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  1. Article ; Online: How does the external context affect an implementation processes? A qualitative study investigating the impact of macro-level variables on the implementation of goal-oriented primary care.

    Huybrechts, Ine / Declercq, Anja / Verté, Emily / Raeymaeckers, Peter / Anthierens, Sibyl

    Implementation science : IS

    2024  Volume 19, Issue 1, Page(s) 32

    Abstract: Background: Although the importance of context in implementation science is not disputed, knowledge about the actual impact of external context variables on implementation processes remains rather fragmented. Current frameworks, models, and studies ... ...

    Abstract Background: Although the importance of context in implementation science is not disputed, knowledge about the actual impact of external context variables on implementation processes remains rather fragmented. Current frameworks, models, and studies merely describe macro-level barriers and facilitators, without acknowledging their dynamic character and how they impact and steer implementation. Including organizational theories in implementation frameworks could be a way of tackling this problem. In this study, we therefore investigate how organizational theories can contribute to our understanding of the ways in which external context variables shape implementation processes. We use the implementation process of goal-oriented primary care in Belgium as a case.
    Methods: A qualitative study using in-depth semi-structured interviews was conducted with actors from a variety of primary care organizations. Data was collected and analyzed with an iterative approach. We assessed the potential of four organizational theories to enrich our understanding of the impact of external context variables on implementation processes. The organizational theories assessed are as follows: institutional theory, resource dependency theory, network theory, and contingency theory. Data analysis was based on a combination of inductive and deductive thematic analysis techniques using NVivo 12.
    Results: Institutional theory helps to understand mechanisms that steer and facilitate the implementation of goal-oriented care through regulatory and policy measures. For example, the Flemish government issued policy for facilitating more integrated, person-centered care by means of newly created institutions, incentives, expectations, and other regulatory factors. The three other organizational theories describe both counteracting or reinforcing mechanisms. The financial system hampers interprofessional collaboration, which is key for GOC. Networks between primary care providers and health and/or social care organizations on the one hand facilitate GOC, while on the other hand, technology to support interprofessional collaboration is lacking. Contingent variables such as the aging population and increasing workload and complexity within primary care create circumstances in which GOC is presented as a possible answer.
    Conclusions: Insights and propositions that derive from organizational theories can be utilized to expand our knowledge on how external context variables affect implementation processes. These insights can be combined with or integrated into existing implementation frameworks and models to increase their explanatory power.
    MeSH term(s) Humans ; Aged ; Motivation ; Goals ; Qualitative Research ; Technology ; Patient-Centered Care
    Language English
    Publishing date 2024-04-16
    Publishing country England
    Document type Journal Article
    ZDB-ID 2225822-X
    ISSN 1748-5908 ; 1748-5908
    ISSN (online) 1748-5908
    ISSN 1748-5908
    DOI 10.1186/s13012-024-01360-0
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  2. Article ; Online: Psychosocial stress and cancer risk: a narrative review.

    Mohan, Ananyaa / Huybrechts, Inge / Michels, Nathalie

    European journal of cancer prevention : the official journal of the European Cancer Prevention Organisation (ECP)

    2022  Volume 31, Issue 6, Page(s) 585–599

    Abstract: Background: It is unclear which psychological factors (stressors, emotional correlates, and psychophysiological markers) induce cancer risk. This currently limits the potential for prevention strategies.: Purpose: The aim of this review is to bring ... ...

    Abstract Background: It is unclear which psychological factors (stressors, emotional correlates, and psychophysiological markers) induce cancer risk. This currently limits the potential for prevention strategies.
    Purpose: The aim of this review is to bring forth evidence of stress as a determinant of cancer risk from a public health perspective, written for a broad public of practitioners and scientists.
    Methods: Based on a semisystematic literature search, the impact of different aspects/types of stress and the potential physiological and behavioral pathways are summarized, while highlighting further research, public health and clinical implications.
    Results: Between 2007 and 2020, 65 case-control or cohort studies have been identified. Apart from overall cancer ( N = 24), 12 cancer types have been associated with psychological stress with most for breast ( N = 21), colorectal ( N = 11) and lung/prostate/pancreas cancer ( N = 8 each). Although the evidence regarding the mechanisms is still scarce, cancer development in relation to stress might be due to interacting and combined effects of different stress(or) types, but such interaction has not really been tested yet. The path from stress towards cancer incidence consists of a biological pathway with endocrinology and immunology as well as stress-induced behavioral pathways, including smoking, alcoholism, sleep disruption, an unhealthy diet, and low physical activity together with the related phenomenon of obesity.
    Conclusion: Not only the stress but also the stress-induced lifestyle should be targeted for cancer prevention and treatment. Future research should include a more diverse spectrum of cancer types (not only hormonal related like breast cancer) and of stress measures while also considering behavioral covariates.
    MeSH term(s) Breast Neoplasms/psychology ; Diet ; Exercise ; Humans ; Life Style ; Male ; Stress, Psychological/complications ; Stress, Psychological/epidemiology
    Language English
    Publishing date 2022-03-29
    Publishing country England
    Document type Journal Article ; Review ; Research Support, Non-U.S. Gov't
    ZDB-ID 1137033-6
    ISSN 1473-5709 ; 0959-8278
    ISSN (online) 1473-5709
    ISSN 0959-8278
    DOI 10.1097/CEJ.0000000000000752
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  3. Article ; Online: Role of dietary intake of specific polyunsaturated fatty acids (PUFAs) on colorectal cancer risk in Iran.

