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Article ; Online: Statistical optimization of environmental factors to produce the cytotoxic enniatins H, I and MK1688 against human multidrug resistance cancer cell lines.

Hwang, YoungMin / Lee, Hee-Seok

2023 Volume 33, Issue 3, Page(s) 579–587

Abstract: The environmental conditions were optimized to produce the enniatin H, I, and MK1688 ... ...

Abstract	The environmental conditions were optimized to produce the enniatin H, I, and MK1688 by
Language	English
Publishing date	2023-08-02
Publishing country	Korea (South)
Document type	Journal Article
ZDB-ID	2000008-X
ISSN	2092-6456 ; 1226-7708
ISSN (online)	2092-6456
ISSN	1226-7708
DOI	10.1007/s10068-023-01363-5
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Article: Enhanced Transport and Permeation of a Polymeric Nanocarrier across the Retina by Mixing with ATP upon Intravitreal Injection.

Kwon, Kiyoon / Hwang, Youngmin / Jung, Junyoung / Tae, Giyoong

Pharmaceutics

2021 Volume 13, Issue 4

Abstract: The outer part of the retina pigment epithelium (RPE) in the retina is the main site of neovascularization associated with retinal diseases. However, various obstacles interrupt the delivery of medicines across the RPE, mainly due to the well-developed ... ...

Abstract	The outer part of the retina pigment epithelium (RPE) in the retina is the main site of neovascularization associated with retinal diseases. However, various obstacles interrupt the delivery of medicines across the RPE, mainly due to the well-developed tight junctions in the RPE. Currently, there is no practical formulation to overcome this issue. In this study, we demonstrated that simple mixing with adenosine tetraphosphate (ATP) has the potential to greatly enhance the transport and permeation of a polymeric nanocarrier across the retina via intravitreal administration. Chitosan-functionalized, pluronic-based nanocarrier (NC), which can deliver various biomolecules efficiently, was used as a polymeric nanocarrier. Mixing with ATP facilitated the diffusion of the nanocarrier in the vitreous humor by reducing the electrostatic interaction between NC and negatively charged glycosaminoglycans (GAGs) in the vitreous humor. Mixing with ATP also allowed the penetration of NC across the whole retina, and it resulted in a great increase (approximately nine times) in the transport of NC across the retina, as well as spreading it throughout the whole retina upon intravitreal administration in a mouse model. This enhanced permeation across the retina was specific to ATP but not to GTP, suggesting the possibility of P2Y receptor-mediated tight junction disruption by ATP.
Language	English
Publishing date	2021-03-29
Publishing country	Switzerland
Document type	Journal Article
ZDB-ID	2527217-2
ISSN	1999-4923
ISSN	1999-4923
DOI	10.3390/pharmaceutics13040463
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Article ; Online: Effect of heating rate, temperature, and residence time during graphitization on the mechanical and electrical properties of isotropic graphite blocks

Lee, Sang-Hye / Hwang, Young-Min / Byun, Tae-Sub / Ko, Jong-Hwan / Roh, Jae-Seung

Carbon. 2023 May, v. 208, p. 443-451

2023 , Page(s) 443–451

Abstract: The present study aimed to determine the correlation between graphitization parameters during the manufacturing of isotropic graphite blocks, including temperature, residence time, and heating rate, and the physical properties of the obtained graphite ... ...

Abstract	The present study aimed to determine the correlation between graphitization parameters during the manufacturing of isotropic graphite blocks, including temperature, residence time, and heating rate, and the physical properties of the obtained graphite blocks. It was found that during graphitization, nitrogen- and sulfur-containing gases were generated, and the isotropic graphite blocks exhibited volume shrinkage, and their apparent density and bulk density increased, regardless of any changes in the process parameters, due to the intrinsic microstructure of the isotropic coke. Graphite blocks with varying graphitization temperatures and residence time exhibited increased bulk density and open porosity but decreased flexural strength and electrical resistivity compared to carbonized blocks. It was also confirmed that the heating rate process parameter was related to gas release rates and crystallization. In addition, it was observed that micron-sized pores were created around the developed graphite layered structure with increasing graphitization degree.
Keywords	bulk density ; crystallization ; electrical resistance ; graphene ; isotropy ; microstructure ; modulus of rupture ; porosity ; shrinkage ; temperature ; Isotropic ; Graphite block ; Graphitization ; Heating rate ; Shrinkage rate ; Isotropic coke
Language	English
Dates of publication	2023-05
Size	p. 443-451
Publishing place	Elsevier Ltd
Document type	Article ; Online
ISSN	0008-6223
DOI	10.1016/j.carbon.2023.03.069
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Article ; Online: Comparative Evaluation of Egg Quality in Response to Temperature Variability: From Farm to Table Exposure Scenarios.

