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Article ; Online: Impact of sex on outcomes after percutaneous repair of functional mitral valve regurgitation.

Chan, Vincent / Messika-Zeitoun, David / Labinaz, Marino / Hynes, Mark / Nicholson, Donna / Dryden, Adam / Mesana, Thierry / Hibbert, Benjamin

Journal of cardiac surgery

2021 Volume 36, Issue 6, Page(s) 1900–1903

Abstract: Background: The role of percutaneous repair of functional mitral regurgitation (MR) is evolving. Left ventricle remodeling is known to be different between men and women; however, outcomes following percutaneous repair of functional MR have not ... ...

Abstract	Background: The role of percutaneous repair of functional mitral regurgitation (MR) is evolving. Left ventricle remodeling is known to be different between men and women; however, outcomes following percutaneous repair of functional MR have not considered the impact of sex. Methods: Between 2012 and 2018, 175 patients underwent percutaneous repair of functional MR with the Mitra Clip NT/NTR (Abbott) at our institution. Patients were assessed in a dedicated clinic with a follow-up that averaged 0.7 ± 1.2 years and extended to 5.7 years. Results: Men had a larger body surface area than women (p < .001), and were more likely than women to have diabetes preoperatively (p = .02). There were no deaths or instances of single leaflet detachment. Immediate postprocedure MR was ≤2+ in 158 (90%) with a mean trans-mitral valve repair gradient of 3.4 ± 1.0 and 3.5 ± 2.1 mmHg, respectively for women and men (p = .8). One- and 2-year freedom from MR ≥3+ was 86.0 ± 3.5% and 77.6 ± 5.1%, respectively. After adjusting for differences between male and female patients, women were more likely to have recurrent MR ≥3+ (hazard ratio, 4.7; 95% confidence interval, 1.2-18.4; p = .03). Upon adjusted analysis, there was also no association between gender and survival (p = .2). One- and 2-year survival was 69.8 ± 4.3% and 54.3 ± 5.5%, respectively. Conclusion: Women are more likely to have recurrent severe MR after percutaneous repair of functional MR. The mechanism for this remains undetermined.
MeSH term(s)	Cardiac Surgical Procedures ; Female ; Humans ; Male ; Mitral Valve Insufficiency/surgery ; Proportional Hazards Models ; Retrospective Studies ; Treatment Outcome ; Ventricular Remodeling
Language	English
Publishing date	2021-02-22
Publishing country	United States
Document type	Journal Article
ZDB-ID	639059-6
ISSN	1540-8191 ; 0886-0440
ISSN (online)	1540-8191
ISSN	0886-0440
DOI	10.1111/jocs.15445
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Zs.A 2221: Show issues

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Article ; Online: Mitral valve repair in acquired dextrocardia.

Elmistekawy, Elsayed / Chan, Vincent / Hynes, Mark / Mesana, Thierry

Asian cardiovascular & thoracic annals

2015 Volume 23, Issue 8, Page(s) 979–981

Abstract: Surgical correction of valvular heart disease in patients with dextrocardia is extremely rare. We report a surgical case of mitral valve repair in a patient with acquired dextrocardia. Successful mitral valve repair was performed through a right lateral ... ...

Abstract	Surgical correction of valvular heart disease in patients with dextrocardia is extremely rare. We report a surgical case of mitral valve repair in a patient with acquired dextrocardia. Successful mitral valve repair was performed through a right lateral thoracotomy. We describe our surgical strategy and summarize the literature.
MeSH term(s)	Adult ; Dextrocardia/complications ; Dextrocardia/diagnosis ; Female ; Heart Valve Prosthesis Implantation ; Humans ; Mitral Valve/diagnostic imaging ; Mitral Valve/physiopathology ; Mitral Valve/surgery ; Mitral Valve Annuloplasty ; Mitral Valve Insufficiency/complications ; Mitral Valve Insufficiency/diagnosis ; Mitral Valve Insufficiency/physiopathology ; Mitral Valve Insufficiency/surgery ; Tomography, X-Ray Computed ; Treatment Outcome
Language	English
Publishing date	2015-10
Publishing country	England
Document type	Case Reports ; Journal Article ; Review
ZDB-ID	1400468-9
ISSN	1816-5370 ; 0218-4923
ISSN (online)	1816-5370
ISSN	0218-4923
DOI	10.1177/0218492314530975
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Zs.A 5193: Show issues

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Article ; Online: Percutaneous Mitral Repair as Salvage Therapy in Patients With Mitral Regurgitation and Refractory Cardiogenic Shock.

