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  1. Article: A G4·K+ Hydrogel Stabilized by an Anion

    Peters, Gretchen Marie / Brown Steven P / Davis Jeffery T / Hyman Brooke J / Manjunatha Reddy G. N / Marsh Andrew / Plank Taylor N / Skala Luke P

    Journal of the American Chemical Society. 2014 Sept. 10, v. 136, no. 36

    2014  

    Abstract: Supramolecular hydrogels derived from natural products have promising applications in diagnostics, drug delivery, and tissue engineering. We studied the formation of a long-lived hydrogel made by mixing guanosine (G, 1) with 0.5 equiv of KB(OH)₄. This ... ...

    Abstract Supramolecular hydrogels derived from natural products have promising applications in diagnostics, drug delivery, and tissue engineering. We studied the formation of a long-lived hydrogel made by mixing guanosine (G, 1) with 0.5 equiv of KB(OH)₄. This ratio of borate anion to ligand is crucial for gelation as it links two molecules of 1, which facilitates cation-templated assembly of G₄·K⁺ quartets. The guanosine–borate (GB) hydrogel, which was characterized by cryogenic transmission electron microscopy and circular dichroism and ¹¹B magic-angle-spinning NMR spectroscopy, is stable in water that contains physiologically relevant concentrations of K⁺. Furthermore, non-covalent interactions, such as electrostatics, π-stacking, and hydrogen bonding, enable the incorporation of a cationic dye and nucleosides into the GB hydrogel.
    Keywords borates ; circular dichroism spectroscopy ; diagnostic techniques ; drugs ; gelation ; guanosine ; hydrogels ; hydrogen bonding ; ligands ; mixing ; nuclear magnetic resonance spectroscopy ; potassium ; tissue engineering ; transmission electron microscopy
    Language English
    Dates of publication 2014-0910
    Size p. 12596-12599.
    Publishing place American Chemical Society
    Document type Article
    ZDB-ID 3155-0
    ISSN 1520-5126 ; 0002-7863
    ISSN (online) 1520-5126
    ISSN 0002-7863
    DOI 10.1021%2Fja507506c
    Database NAL-Catalogue (AGRICOLA)

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  2. Article ; Online: A G₄·K⁺ hydrogel stabilized by an anion.

    Peters, Gretchen Marie / Skala, Luke P / Plank, Taylor N / Hyman, Brooke J / Manjunatha Reddy, G N / Marsh, Andrew / Brown, Steven P / Davis, Jeffery T

    Journal of the American Chemical Society

    2014  Volume 136, Issue 36, Page(s) 12596–12599

    Abstract: Supramolecular hydrogels derived from natural products have promising applications in diagnostics, drug delivery, and tissue engineering. We studied the formation of a long-lived hydrogel made by mixing guanosine (G, 1) with 0.5 equiv of KB(OH)4. This ... ...

    Abstract Supramolecular hydrogels derived from natural products have promising applications in diagnostics, drug delivery, and tissue engineering. We studied the formation of a long-lived hydrogel made by mixing guanosine (G, 1) with 0.5 equiv of KB(OH)4. This ratio of borate anion to ligand is crucial for gelation as it links two molecules of 1, which facilitates cation-templated assembly of G4·K(+) quartets. The guanosine-borate (GB) hydrogel, which was characterized by cryogenic transmission electron microscopy and circular dichroism and (11)B magic-angle-spinning NMR spectroscopy, is stable in water that contains physiologically relevant concentrations of K(+). Furthermore, non-covalent interactions, such as electrostatics, π-stacking, and hydrogen bonding, enable the incorporation of a cationic dye and nucleosides into the GB hydrogel.
    MeSH term(s) Anions/chemistry ; Borates/chemistry ; Guanosine/chemistry ; Hydrogel, Polyethylene Glycol Dimethacrylate/chemistry ; Magnetic Resonance Spectroscopy ; Molecular Structure ; Potassium/chemistry
    Chemical Substances Anions ; Borates ; Guanosine (12133JR80S) ; Hydrogel, Polyethylene Glycol Dimethacrylate (25852-47-5) ; Potassium (RWP5GA015D)
    Language English
    Publishing date 2014-09-10
    Publishing country United States
    Document type Journal Article ; Research Support, Non-U.S. Gov't ; Research Support, U.S. Gov't, Non-P.H.S.
    ZDB-ID 3155-0
    ISSN 1520-5126 ; 0002-7863
    ISSN (online) 1520-5126
    ISSN 0002-7863
    DOI 10.1021/ja507506c
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    In stock of ZB MED Bonn / Germany

    Z 4' 55/32: Show issues
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    Inter-library loan at ZB MED

    Your chosen title can be delivered directly to ZB MED Cologne location if you are registered as a user at ZB MED Cologne.

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