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Article ; Online: Systolic Blood Pressure, Diastolic Blood Pressure and Pulse Pressure and the Risk of Subclinical Myocardial Injury: The HUNT Study.

Young, Juliet / Lyngbakken, Magnus Nakrem / Hveem, Kristian / Røsjø, Helge / Omland, Torbjørn

Journal of the American Heart Association

2024 , Page(s) e031107

Abstract: Background: Subclinical myocardial injury expressed as higher cardiac troponin concentrations may represent an important intermediary between hypertension and the risk of cardiovascular disease. The study aimed to assess the relative strength of ... ...

Abstract	Background: Subclinical myocardial injury expressed as higher cardiac troponin concentrations may represent an important intermediary between hypertension and the risk of cardiovascular disease. The study aimed to assess the relative strength of associations between systolic blood pressure (BP), diastolic BP, and pulse pressure, and subclinical myocardial injury, and how change in BP variables over time associates with subclinical myocardial injury. Methods and results: cTnl (cardiac troponin I) was measured in 32 968 participants of the fourth wave of the population-based cohort HUNT4 (Trøndelag Health Study) without a history of cardiovascular disease. An additional longitudinal analysis included participants from HUNT4 with BP measurements from HUNT3 (n=18 681). Associations between BP variables and cTnI concentrations were assessed by linear and logistic regression analyses. The median cTnI concentration was 1.6 ng/L (25th-75th percentiles, 0.6-3.1 ng/L), median age was 52 years (39.1-65.6 years), and 57% were female subjects. Cross-sectionally, only systolic BP categories ≥130 mm Hg associated with higher cTnI concentrations, compared with a reference systolic BP of <110 mm Hg. All categories of diastolic BP and pulse pressure were positively associated with higher cTnI concentrations when diastolic BP 70 to 79 mm Hg and pulse pressure <40 mm Hg were used as references, respectively. When comparing systolic BP, diastolic BP, and pulse pressure as continuous variables, cross-sectionally, pulse pressure most strongly associated with cTnI concentrations ( Conclusions: Subjects with high pulse pressure and longitudinal increase in diastolic BP are at higher risk for subclinical myocardial injury.
Language	English
Publishing date	2024-04-19
Publishing country	England
Document type	Journal Article
ZDB-ID	2653953-6
ISSN	2047-9980 ; 2047-9980
ISSN (online)	2047-9980
ISSN	2047-9980
DOI	10.1161/JAHA.123.031107
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Article ; Online: High microRNA-145 plasma levels are associated with decreased risk of future incident venous thromboembolism: the HUNT study.

Morelli, Vânia M / Snir, Omri / Hindberg, Kristian Dalsbø / Hveem, Kristian / Brækkan, Sigrid K / Hansen, John-Bjarne

Blood

2024 Volume 143, Issue 17, Page(s) 1773–1781

Abstract: Abstract: MicroRNA-145 (miR-145) has been reported to downregulate the expression of tissue factor and factor XI in vitro and decrease venous thrombus formation in animal models. However, the association between miR-145 and risk of future venous ... ...