    Seyyedsalehi, Monireh Sadat / Hadji, Maryam / Collatuzzo, Giulia / Rashidian, Hamideh / Sasanfar, Bahareh / Huybrechts, Inge / Chajes, Veronique / Boffetta, Paolo / Zendehdel, Kazem

    Lipids

    2024  Volume 59, Issue 2, Page(s) 41–53

    Abstract: High-fat diets have been associated with colorectal cancer (CRC) risk, and the role of polyunsaturated fatty acids (PUFAs) has been reported to vary based on the length of PUFAs. We explored the association between dietary omega-6 and omega-3 PUFAs ... ...

    Abstract High-fat diets have been associated with colorectal cancer (CRC) risk, and the role of polyunsaturated fatty acids (PUFAs) has been reported to vary based on the length of PUFAs. We explored the association between dietary omega-6 and omega-3 PUFAs intake and CRC. We analyzed 865 CRC patients and 3206 controls from a case-control study of Iran (IROPICAN study). We used multivariate logistic regression models to calculate the odds ratios (OR) and 95% confidence intervals (CI) for the association between PUFAs intake and CRC risk. Our results showed that gamma-linolenic acid (18:3 n-6, GLA), arachidonic acid (20:4n-6, ARA), a-linolenic acid (Cis-18:3n-3, ALA), eicosapentaenoic acid (20:5n-3, EPA), docosahexaenoic acid (22:6n-3, DHA) consumption was not associated with the risk of CRC. However, the OR of linoleic acid (18: 2n-6, LA) intake was 1.47 (95% CI 1.01-2.14, p = 0.04) for proximal colon and that of docosapentaenoic acid (22:5n-3, DPA) intake was 1.33 (95% CI 1.05-1.69, p = 0.01) for rectum. This study indicates a high level of LA is associated with an increased risk of proximal colon cancer, and DPA intake was positively associated with rectum cancer risk. Furthermore, our study noted a high intake of n-6 (from vegetable oils) compared to n-3 PUFAs (from fish and seafood) in this population. Public awareness and government support is needed to increase fish and seafood production and consumption in Iran.
    MeSH term(s) Animals ; Humans ; Iran/epidemiology ; Case-Control Studies ; Fatty Acids, Unsaturated ; Fatty Acids, Omega-3 ; Eicosapentaenoic Acid ; Docosahexaenoic Acids ; Linoleic Acid ; gamma-Linolenic Acid ; Eating ; Colorectal Neoplasms/epidemiology ; Fatty Acids
    Chemical Substances Fatty Acids, Unsaturated ; Fatty Acids, Omega-3 ; Eicosapentaenoic Acid (AAN7QOV9EA) ; Docosahexaenoic Acids (25167-62-8) ; Linoleic Acid (9KJL21T0QJ) ; gamma-Linolenic Acid (78YC2MAX4O) ; Fatty Acids
    Language English
    Publishing date 2024-01-29
    Publishing country United States
    Document type Journal Article
    ZDB-ID 241539-2
    ISSN 1558-9307 ; 0024-4201
    ISSN (online) 1558-9307
    ISSN 0024-4201
    DOI 10.1002/lipd.12386
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  4. Article ; Online: Will the implementation process for goal-oriented primary care succeed? A qualitative study investigating five perceived attributes of goal-oriented care.

    Huybrechts, Ine / Declercq, Anja / Verté, Emily / Boeckxstaens, Pauline / Raeymaeckers, Peter / Anthierens, Sibyl

    Social science & medicine (1982)

    2023  Volume 331, Page(s) 116048

    Abstract: Throughout the western world, goal oriented care (GOC) is increasingly promoted as a strategy towards more person-centered, integrated care. The implementation of goal-oriented care not only takes place at the micro-level with individual primary care ... ...