An, Ji-Hoon / Hwang, Youngmin / Hwang, Sumin / Kwon, Hyojin / Gu, Hyelim / Park, Kihwan / Choi, Changsun

Food science of animal resources

2023 Volume 43, Issue 6, Page(s) 1002–1016

Abstract: This study aimed to develop appropriate temperature management practices and provide scientific evidence to support the development of sell-by-date guidance for eggs. Washed and unwashed eggs were subjected to storage under six different scenarios, and ... ...

Abstract	This study aimed to develop appropriate temperature management practices and provide scientific evidence to support the development of sell-by-date guidance for eggs. Washed and unwashed eggs were subjected to storage under six different scenarios, and both types of eggs were stored at temperatures up to 35°C to evaluate the sell-by-date. Despite temperature fluctuations or continuous storage at 30°C for 5 days, subsequent storage at 10°C resulted in significantly higher Haugh unit and yolk index on day 15. These results indicate that refrigerating eggs from retail sales until consumption is effective for egg quality management, despite the exposure of up to 35°C during distribution. In terms of sell-by-date evaluation, washed eggs retained class B quality for an additional 37 days beyond the recommended sell-by-date at 15°C, which is above the regulated storage temperature. However, unwashed eggs maintained class B quality for approximately 20 days at 30°C-35°C, emphasizing the need for sell-by-date guidelines for unwashed eggs. This study is the first to provide appropriate egg-handling practices based on the actual distribution environment in Korea.
Language	English
Publishing date	2023-11-01
Publishing country	Korea (South)
Document type	Journal Article
ZDB-ID	3016289-0
ISSN	2636-0780 ; 2636-0772
ISSN (online)	2636-0780
ISSN	2636-0772
DOI	10.5851/kosfa.2023.e62
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Article: Towards human organ generation using interspecies blastocyst complementation: Challenges and perspectives for therapy.

Sarmah, Hemanta / Sawada, Anri / Hwang, Youngmin / Miura, Akihiro / Shimamura, Yuko / Tanaka, Junichi / Yamada, Kazuhiko / Mori, Munemasa

Frontiers in cell and developmental biology

2023 Volume 11, Page(s) 1070560

Abstract: Millions of people suffer from end-stage refractory diseases. The ideal treatment option for terminally ill patients is organ transplantation. However, donor organs are in absolute shortage, and sadly, most patients die while waiting for a donor organ. ... ...

Abstract	Millions of people suffer from end-stage refractory diseases. The ideal treatment option for terminally ill patients is organ transplantation. However, donor organs are in absolute shortage, and sadly, most patients die while waiting for a donor organ. To date, no technology has achieved long-term sustainable patient-derived organ generation. In this regard, emerging technologies of chimeric human organ production
Language	English
Publishing date	2023-01-19
Publishing country	Switzerland
Document type	Journal Article ; Review
ZDB-ID	2737824-X
ISSN	2296-634X
ISSN	2296-634X
DOI	10.3389/fcell.2023.1070560
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Article ; Online: Simulation of contamination and elimination of Escherichia coli, Listeria monocytogenes, and Murine norovirus 1 (MNV-1) from the washing process when handling of potatoes.

Kwon, Hyojin / Wang, Zhaoqi / Gu, Hyelim / Hwang, Sumin / Hwang, Youngmin / An, Jihoon / Lee, Dong-Un / Jeong, Myeong-In / Choi, Changsun

International journal of food microbiology

2023 Volume 397, Page(s) 110221

Abstract: Root vegetables, which are in close contact with soil, are particularly vulnerable to soil contamination or decay as they can be contaminated from multiple sources, including primary production and processing. This study investigated effective washing ... ...