Abstract	Abstract: MicroRNA-145 (miR-145) has been reported to downregulate the expression of tissue factor and factor XI in vitro and decrease venous thrombus formation in animal models. However, the association between miR-145 and risk of future venous thromboembolism (VTE) in the general population remains unknown. We investigated the association between plasma levels of miR-145 and risk of future VTE in a case-cohort study. Incident VTE cases (n = 510) and a subcohort (n = 1890) were derived from the third survey of the Trøndelag Health Study (HUNT3), a population-based cohort. The expression levels of miR-145 were measured in plasma samples obtained at baseline. The study population was divided into quartiles based on miR-145 levels in participants in the subcohort, and weighted Cox regression was used to estimate hazard ratios (HRs) with 95% confidence intervals (CIs). Plasma levels of miR-145 were inversely associated with VTE risk. Participants with miR-145 levels in the highest quartile had a 49% lower risk of VTE (HR, 0.51; 95% CI, 0.38-0.68) than those with miR-145 in the lowest quartile in age- and sex-adjusted analysis, and the inverse association was most pronounced for unprovoked VTE (HR, 0.39; 95% CI, 0.25-0.61). Risk estimates remained virtually the same after further adjustment for body mass index, and cancer and arterial cardiovascular disease at baseline. In conclusion, elevated expression levels of miR-145 in plasma were associated with decreased risk of future incident VTE. The protective role of miR-145 against VTE is consistent with previous experimental data and suggests that miR-145 has the potential to be a target for VTE prevention.
MeSH term(s)	Humans ; Venous Thromboembolism/blood ; Venous Thromboembolism/epidemiology ; Venous Thromboembolism/genetics ; Male ; MicroRNAs/blood ; Female ; Middle Aged ; Aged ; Incidence ; Risk Factors ; Adult ; Cohort Studies ; Norway/epidemiology ; Case-Control Studies
Chemical Substances	MIRN145 microRNA, human ; MicroRNAs
Language	English
Publishing date	2024-01-09
Publishing country	United States
Document type	Journal Article ; Research Support, Non-U.S. Gov't
ZDB-ID	80069-7
ISSN	1528-0020 ; 0006-4971
ISSN (online)	1528-0020
ISSN	0006-4971
DOI	10.1182/blood.2023022285
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Article ; Online: Subclinical Myocardial Injury and Risk of COVID-19 in the General Population: The Trøndelag Health Study.

Lyngbakken, Magnus Nakrem / Hveem, Kristian / Røsjø, Helge / Omland, Torbjørn

Clinical chemistry

2022 Volume 68, Issue 3, Page(s) 473–475

MeSH term(s)	Biomarkers ; COVID-19/epidemiology ; Heart Injuries/epidemiology ; Humans ; Norway/epidemiology ; SARS-CoV-2 ; Troponin I
Chemical Substances	Biomarkers ; Troponin I
Language	English
Publishing date	2022-03-29
Publishing country	England
Document type	Journal Article
ZDB-ID	80102-1
ISSN	1530-8561 ; 0009-9147
ISSN (online)	1530-8561
ISSN	0009-9147
DOI	10.1093/clinchem/hvab267
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Article ; Online: Proportion of venous thromboembolism attributed to recognized prothrombotic genotypes in men and women.

Løchen Arnesen, Carl Arne / Evensen, Line H / Hveem, Kristian / Gabrielsen, Maiken E / Hansen, John-Bjarne / Brækkan, Sigrid K

Research and practice in thrombosis and haemostasis

2024 Volume 8, Issue 2, Page(s) 102343

Abstract: Background: Data on the proportion of venous thromboembolism (VTE) risk attributed to prothrombotic genotypes in men and women are limited.: Objectives: We aimed to estimate the population attributable fraction (PAF) of VTE for recognized, common ... ...

Abstract	Background: Data on the proportion of venous thromboembolism (VTE) risk attributed to prothrombotic genotypes in men and women are limited. Objectives: We aimed to estimate the population attributable fraction (PAF) of VTE for recognized, common prothrombotic genotypes in men and women using a population-based case cohort. Methods: Cases with incident VTE ( Results: In women, the individual PAFs for SNPs included in the cumulative model were 16.9% for Conclusion: Our findings in a Norwegian population suggest that 52% and 38% of the VTEs can be attributed to known prothrombotic genotypes in men and women, respectively.
Language	English
Publishing date	2024-02-08
Publishing country	United States
Document type	Journal Article
ISSN	2475-0379
ISSN (online)	2475-0379
DOI	10.1016/j.rpth.2024.102343
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Article ; Online: Glucagon-like peptide 1 receptor agonist use and risk of thyroid cancer: Scandinavian cohort study.

Pasternak, Björn / Wintzell, Viktor / Hviid, Anders / Eliasson, Björn / Gudbjörnsdottir, Soffia / Jonasson, Christian / Hveem, Kristian / Svanström, Henrik / Melbye, Mads / Ueda, Peter

BMJ (Clinical research ed.)

2024 Volume 385, Page(s) e078225

Abstract: Objective: To investigate whether use of glucagon-like peptide 1 (GLP1) receptor agonists is associated with increased risk of thyroid cancer.: Design: Scandinavian cohort study.: Setting: Denmark, Norway, and Sweden, 2007-21.: Participants: ... ...

