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Artikel ; Online: Enantioselective Transfer Hydrogenative Cycloaddition Unlocks the Total Synthesis of SF2446 B3: An Aglycone of Arenimycin and SF2446 Type II Polyketide Antibiotics.

Huynh, Nancy O / Hodík, Tomáš / Krische, Michael J

Journal of the American Chemical Society

2023 Band 145, Heft 31, Seite(n) 17461–17467

Abstract: The first total synthesis and structure validation of an arenimycin/SF2446 type II polyketide is described, as represented ... ...

Abstract	The first total synthesis and structure validation of an arenimycin/SF2446 type II polyketide is described, as represented by
Mesh-Begriff(e)	Anti-Bacterial Agents ; Cycloaddition Reaction ; Polyketides/chemistry ; Stereoisomerism ; Catalysis
Chemische Substanzen	Anti-Bacterial Agents ; arenimycin ; Polyketides
Sprache	Englisch
Erscheinungsdatum	2023-07-26
Erscheinungsland	United States
Dokumenttyp	Journal Article ; Research Support, N.I.H., Extramural ; Research Support, Non-U.S. Gov't
ZDB-ID	3155-0
ISSN	1520-5126 ; 0002-7863
ISSN (online)	1520-5126
ISSN	0002-7863
DOI	10.1021/jacs.3c06225
Datenquelle	MEDical Literature Analysis and Retrieval System OnLINE

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Artikel ; Online: Ruthenium-Catalyzed Cycloadditions to Form Five-, Six-, and Seven-Membered Rings.

Doerksen, Rosalie S / Hodík, Tomáš / Hu, Guanyu / Huynh, Nancy O / Shuler, William G / Krische, Michael J

Chemical reviews

2021 Band 121, Heft 7, Seite(n) 4045–4083

Abstract: Ruthenium-catalyzed cycloadditions to form five-, six-, and seven-membered rings are summarized, including applications in natural product total synthesis. Content is organized by ring size and reaction type. Coverage is limited to processes that involve ...

Abstract	Ruthenium-catalyzed cycloadditions to form five-, six-, and seven-membered rings are summarized, including applications in natural product total synthesis. Content is organized by ring size and reaction type. Coverage is limited to processes that involve formation of at least one C-C bond. Processes that are stoichiometric in ruthenium or exploit ruthenium as a Lewis acid (without intervention of organometallic intermediates), ring formations that occur through dehydrogenative condensation-reduction, σ-bond activation-initiated annulations that do not result in net reduction of bond multiplicity, and photochemically promoted ruthenium-catalyzed cycloadditions are not covered.
Mesh-Begriff(e)	Catalysis ; Cyclization ; Heterocyclic Compounds/chemical synthesis ; Organometallic Compounds/chemistry ; Oxidation-Reduction ; Photochemical Processes ; Polycyclic Compounds/chemical synthesis ; Ruthenium/chemistry ; Stereoisomerism
Chemische Substanzen	Heterocyclic Compounds ; Organometallic Compounds ; Polycyclic Compounds ; Ruthenium (7UI0TKC3U5)
Sprache	Englisch
Erscheinungsdatum	2021-02-12
Erscheinungsland	United States
Dokumenttyp	Journal Article ; Research Support, N.I.H., Extramural ; Research Support, Non-U.S. Gov't ; Research Support, U.S. Gov't, Non-P.H.S. ; Review
ZDB-ID	207949-5
ISSN	1520-6890 ; 0009-2665
ISSN (online)	1520-6890
ISSN	0009-2665
DOI	10.1021/acs.chemrev.0c01133
Datenquelle	MEDical Literature Analysis and Retrieval System OnLINE

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Artikel ; Online: Dilated fundus exam and associated findings in spontaneous subconjunctival haemorrhage.

Huynh, Nancy / Wang, Jay / Vavvas, Demetrios

Acta ophthalmologica

2017 Band 95, Heft 5, Seite(n) e432–e433

Sprache	Englisch
Erscheinungsdatum	2017-08
Erscheinungsland	England
Dokumenttyp	Letter
ZDB-ID	2408333-1
ISSN	1755-3768 ; 1755-375X
ISSN (online)	1755-3768
ISSN	1755-375X
DOI	10.1111/aos.13309
Datenquelle	MEDical Literature Analysis and Retrieval System OnLINE

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Artikel ; Online: Uveal coloboma.