    Abstract Throughout the western world, goal oriented care (GOC) is increasingly promoted as a strategy towards more person-centered, integrated care. The implementation of goal-oriented care not only takes place at the micro-level with individual primary care providers (PCPs) changing their approach, but also requires meso- and macro-level investment. In this study, we zoom in on experiences and actions of various meso- and macro-level actors that are actively engaged with implementing GOC, both within their organization or at the policy level. In-depth interviews were conducted with n = 23 actors from a variety of different organizations (governmental institutions, provider organizations, patient organizations, health/social care organizations, primary care zones/care councils, etc.), using a semi- interview guide inspired by realist interviewing. Three main drivers for implementation were identified: recognition, commitment and coordination. On top of that, results were interpreted through Rogers' Diffusion of Innovations (Dol) theory in which five attributes are discussed that contribute to or hinder implementation success. Our findings can help define actions to support and facilitate the implementation process of an innovation such as GOC.
    MeSH term(s) Humans ; Goals ; Patient-Centered Care/methods ; Qualitative Research ; Motivation
    Language English
    Publishing date 2023-06-29
    Publishing country England
    Document type Journal Article ; Research Support, Non-U.S. Gov't
    ZDB-ID 4766-1
    ISSN 1873-5347 ; 0037-7856 ; 0277-9536
    ISSN (online) 1873-5347
    ISSN 0037-7856 ; 0277-9536
    DOI 10.1016/j.socscimed.2023.116048
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  5. Article: Lung separation in adult thoracic anesthesia.

    Huybrechts, Isabelle / Tuna, Turgay / Szegedi, Laszlo L

    Saudi journal of anaesthesia

    2021  Volume 15, Issue 3, Page(s) 272–279

    Abstract: Thoracic anesthesia is mainly the world of OLV during anesthesia. The indications for OLV, classified as absolute or relative are more representative of the new concepts in OLV: It includes either the separation or the isolation of the lungs. Modern DLTs ...

    Abstract Thoracic anesthesia is mainly the world of OLV during anesthesia. The indications for OLV, classified as absolute or relative are more representative of the new concepts in OLV: It includes either the separation or the isolation of the lungs. Modern DLTs are most widely employed worldwide to perform OLV including the concept of one lung separation. Endobronchial blockers are a valid alternative to DLTs, and they are mandatory in the education of lung separation and in case of predicted difficult airways as they are the safest approach (with an awake intubation with an SLT through a FOB). Every general anesthesiologist should know how to insert a left-sided DLT, but he/she should also have in his technical luggage and toolbox, basic knowledge and minimal expertise with BBs, this option being considered a suitable alternative, particularly in emergency situation where the patient is already intubated and/or in case of difficult airways. One should keep in mind that extubation or re-intubation after DLT might be difficult too, and additional intubation tools are necessary for the safety conditions.
    Language English
    Publishing date 2021-06-19
    Publishing country India
    Document type Journal Article ; Review
    ZDB-ID 2562174-9
    ISSN 0975-3125 ; 1658-354X
    ISSN (online) 0975-3125
    ISSN 1658-354X
    DOI 10.4103/sja.sja_78_21
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  6. Article ; Online: Identifying the effective behaviour change techniques in nutrition and physical activity interventions for the treatment of overweight/obesity in post-treatment breast cancer survivors: a systematic review.

    Perperidi, Maria / Saliari, Dimitra / Christakis, Christos / Huybrechts, Inge / Saloustros, Emmanouil / Theodorakis, Yannis / Androutsos, Odysseas

    Cancer causes & control : CCC

    2023  Volume 34, Issue 8, Page(s) 683–703

    Abstract: Purpose: Updated evidence for the treatment of obesity in cancer survivors includes behavioural lifestyle interventions underpinning at least one theoretical framework. The aim of this systematic review was to assess the effectiveness of theory-based ... ...