Abstract	Objective: To investigate whether use of glucagon-like peptide 1 (GLP1) receptor agonists is associated with increased risk of thyroid cancer. Design: Scandinavian cohort study. Setting: Denmark, Norway, and Sweden, 2007-21. Participants: Patients who started GLP1 receptor agonist treatment were compared with patients who started dipeptidyl peptidase 4 (DPP4) inhibitor treatment, and in an additional analysis, patients who started sodium-glucose cotransporter 2 (SGLT2) inhibitor treatment. Main outcome measures: Thyroid cancer identified from nationwide cancer registers. An active-comparator new user study design was used to minimise risks of confounding and time related biases from using real world studies of drug effects. Cox regression was used to estimate hazard ratios, controlling for potential confounders with propensity score weighting. Results: The mean follow-up time was 3.9 years (standard deviation 3.5 years) in the GLP1 receptor agonist group and 5.4 years (standard deviation 3.5 years) in the DPP4 inhibitor group. 76 of 145 410 patients (incidence rate 1.33 events per 10 000 person years) treated with GLP1 receptor agonists and 184 of 291 667 patients (incidence rate 1.46 events per 10 000 person years) treated with DPP4 inhibitors developed thyroid cancer. GLP1 receptor agonist use was not associated with increased risk of thyroid cancer (hazard ratio 0.93, 95% confidence interval 0.66 to 1.31; rate difference -0.13, 95% confidence interval -0.61 to 0.36 events per 10 000 person years). The hazard ratio for medullary thyroid cancer was 1.19 (0.37 to 3.86). In the additional analysis comparing the GLP1 receptor agonist group with the SGLT2 inhibitor group, the hazard ratio for thyroid cancer was 1.16 (0.65 to 2.05). Conclusions: In this large cohort study using nationwide data from three countries, GLP1 receptor agonist use was not associated with a substantially increased risk of thyroid cancer over a mean follow-up of 3.9 years. In the main analysis comparing GLP1 receptor agonists with DPP4 inhibitors, the upper limit of the confidence interval was consistent with no more than a 31% increase in relative risk.
MeSH term(s)	Humans ; Thyroid Neoplasms/epidemiology ; Thyroid Neoplasms/chemically induced ; Glucagon-Like Peptide-1 Receptor/agonists ; Male ; Female ; Middle Aged ; Dipeptidyl-Peptidase IV Inhibitors/adverse effects ; Dipeptidyl-Peptidase IV Inhibitors/therapeutic use ; Aged ; Denmark/epidemiology ; Incidence ; Sodium-Glucose Transporter 2 Inhibitors/adverse effects ; Sodium-Glucose Transporter 2 Inhibitors/therapeutic use ; Cohort Studies ; Adult ; Sweden/epidemiology ; Hypoglycemic Agents/adverse effects ; Hypoglycemic Agents/therapeutic use ; Risk Factors ; Diabetes Mellitus, Type 2/drug therapy ; Diabetes Mellitus, Type 2/epidemiology ; Norway/epidemiology ; Scandinavian and Nordic Countries/epidemiology ; Proportional Hazards Models
Chemical Substances	Glucagon-Like Peptide-1 Receptor ; Dipeptidyl-Peptidase IV Inhibitors ; Sodium-Glucose Transporter 2 Inhibitors ; Hypoglycemic Agents
Language	English
Publishing date	2024-04-10
Publishing country	England
Document type	Journal Article ; Research Support, Non-U.S. Gov't
ZDB-ID	1362901-3
ISSN	1756-1833 ; 0959-8154 ; 0959-8146 ; 0959-8138 ; 0959-535X ; 1759-2151
ISSN (online)	1756-1833
ISSN	0959-8154 ; 0959-8146 ; 0959-8138 ; 0959-535X ; 1759-2151
DOI	10.1136/bmj-2023-078225
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Article ; Online: Healthcare costs associated with overweight and obesity at an individual versus a population level - a HUNT study.

Edwards, Christina Hansen / Bjørnelv, Gudrun Waaler / Øvretveit, Karsten / Hveem, Kristian / Bjørngaard, Johan Håkon

Tidsskrift for den Norske laegeforening : tidsskrift for praktisk medicin, ny raekke

2023 Volume 143, Issue 13

Abstract: Background: The interpretation of research results is affected by how results are presented. We show the importance of presenting the association between body mass index (BMI) and healthcare costs from both the individual perspective and the population ... ...