Huynh, Nancy / Brooks, Brian P

JAMA ophthalmology

2013 Band 131, Heft 10, Seite(n) 1274

Mesh-Begriff(e)	Choroid/abnormalities ; Coloboma/diagnosis ; Exophthalmos/diagnosis ; Humans ; Iris/abnormalities ; Magnetic Resonance Imaging ; Retina/abnormalities ; Visual Acuity
Sprache	Englisch
Erscheinungsdatum	2013-10
Erscheinungsland	United States
Dokumenttyp	Case Reports ; Journal Article
ZDB-ID	2701705-9
ISSN	2168-6173 ; 2168-6165
ISSN (online)	2168-6173
ISSN	2168-6165
DOI	10.1001/jamaophthalmol.2013.4515
Datenquelle	MEDical Literature Analysis and Retrieval System OnLINE

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Artikel ; Online: Total Synthesis of (±)-Brazilin Using [4 + 1] Palladium-Catalyzed Carbenylative Annulation.

Arredondo, Vanessa / Roa, Daniel E / Gutman, Eugene S / Huynh, Nancy O / Van Vranken, David L

The Journal of organic chemistry

2019 Band 84, Heft 22, Seite(n) 14745–14759

Abstract: Palladium-catalyzed carbene insertion was utilized in a formal synthesis of (±)-picropodophyllone and a total synthesis of (±)-brazilin. All prior syntheses of brazilin have involved a Friedel-Crafts alkylation in the key carbon-carbon bond forming ... ...

Abstract	Palladium-catalyzed carbene insertion was utilized in a formal synthesis of (±)-picropodophyllone and a total synthesis of (±)-brazilin. All prior syntheses of brazilin have involved a Friedel-Crafts alkylation in the key carbon-carbon bond forming events. The palladium-catalyzed [4 + 1] reaction generates a 1-arylindane with all of the functionalities needed for formation of the indano[2,1-
Sprache	Englisch
Erscheinungsdatum	2019-10-31
Erscheinungsland	United States
Dokumenttyp	Journal Article ; Research Support, U.S. Gov't, Non-P.H.S. ; Research Support, Non-U.S. Gov't
ZDB-ID	123490-0
ISSN	1520-6904 ; 0022-3263
ISSN (online)	1520-6904
ISSN	0022-3263
DOI	10.1021/acs.joc.9b02343
Datenquelle	MEDical Literature Analysis and Retrieval System OnLINE

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Artikel ; Online: From Skin Infections to Ebola: Practice, Policy, and Beyond: An Interview with Gregory Raczniak, MD, PhD .

Mirza, Fatima N / Mirza, Humza N / Horien, Corey / Huynh, Nancy

The Yale journal of biology and medicine

2017 Band 90, Heft 2, Seite(n) 341–343

Mesh-Begriff(e)	Hemorrhagic Fever, Ebola/epidemiology ; History, 20th Century ; History, 21st Century ; Humans ; Mass Media ; Policy ; Public Health/history ; Skin Diseases, Infectious/epidemiology
Sprache	Englisch
Erscheinungsdatum	2017
Erscheinungsland	United States
Dokumenttyp	Autobiography ; Historical Article ; Interview
ZDB-ID	200515-3
ISSN	1551-4056 ; 0044-0086
ISSN (online)	1551-4056
ISSN	0044-0086
Datenquelle	MEDical Literature Analysis and Retrieval System OnLINE

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Artikel: Total Synthesis of (±)-Brazilin Using [4 + 1] Palladium-Catalyzed Carbenylative Annulation

Arredondo, Vanessa / Roa, Daniel E / Gutman, Eugene S / Huynh, Nancy O / Van Vranken, David L

Journal of organic chemistry. 2019 Oct. 22, v. 84, no. 22

2019

Abstract: Palladium-catalyzed carbene insertion was utilized in a formal synthesis of (±)-picropodophyllone and a total synthesis of (±)-brazilin. All prior syntheses of brazilin have involved a Friedel–Crafts alkylation in the key carbon–carbon bond forming ... ...

Abstract	Palladium-catalyzed carbene insertion was utilized in a formal synthesis of (±)-picropodophyllone and a total synthesis of (±)-brazilin. All prior syntheses of brazilin have involved a Friedel–Crafts alkylation in the key carbon–carbon bond forming events. The palladium-catalyzed [4 + 1] reaction generates a 1-arylindane with all of the functionalities needed for formation of the indano[2,1-c]chroman ring system of brazilin. The synthesis of (±)-brazilin was achieved in 11 steps (longest linear sequence) with an overall 11% yield.
Schlagwörter	alkylation ; carbenes ; catalytic activity ; chemical bonding ; chemical structure ; palladium
Sprache	Englisch
Erscheinungsverlauf	2019-1022
Umfang	p. 14745-14759.
Erscheinungsort	American Chemical Society
Dokumenttyp	Artikel
ZDB-ID	123490-0
ISSN	1520-6904 ; 0022-3263
ISSN (online)	1520-6904
ISSN	0022-3263
DOI	10.1021/acs.joc.9b02343
Datenquelle	NAL Katalog (AGRICOLA)

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Artikel: Assessing the Impact of Parental Depressive Symptoms on Offspring Temperament and Development in Infancy.

