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  1. Article: Down-Regulation of Tinnitus Negative Valence via Concurrent HD-tDCS and PEI Technique: A Pilot Study.

    Vaziri, Zahra / Salmon, Carlos E G / Ghodratitoostani, Iman / Santos, Antonio Carlos Dos / Hyppolito, Miguel A / Delbem, Alexandre C B / Leite, João P

    Brain sciences

    2023  Volume 13, Issue 5

    Abstract: Around 30% of the general population experience subjective tinnitus, characterized by conscious attended awareness perception of sound without an external source. Clinical distress tinnitus is more than just experiencing a phantom sound, as it can be ... ...

    Abstract Around 30% of the general population experience subjective tinnitus, characterized by conscious attended awareness perception of sound without an external source. Clinical distress tinnitus is more than just experiencing a phantom sound, as it can be highly disruptive and debilitating, leading those affected to seek clinical help. Effective tinnitus treatments are crucial for psychological well-being, but our limited understanding of the underlying neural mechanisms and a lack of a universal cure necessitate further treatment development. In light of the neurofunctional tinnitus model predictions and transcranial electrical stimulation, we conducted an open-label, single-arm, pilot study that utilized high-definition transcranial direct current stimulation (HD-tDCS) concurrent with positive emotion induction (PEI) techniques for ten consecutive sessions to down-regulate tinnitus negative valence in patients with clinical distress tinnitus. We acquired resting-state functional magnetic resonance imaging scans of 12 tinnitus patients (7 females, mean age = 51.25 ± 12.90 years) before and after the intervention to examine resting-state functional connectivity (rsFC) alterations in specific seed regions. The results showed reduced rsFC at post-intervention between the attention and emotion processing regions as follows: (1) bilateral amygdala and left superior parietal lobule (SPL), (2) left amygdala and right SPL, (3) bilateral dorsolateral prefrontal cortex (dlPFC) and bilateral pregenual anterior cingulate cortex (pgACC), and (4) left dlPFC and bilateral pgACC (FWE corrected
    Language English
    Publishing date 2023-05-19
    Publishing country Switzerland
    Document type Journal Article
    ZDB-ID 2651993-8
    ISSN 2076-3425
    ISSN 2076-3425
    DOI 10.3390/brainsci13050826
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  2. Article: Cochlear turns measurements in patients with meningitis: A histopathological study.

    Pauna, Henrique F / Paparella, Michael M / Cureoglu, Sebahattin / Hyppolito, Miguel A

    Laryngoscope investigative otolaryngology

    2020  Volume 5, Issue 3, Page(s) 506–510

    Abstract: Objective: To demonstrate the cochlear turns area changes among patients with a history of meningitis, through otopatologic study.: Methods: We performed an analysis of the area of the bony cochlear turns and the cochlear lumen of the horizontal ... ...

    Abstract Objective: To demonstrate the cochlear turns area changes among patients with a history of meningitis, through otopatologic study.
    Methods: We performed an analysis of the area of the bony cochlear turns and the cochlear lumen of the horizontal sections containing the modiolus and the area of the basal turn at the level of round window, in temporal bones obtained from patients with a history of meningitis and compared to a nondiseased control group.
    Results: The mean area of the bony walls and the lumen of all cochlear turns are reduced within the meningitis group. Patients who presented a time from the diagnosis of meningitis to death longer than 30 days had a significant reduction in the cochlear turns area, as compared to the control group.
    Conclusion: Future studies may further correlate audiologic outcomes, cochlear volume, and cochlear area among patients with meningitis.
    Language English
    Publishing date 2020-05-06
    Publishing country United States
    Document type Journal Article
    ISSN 2378-8038
    ISSN 2378-8038
    DOI 10.1002/lio2.383
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  3. Article: Dose-Response Transcranial Electrical Stimulation Study Design: A Well-Controlled Adaptive Seamless Bayesian Method to Illuminate Negative Valence Role in Tinnitus Perception.

    Ghodratitoostani, Iman / Gonzatto, Oilson A / Vaziri, Zahra / Delbem, Alexandre C B / Makkiabadi, Bahador / Datta, Abhishek / Thomas, Chris / Hyppolito, Miguel A / Santos, Antonio C D / Louzada, Francisco / Leite, João Pereira

    Frontiers in human neuroscience

    2022  Volume 16, Page(s) 811550

    Abstract: The use of transcranial Electrical Stimulation (tES) in the modulation of cognitive brain functions to improve neuropsychiatric conditions has extensively increased over the decades. tES techniques have also raised new challenges associated with study ... ...