Abstract	Root vegetables, which are in close contact with soil, are particularly vulnerable to soil contamination or decay as they can be contaminated from multiple sources, including primary production and processing. This study investigated effective washing conditions to reduce the microbial contamination of potatoes by using soaking and shaking in the washing process. The reduction of Escherichia coli, Listeria monocytogenes, and Murine norovirus 1 (MNV-1) in four washing processes (soaking only, shaking only, combined soaking-shaking I, and combined soaking-shaking I-shaking II) were compared. The numbers of E. coli and L. monocytogenes decreased by 0.55 and 0.49 log CFU/g after shaking only, 1.96 and 1.80 log CFU/g after soaking, 2.07 and 1.67 log CFU/g after soaking-shaking I, and 2.42 and 1.90 log CFU/g after soaking-shaking I-shaking II, respectively. The combined process reduced the microbial contamination more efficiently than shaking only. The reduction of E. coli in the washing process was higher than that of L. monocytogenes by approximately 0.5 logs. MNV-1 showed a reduction in the soaking and shaking steps by 1.34 and 1.98 log GC/100 g, with no significant reduction observed after the combination process. A combined process of soaking-shaking I-shaking II was effective to eliminate E. coli, L. monocytogenes, and MNV-1 from potatoes during the handling and washing process.
MeSH term(s)	Animals ; Mice ; Food Microbiology ; Listeria monocytogenes ; Solanum tuberosum ; Food Handling ; Norovirus ; Escherichia coli O157 ; Colony Count, Microbial
Language	English
Publishing date	2023-04-23
Publishing country	Netherlands
Document type	Journal Article
ZDB-ID	87122-9
ISSN	1879-3460 ; 0168-1605
ISSN (online)	1879-3460
ISSN	0168-1605
DOI	10.1016/j.ijfoodmicro.2023.110221
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Article: Significantly enhanced recovery of acute liver failure by liver targeted delivery of stem cells via heparin functionalization

Hwang, Youngmin / Kim, Jong Chul / Tae, Giyoong

Biomaterials. 2019 July, v. 209

2019

Abstract: Acute liver failure (ALF) occurs by insufficient detoxification of toxic materials in the liver, generating excess reactive oxygen species (ROS). Mesenchymal stem cell (MSC) therapy can be a promising approach for the treatment of liver diseases ... ...

Abstract	Acute liver failure (ALF) occurs by insufficient detoxification of toxic materials in the liver, generating excess reactive oxygen species (ROS). Mesenchymal stem cell (MSC) therapy can be a promising approach for the treatment of liver diseases including ALF by anti-inflammatory activity and secretion of cytokines associated with tissue regeneration. However, the efficacy of MSC therapy is generally poor, mainly due to a low survival and engraftment of administered cells. In this study, we demonstrated that the enhanced delivery of human adipose-derived stem cells (hADSCs) to the damaged liver by the coating of lipid-conjugated heparin could result in significantly improved recovery from ALF in a mouse model. First, the therapeutic effect of secretomes of hADSCs on acetaminophen (APAP)-induced hepatic cell damage was confirmed regardless of the coating of lipid-conjugated heparin on hADSCs in vitro. Then, the therapeutic effects of lipid-conjugated heparin coated hADSCs (Lip-Hep/hADSC group) were analyzed compared to hADSCs themselves (hADSC group) using an APAP-induced ALF model in vivo. Intravenous administration of hADSCs could lower the elevated serum levels of aspartate transaminase (AST) and alanine transaminase (ALT), but Lip-Hep/hADSC group showed faster decrease in serum levels of AST and ALT to the normal values compared to hADSC group. Enhanced delivery and longer retention of hADSCs in the damage liver by the coating of lipid-conjugated heparin were confirmed by optical imaging of isolated organs using labeled cells and immunofluorescence staining of liver tissue sections against human nuclei. A significantly increased level of human hepatic growth factor (hHGF), a representative secretome from hADSC, significantly reduced levels of macrophage and CYP2E1, implying alleviated inflammatory response, were detected by immunofluorescence staining from Lip-Hep/hADSC group compared to hADSC group. These results well coincided with the improved recovery of the damaged liver from Lip-Hep/hADSC group than hADSC group in histological analysis. Thus, the coating of lipid-conjugated heparin on hADSCs has a great potential to improve the therapeutic effect of cells on the liver injury.
Keywords	acetaminophen ; alanine transaminase ; animal models ; anti-inflammatory activity ; aspartate transaminase ; blood serum ; coatings ; cytokines ; fluorescent antibody technique ; heparin ; histology ; humans ; image analysis ; inflammation ; intravenous injection ; liver ; liver failure ; macrophages ; mesenchymal stromal cells ; normal values ; reactive oxygen species ; secretion ; staining ; stem cells ; therapeutics ; tissue repair ; toxicity
Language	English
Dates of publication	2019-07
Size	p. 67-78.
Publishing place	Elsevier Ltd
Document type	Article
ZDB-ID	603079-8
ISSN	0142-9612
ISSN	0142-9612
DOI	10.1016/j.biomaterials.2019.04.019
Database	NAL-Catalogue (AGRICOLA)