Huynh, Nancy / Finik, Jackie / Ly, Jenny / Nomura, Yoko

Journal of depression & anxiety

2014 Band 2014, Heft Suppl 1

Abstract: The study prospectively followed 135 women during their pregnancy and their offspring till 6 months of age, to examine the roles of maternal and paternal depression during pregnancy on offspring neurobehavioral development as measured by their early ... ...

Abstract	The study prospectively followed 135 women during their pregnancy and their offspring till 6 months of age, to examine the roles of maternal and paternal depression during pregnancy on offspring neurobehavioral development as measured by their early temperament. Maternal and paternal depression statuses were ascertained during the third trimester, and infant temperament was evaluated at 6 months, via mothers self-report. Multivariable general linear model was used to assess 1) the main effects of maternal and paternal depression on infant temperament and 2) the interaction effect between maternal and paternal depression on infant temperament. Results show that maternal depression, but not paternal depression, was directly associated with greater neurobehavioral impairment in offspring as evident by more difficult temperament, including lower Smiling and Laughter (p= .006), lower Soothability (p= .02), elevated Sadness (p= .04) and lower Vocal Reactivity (p= .001). Moreover, only in the presence of maternal depression, was paternal depression significantly associated with signs of offspring neurobehavioral impairment, including lower Smiling and Laughter (p= .01) lower High Pleasure Seeking (p= .03), lower Soothability (p= .05), lower Cuddliness (p= .05) and lower Vocal Reactivity (p< .0001). These findings suggest that maternal, but not paternal, depression was directly associated with infant neurobehavioral impairment. Significant interaction effect suggests that in the presence of maternal depression, paternal depression amplifies its negative valence on infant neurobehavioral development. Providing intervention services not only for depressed mothers but also their partners during pregnancy may prove to be an effective prevention strategy for suboptimal neurobehavioral development in offspring.
Sprache	Englisch
Erscheinungsdatum	2014-05-01
Erscheinungsland	United States
Dokumenttyp	Journal Article
ZDB-ID	2765350-X
ISSN	2167-1044
ISSN	2167-1044
DOI	10.4172/2167-1044.S1-005
Datenquelle	MEDical Literature Analysis and Retrieval System OnLINE

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Artikel ; Online: Statin therapy associated with improved thrombus resolution in patients with deep vein thrombosis.

Hsu, Charles / Brahmandam, Anand / Brownson, Kirstyn E / Huynh, Nancy / Reynolds, Jesse / Lee, Alfred I / Fares, Wassim H / Ochoa Chaar, Cassius Iyad

Journal of vascular surgery. Venous and lymphatic disorders

2019 Band 7, Heft 2, Seite(n) 169–175.e4

Abstract: Objective: Statin therapy has been associated with a decreased incidence of venous thromboembolism (VTE) in clinical trials and enhanced thrombus resolution in animal models. The effect of statins on thrombus resolution has not been reported clinically. ...

