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  1. Article: Effect of

    Hwang, Eun-Sun / Kim, Soyeon

    Preventive nutrition and food science

    2023  Volume 28, Issue 3, Page(s) 312–320

    Abstract: We investigated the impact of ... ...

    Abstract We investigated the impact of simulated
    Language English
    Publishing date 2023-09-20
    Publishing country Korea (South)
    Document type Journal Article
    ZDB-ID 2668373-8
    ISSN 2287-8602 ; 2287-1098
    ISSN (online) 2287-8602
    ISSN 2287-1098
    DOI 10.3746/pnf.2023.28.3.312
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  2. Article ; Online: The Landmark Series-Ductal Carcinoma in Situ: The Evolution of Treatment.

    Nash, Amanda L / Hwang, E Shelley

    Annals of surgical oncology

    2023  Volume 30, Issue 6, Page(s) 3206–3214

    Abstract: The evolution of ductal carcinoma in situ (DCIS) management has been driven by a parallel evolution in our understanding of its natural history. Early trials established the benefit of adjuvant therapies in all patients with DCIS. In contrast, subsequent ...

    Abstract The evolution of ductal carcinoma in situ (DCIS) management has been driven by a parallel evolution in our understanding of its natural history. Early trials established the benefit of adjuvant therapies in all patients with DCIS. In contrast, subsequent studies have stratified patients to determine their eligibility for progressively less invasive and less intensive therapies. Large, randomized trials and meta-analyses have supported this shift away from treating DCIS as an homogenous disease treated with similar intensity to invasive breast cancer. This review describes the landmark studies on which current DCIS management is based.
    MeSH term(s) Humans ; Female ; Carcinoma, Intraductal, Noninfiltrating/therapy ; Carcinoma, Intraductal, Noninfiltrating/pathology ; Breast Neoplasms/therapy ; Breast Neoplasms/pathology ; Combined Modality Therapy ; Carcinoma, Ductal, Breast/pathology ; Carcinoma in Situ/pathology
    Language English
    Publishing date 2023-04-06
    Publishing country United States
    Document type Journal Article ; Review
    ZDB-ID 1200469-8
    ISSN 1534-4681 ; 1068-9265
    ISSN (online) 1534-4681
    ISSN 1068-9265
    DOI 10.1245/s10434-023-13370-1
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    Zs.A 4042: Show issues Location:
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    bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular
    Jg. 1995 - 2021: Lesesall (2.OG)
    ab Jg. 2022: Lesesaal (EG)

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  3. Article ; Online: Impaired Autophagic Flux in Glucose-Deprived Cells: An Outcome of Lysosomal Acidification Failure Exacerbated by Mitophagy Dysfunction.

    Hwang, Eun Seong / Song, Seon Beom

    Molecules and cells

    2023  Volume 46, Issue 11, Page(s) 655–663

    Abstract: Autophagy dysfunction is associated with human diseases and conditions including neurodegenerative diseases, metabolic issues, and chronic infections. Additionally, the decline in autophagic activity contributes to tissue and organ dysfunction and aging- ... ...