    Abstract The use of transcranial Electrical Stimulation (tES) in the modulation of cognitive brain functions to improve neuropsychiatric conditions has extensively increased over the decades. tES techniques have also raised new challenges associated with study design, stimulation protocol, functional specificity, and dose-response relationship. In this paper, we addressed challenges through the emerging methodology to investigate the dose-response relationship of High Definition-transcranial Direct Current Stimulation (HD tDCS), identifying the role of negative valence in tinnitus perception. In light of the neurofunctional testable framework and tES application, hypotheses were formulated to measure clinical and surrogate endpoints. We posited that conscious pairing adequately pleasant stimuli with tinnitus perception results in correction of the loudness misperception and would be reinforced by concurrent active HD-tDCS on the left Dorsolateral Prefrontal Cortex (dlPFC). The dose-response relationship between HD-tDCS specificity and the loudness perception is also modeled. We conducted a double-blind, randomized crossover pilot study with six recruited tinnitus patients. Accrued data was utilized to design a well-controlled adaptive seamless Bayesian dose-response study. The sample size (
    Language English
    Publishing date 2022-05-12
    Publishing country Switzerland
    Document type Journal Article
    ZDB-ID 2425477-0
    ISSN 1662-5161
    ISSN 1662-5161
    DOI 10.3389/fnhum.2022.811550
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  4. Article ; Online: Morphological and molecular correlates of altered hearing sensitivity in the genetically audiogenic seizure-prone hamster GASH/Sal.

    Sánchez-Benito, David / Hyppolito, Miguel A / Alvarez-Morujo, Antonio J / López, Dolores E / Gómez-Nieto, Ricardo

    Hearing research

    2020  Volume 392, Page(s) 107973

    Abstract: Rodent models of audiogenic seizures, in which seizures are precipitated by an abnormal response of the brain to auditory stimuli, are crucial to investigate the neural bases underlying ictogenesis. Despite significant advances in understanding seizure ... ...

    Abstract Rodent models of audiogenic seizures, in which seizures are precipitated by an abnormal response of the brain to auditory stimuli, are crucial to investigate the neural bases underlying ictogenesis. Despite significant advances in understanding seizure generation in the inferior colliculus, namely the epileptogenic nucleus, little is known about the contribution of lower auditory stations to the seizure-prone network. Here, we examined the cochlea and cochlear nucleus of the genetic audiogenic seizure hamster from Salamanca (GASH/Sal), a model of reflex epilepsy that exhibits generalized tonic-clonic seizures in response to loud sound. GASH/Sal animals under seizure-free conditions were compared with matched control hamsters in a multi-technical approach that includes auditory brainstem responses (ABR) testing, histology, scanning electron microscopy analysis, immunohistochemistry, quantitative morphometry and gene expression analysis (RT-qPCR). The cochlear histopathology of the GASH/Sal showed preservation of the sensory hair cells, but a significant loss of spiral ganglion neurons and mild atrophy of the stria vascularis. At the electron microscopy level, the reticular lamina exhibited disarray of stereociliary tufts with blebs, loss or elongated stereocilia as well as non-parallel rows of outer hair cells due to protrusions of Deiters' cells. At the molecular level, the abnormal gene expression patterns of prestin, cadherin 23, protocadherin 15, vesicular glutamate transporters 1 (Vglut1) and -2 (Vglut2) indicated that the hair-cell mechanotransduction and cochlear amplification were markedly altered. These were manifestations of a cochlear neuropathy that correlated to ABR waveform I alterations and elevated auditory thresholds. In the cochlear nucleus, the distribution of VGLUT2-immunolabeled puncta was differently affected in each subdivision, showing significant increases in magnocellular regions of the ventral cochlear nucleus and drastic reductions in the granule cell domain. This modified inputs lead to disruption of Vglut1 and Vglut2 gene expression in the cochlear nucleus. In sum, our study provides insight into the morphological and molecular traits associated with audiogenic seizure susceptibility in the GASH/Sal, suggesting an upward spread of abnormal glutamatergic transmission throughout the primary acoustic pathway to the epileptogenic region.
    MeSH term(s) Animals ; Auditory Threshold ; Behavior, Animal ; Cochlea/metabolism ; Cochlea/physiopathology ; Cochlea/ultrastructure ; Cricetinae ; Disease Models, Animal ; Epilepsy, Reflex/genetics ; Epilepsy, Reflex/metabolism ; Epilepsy, Reflex/physiopathology ; Epilepsy, Reflex/psychology ; Epilepsy, Tonic-Clonic/genetics ; Epilepsy, Tonic-Clonic/metabolism ; Epilepsy, Tonic-Clonic/physiopathology ; Epilepsy, Tonic-Clonic/psychology ; Glutamic Acid/metabolism ; Hearing ; Male ; Noise ; Vesicular Glutamate Transport Protein 1/genetics ; Vesicular Glutamate Transport Protein 1/metabolism ; Vesicular Glutamate Transport Protein 2/genetics ; Vesicular Glutamate Transport Protein 2/metabolism
    Chemical Substances Vesicular Glutamate Transport Protein 1 ; Vesicular Glutamate Transport Protein 2 ; Glutamic Acid (3KX376GY7L)
    Language English
    Publishing date 2020-04-26
    Publishing country Netherlands
    Document type Journal Article ; Research Support, Non-U.S. Gov't
    ZDB-ID 282629-x
    ISSN 1878-5891 ; 0378-5955
    ISSN (online) 1878-5891
    ISSN 0378-5955
    DOI 10.1016/j.heares.2020.107973
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    Zs.A 1467: Show issues Location:
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  5. Article: Histopathological changes to the peripheral vestibular system following meningitic labyrinthitis.

