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  1. Article: Understanding glioblastoma stromal barriers against NK cell attack using tri-culture 3D spheroid model.

    Heinrich, Marcel Alexander / Huynh, Ngoc-Tien / Heinrich, Lena / Prakash, Jai

    Heliyon

    2024  Volume 10, Issue 3, Page(s) e24808

    Abstract: Glioblastoma multiforme (GBM), a highly aggressive tumor type with a dismal survival rate, has a poor outcome which is at least partly attributed to the crosstalk between cancer cells and cells from the tumor microenvironment such as astrocytes and ... ...

    Abstract Glioblastoma multiforme (GBM), a highly aggressive tumor type with a dismal survival rate, has a poor outcome which is at least partly attributed to the crosstalk between cancer cells and cells from the tumor microenvironment such as astrocytes and microglia. We aimed to decipher the effect of these cells on GBM progression and on cell-based therapies using 3D co-cultures. Co-culturing of glioblastoma cells with patient-derived astrocytes or microglia or both formed dense and heterogeneous spheroids. Both, astrocytes and microglia, enhanced the spheroid growth rate and formed a physical barrier for macromolecules penetration, while only astrocytes enhanced the migration. Interestingly bi-/tri-cultured spheroids showed significant resistance against NK-92 cells, likely attributed to dense stroma and induced expression of immunosuppressive genes such as IDO1 or PTGES2. Altogether, our novel 3D GBM spheroid model recapitulates the cell-to-cell interactions of human glioblastoma and can serve as a suitable platform for evaluating cancer therapeutics.
    Language English
    Publishing date 2024-01-20
    Publishing country England
    Document type Journal Article
    ZDB-ID 2835763-2
    ISSN 2405-8440
    ISSN 2405-8440
    DOI 10.1016/j.heliyon.2024.e24808
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  2. Article ; Online: Three-Dimensional Porous Nitrogen-Doped NiO Nanostructures as Highly Sensitive NO2 Sensors

    Van Hoang Luan / Huynh Ngoc Tien / Seung Hyun Hur / Jong Hun Han / Wonoh Lee

    Nanomaterials, Vol 7, Iss 10, p

    2017  Volume 313

    Abstract: Nickel oxide has been widely used in chemical sensing applications, because it has an excellent p-type semiconducting property with high chemical stability. Here, we present a novel technique of fabricating three-dimensional porous nitrogen-doped nickel ... ...

    Abstract Nickel oxide has been widely used in chemical sensing applications, because it has an excellent p-type semiconducting property with high chemical stability. Here, we present a novel technique of fabricating three-dimensional porous nitrogen-doped nickel oxide nanosheets as a highly sensitive NO2 sensor. The elaborate nanostructure was prepared by a simple and effective hydrothermal synthesis method. Subsequently, nitrogen doping was achieved by thermal treatment with ammonia gas. When the p-type dopant, i.e., nitrogen atoms, was introduced in the three-dimensional nanostructures, the nickel-oxide-nanosheet-based sensor showed considerable NO2 sensing ability with two-fold higher responsivity and sensitivity compared to non-doped nickel-oxide-based sensors.
    Keywords sensor ; porous nanostructure ; nickel oxide ; nitrogen doping ; NO2 gas sensor ; Chemistry ; QD1-999
    Language English
    Publishing date 2017-10-01T00:00:00Z
    Publisher MDPI AG
    Document type Article ; Online
    Database BASE - Bielefeld Academic Search Engine (life sciences selection)

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  3. Article: Fabrication of 3D structured ZnO nanorod/reduced graphene oxide hydrogels and their use for photo-enhanced organic dye removal

    Luan, Van Hoang / Huynh Ngoc Tien / Seung Hyun Hur

    Journal of colloid and interface science. 2015 Jan. 01, v. 437

    2015  

    Abstract: Hybrid 3-dimensional (3D) structures composed of zinc oxide (ZnO) nanorods and reduced graphene oxide hydrogel (rGOH) were fabricated by chemical reaction between Zn ions and GO followed by in-situ lateral growth of ZnO nanorods using Zn ions as seed ... ...