Chan, Vincent / Messika-Zeitoun, David / Labinaz, Marino / Hynes, Mark / Nicholson, Donna / Dryden, Adam / Mesana, Thierry / Hibbert, Benjamin

Circulation. Cardiovascular interventions

2019 Volume 12, Issue 11, Page(s) e008435

MeSH term(s)	Aged ; Aged, 80 and over ; Cardiac Catheterization/adverse effects ; Cardiac Catheterization/instrumentation ; Cardiac Catheterization/mortality ; Female ; Heart Valve Prosthesis ; Heart Valve Prosthesis Implantation/adverse effects ; Heart Valve Prosthesis Implantation/instrumentation ; Heart Valve Prosthesis Implantation/mortality ; Hemodynamics ; Hospital Mortality ; Humans ; Male ; Middle Aged ; Mitral Valve/diagnostic imaging ; Mitral Valve/physiopathology ; Mitral Valve/surgery ; Mitral Valve Insufficiency/diagnostic imaging ; Mitral Valve Insufficiency/mortality ; Mitral Valve Insufficiency/physiopathology ; Mitral Valve Insufficiency/surgery ; Prosthesis Design ; Recovery of Function ; Salvage Therapy/adverse effects ; Salvage Therapy/instrumentation ; Salvage Therapy/mortality ; Shock, Cardiogenic/diagnosis ; Shock, Cardiogenic/mortality ; Shock, Cardiogenic/physiopathology ; Shock, Cardiogenic/therapy ; Time Factors ; Treatment Outcome ; Ventricular Function, Left
Language	English
Publishing date	2019-11-07
Publishing country	United States
Document type	Letter
ZDB-ID	2450797-0
ISSN	1941-7632 ; 1941-7640
ISSN (online)	1941-7632
ISSN	1941-7640
DOI	10.1161/CIRCINTERVENTIONS.119.008435
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Zs.A 6746: Show issues

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Article ; Online: Transcatheter mitral valve repair for inotrope dependent cardiogenic shock - Design and rationale of the CAPITAL MINOS trial.

Parlow, Simon / Di Santo, Pietro / Jung, Richard G / Fam, Neil / Czarnecki, Andrew / Horlick, Eric / Abdel-Razek, Omar / Chan, Vincent / Hynes, Mark / Nicholson, Donna / Dryden, Adam / Fernando, Shannon M / Wells, George A / Bernick, Jordan / Labinaz, Marino / Mathew, Rebecca / Simard, Trevor / Hibbert, Benjamin

American heart journal

2022 Volume 254, Page(s) 81–87

Abstract: Background: Functional mitral regurgitation (MR) is an important clinical consideration in patients with heart failure. Transcatheter edge-to-edge repair (TEER) has emerged as a useful therapeutic tool for patients with chronic heart failure, however ... ...

Abstract	Background: Functional mitral regurgitation (MR) is an important clinical consideration in patients with heart failure. Transcatheter edge-to-edge repair (TEER) has emerged as a useful therapeutic tool for patients with chronic heart failure, however the role of TEER in patients with cardiogenic shock (CS) and MR has not yet been studied in a randomized trial. The Transcatheter Mitral Valve Repair for Inotrope Dependent Cardiogenic Shock (CAPITAL MINOS) trial was therefore designed to determine if TEER improves clinical outcomes in the CS population. Methods and design: The CAPITAL MINOS trial is an open-label, multi-center randomized clinical trial comparing TEER to medical therapy in patients with CS and MR. A total of 144 patients with Society for Cardiovascular Angiography and Interventions (SCAI) class C or D CS and at least 3+ MR will be randomized in a 1:1 ratio to TEER or medical therapy alone. The primary outcome will be a composite of in-hospital all-cause mortality, cardiac transplantation, implantation of durable left ventricular assist device, or discharge on palliative inotropic therapy. Patients will be followed for the duration of their index hospitalization for the primary outcome. Secondary outcomes include 6 month mortality. Implications: The CAPITAL MINOS trial will determine whether TEER improves outcomes in patients with CS and MR and will be an important step in optimizing treatment for this high-risk patient population.
Language	English
Publishing date	2022-08-21
Publishing country	United States
Document type	Journal Article
ZDB-ID	80026-0
ISSN	1097-6744 ; 0002-8703
ISSN (online)	1097-6744
ISSN	0002-8703
DOI	10.1016/j.ahj.2022.08.008
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Ui IV Zs.15: Show issues

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Article ; Online: How Does Mitral Valve Repair Fail in Patients With Prolapse?-Insights From Longitudinal Echocardiographic Follow-Up.

