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Article: Shewanella putrefaciens: A Critically Emerging Pathogen of Ventilator-Associated Pneumonia.

Huynh, Kevin / Abdeen, Yazan

2023 Volume 15, Issue 5, Page(s) e38858

Abstract: Shewanella ... ...

Abstract	Shewanella putrefaciens
Language	English
Publishing date	2023-05-10
Publishing country	United States
Document type	Case Reports
ZDB-ID	2747273-5
ISSN	2168-8184
ISSN	2168-8184
DOI	10.7759/cureus.38858
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Article ; Online: Dendrite intercalation between epidermal cells tunes nociceptor sensitivity to mechanical stimuli in Drosophila larvae.

Luedke, Kory P / Yoshino, Jiro / Yin, Chang / Jiang, Nan / Huang, Jessica M / Huynh, Kevin / Parrish, Jay Z

PLoS genetics

2024 Volume 20, Issue 4, Page(s) e1011237

Abstract: An animal's skin provides a first point of contact with the sensory environment, including noxious cues that elicit protective behavioral responses. Nociceptive somatosensory neurons densely innervate and intimately interact with epidermal cells to ... ...

Abstract	An animal's skin provides a first point of contact with the sensory environment, including noxious cues that elicit protective behavioral responses. Nociceptive somatosensory neurons densely innervate and intimately interact with epidermal cells to receive these cues, however the mechanisms by which epidermal interactions shape processing of noxious inputs is still poorly understood. Here, we identify a role for dendrite intercalation between epidermal cells in tuning sensitivity of Drosophila larvae to noxious mechanical stimuli. In wild-type larvae, dendrites of nociceptive class IV da neurons intercalate between epidermal cells at apodemes, which function as body wall muscle attachment sites, but not at other sites in the epidermis. From a genetic screen we identified miR-14 as a regulator of dendrite positioning in the epidermis: miR-14 is expressed broadly in the epidermis but not in apodemes, and miR-14 inactivation leads to excessive apical dendrite intercalation between epidermal cells. We found that miR-14 regulates expression and distribution of the epidermal Innexins ogre and Inx2 and that these epidermal gap junction proteins restrict epidermal dendrite intercalation. Finally, we found that altering the extent of epidermal dendrite intercalation had corresponding effects on nociception: increasing epidermal intercalation sensitized larvae to noxious mechanical inputs and increased mechanically evoked calcium responses in nociceptive neurons, whereas reducing epidermal dendrite intercalation had the opposite effects. Altogether, these studies identify epidermal dendrite intercalation as a mechanism for mechanical coupling of nociceptive neurons to the epidermis, with nociceptive sensitivity tuned by the extent of intercalation.
Language	English
Publishing date	2024-04-25
Publishing country	United States
Document type	Journal Article
ZDB-ID	2186725-2
ISSN	1553-7404 ; 1553-7390
ISSN (online)	1553-7404
ISSN	1553-7390
DOI	10.1371/journal.pgen.1011237
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Article ; Online: Comprehensive Targeted Lipidomic Profiling for Research and Clinical Applications.

Huynh, Kevin / Duong, Thy / Mellett, Natalie A / Cinel, Michelle / Giles, Corey / Meikle, Peter J

Methods in molecular biology (Clifton, N.J.)

2023 Volume 2628, Page(s) 489–504

Abstract: Mass spectrometry remains one of the gold standard approaches in examining the lipidome in biological samples. Recently, advancements in chromatography and mass spectrometry approaches have enabled broad coverage of the lipidome. However, many ... ...

Abstract	Mass spectrometry remains one of the gold standard approaches in examining the lipidome in biological samples. Recently, advancements in chromatography and mass spectrometry approaches have enabled broad coverage of the lipidome. However, many limitations still exist, and lipidomic analysis often requires a fine balance between coverage of the lipidome, structural detail, and sample throughput. For biomedical and clinical research using human samples, the diversity and natural variation between different individuals necessitate larger sample numbers to identify significant associations with clinical outcomes and account for potential confounding factors. Here we describe a targeted lipidomics workflow that enables reproducible profiling of thousands of plasma samples in a systematic manner, while maintaining good structural detail and high coverage of the lipidome.
MeSH term(s)	Humans ; Lipidomics ; Lipids/chemistry ; Mass Spectrometry/methods ; Workflow
Chemical Substances	Lipids
Language	English
Publishing date	2023-02-13
Publishing country	United States
Document type	Journal Article
ISSN	1940-6029
ISSN (online)	1940-6029
DOI	10.1007/978-1-0716-2978-9_29
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Article ; Online: Clinical lipidomics: realizing the potential of lipid profiling.

