewis, Terri / Hutchinson, Raymond J / Dudding, Katherine M / Bridges, Celia / Lavoie Smith, Ellen M

    The Clinical journal of pain

    2023  Volume 39, Issue 7, Page(s) 326–333

    Abstract: Objectives: Some patients with sickle cell disease (SCD) have features of nociplastic pain. While research suggests that many patients with nociplastic pain consume more opioids due to opioid nonresponsiveness, little is known about the impact of ... ...

    Abstract Objectives: Some patients with sickle cell disease (SCD) have features of nociplastic pain. While research suggests that many patients with nociplastic pain consume more opioids due to opioid nonresponsiveness, little is known about the impact of nociplastic pain and pain catastrophizing on opioid consumption and pain interference among adolescents and young adults (AYA) with SCD. The purpose of this study was to (1) characterize nociplastic pain and pain catastrophizing among AYA with SCD, and (2) determine whether these characterizations are associated with subsequent opioid consumption and pain interference 1 month after characterization.
    Methods: Participants completed surveys characterizing nociplastic pain and catastrophizing at a routine clinic visit (baseline). Thereafter, participants received weekly text messages that included pain interference and opioid consumption surveys. Multipredictor 2-part models were used to evaluate the predictive relationships between baseline characterizations and subsequent pain interference, and opioid consumption.
    Results: Forty-eight AYA aged 14 to 35 completed baseline measures. Twenty-five percent of participants had scores suggestive of nociplastic pain. Greater nociplastic pain features significantly increased the odds of consuming opioids (odds ratio=1.2) and having greater interference from pain (odds ratio=1.46). Regression analyses found that greater baseline nociplastic pain characteristics were significantly associated with opioid consumption (β=0.13) and pain interference (β=0.061); whereas higher pain catastrophizing scores predicted less opioid consumption (β=-0.03) and less pain interference (β=-0.0007).
    Discussion: In this sample of AYA with SCD, features of nociplastic pain predicted higher subsequent opioid consumption and pain interference. Being aware of nociplastic pain features in patients with SCD may better guide individualized pain management.
    MeSH term(s) Humans ; Adolescent ; Young Adult ; Analgesics, Opioid/therapeutic use ; Pain Measurement ; Pain/etiology ; Pain/complications ; Anemia, Sickle Cell/complications ; Catastrophization
    Chemical Substances Analgesics, Opioid
    Language English
    Publishing date 2023-07-01
    Publishing country United States
    Document type Journal Article
    ZDB-ID 632582-8
    ISSN 1536-5409 ; 0749-8047
    ISSN (online) 1536-5409
    ISSN 0749-8047
    DOI 10.1097/AJP.0000000000001119
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