Chan, Vincent / Elmistekawy, Elsayed / Ruel, Marc / Hynes, Mark / Mesana, Thierry G

The Annals of thoracic surgery

2016 Volume 102, Issue 5, Page(s) 1459–1465

Abstract: Background: Repair of mitral regurgitation (MR) caused by prolapse has been well validated. Although favorable early and late results after repair have been reported, few data are available that mechanistically describe how a mitral repair fails beyond ... ...

Abstract	Background: Repair of mitral regurgitation (MR) caused by prolapse has been well validated. Although favorable early and late results after repair have been reported, few data are available that mechanistically describe how a mitral repair fails beyond the mere need for mitral valve reoperation. We therefore sought to determine the modes of valve repair failure in patients who underwent surgical correction of MR caused by prolapse. Methods: Between 2001 and 2015, 855 patients underwent repair of MR caused by prolapse. Patients were a mean age of 63.7 ± 12.7 years, and 380 (44%) had bileaflet prolapse. The overall repair rate was 97.2%. These patients were monitored as part of a cohort initiative and underwent serial clinical and echocardiographic assessments at 1, 3 to 6, and 12 months after the operation. Beyond the first year of the MR repair, patients were assessed by echocardiography every 1 to 2 years or when clinically indicated. Clinical and echocardiographic follow-up averaged 4.3 ± 3.5 years. Results: Freedom from recurrent MR of 2+ or higher was 92.4% ± 1.3% at 5 years and 86.6% ± 2.4% at 10 years. Overall, recurrent MR of 2+ or higher developed in 49 patients (5.7%) at a mean of 3.1 ± 2.5 years after the repair, of whom 14 (1.6%) had recurrent MR of 3+ or 4+. Among patients with bileaflet prolapse, recurrent MR of 2+ or higher was observed in 24, of whom 9 had 3+ or 4+ MR., The development of recurrent MR of 2+ or higher was categorized as prolapse in 6 and nonprolapse in 43. Severe mitral stenosis occurred in 3 patients at 8.2 years after the MR repair. Mitral reoperation was ultimately performed in 21 patients. Patients who had recurrent MR 2+ or higher within the first year after the operation were more likely to undergo a subsequent mitral valve reoperation (incident rate ratio, 5.2 ± 2.9; p = 0.003), although no association between recurrent MR and reoperation was observed after the first year. Conclusions: Severe MR after repair is rare, although some may have recurrent moderate MR. Patients who required a subsequent mitral valve reoperation were most likely to have recurrent MR of 2+ or higher within the first year after the operation.
MeSH term(s)	Echocardiography/methods ; Female ; Follow-Up Studies ; Heart Valve Prosthesis Implantation/adverse effects ; Humans ; Male ; Middle Aged ; Mitral Valve/diagnostic imaging ; Mitral Valve/surgery ; Mitral Valve Insufficiency/diagnosis ; Mitral Valve Insufficiency/mortality ; Mitral Valve Insufficiency/surgery ; Ontario/epidemiology ; Reoperation ; Retrospective Studies ; Survival Rate/trends ; Time Factors ; Treatment Failure ; Treatment Outcome
Language	English
Publishing date	2016-11
Publishing country	Netherlands
Document type	Journal Article
ZDB-ID	211007-6
ISSN	1552-6259 ; 0003-4975
ISSN (online)	1552-6259
ISSN	0003-4975
DOI	10.1016/j.athoracsur.2016.08.088
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Zs.A 252: Show issues

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Article: Clinical Diagnostic Tests versus Medial Branch Blocks for Adults with Persisting Cervical Zygapophyseal Joint Pain: A Systematic Review and Meta-Analysis.

Usunier, Kendra / Hynes, Mark / Schuster, James Michael / Cornelio-Jin Suen, Annie / Sadi, Jackie / Walton, David

Physiotherapy Canada. Physiotherapie Canada

2018 Volume 70, Issue 2, Page(s) 179–187

Abstract: Purpose: ...

Abstract	Purpose:
Language	English
Publishing date	2018-05-14
Publishing country	Canada
Document type	Journal Article
ZDB-ID	639189-8
ISSN	1708-8313 ; 0300-0508
ISSN (online)	1708-8313
ISSN	0300-0508
DOI	10.3138/ptc.2016-89.mt
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Zs.B 3116: Show issues

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Article: Repair of quadricuspid aortic valve associated with ascending aorta dilatation.

Elmistekawy, Elsayed M / Malas, Tarek / Hynes, Mark / Boodhwani, Munir

The Journal of heart valve disease

2012 Volume 21, Issue 6, Page(s) 740–742

Abstract: Quadricuspid aortic valve is a rare congenital anomaly that may require surgical intervention because of valvular dysfunction. Rarely, it may be associated with enlargement of the ascending aorta. Here, the case is presented of a quadricuspid aortic ... ...