Meikle, Thomas G / Huynh, Kevin / Giles, Corey / Meikle, Peter J

Journal of lipid research

2021 Volume 62, Page(s) 100127

Abstract: Dysregulation of lipid metabolism plays a major role in the etiology and sequelae of inflammatory disorders, cardiometabolic and neurological diseases, and several forms of cancer. Recent advances in lipidomic methodology allow comprehensive lipidomic ... ...

Abstract	Dysregulation of lipid metabolism plays a major role in the etiology and sequelae of inflammatory disorders, cardiometabolic and neurological diseases, and several forms of cancer. Recent advances in lipidomic methodology allow comprehensive lipidomic profiling of clinically relevant biological samples, enabling researchers to associate lipid species and metabolic pathways with disease onset and progression. The resulting data serve not only to advance our fundamental knowledge of the underlying disease process but also to develop risk assessment models to assist in the diagnosis and management of disease. Currently, clinical applications of in-depth lipidomic profiling are largely limited to the use of research-based protocols in the analysis of population or clinical sample sets. However, we foresee the development of purpose-built clinical platforms designed for continuous operation and clinical integration-assisting health care providers with disease risk assessment, diagnosis, and monitoring. Herein, we review the current state of clinical lipidomics, including the use of research-based techniques and platforms in the analysis of clinical samples as well as assays already available to clinicians. With a primary focus on MS-based strategies, we examine instrumentation, analysis techniques, statistical models, prospective design of clinical platforms, and the possible pathways toward implementation of clinical lipidomics.
MeSH term(s)	Humans ; Lipid Metabolism ; Lipidomics ; Lipids/chemistry ; Neoplasms/metabolism
Chemical Substances	Lipids
Language	English
Publishing date	2021-09-25
Publishing country	United States
Document type	Journal Article ; Review
ZDB-ID	80154-9
ISSN	1539-7262 ; 0022-2275
ISSN (online)	1539-7262
ISSN	0022-2275
DOI	10.1016/j.jlr.2021.100127
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Article: Dendrite intercalation between epidermal cells tunes nociceptor sensitivity to mechanical stimuli in

Luedke, Kory P / Yoshino, Jiro / Yin, Chang / Jiang, Nan / Huang, Jessica M / Huynh, Kevin / Parrish, Jay Z

bioRxiv : the preprint server for biology

2023

Abstract	An animal's skin provides a first point of contact with the sensory environment, including noxious cues that elicit protective behavioral responses. Nociceptive somatosensory neurons densely innervate and intimately interact with epidermal cells to receive these cues, however the mechanisms by which epidermal interactions shape processing of noxious inputs is still poorly understood. Here, we identify a role for dendrite intercalation between epidermal cells in tuning sensitivity of
Language	English
Publishing date	2023-09-15
Publishing country	United States
Document type	Preprint
DOI	10.1101/2023.09.14.557275
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Article ; Online: Role of femoral head material on readmission and mortality rates following elective primary total hip arthroplasty in Medicare patients.

Sicat, Chelsea Sue / Singh, Vivek / Muthusamy, Nishanth / Spano, Paul J / Nezwek, Trevor A / Huynh, Kevin / Schwarzkopf, Ran

Archives of orthopaedic and trauma surgery

2023 Volume 144, Issue 1, Page(s) 459–464

Abstract: Introduction: The role of different femoral head materials for total hip arthroplasty (THA) has been widely studied in the context of wear properties and corrosion. Cobalt chrome (CoCr) femoral heads are commonly used as a standard of comparison to ... ...