    Abstract Autophagy dysfunction is associated with human diseases and conditions including neurodegenerative diseases, metabolic issues, and chronic infections. Additionally, the decline in autophagic activity contributes to tissue and organ dysfunction and aging-related diseases. Several factors, such as down-regulation of autophagy components and activators, oxidative damage, microinflammation, and impaired autophagy flux, are linked to autophagy decline. An autophagy flux impairment (AFI) has been implicated in neurological disorders and in certain other pathological conditions. Here, to enhance our understanding of AFI, we conducted a comprehensive literature review of findings derived from two well-studied cellular stress models: glucose deprivation and replicative senescence. Glucose deprivation is a condition in which cells heavily rely on oxidative phosphorylation for ATP generation. Autophagy is activated, but its flux is hindered at the autolysis step, primarily due to an impairment of lysosomal acidity. Cells undergoing replicative senescence also experience AFI, which is also known to be caused by lysosomal acidity failure. Both glucose deprivation and replicative senescence elevate levels of reactive oxygen species (ROS), affecting lysosomal acidification. Mitochondrial alterations play a crucial role in elevating ROS generation and reducing lysosomal acidity, highlighting their association with autophagy dysfunction and disease conditions. This paper delves into the underlying molecular and cellular pathways of AFI in glucose-deprived cells, providing insights into potential strategies for managing AFI that is driven by lysosomal acidity failure. Furthermore, the investigation on the roles of mitochondrial dysfunction sheds light on the potential effectiveness of modulating mitochondrial function to overcome AFI, offering new possibilities for therapeutic interventions.
    MeSH term(s) Humans ; Mitophagy ; Reactive Oxygen Species/metabolism ; Glucose/metabolism ; Autophagy/physiology ; Lysosomes/metabolism ; Hydrogen-Ion Concentration
    Chemical Substances Reactive Oxygen Species ; Glucose (IY9XDZ35W2)
    Language English
    Publishing date 2023-10-23
    Publishing country United States
    Document type Journal Article ; Review
    ZDB-ID 1148964-9
    ISSN 0219-1032 ; 1016-8478
    ISSN (online) 0219-1032
    ISSN 1016-8478
    DOI 10.14348/molcells.2023.0121
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    Zs.A 4713: Show issues Location:
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    Jg. 1995 - 2021: Lesesall (2.OG)
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  4. Article ; Online: Ophthalmoplegia in Patient With Papilledema.

    Hwang, Eric S / Frohman, Larry

    Journal of neuro-ophthalmology : the official journal of the North American Neuro-Ophthalmology Society

    2022  Volume 42, Issue 4, Page(s) e609–e610

    MeSH term(s) Humans ; Papilledema/diagnosis ; Papilledema/etiology ; Ophthalmoplegia/complications ; Ophthalmoplegia/diagnosis
    Language English
    Publishing date 2022-10-18
    Publishing country United States
    Document type Journal Article
    ZDB-ID 1189901-3
    ISSN 1536-5166 ; 1070-8022
    ISSN (online) 1536-5166
    ISSN 1070-8022
    DOI 10.1097/WNO.0000000000001707
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    Zs.A 1670: Show issues Location:
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    Jg. 1995 - 2021: Lesesall (1.OG)
    ab Jg. 2022: Lesesaal (EG)

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  5. Article: Effect of Cooking Method on Antioxidant Compound Contents in Cauliflower.

    Hwang, Eun-Sun

    Preventive nutrition and food science

    2019  Volume 24, Issue 2, Page(s) 210–216

    Abstract: In this study, we determined the contents of glucosinolate, polyphenol, and flavonoid, and the antioxidant activities of uncooked, steamed, and boiled cauliflower. Eight glucosinolate peaks were detected, representing glucoiberin, progoitrin, ... ...

    Abstract In this study, we determined the contents of glucosinolate, polyphenol, and flavonoid, and the antioxidant activities of uncooked, steamed, and boiled cauliflower. Eight glucosinolate peaks were detected, representing glucoiberin, progoitrin, glucoraphanin, sinigrin, gluconapin, glucoiberverin, glucobrassicin, and gluconasturtiin. Boiled cauliflower contained significantly lowered concentrations of glucosinolate, total polyphenol, and total flavonoid compared to uncooked or steamed cauliflower. These results clearly indicate that health-promoting compounds in cauliflower are significantly impacted by different cooking methods: uncooked> steamed> boiled. The amounts of total polyphenols and total flavonoids in uncooked cauliflower extracted with 80% ethanol were higher than extracts of steamed and boiled cauliflower. The highest antioxidant activity was observed in uncooked cauliflower extracted using 80% ethanol compared to those extracted with water at the same concentration. Steamed and boiled cauliflower extracts also showed lower antioxidant activity than uncooked extracts. Based on these results, fresh uncooked cauliflower contains higher contents of health-promoting compounds and elevated antioxidant activity. Moreover, steaming may be more desirable than boiling in order to minimize loss of glucosinolates when storing, pretreating, processing, and cooking cruciferous vegetables.
    Language English
    Publishing date 2019-06-30
    Publishing country Korea (South)
    Document type Journal Article
    ZDB-ID 2668373-8
    ISSN 2287-8602 ; 2287-1098
    ISSN (online) 2287-8602
    ISSN 2287-1098
    DOI 10.3746/pnf.2019.24.2.210
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  6. Article ; Online: How to Navigate the Treatment Spectrum from Multimodality Therapy to Observation Alone for ductal carcinoma in situ.