Abstract	Objective: Statin therapy has been associated with a decreased incidence of venous thromboembolism (VTE) in clinical trials and enhanced thrombus resolution in animal models. The effect of statins on thrombus resolution has not been reported clinically. This study investigates the association of statins with thrombus resolution or improvement in patients with deep venous thrombosis (DVT). Methods: A retrospective study of the electronic medical records of consecutive adult patients presenting with lower extremity DVT was performed. Patients were divided into two groups based on statin therapy (statin group) or lack thereof (nonstatin group). The two groups were compared with respect to demographics, comorbidities, and risk factors for VTE. Initial as well as all subsequent ultrasound reports were reviewed for each patient to determine extent of DVT and subsequent change in thrombus characteristics. Long-term outcomes examined were mortality, VTE recurrence, and thrombus improvement or resolution on follow-up ultrasound examination. Multivariable analysis was used to determine independent predictors of thrombus resolution or improvement, VTE recurrence, and mortality. Results: A total of 818 patients with DVT were identified (statin group, n = 279 [34%]; nonstatin group, n = 539 [66%]). The patients in the statin group were significantly older (P < .001). Patients on statins were more likely to have risk factors for and manifestations of atherosclerosis and to be on antiplatelet therapy (P < .001), whereas those in the nonstatin group were more likely to have a hypercoagulable disorder (P = .009) or prior DVT (P = .033). There was no significant difference in provoked DVT, extent of DVT, or association with pulmonary embolism (PE), but patients on statins were more likely to have high-risk PE (P = .046). There was no difference in patients receiving anticoagulation, type and duration of anticoagulation, inferior vena cava filter placement, or treatment with lytic therapy. There was no difference in thrombus resolution, mortality, or recurrence of DVT, PE, or VTE between the groups. On multivariable analysis, age, proximal DVT, CAD, and cancer were associated with higher mortality, whereas anticoagulation with coumadin and direct oral anticoagulants and antiplatelet therapy were associated with lower mortality. Statin therapy, antiplatelet therapy, and younger age were associated with thrombus resolution or improvement. Conclusions: Statin therapy is associated with greater thrombus resolution or improvement in patients with DVT. However, statin therapy in this study was not associated with different clinical outcomes of VTE recurrence or mortality.
Mesh-Begriff(e)	Aged ; Aged, 80 and over ; Anticoagulants/adverse effects ; Anticoagulants/therapeutic use ; Electronic Health Records ; Female ; Humans ; Hydroxymethylglutaryl-CoA Reductase Inhibitors/adverse effects ; Hydroxymethylglutaryl-CoA Reductase Inhibitors/therapeutic use ; Male ; Middle Aged ; Platelet Aggregation Inhibitors/adverse effects ; Platelet Aggregation Inhibitors/therapeutic use ; Pulmonary Embolism/diagnostic imaging ; Pulmonary Embolism/drug therapy ; Pulmonary Embolism/mortality ; Recurrence ; Retrospective Studies ; Risk Assessment ; Risk Factors ; Thrombolytic Therapy ; Time Factors ; Treatment Outcome ; Vena Cava Filters ; Venous Thromboembolism/diagnostic imaging ; Venous Thromboembolism/drug therapy ; Venous Thromboembolism/mortality ; Venous Thrombosis/diagnostic imaging ; Venous Thrombosis/drug therapy ; Venous Thrombosis/mortality
Chemische Substanzen	Anticoagulants ; Hydroxymethylglutaryl-CoA Reductase Inhibitors ; Platelet Aggregation Inhibitors
Sprache	Englisch
Erscheinungsdatum	2019-01-16
Erscheinungsland	United States
Dokumenttyp	Journal Article ; Research Support, N.I.H., Extramural
ISSN	2213-3348
ISSN (online)	2213-3348
DOI	10.1016/j.jvsv.2018.10.020
Datenquelle	MEDical Literature Analysis and Retrieval System OnLINE

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Artikel ; Online: Ocular involvement in hospitalized patients with candidemia: analysis at a Boston tertiary care center.

Huynh, Nancy / Chang, Han-Ying Peggy / Borboli-Gerogiannis, Sheila

Ocular immunology and inflammation

2012 Band 20, Heft 2, Seite(n) 100–103

Abstract: Purpose: To study the prevalence, microbial profile, and risk factors for ocular involvement in patients with candidemia.: Methods: The records of all inpatient consultations requested at the Brigham and Women's Hospital from October 2009 to June ... ...

Abstract	Purpose: To study the prevalence, microbial profile, and risk factors for ocular involvement in patients with candidemia. Methods: The records of all inpatient consultations requested at the Brigham and Women's Hospital from October 2009 to June 2011 to evaluate for ocular involvement in patients with candidemia were retrospectively reviewed. Results: Forty-nine consults were requested to rule out ocular involvement in patients with candidemia. The mean patient age was 55 years. In decreasing frequency, the organisms isolated were Candida albicans (42%), Candida parapsilosis (23%), Candida glabrata (17%), Candida tropicalis (8%), Candida dublinensis (5%), Candida krusei (3%), and Candida lusitaniae (3%). All patients were on antifungal treatment at the time of their initial ophthalmologic examination. One patient had evidence of chorioretinitis, and 3 patients had nonspecific fundus findings. Common risk factors included presence of an intravenous catheter, malignancy, and abdominal surgery. Conclusions: Ocular involvement is rare among patients with systemic Candida infection.
Mesh-Begriff(e)	Abdomen/surgery ; Adolescent ; Adult ; Antifungal Agents/therapeutic use ; Boston/epidemiology ; Candida/isolation & purification ; Candidemia/drug therapy ; Candidemia/epidemiology ; Catheter-Related Infections/epidemiology ; Catheter-Related Infections/microbiology ; Eye Diseases/epidemiology ; Eye Diseases/microbiology ; Female ; Humans ; Male ; Middle Aged ; Neoplasms/complications ; Postoperative Complications/epidemiology ; Postoperative Complications/microbiology ; Prevalence ; Risk Factors ; Treatment Outcome
Chemische Substanzen	Antifungal Agents
Sprache	Englisch
Erscheinungsdatum	2012-04
Erscheinungsland	England
Dokumenttyp	Journal Article
ZDB-ID	1193873-0
ISSN	1744-5078 ; 0927-3948
ISSN (online)	1744-5078
ISSN	0927-3948
DOI	10.3109/09273948.2011.646383
Datenquelle	MEDical Literature Analysis and Retrieval System OnLINE

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