Abstract	Introduction: The role of different femoral head materials for total hip arthroplasty (THA) has been widely studied in the context of wear properties and corrosion. Cobalt chrome (CoCr) femoral heads are commonly used as a standard of comparison to other materials such as ceramic and oxidized zirconium (OxZi). This study aims to evaluate the impact of femoral head material on clinical outcomes in elective primary THA patients. Methods: Retrospective analysis of THA patients within the Medicare claims database between October 2017 and September 2020 using diagnosis-related group codes was conducted. Information collected included sex, age, Charlson Comorbidity Index, and femoral head type. Patients with CoCr femoral heads were compared against patients with either OxZi or ceramic femoral heads using 1:1 propensity score matching. Z-testing and Chi-square analysis were used to determine between-group significance. Results: In total, 112,960 elective THA patients were included, with 56,480 in OxZi or ceramic and 56,480 in CoCr. Readmission rates were lower in patients that received OxZi or ceramic femoral heads at 30-day (p < 0.0001), 60-day (p < 0.0001), and 90-day postoperatively (p < 0.0001) compared to CoCr. Mortality rates were also lower in patients that received OxZi or ceramic femoral heads at 30-day (p = 0.004), 60-day (p = 0.018), and 90-day postoperatively (p = 0.009) compared to CoCr. Conclusion: CoCr femoral heads had higher rates of readmissions and mortality compared to OxZi or ceramic. Further analysis of bearing surface combinations and sub-group analyses to determine significance between-group differences is needed. Level iii evidence: Retrospective analysis.
MeSH term(s)	Humans ; Aged ; United States/epidemiology ; Arthroplasty, Replacement, Hip ; Hip Prosthesis ; Femur Head/surgery ; Patient Readmission ; Retrospective Studies ; Time Factors ; Prosthesis Design ; Medicare ; Chromium Alloys ; Zirconium ; Ceramics ; Prosthesis Failure
Chemical Substances	Chromium Alloys ; Zirconium (C6V6S92N3C)
Language	English
Publishing date	2023-08-24
Publishing country	Germany
Document type	Journal Article
ZDB-ID	80407-1
ISSN	1434-3916 ; 0003-9330 ; 0344-8444
ISSN (online)	1434-3916
ISSN	0003-9330 ; 0344-8444
DOI	10.1007/s00402-023-05027-1
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Article ; Online: Association Between Thigh Muscle Fat Infiltration and Incident Heart Failure: The Health ABC Study.

Huynh, Kevin / Ayers, Colby / Butler, Javed / Neeland, Ian / Kritchevsky, Stephen / Pandey, Ambarish / Barton, Gregory / Berry, Jarett D

JACC. Heart failure

2022 Volume 10, Issue 7, Page(s) 485–493

Abstract: Background: Excess adiposity is a well-known risk factor for heart failure (HF). Fat accumulation in and around the peripheral skeletal muscle may further inform risk for HF.: Objectives: The purpose of this study was to evaluate the association ... ...

Abstract	Background: Excess adiposity is a well-known risk factor for heart failure (HF). Fat accumulation in and around the peripheral skeletal muscle may further inform risk for HF. Objectives: The purpose of this study was to evaluate the association between intramuscular and intermuscular fat deposition and incident HF in a longitudinal cohort of community-dwelling older adults. Methods: The associations of intramuscular and intermuscular fat with incident HF were assessed using Cox models among 2,399 participants from the Health ABC (Health, Aging and Body Composition) study (70-79 years of age, 48% male, 40.2% Black) without baseline HF. Intramuscular fat was determined by bilateral thigh muscle density on computed tomography and intermuscular fat area was determined with computed tomography. Results: After a median follow-up of 12.2 years, there were 485 incident HF events. Higher sex-specific tertiles of intramuscular and intermuscular fat were each associated with HF risk. After multivariable adjustment for age, sex, race, education, blood pressure, fasting blood sugar, current smoking, prevalent coronary disease, and creatinine, higher intramuscular fat, but not intermuscular fat, was associated with higher risk for HF (HR: 1.34 [95% CI: 1.06-1.69]; P = 0.012, tertile 3 vs tertile 1). This association remained significant after additional adjustment for body mass index (HR: 1.32 [95% CI: 1.03-1.69]), total percent fat (HR: 1.33 [95% CI: 1.03-1.72]), visceral fat (HR: 1.30 [95% CI: 1.01-1.65]), and indexed thigh muscle strength (HR: 1.30 [95% CI: 1.03-1.64]). The association between higher intramuscular fat and HF appeared specific to higher risk of incident HF with reduced ejection fraction (HR: 1.53 [95% CI: 1.03-2.29]), but not with HF with preserved ejection fraction (HR: 1.28 [95% CI: 0.82-1.98]). Conclusions: Intramuscular, but not intermuscular, thigh muscle fat is independently associated with HF after adjustment for cardiometabolic risk factors and other measurements of adiposity.
MeSH term(s)	Aged ; Body Composition/physiology ; Female ; Heart Failure ; Humans ; Male ; Muscle, Skeletal/diagnostic imaging ; Obesity/complications ; Risk Factors ; Stroke Volume/physiology ; Thigh
Language	English
Publishing date	2022-07-07
Publishing country	United States
Document type	Journal Article ; Research Support, N.I.H., Extramural
ZDB-ID	2705621-1
ISSN	2213-1787 ; 2213-1779
ISSN (online)	2213-1787
ISSN	2213-1779
DOI	10.1016/j.jchf.2022.04.012
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Article ; Online: Imputation of plasma lipid species to facilitate integration of lipidomic datasets.