    Record, Sydney M / Hwang, Eun-Sil Shelley / Chiba, Akiko

    Surgical oncology clinics of North America

    2023  Volume 32, Issue 4, Page(s) 663–673

    Abstract: DCIS detection has increased dramatically since the introduction of screening mammography. Current guidance concordant care recommends surgical intervention for all patients with DCIS, followed by radiation and/or endocrine therapy for some. Adjuvant ... ...

    Abstract DCIS detection has increased dramatically since the introduction of screening mammography. Current guidance concordant care recommends surgical intervention for all patients with DCIS, followed by radiation and/or endocrine therapy for some. Adjuvant therapies after surgical excision have reduced recurrence rates but not breast cancer mortality. Given the lack of evidence of current treatment regimens and the morbidity associated with these treatments, there is concern that DCIS is over-treated. Active surveillance may be a favorable alternative for selected patients and is currently being investigated through four international clinical trials.
    MeSH term(s) Humans ; Female ; Carcinoma, Intraductal, Noninfiltrating/therapy ; Breast Neoplasms/therapy ; Early Detection of Cancer ; Mammography ; Combined Modality Therapy
    Language English
    Publishing date 2023-06-15
    Publishing country United States
    Document type Journal Article ; Review ; Research Support, Non-U.S. Gov't ; Research Support, N.I.H., Extramural ; Research Support, U.S. Gov't, Non-P.H.S.
    ZDB-ID 1196919-2
    ISSN 1558-5042 ; 1055-3207
    ISSN (online) 1558-5042
    ISSN 1055-3207
    DOI 10.1016/j.soc.2023.05.011
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    Se 1339: Show issues Location:
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    bis Jg. 2021: Bestellungen von Artikeln über das Online-Bestellformular
    ab Jg. 2022: Lesesaal (EG)

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  7. Article ; Online: Bilateral Cataracts and Posterior Lentiglobus in USP9X Syndrome.

    Hwang, Eileen S / Harrie, Roger P / Desautels, Jordan

    Ophthalmology

    2023  

    Language English
    Publishing date 2023-12-15
    Publishing country United States
    Document type Journal Article
    ZDB-ID 392083-5
    ISSN 1549-4713 ; 0161-6420
    ISSN (online) 1549-4713
    ISSN 0161-6420
    DOI 10.1016/j.ophtha.2023.10.023
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    Ul II Zs.83: Show issues Location:
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  8. Article ; Online: Lipofuscin Granule Accumulation Requires Autophagy Activation.

    Song, Seon Beom / Shim, Woosung / Hwang, Eun Seong

    Molecules and cells

    2023  Volume 46, Issue 8, Page(s) 486–495

    Abstract: Lipofuscins are oxidized lipid and protein complexes that accumulate during cellular senescence and tissue aging, regarded as markers for cellular oxidative damage, tissue aging, and certain aging-associated diseases. Therefore, understanding their ... ...

    Abstract Lipofuscins are oxidized lipid and protein complexes that accumulate during cellular senescence and tissue aging, regarded as markers for cellular oxidative damage, tissue aging, and certain aging-associated diseases. Therefore, understanding their cellular biological properties is crucial for effective treatment development. Through traditional microscopy, lipofuscins are readily observed as fluorescent granules thought to accumulate in lysosomes. However, lipofuscin granule formation and accumulation in senescent cells are poorly understood. Thus, this study examined lipofuscin accumulation in human fibroblasts exposed to various stressors. Our results substantiate that in glucose-starved or replicative senescence cells, where elevated oxidative stress levels activate autophagy, lipofuscins predominately appear as granules that co-localize with autolysosomes due to lysosomal acidity or impairment. Meanwhile, autophagosome formation is attenuated in cells experiencing oxidative stress induced by a doxorubicin pulse and chase, and lipofuscin fluorescence granules seldom manifest in the cytoplasm. As Torin-1 treatment activates autophagy, granular lipofuscins intensify and dominate, indicating that autophagy activation triggers their accumulation. Our results suggest that high oxidative stress activates autophagy but fails in lipofuscin removal, leaving an abundance of lipofuscin-filled impaired autolysosomes, referred to as residual bodies. Therefore, future endeavors in treating lipofuscin pathology-associated diseases and dysfunctions through autophagy activation demand meticulous consideration.
    MeSH term(s) Humans ; Lipofuscin/metabolism ; Lipofuscin/pharmacology ; Aging ; Cellular Senescence/physiology ; Oxidative Stress ; Lysosomes/metabolism ; Autophagy/physiology
    Chemical Substances Lipofuscin
    Language English
    Publishing date 2023-07-13
    Publishing country United States
    Document type Journal Article
    ZDB-ID 1148964-9
    ISSN 0219-1032 ; 1016-8478
    ISSN (online) 0219-1032
    ISSN 1016-8478
    DOI 10.14348/molcells.2023.0019
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    In stock of ZB MED Cologne/Königswinter