Title translation	Helsetjenestekostnader ved overvekt og fedme på individnivå versus populasjonsnivå – en HUNT-studie.
Abstract	Background: The interpretation of research results is affected by how results are presented. We show the importance of presenting the association between body mass index (BMI) and healthcare costs from both the individual perspective and the population perspective. Material and method: Using measurements of height and weight from the Nord-Trøndelag Health Study (HUNT Study) linked to register data on specialist healthcare costs and demographics, we estimated the association between BMI and specialist healthcare costs by means of regression analyses. Results: From an individual perspective, the association between BMI and specialist healthcare costs was strongest in people in obesity classes 2 and 3 (BMI ≥ 35 kg/m2). In contrast, from a population perspective, the association was strongest in the case of overweight (BMI ≥ 25 kg/m2) or obesity class 1 (BMI ≥ 30 kg/m2), as there are more people in this BMI range. Interpretation: The study emphasises the importance of including the population perspective in research studies and policy decision-making processes. People with severe obesity have a high individual risk, but their use of health services has less significance for the overall costs of health care since they are fewer people in this group.
MeSH term(s)	Humans ; Overweight/epidemiology ; Obesity/epidemiology ; Health Care Costs ; Obesity, Morbid ; Body Mass Index
Language	Norwegian
Publishing date	2023-09-19
Publishing country	Norway
Document type	Journal Article
ZDB-ID	603504-8
ISSN	0807-7096 ; 0029-2001
ISSN (online)	0807-7096
ISSN	0029-2001
DOI	10.4045/tidsskr.22.0726
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Article ; Online: Patterns of Cardiac Troponin I Concentrations as Risk Predictors of Cardiovascular Disease and Death: The Trøndelag Health Study.

Lyngbakken, Magnus Nakrem / Kimenai, Dorien M / Hveem, Kristian / Dalen, Håvard / Røsjø, Helge / Omland, Torbjørn

The American journal of medicine

2023 Volume 136, Issue 9, Page(s) 902–909.e4

Abstract: Background: Concentrations of cardiac troponin predict risk of cardiovascular disease and death in the general population. There is limited evidence on changing patterns of cardiac troponin in the years preceding cardiovascular events.: Methods: We ... ...

Abstract	Background: Concentrations of cardiac troponin predict risk of cardiovascular disease and death in the general population. There is limited evidence on changing patterns of cardiac troponin in the years preceding cardiovascular events. Methods: We analyzed cardiac troponin I (cTnI) with a high-sensitivity assay in 3272 participants in the Trøndelag Health (HUNT) Study at study visit 4 (2017-2019). Of these, 3198 had measurement of cTnI at study visit 2 (1995-1997), 2661 at study visit 3, and 2587 at all 3 study visits. We assessed the trajectories of cTnI concentrations in the years prior to cardiovascular events using a generalized linear mixed model, with adjustment for age, sex, cardiovascular risk factors, and comorbidities. Results: At HUNT4 baseline, median age was 64.8 (range 39.4-101.3) years, and 55% were women. Study participants who were admitted because of heart failure or died from cardiovascular cause on follow-up had a steeper increase in cTnI compared with study participants with no events (P < .001). The average yearly change in cTnI was 0.235 (95% confidence interval, 0.192-0.289) ng/L for study participants with heart failure or cardiovascular death, and -0.022 (95% confidence interval, -0.022 to -0.023) ng/L for study participants with no events. Study participants who experienced myocardial infarction, ischemic stroke, or noncardiovascular mortality exhibited similar cTnI patterns. Conclusions: Fatal and nonfatal cardiovascular events are preceded by slowly increasing concentrations of cardiac troponin, independently of established cardiovascular risk factors. Our results support the use of cTnI measurements to identify at-risk subjects who progress to subclinical and later overt cardiovascular disease.
MeSH term(s)	Humans ; Female ; Adult ; Middle Aged ; Aged ; Aged, 80 and over ; Male ; Cardiovascular Diseases/epidemiology ; Troponin I ; Myocardial Infarction ; Heart Failure/epidemiology ; Ischemic Stroke ; Biomarkers
Chemical Substances	Troponin I ; Biomarkers
Language	English
Publishing date	2023-05-23
Publishing country	United States
Document type	Journal Article ; Research Support, Non-U.S. Gov't
ZDB-ID	80015-6
ISSN	1555-7162 ; 1873-2178 ; 0002-9343 ; 1548-2766
ISSN (online)	1555-7162 ; 1873-2178
ISSN	0002-9343 ; 1548-2766
DOI	10.1016/j.amjmed.2023.05.009
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Article ; Online: Creation of a new prospective research biobank: the example of HUNT3.