Dakic, Aleksandar / Wu, Jingqin / Wang, Tingting / Huynh, Kevin / Mellett, Natalie / Duong, Thy / Beyene, Habtamu B / Magliano, Dianna J / Shaw, Jonathan E / Carrington, Melinda J / Inouye, Michael / Yang, Jean Y / Figtree, Gemma A / Curran, Joanne E / Blangero, John / Simes, John / Giles, Corey / Meikle, Peter J

Nature communications

2024 Volume 15, Issue 1, Page(s) 1540

Abstract: Recent advancements in plasma lipidomic profiling methodology have significantly increased specificity and accuracy of lipid measurements. This evolution, driven by improved chromatographic and mass spectrometric resolution of newer platforms, has made ... ...

Abstract	Recent advancements in plasma lipidomic profiling methodology have significantly increased specificity and accuracy of lipid measurements. This evolution, driven by improved chromatographic and mass spectrometric resolution of newer platforms, has made it challenging to align datasets created at different times, or on different platforms. Here we present a framework for harmonising such plasma lipidomic datasets with different levels of granularity in their lipid measurements. Our method utilises elastic-net prediction models, constructed from high-resolution lipidomics reference datasets, to predict unmeasured lipid species in lower-resolution studies. The approach involves (1) constructing composite lipid measures in the reference dataset that map to less resolved lipids in the target dataset, (2) addressing discrepancies between aligned lipid species, (3) generating prediction models, (4) assessing their transferability into the targe dataset, and (5) evaluating their prediction accuracy. To demonstrate our approach, we used the AusDiab population-based cohort (747 lipid species) as the reference to impute unmeasured lipid species into the LIPID study (342 lipid species). Furthermore, we compared measured and imputed lipids in terms of parameter estimation and predictive performance, and validated imputations in an independent study. Our method for harmonising plasma lipidomic datasets will facilitate model validation and data integration efforts.
MeSH term(s)	Humans ; Lipidomics ; Mass Spectrometry ; Plasma ; Lipids
Chemical Substances	Lipids
Language	English
Publishing date	2024-02-20
Publishing country	England
Document type	Journal Article
ZDB-ID	2553671-0
ISSN	2041-1723 ; 2041-1723
ISSN (online)	2041-1723
ISSN	2041-1723
DOI	10.1038/s41467-024-45838-3
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Article ; Online: Real-world experience with 11C-methionine positron emission tomography in the management of acromegaly.

Haberbosch, Linus / MacFarlane, James / Koulouri, Olympia / Gillett, Daniel / Powlson, Andrew S / Oddy, Sue / Halsall, David J / Huynh, Kevin A / Jones, Jonathan / Cheow, Heok K / Spranger, Joachim / Mai, Knut / Strasburger, Christian J / Mannion, Richard J / Gurnell, Mark

European journal of endocrinology

2024 Volume 190, Issue 4, Page(s) 307–313

Abstract: Background: L-[methyl-11C]-methionine-positron emission tomography (Met-PET) is a potentially important imaging adjunct in the diagnostic workup of pituitary adenomas, including somatotroph tumors. Met-PET can identify residual or occult disease and ... ...