Abstract	Quadricuspid aortic valve is a rare congenital anomaly that may require surgical intervention because of valvular dysfunction. Rarely, it may be associated with enlargement of the ascending aorta. Here, the case is presented of a quadricuspid aortic valve-associated enlargement of the ascending aorta and functional aortic annulus dilatation in a 36-year-old patient. The patient subsequently underwent a successful aortic valve repair and replacement of the ascending aorta.
MeSH term(s)	Adult ; Aortic Aneurysm/complications ; Aortic Aneurysm/diagnostic imaging ; Aortic Aneurysm/surgery ; Aortic Valve/abnormalities ; Aortic Valve/diagnostic imaging ; Aortic Valve/surgery ; Aortic Valve Insufficiency/etiology ; Aortic Valve Insufficiency/surgery ; Blood Vessel Prosthesis Implantation ; Cardiac Valve Annuloplasty ; Dilatation, Pathologic ; Echocardiography, Transesophageal ; Heart Defects, Congenital/complications ; Heart Defects, Congenital/diagnostic imaging ; Heart Defects, Congenital/surgery ; Humans ; Male ; Treatment Outcome
Language	English
Publishing date	2012-11
Publishing country	England
Document type	Case Reports ; Journal Article
ZDB-ID	1205265-6
ISSN	2053-2644 ; 0966-8519
ISSN (online)	2053-2644
ISSN	0966-8519
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Zs.A 4109: Show issues

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Article ; Online: Mechanical valve thrombosis with dabigatran.

Price, Joel / Hynes, Mark / Labinaz, Marino / Ruel, Marc / Boodhwani, Munir

Journal of the American College of Cardiology

2012 Volume 60, Issue 17, Page(s) 1710–1711

MeSH term(s)	Antithrombins/therapeutic use ; Benzimidazoles/therapeutic use ; Dabigatran ; Diagnosis, Differential ; Echocardiography, Transesophageal ; Female ; Follow-Up Studies ; Heart Diseases/diagnosis ; Heart Diseases/drug therapy ; Heart Diseases/etiology ; Heart Valve Diseases/surgery ; Heart Valve Prosthesis/adverse effects ; Humans ; Middle Aged ; Prosthesis Failure ; Thrombosis/diagnosis ; Thrombosis/drug therapy ; Thrombosis/etiology ; beta-Alanine/analogs & derivatives ; beta-Alanine/therapeutic use
Chemical Substances	Antithrombins ; Benzimidazoles ; beta-Alanine (11P2JDE17B) ; Dabigatran (I0VM4M70GC)
Language	English
Publishing date	2012-10-23
Publishing country	United States
Document type	Case Reports ; Letter
ZDB-ID	605507-2
ISSN	1558-3597 ; 0735-1097
ISSN (online)	1558-3597
ISSN	0735-1097
DOI	10.1016/j.jacc.2012.06.039
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Zs.A 1846: Show issues			Location: Je nach Verfügbarkeit (siehe Angabe bei Bestand) bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular Jg. 1995 - 2021: Lesesall (1.OG) ab Jg. 2022: Lesesaal (EG)
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Article ; Online: Aortic root geometry in bicuspid aortic insufficiency versus stenosis: implications for valve repair.

Al-Atassi, Talal / Hynes, Mark / Sohmer, Benjamin / Lam, Buu-Khanh / Mesana, Thierry / Boodhwani, Munir

European journal of cardio-thoracic surgery : official journal of the European Association for Cardio-thoracic Surgery

2014 Volume 47, Issue 4, Page(s) e151–4

Abstract: Objectives: The contribution of aortic annular and root disease in bicuspid aortic valve (BAV) insufficiency remains unclear. We compared aortic root geometry between BAV stenosis and aortic insufficiency (AI), before and after repair.: Methods: ... ...