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Article ; Online: Significantly enhanced recovery of acute liver failure by liver targeted delivery of stem cells via heparin functionalization.

Hwang, Youngmin / Kim, Jong Chul / Tae, Giyoong

Biomaterials

2019 Volume 209, Page(s) 67–78

Abstract	Acute liver failure (ALF) occurs by insufficient detoxification of toxic materials in the liver, generating excess reactive oxygen species (ROS). Mesenchymal stem cell (MSC) therapy can be a promising approach for the treatment of liver diseases including ALF by anti-inflammatory activity and secretion of cytokines associated with tissue regeneration. However, the efficacy of MSC therapy is generally poor, mainly due to a low survival and engraftment of administered cells. In this study, we demonstrated that the enhanced delivery of human adipose-derived stem cells (hADSCs) to the damaged liver by the coating of lipid-conjugated heparin could result in significantly improved recovery from ALF in a mouse model. First, the therapeutic effect of secretomes of hADSCs on acetaminophen (APAP)-induced hepatic cell damage was confirmed regardless of the coating of lipid-conjugated heparin on hADSCs in vitro. Then, the therapeutic effects of lipid-conjugated heparin coated hADSCs (Lip-Hep/hADSC group) were analyzed compared to hADSCs themselves (hADSC group) using an APAP-induced ALF model in vivo. Intravenous administration of hADSCs could lower the elevated serum levels of aspartate transaminase (AST) and alanine transaminase (ALT), but Lip-Hep/hADSC group showed faster decrease in serum levels of AST and ALT to the normal values compared to hADSC group. Enhanced delivery and longer retention of hADSCs in the damage liver by the coating of lipid-conjugated heparin were confirmed by optical imaging of isolated organs using labeled cells and immunofluorescence staining of liver tissue sections against human nuclei. A significantly increased level of human hepatic growth factor (hHGF), a representative secretome from hADSC, significantly reduced levels of macrophage and CYP2E1, implying alleviated inflammatory response, were detected by immunofluorescence staining from Lip-Hep/hADSC group compared to hADSC group. These results well coincided with the improved recovery of the damaged liver from Lip-Hep/hADSC group than hADSC group in histological analysis. Thus, the coating of lipid-conjugated heparin on hADSCs has a great potential to improve the therapeutic effect of cells on the liver injury.
MeSH term(s)	Acetaminophen/toxicity ; Adipose Tissue/cytology ; Alanine Transaminase/blood ; Aspartate Aminotransferases/blood ; Cell Survival/drug effects ; Hep G2 Cells ; Heparin/chemistry ; Humans ; Lipids/chemistry ; Liver/cytology ; Liver/injuries ; Liver/metabolism ; Liver Failure, Acute/blood ; Liver Failure, Acute/chemically induced ; Liver Failure, Acute/therapy ; Reactive Oxygen Species/metabolism ; Stem Cell Transplantation/methods
Chemical Substances	Lipids ; Reactive Oxygen Species ; Acetaminophen (362O9ITL9D) ; Heparin (9005-49-6) ; Aspartate Aminotransferases (EC 2.6.1.1) ; Alanine Transaminase (EC 2.6.1.2)
Language	English
Publishing date	2019-04-17
Publishing country	Netherlands
Document type	Journal Article ; Research Support, Non-U.S. Gov't
ZDB-ID	603079-8
ISSN	1878-5905 ; 0142-9612
ISSN (online)	1878-5905
ISSN	0142-9612
DOI	10.1016/j.biomaterials.2019.04.019
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Article ; Online: All-in-one nanosponge with pluronic shell for synergistic anticancer therapy through effectively overcoming multidrug resistance in cancer.