Hveem, Kristian

Methods in molecular biology (Clifton, N.J.)

2011 Volume 675, Page(s) 231–239

Abstract: When establishing a biobank, there are a number of issues to consider with significant impact on the outcome of your efforts and the quality of your work. Some of the most relevant are: (1) study design, (2) the size and composition of your cohort, (3) ... ...

Abstract	When establishing a biobank, there are a number of issues to consider with significant impact on the outcome of your efforts and the quality of your work. Some of the most relevant are: (1) study design, (2) the size and composition of your cohort, (3) the nature and desired quality of the biological material, and (4) how to handle, store, and retrieve your samples to maintain the best quality for future analyses. In this chapter, we in particular describe the organisation of biobanks derived from population-based prospective health surveys illustrated by the Norwegian HUNT study as a basis for more general considerations.
MeSH term(s)	Adolescent ; Adult ; Biological Specimen Banks ; Humans ; Norway ; Research Design ; Young Adult
Language	English
Publishing date	2011
Publishing country	United States
Document type	Journal Article
ISSN	1940-6029
ISSN (online)	1940-6029
DOI	10.1007/978-1-59745-423-0_12
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Article ; Online: Corrigendum to "A validated clinical risk prediction model for lung cancer in smokers of all ages and exposure types: A HUNT study" [EBioMedicine 31 (2018) 36-46].

Markaki, Maria / Tsamardinos, Ioannis / Langhammer, Arnulf / Lagani, Vincenzo / Hveem, Kristian / Røe, Oluf Dimitri

EBioMedicine

2022 Volume 82, Page(s) 104187

Language	English
Publishing date	2022-07-23
Publishing country	Netherlands
Document type	Published Erratum
ZDB-ID	2851331-9
ISSN	2352-3964
ISSN (online)	2352-3964
DOI	10.1016/j.ebiom.2022.104187
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Article ; Online: Tobacco Consumption and High-Sensitivity Cardiac Troponin I in the General Population: The HUNT Study.

Skranes, Julia Brox / Lyngbakken, Magnus Nakrem / Hveem, Kristian / Røsjø, Helge / Omland, Torbjørn

Journal of the American Heart Association

2022 Volume 11, Issue 2, Page(s) e021776

Abstract: Background Cardiac troponins represent a sensitive index of subclinical myocardial injury and are associated with increased risk of cardiovascular events in the general population. Despite positive associations with cardiovascular risk of both cardiac ... ...

Abstract	Background Cardiac troponins represent a sensitive index of subclinical myocardial injury and are associated with increased risk of cardiovascular events in the general population. Despite positive associations with cardiovascular risk of both cardiac troponins and cigarette smoking, concentrations of cardiac troponin I measured by high-sensitivity assays (hs-cTnI) are paradoxically lower in current smokers than in never-smokers. The impact of smoking intensity and time from smoking cessation on hs-cTnI remains unknown. Methods and Results hs-cTnI concentrations were measured in 32028 subjects free from cardiovascular disease enrolled in the prospective, population-based HUNT (Trøndelag Health Study). Tobacco habits were self-reported and classified as never (n=14 559), former (n=14 248), and current (n=3221) smokers. Current smokers exhibited significantly lower concentrations of hs-cTnI than never-smokers (
MeSH term(s)	Biomarkers ; Cardiovascular Diseases ; Humans ; Prospective Studies ; Tobacco Use ; Troponin I ; Troponin T
Chemical Substances	Biomarkers ; Troponin I ; Troponin T
Language	English
Publishing date	2022-01-08
Publishing country	England
Document type	Journal Article ; Research Support, Non-U.S. Gov't
ZDB-ID	2653953-6
ISSN	2047-9980 ; 2047-9980
ISSN (online)	2047-9980
ISSN	2047-9980
DOI	10.1161/JAHA.121.021776
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