Abstract	Objectives: The contribution of aortic annular and root disease in bicuspid aortic valve (BAV) insufficiency remains unclear. We compared aortic root geometry between BAV stenosis and aortic insufficiency (AI), before and after repair. Methods: Patients presenting for surgery for BAV insufficiency (n = 58) were compared with patients with BAV stenosis (n = 58). Clinical and transoesophageal echocardiographic data were collected, including end-diastolic diameters of the ventriculo-aortic junction (VAJ), aortic root, sinotubular junction (STJ) and ascending aorta (AA). Results: AI patients were younger and more likely to be male compared with aortic stenosis (AS) patients. VAJ, aortic root and STJ diameters were significantly larger in AI compared with AS patients (30 ± 0.5 vs 25 ± 0.4 mm, P < 0.001; 41 ± 0.8 vs 34 ± 0.6 mm, P < 0.001; 36 ± 0.9 vs 30 ± 0.6 mm, P < 0.001, respectively). Following multivariable adjustment for age, sex, body surface area and ascending aortic diameter, these diameters remained larger in AI patients with a mean difference of 3, 6 and 4 mm, respectively (all P < 0.001). Mean AA diameter in the AI group was similar to the AS group (37 ± 1.0 vs 34 ± 0.8 mm, P = 0.06). Forty (69%) AI patients had BAV repair with a mean reduction in VAJ and STJ diameters of 5 and 9 mm compared with prerepair (P < 0.0001). Conclusions: Despite the absence of aortic aneurysms, aortic annulus and root dimensions are significantly larger in patients with BAV insufficiency compared with stenosis. Alterations in aortic root geometry contribute to the pathophysiology of BAV insufficiency and require correction for a successful repair.
MeSH term(s)	Aortic Valve/abnormalities ; Aortic Valve/pathology ; Aortic Valve/surgery ; Aortic Valve Insufficiency/epidemiology ; Aortic Valve Insufficiency/pathology ; Aortic Valve Insufficiency/surgery ; Aortic Valve Stenosis/epidemiology ; Aortic Valve Stenosis/pathology ; Aortic Valve Stenosis/surgery ; Bicuspid Aortic Valve Disease ; Female ; Heart Valve Diseases/epidemiology ; Heart Valve Diseases/pathology ; Heart Valve Diseases/surgery ; Humans ; Male ; Middle Aged ; Retrospective Studies
Language	English
Publishing date	2014-12-30
Publishing country	Germany
Document type	Journal Article
ZDB-ID	639293-3
ISSN	1873-734X ; 1010-7940 ; 1567-4258
ISSN (online)	1873-734X
ISSN	1010-7940 ; 1567-4258
DOI	10.1093/ejcts/ezu499
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Zs.A 2303: Show issues

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Article ; Online: Perioperative deaths after mitral valve operations may be overestimated by contemporary risk models.

Chan, Vincent / Ahrari, Azin / Ruel, Marc / Elmistekawy, Elsayed / Hynes, Mark / Mesana, Thierry G

The Annals of thoracic surgery

2014 Volume 98, Issue 2, Page(s) 605–10; discussion 610

Abstract: Background: Percutaneous therapies to manage mitral regurgitation are emerging as an alternative to conventional operations, especially for patients with a high estimated perioperative risk. However, contemporary risk models may not accurately reflect ... ...

Abstract	Background: Percutaneous therapies to manage mitral regurgitation are emerging as an alternative to conventional operations, especially for patients with a high estimated perioperative risk. However, contemporary risk models may not accurately reflect outcomes at reference mitral valve centers. The purpose of this study was to describe perioperative mortality rates after mitral valve operations in a contemporary cohort. Methods: Between 2001 and 2011, 1,154 patients underwent mitral valve operations at a reference center. Of these, 851 underwent repair and 303 underwent replacement. Concomitant coronary artery bypass grafting was performed in 201 (17%). The Society of Thoracic Surgeons (STS) risk score version 2.73 and European System for Cardiac Operative Risk Evaluation (EuroSCORE) II were used to estimate the number of perioperative deaths. Results: The observed perioperative mortality was 1.0%. The STS score was 2.3%±2.6% and was higher than the observed mortality rate for each of the STS subgroups (all p<0.001). The EuroSCORE II expected mortality was 3.0%±3.4% and was greater than the observed mortality rate for isolated and combined procedures (both p<0.001). The STS and EuroSCORE II provided fair death discrimination, with an area under the receiver operating characteristic curve of 0.74 and 0.67, respectively. Conclusions: Although current risk models aid in risk stratifying patients, the contemporary perioperative mortality rate at a reference mitral valve center is significantly lower than expected. The use of alternate therapies must therefore take into consideration differences in perioperative risk based on the treating center.
MeSH term(s)	Cohort Studies ; Female ; Heart Valve Prosthesis Implantation ; Humans ; Male ; Middle Aged ; Mitral Valve Insufficiency/surgery ; Models, Statistical ; Postoperative Complications/mortality ; Prognosis ; Risk Assessment
Language	English
Publishing date	2014-08
Publishing country	Netherlands
Document type	Journal Article
ZDB-ID	211007-6
ISSN	1552-6259 ; 0003-4975
ISSN (online)	1552-6259
ISSN	0003-4975
DOI	10.1016/j.athoracsur.2014.05.011
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