Lee, Jin Sil / Hwang, Youngmin / Oh, Hyeryeon / Sung, Daekyung / Tae, Giyoong / Choi, Won Il

Nanomedicine : nanotechnology, biology, and medicine

2021 Volume 40, Page(s) 102486

Abstract: Overexpression of P-glycoprotein (P-gp) on cancer cells is a major hurdle to effectively treat tumors with multidrug resistance (MDR). The current study aimed to explore anticancer drug and P-gp inhibitor delivery as a promising strategy to efficiently ... ...

Abstract	Overexpression of P-glycoprotein (P-gp) on cancer cells is a major hurdle to effectively treat tumors with multidrug resistance (MDR). The current study aimed to explore anticancer drug and P-gp inhibitor delivery as a promising strategy to efficiently treat colorectal cancer with MDR. To this end, a multidrug-loaded all-in-one nanosponge (ANS) was developed to simultaneously deliver doxorubicin (DOX), paclitaxel (PTX), and the P-gp inhibitor tetrandrine (TET), referred to as DOX/PTX/TET@ANS, without chemical conjugation. ANS with high loading content and efficiency facilitated a pH-dependent and controlled release with different profiles. Compared to free drugs and DOX/PTX@ANS, DOX/PTX/TET@ANS exhibited more effective anticancer effects on P-gp-overexpressing colorectal cancer cells and solid tumor mouse xenografts, without major toxicity. Notably, ANS composed of pluronic shell induced in vitro P-gp inhibition compared to TET, implying a synergistic anticancer effect. These findings suggest that ANS can encapsulate multiple drugs to efficiently deliver chemotherapy, particularly in MDR tumors.
MeSH term(s)	ATP Binding Cassette Transporter, Subfamily B, Member 1 ; Animals ; Cell Line, Tumor ; Doxorubicin/pharmacology ; Doxorubicin/therapeutic use ; Drug Resistance, Multiple ; Drug Resistance, Neoplasm ; Humans ; Mice ; Neoplasms ; Poloxamer/pharmacology
Chemical Substances	ATP Binding Cassette Transporter, Subfamily B, Member 1 ; Poloxamer (106392-12-5) ; Doxorubicin (80168379AG)
Language	English
Publishing date	2021-11-05
Publishing country	United States
Document type	Journal Article ; Research Support, Non-U.S. Gov't
ZDB-ID	2183417-9
ISSN	1549-9642 ; 1549-9634
ISSN (online)	1549-9642
ISSN	1549-9634
DOI	10.1016/j.nano.2021.102486
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Article: High Device Performances and Noise Characteristics of AlGaN/GaN HEMTs Using In Situ SiCN and SiN Cap Layer.

Im, Ki-Sik / Mallem, Siva Pratap Reddy / Choi, Jin-Seok / Hwang, Young-Min / Roh, Jae-Seung / An, Sung-Jin / Lee, Jae-Hoon

Nanomaterials (Basel, Switzerland)

2022 Volume 12, Issue 4

Abstract: We fabricated and characterized AlGaN/GaN high-electron mobility transistors (HEMTs) with a nano-sized in situ cap layer (one is a silicon carbon nitride (SiCN) layer, and the other is a silicon nitride (SiN) layer) comparing to the conventional device ... ...

Abstract	We fabricated and characterized AlGaN/GaN high-electron mobility transistors (HEMTs) with a nano-sized in situ cap layer (one is a silicon carbon nitride (SiCN) layer, and the other is a silicon nitride (SiN) layer) comparing to the conventional device without an in situ cap layer. The pulse characteristics and noise behaviors for two devices with in situ cap layers are much superior to those of the reference device without a cap layer, which means that the in situ cap layer effectively passivates the AlGaN surface. On the other hand, the device with an in situ SiCN cap layer showed the excellent device characteristics and noise performances compared to the other devices because of the reduced positive ionic charges and enhanced surface morphology caused by carbon (C) surfactant atoms during the growth of the SiCN cap layer. These results indicate that the AlGaN/GaN HEMT with the in situ SiCN cap layer is very promising for the next high-power device by replacing the conventional HEMT.
Language	English
Publishing date	2022-02-14
Publishing country	Switzerland
Document type	Journal Article
ZDB-ID	2662255-5
ISSN	2079-4991
ISSN	2079-4991
DOI	10.3390/nano12040643
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