    Abstract Purpose: Updated evidence for the treatment of obesity in cancer survivors includes behavioural lifestyle interventions underpinning at least one theoretical framework. The aim of this systematic review was to assess the effectiveness of theory-based lifestyle interventions for the treatment of overweight/obesity in breast cancer survivors and to report effective behavioural change techniques (BCTs) and components used in these interventions.
    Methods: Four databases were searched for RCTs published between database inception and July 2022. The search strategy included MeSH terms and text words, using the PICO-framework to guide the eligibility criteria. The PRISMA guidelines were followed. Risk-of-bias, TIDier Checklist for interventions' content, and the extent of behaviour change theories and techniques application were assessed. To evaluate the effectiveness of interventions, trials were categorised as "very," "quite," or "non" promising according to their potential to reduce body weight, and BCTs promise ratios were calculated to assess the potential of BCTs within interventions to decrease body weight.
    Results: Eleven RCTs met the inclusion criteria. Seven trials were classified as "very", three as "quite" and one study was "non" promising. Studies' size, design, and intervention strategies varied greatly, but the weight-loss goal in all studies was ≥ 5% of the initial body weight through a 500-1000 kcal/day energy deficit and a gradually increased exercise goal of ≥ 30 min/day. Social Cognitive Theory was the most commonly used theory (n = 10). BCTs ranged from 10 to 23 in the interventions, but all trials included behaviour goal setting, self-monitoring, instructions on the behaviour, and credible source. The risk-of-bias was "moderate" in eight studies and "high" in three.
    Conclusion: The present systematic review identified the components of theory-based nutrition and physical activity behaviour change interventions that may be beneficial for the treatment of overweight/obesity in breast cancer survivors. The strategies mentioned, in addition to reported behavioural models and BCTs, should be considered when developing weight-loss interventions for breast cancer survivors.
    MeSH term(s) Humans ; Female ; Overweight/therapy ; Breast Neoplasms/therapy ; Cancer Survivors ; Obesity/therapy ; Exercise ; Behavior Therapy/methods ; Body Weight
    Language English
    Publishing date 2023-05-06
    Publishing country Netherlands
    Document type Systematic Review ; Journal Article ; Review
    ZDB-ID 1064022-8
    ISSN 1573-7225 ; 0957-5243
    ISSN (online) 1573-7225
    ISSN 0957-5243
    DOI 10.1007/s10552-023-01707-w
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  7. Article ; Online: Climate change and cancer: converging policies.

    Vineis, Paolo / Huybrechts, Inge / Millett, Christopher / Weiderpass, Elisabete

    Molecular oncology

    2020  Volume 15, Issue 3, Page(s) 764–769

    Abstract: Intervening on risk factors for noncommunicable diseases (including cancer) in industrialized countries could achieve a reduction of between 30% and 40% of premature deaths. In the meantime, the need to intervene against the threat of climate change has ... ...

    Abstract Intervening on risk factors for noncommunicable diseases (including cancer) in industrialized countries could achieve a reduction of between 30% and 40% of premature deaths. In the meantime, the need to intervene against the threat of climate change has become obvious. CO
    MeSH term(s) Animals ; Carcinogens, Environmental/toxicity ; Climate Change ; Fast Foods/adverse effects ; Food Quality ; Humans ; Neoplasms/etiology ; Neoplasms/prevention & control ; Risk Factors
    Chemical Substances Carcinogens, Environmental
    Language English
    Publishing date 2020-09-22
    Publishing country United States
    Document type Journal Article ; Review
    ZDB-ID 2415106-3
    ISSN 1878-0261 ; 1574-7891
    ISSN (online) 1878-0261
    ISSN 1574-7891
    DOI 10.1002/1878-0261.12781
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  8. Article ; Online: The Building Blocks of Implementation Frameworks and Models in Primary Care: A Narrative Review.

    Huybrechts, Ine / Declercq, Anja / Verté, Emily / Raeymaeckers, Peter / Anthierens, Sibyl

    Frontiers in public health

    2021  Volume 9, Page(s) 675171

    Abstract: Background: ...

    Abstract Background:
    MeSH term(s) Evidence-Based Practice ; Implementation Science ; Primary Health Care
    Language English
    Publishing date 2021-08-03
    Publishing country Switzerland
    Document type Journal Article ; Research Support, Non-U.S. Gov't ; Review
    ZDB-ID 2711781-9
    ISSN 2296-2565 ; 2296-2565
    ISSN (online) 2296-2565
    ISSN 2296-2565
    DOI 10.3389/fpubh.2021.675171
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  9. Article ; Online: Human microbiome and metabolic health: An overview of systematic reviews.

    Michels, Nathalie / Zouiouich, Semi / Vanderbauwhede, Bert / Vanacker, Judith / Indave Ruiz, B Iciar / Huybrechts, Inge

    Obesity reviews : an official journal of the International Association for the Study of Obesity

    2022  Volume 23, Issue 4, Page(s) e13409

    Abstract: To summarize the microbiome's role in metabolic disorders (insulin resistance, hyperglycemia, type 2 diabetes, obesity, hyperlipidemia, hypertension, nonalcoholic fatty liver disease [NAFLD], and metabolic syndrome), systematic reviews on observational ... ...