Abstract	Background: L-[methyl-11C]-methionine-positron emission tomography (Met-PET) is a potentially important imaging adjunct in the diagnostic workup of pituitary adenomas, including somatotroph tumors. Met-PET can identify residual or occult disease and make definitive therapies accessible to a subgroup of patients who would otherwise require lifelong medical therapy. However, existing data on its use are still limited to small case series. Here, we report the largest single-center experience (n = 61) in acromegaly. Methods: A total of 189 cases of acromegaly were referred to our national Met-PET service in the last 12 years. For this analysis, we have reviewed outcomes in those 61 patients managed exclusively by our multidisciplinary team (single center, single surgeon). Referral indications were as follows: indeterminate magnetic resonance imaging (MRI; n = 38, 62.3%), occult residual (n = 14, 23.0%), (radio-)surgical planning (n = 6, 9.8%), and occult de novo tumor (n = 3, 4.9%). Results: A total of 33/61 patients (54.1%) underwent PET-guided surgery. Twenty-four of 33 patients (72.7%) achieved complete biochemical remission following (re-)surgery. Insulin-like growth factor 1 levels were reduced to <2 × upper limit of normal (ULN) in 6 of the remaining 9 cases, 3 of whom achieved levels of <1.1 × ULN compared with mean preoperative levels of 2.4 × ULN (SD 0.8) for n = 9. Only 3 patients developed single new hormonal deficits (gonadotropic/thyrotropic insufficiency). There were no neurovascular complications after surgery. Conclusion: In patients with persistent/recurrent acromegaly or occult tumors, Met-PET can facilitate further targeted intervention (surgery/radiosurgery). This led to complete remission in most cases (24/33) or significant improvement with comparatively low risk of complications. L-[methyl-11C]-methionine-positron emission tomography should therefore be considered in all patients who are potential candidates for further surgical intervention but present no clear target on MRI.
MeSH term(s)	Humans ; Acromegaly/diagnostic imaging ; Acromegaly/etiology ; Acromegaly/therapy ; Carbon Radioisotopes ; Positron-Emission Tomography/methods ; Adenoma/diagnostic imaging ; Adenoma/surgery ; Methionine ; Magnetic Resonance Imaging/methods ; Racemethionine
Chemical Substances	Carbon-11 ; Carbon Radioisotopes ; carbon-11 methionine (58576-49-1) ; Methionine (AE28F7PNPL) ; Racemethionine (73JWT2K6T3)
Language	English
Publishing date	2024-04-17
Publishing country	England
Document type	Journal Article
ZDB-ID	1183856-5
ISSN	1479-683X ; 0804-4643
ISSN (online)	1479-683X
ISSN	0804-4643
DOI	10.1093/ejendo/lvae028
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Book ; Online: S-OPT

Lauzon, Jessica T. / Cheung, Siu Wun / Shin, Yeonjong / Choi, Youngsoo / Copeland, Dylan Matthew / Huynh, Kevin

A Points Selection Algorithm for Hyper-Reduction in Reduced Order Models

2022

Abstract: While projection-based reduced order models can reduce the dimension of full order solutions, the resulting reduced models may still contain terms that scale with the full order dimension. Hyper-reduction techniques are sampling-based methods that ... ...

Abstract	While projection-based reduced order models can reduce the dimension of full order solutions, the resulting reduced models may still contain terms that scale with the full order dimension. Hyper-reduction techniques are sampling-based methods that further reduce this computational complexity by approximating such terms with a much smaller dimension. The goal of this work is to introduce a points selection algorithm developed by Shin and Xiu [SIAM J. Sci. Comput., 38 (2016), pp. A385--A411], as a hyper-reduction method. The selection algorithm is originally proposed as a stochastic collocation method for uncertainty quantification. Since the algorithm aims at maximizing a quantity S that measures both the column orthogonality and the determinant, we refer to the algorithm as S-OPT. Numerical examples are provided to demonstrate the performance of S-OPT and to compare its performance with an over-sampled Discrete Empirical Interpolation (DEIM) algorithm. We found that using the S-OPT algorithm is shown to predict the full order solutions with higher accuracy for a given number of indices. Comment: 26 pages, 15 figures, submitted to SIAM Journal of Scientific Computing
Keywords	Mathematics - Numerical Analysis ; Computer Science - Computational Engineering ; Finance ; and Science ; 37M99 ; 65M99 ; 76D05 ; 67Q05
Subject code	518
Publishing date	2022-03-29
Publishing country	us
Document type	Book ; Online
Database	BASE - Bielefeld Academic Search Engine (life sciences selection)

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