    Zs.A 4713: Show issues Location:
    Je nach Verfügbarkeit (siehe Angabe bei Bestand)
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    Jg. 1995 - 2021: Lesesall (2.OG)
    ab Jg. 2022: Lesesaal (EG)

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  9. Article ; Online: Classification performance bias between training and test sets in a limited mammography dataset.

    Hou, Rui / Lo, Joseph Y / Marks, Jeffrey R / Hwang, E Shelley / Grimm, Lars J

    PloS one

    2024  Volume 19, Issue 2, Page(s) e0282402

    Abstract: Objectives: To assess the performance bias caused by sampling data into training and test sets in a mammography radiomics study.: Methods: Mammograms from 700 women were used to study upstaging of ductal carcinoma in situ. The dataset was repeatedly ... ...

    Abstract Objectives: To assess the performance bias caused by sampling data into training and test sets in a mammography radiomics study.
    Methods: Mammograms from 700 women were used to study upstaging of ductal carcinoma in situ. The dataset was repeatedly shuffled and split into training (n = 400) and test cases (n = 300) forty times. For each split, cross-validation was used for training, followed by an assessment of the test set. Logistic regression with regularization and support vector machine were used as the machine learning classifiers. For each split and classifier type, multiple models were created based on radiomics and/or clinical features.
    Results: Area under the curve (AUC) performances varied considerably across the different data splits (e.g., radiomics regression model: train 0.58-0.70, test 0.59-0.73). Performances for regression models showed a tradeoff where better training led to worse testing and vice versa. Cross-validation over all cases reduced this variability, but required samples of 500+ cases to yield representative estimates of performance.
    Conclusions: In medical imaging, clinical datasets are often limited to relatively small size. Models built from different training sets may not be representative of the whole dataset. Depending on the selected data split and model, performance bias could lead to inappropriate conclusions that might influence the clinical significance of the findings.
    Advances in knowledge: Performance bias can result from model testing when using limited datasets. Optimal strategies for test set selection should be developed to ensure study conclusions are appropriate.
    MeSH term(s) Humans ; Female ; Mammography ; Machine Learning ; Retrospective Studies
    Language English
    Publishing date 2024-02-07
    Publishing country United States
    Document type Journal Article
    ZDB-ID 2267670-3
    ISSN 1932-6203 ; 1932-6203
    ISSN (online) 1932-6203
    ISSN 1932-6203
    DOI 10.1371/journal.pone.0282402
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  10. Article: Influence of Cooking Methods on Bioactive Compound Content and Antioxidant Activity of Brussels Sprouts.

    Hwang, Eun-Sun

    Preventive nutrition and food science

    2017  Volume 22, Issue 4, Page(s) 353–358

    Abstract: The effects of different cooking methods on total bioactive compound content were determined, ... ...

    Abstract The effects of different cooking methods on total bioactive compound content were determined, and
    Language English
    Publishing date 2017-12-31
    Publishing country Korea (South)
    Document type Journal Article
    ZDB-ID 2668373-8
    ISSN 2287-8602 ; 2287-1098
    ISSN (online) 2287-8602
    ISSN 2287-1098
    DOI 10.3746/pnf.2017.22.4.353
    Database MEDical Literature Analysis and Retrieval System OnLINE

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