    Abstract Hybrid 3-dimensional (3D) structures composed of zinc oxide (ZnO) nanorods and reduced graphene oxide hydrogel (rGOH) were fabricated by chemical reaction between Zn ions and GO followed by in-situ lateral growth of ZnO nanorods using Zn ions as seed points. The 3D networked ZnO nanorod–rGOH (ZNR–rGOH) fabricated in this study exhibited excellent methylene blue (MB) removal efficiency due to efficient physical adsorption of dye molecules because of electrostatic attractive forces and enhanced photocatalytic activity by the laterally grown ZnO nanorods. The Langmuir–Hinshelwood rate constant of ZNR–rGOH was 4-fold higher than that of pristine rGO due to the enhanced photocatalytic effects obtained by incorporating laterally grown ZnO nanorods inside the rGOH network.
    Keywords adsorption ; graphene oxide ; hydrogels ; ions ; methylene blue ; nanorods ; photocatalysis ; zinc ; zinc oxide
    Language English
    Dates of publication 2015-0101
    Size p. 181-186.
    Publishing place Elsevier Inc.
    Document type Article
    ZDB-ID 241597-5
    ISSN 1095-7103 ; 0021-9797
    ISSN (online) 1095-7103
    ISSN 0021-9797
    DOI 10.1016/j.jcis.2014.08.071
    Database NAL-Catalogue (AGRICOLA)

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  4. Article ; Online: Ultrathin graphene oxide-based hollow fiber membranes with brush-like CO2-philic agent for highly efficient CO2 capture

    Fanglei Zhou / Huynh Ngoc Tien / Weiwei L. Xu / Jung-Tsai Chen / Qiuli Liu / Ethan Hicks / Mahdi Fathizadeh / Shiguang Li / Miao Yu

    Nature Communications, Vol 8, Iss 1, Pp 1-

    2017  Volume 8

    Abstract: Membrane separation technologies show promise for CO2 capture, but typically suffer from a trade-off between permeance and selectivity. Here, the authors produce hollow fiber membranes coated with graphene oxide and a CO2-philic agent that can ... ...

    Abstract Membrane separation technologies show promise for CO2 capture, but typically suffer from a trade-off between permeance and selectivity. Here, the authors produce hollow fiber membranes coated with graphene oxide and a CO2-philic agent that can efficiently separate CO2 from flue gas under wet conditions.
    Keywords Science ; Q
    Language English
    Publishing date 2017-12-01T00:00:00Z
    Publisher Nature Portfolio
    Document type Article ; Online
    Database BASE - Bielefeld Academic Search Engine (life sciences selection)

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  5. Article ; Online: Ultrathin graphene oxide-based hollow fiber membranes with brush-like CO2-philic agent for highly efficient CO2 capture

    Fanglei Zhou / Huynh Ngoc Tien / Weiwei L. Xu / Jung-Tsai Chen / Qiuli Liu / Ethan Hicks / Mahdi Fathizadeh / Shiguang Li / Miao Yu

    Nature Communications, Vol 8, Iss 1, Pp 1-

    2017  Volume 8

    Abstract: Membrane separation technologies show promise for CO2 capture, but typically suffer from a trade-off between permeance and selectivity. Here, the authors produce hollow fiber membranes coated with graphene oxide and a CO2-philic agent that can ... ...

    Abstract Membrane separation technologies show promise for CO2 capture, but typically suffer from a trade-off between permeance and selectivity. Here, the authors produce hollow fiber membranes coated with graphene oxide and a CO2-philic agent that can efficiently separate CO2 from flue gas under wet conditions.
    Keywords Science ; Q
    Language English
    Publishing date 2017-12-01T00:00:00Z
    Publisher Nature Publishing Group
    Document type Article ; Online
    Database BASE - Bielefeld Academic Search Engine (life sciences selection)

    Full text online

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    Inter-library loan at ZB MED

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