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Article ; Online: The ClC-1 chloride channel inhibitor NMD670 improves skeletal muscle function in rat models and patients with myasthenia gravis.

Skov, Martin / Ruijs, Titia Q / Grønnebæk, Thomas S / Skals, Marianne / Riisager, Anders / Winther, Jeppe Blichfeldt / Dybdahl, Kamilla Løhde Tordrup / Findsen, Anders / Morgen, Jeanette J / Huus, Nete / Broch-Lips, Martin / Nielsen, Ole B / de Cuba, Catherine M K E / Heuberger, Jules A A C / de Kam, Marieke L / Tannemaat, Martijn / Verschuuren, Jan J G M / Knutsen, Lars J S / Kelly, Nicholas M /
Jensen, Klaus G / Arnold, William D / Burghes, Arthur H / Olesen, Claus / Bold, Jane / Petersen, Thomas K / Quiroz, Jorge A / Hutchison, John / Chin, Eva R / Groeneveld, Geert J / Pedersen, Thomas H

Science translational medicine

2024  Volume 16, Issue 739, Page(s) eadk9109

Abstract: Myasthenia gravis (MG) is a neuromuscular disease that results in compromised transmission of electrical signals at the neuromuscular junction (NMJ) from motor neurons to skeletal muscle fibers. As a result, patients with MG have reduced skeletal muscle ... ...

Abstract Myasthenia gravis (MG) is a neuromuscular disease that results in compromised transmission of electrical signals at the neuromuscular junction (NMJ) from motor neurons to skeletal muscle fibers. As a result, patients with MG have reduced skeletal muscle function and present with symptoms of severe muscle weakness and fatigue. ClC-1 is a skeletal muscle specific chloride (Cl
MeSH term(s) Humans ; Rats ; Animals ; Chlorides/therapeutic use ; Myasthenia Gravis/drug therapy ; Muscle, Skeletal/physiology ; Neuromuscular Junction ; Chloride Channels
Chemical Substances Chlorides ; Chloride Channels
Language English
Publishing date 2024-03-20
Publishing country United States
Document type Randomized Controlled Trial ; Clinical Trial, Phase I ; Journal Article
ZDB-ID 2518854-9
ISSN 1946-6242 ; 1946-6234
ISSN (online) 1946-6242
ISSN 1946-6234
DOI 10.1126/scitranslmed.adk9109
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Zs.A 6941: Show issues Location:
Je nach Verfügbarkeit (siehe Angabe bei Bestand)
bis Jg. 2021: Bestellungen von Artikeln über das Online-Bestellformular
ab Jg. 2022: Lesesaal (EG)

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