    Abstract To summarize the microbiome's role in metabolic disorders (insulin resistance, hyperglycemia, type 2 diabetes, obesity, hyperlipidemia, hypertension, nonalcoholic fatty liver disease [NAFLD], and metabolic syndrome), systematic reviews on observational or interventional studies (prebiotics/probiotics/synbiotics/transplant) were searched in MEDLINE and Embase until September 2020. The 87 selected systematic reviews included 57 meta-analyses. Methodological quality (AMSTAR2) was moderate in 62%, 12% low, and 26% critically low. Observational studies on obesity (10 reviews) reported less gut bacterial diversity with higher Fusobacterium, Lactobacillus reuteri, Bacteroides fragilis, and Staphylococcus aureus, whereas lower Methanobrevibacter, Lactobacillus plantarum, Akkermansia muciniphila, and Bifidobacterium animalis compared with nonobese. For diabetes (n = 1), the same was found for Fusobacterium and A. muciniphila, whereas higher Ruminococcus and lower Faecalibacterium, Roseburia, Bacteroides vulgatus, and several Bifidobacterium spp. For NAFLD (n = 2), lower Firmicutes, Rikenellaceae, Ruminococcaceae, whereas higher Escherichia and Lactobacillus were detected. Discriminating bacteria overlapped between metabolic disorders, those with high abundance being often involved in inflammation, whereas those with low abundance being used as probiotics. Meta-analyses (n = 54) on interventional studies reported 522 associations: 54% was statistically significant with intermediate effect size and moderate between-study heterogeneity. Meta-evidence was highest for probiotics and lowest for fecal transplant. Future avenues include better methodological quality/comparability, testing functional differences, new intervention strategies, and considerating other body habitats and kingdoms.
    MeSH term(s) Diabetes Mellitus, Type 2 ; Gastrointestinal Microbiome ; Humans ; Microbiota ; Non-alcoholic Fatty Liver Disease ; Obesity ; Probiotics ; Systematic Reviews as Topic
    Language English
    Publishing date 2022-01-03
    Publishing country England
    Document type Journal Article ; Research Support, Non-U.S. Gov't ; Review
    ZDB-ID 2147980-X
    ISSN 1467-789X ; 1467-7881
    ISSN (online) 1467-789X
    ISSN 1467-7881
    DOI 10.1111/obr.13409
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  10. Article: Assessment of Fruit and Vegetables Intake with Biomarkers in Children and Adolescents and Their Level of Validation: A Systematic Review.

    Yuan, Li / Muli, Samuel / Huybrechts, Inge / Nöthlings, Ute / Ahrens, Wolfgang / Scalbert, Augustin / Floegel, Anna

    Metabolites

    2022  Volume 12, Issue 2

    Abstract: Fruit and vegetables (FV) are part of a healthy diet and should be frequently consumed already at a young age. However, intake of FV is difficult to assess in children and adolescents due to various misreporting aspects. Thus, measurement of dietary ... ...

    Abstract Fruit and vegetables (FV) are part of a healthy diet and should be frequently consumed already at a young age. However, intake of FV is difficult to assess in children and adolescents due to various misreporting aspects. Thus, measurement of dietary biomarkers may be a promising alternative to assess FV intake more objectively at young age. To date, dietary biomarkers have been primarily studied in adults, and research focused on their usefulness in children is scarce. However, clinical studies have revealed important differences between children and adults, most importantly in their gut microbiome composition, resulting in differences in postprandial metabolism, as well as in food choices and meal compositions that may influence individual biomarker levels. Therefore, the present review aimed to identify biomarkers of FV intake (BFVI) currently available in children and adolescents and to explore whether there are any differences in the BFVI profile above between children and adolescents and adults. In addition, the current level of validation of BFVI in children and adolescents was examined. In total, 28 studies were eligible for this review, and 18 compounds were identified as potential biomarkers for FV intake in children and adolescents. Carotenoid concentration in skin was a valuable biomarker for total FV intake for both children and adult populations. Common BFVI in blood in adults (e.g., carotenoids and vitamin C) showed inconsistent results in children and adolescents. Biomarkers particularly useful in children included urinary hippuric acid as a biomarker of polyphenolic compound intake originating from FV and the combination of
    Language English
    Publishing date 2022-01-28
    Publishing country Switzerland
    Document type Journal Article ; Review
    ZDB-ID 2662251-8
    ISSN 2218-1989
    ISSN 2218-1989
    DOI 10.3390/metabo12020126
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