    Pauna, Henrique F / Knoll, Renata M / Lubner, Rory J / Brodsky, Jacob R / Cushing, Sharon L / Hyppolito, Miguel A / Nadol, Joseph B / Remenschneider, Aaron K / Kozin, Elliott D

    Laryngoscope investigative otolaryngology

    2020  Volume 5, Issue 2, Page(s) 256–266

    Abstract: Objective: While cochlear ossification is a common sequalae of meningitic labyrinthitis, less is known about the effects of meningitis on peripheral vestibular end organs. Herein, we investigate histopathologic changes in the peripheral vestibular ... ...

    Abstract Objective: While cochlear ossification is a common sequalae of meningitic labyrinthitis, less is known about the effects of meningitis on peripheral vestibular end organs. Herein, we investigate histopathologic changes in the peripheral vestibular system and cochlea in patients with a history of meningitic labyrinthitis.
    Methods: Temporal bone (TB) specimens from patients with a history of meningitis were evaluated and compared to age-matched controls. Specimens were evaluated by light microscopy and assessed for qualitative changes, including the presence of vestibular and/or cochlear endolymphatic hydrops, presence and location of inflammatory cells, new bone formation, and labyrinthitis ossificans; and quantitative changes, including Scarpa's ganglion neuron (ScGN) and spiral ganglion neuron (SGN) counts.
    Results: Fifteen TB from 10 individuals met inclusion and exclusion criteria. Presence of inflammatory cells and fibrous tissue was found in 5 TB. Of these, evidence of labyrinthitis ossificans was found in 2 TB. In the peripheral vestibular system, mild to severe degeneration of the vestibular membranous labyrinth was identified in 60% of cases (n = 9 TBs). There was a 21.2% decrease (range, 3%-64%) in the mean total count of ScGN in patients with meningitis, compared to age-matched controls. In the cochlea, there was a 45% decrease (range, 25.3%-80.9%) in the mean total count of SGN compared to age-matched controls (n = 14 TBs).
    Conclusions: Otopathologic analysis of TB from patients with a history of meningitic labyrinthitis demonstrated distinct peripheral vestibular changes. Future research may help to delineate potential mechanisms for the observed otopathologic changes following meningitis.
    Level of evidence: N/A.
    Language English
    Publishing date 2020-02-14
    Publishing country United States
    Document type Journal Article
    ISSN 2378-8038
    ISSN 2378-8038
    DOI 10.1002/lio2.349
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  6. Article ; Online: Analysis of postural control and muscular performance in young and elderly women in different age groups.

    Gomes, Matheus M / Reis, Júlia G / Carvalho, Regiane L / Tanaka, Erika H / Hyppolito, Miguel A / Abreu, Daniela C C

    Brazilian journal of physical therapy

    2015  Volume 19, Issue 1, Page(s) 1–9

    Abstract: Background: muscle strength and power are two factors affecting balance. The impact of muscle strength and power on postural control has not been fully explored among different age strata over sixty.: Objectives: the aim of the present study was to ... ...

    Abstract Background: muscle strength and power are two factors affecting balance. The impact of muscle strength and power on postural control has not been fully explored among different age strata over sixty.
    Objectives: the aim of the present study was to assess the muscle strength and power of elderly women in different age groups and determine their correlation with postural control.
    Method: eighty women were divided into four groups: the young 18-30 age group (n=20); the 60-64 age group (n=20); the 65-69 age group (n=20); and the 70-74 age group (n=20). The participants underwent maximum strength (one repetition maximum or 1-RM) and muscle power tests to assess the knee extensor and flexor muscles at 40%, 70%, and 90% 1-RM intensity. The time required by participants to recover their balance after disturbing their base of support was also assessed.
    Results: the elderly women in the 60-64, 65-69, and 70-74 age groups exhibited similar muscle strength, power, and postural control (p>0.05); however, these values were lower than those of the young group (p<0.05) as expected. There was a correlation between muscle strength and power and the postural control performance (p<0.05).
    Conclusion: despite the age difference, elderly women aged 60 to 74 years exhibited similar abilities to generate strength and power with their lower limbs, and this ability could be one factor that explains the similar postural control shown by these women.
    MeSH term(s) Adolescent ; Adult ; Age Factors ; Aged ; Female ; Humans ; Middle Aged ; Muscle Strength ; Postural Balance/physiology ; Young Adult
    Language English
    Publishing date 2015-01
    Publishing country Brazil
    Document type Journal Article ; Research Support, Non-U.S. Gov't
    ZDB-ID 2252917-2
    ISSN 1809-9246 ; 1413-3555
    ISSN (online) 1809-9246
    ISSN 1413-3555
    DOI 10.1590/bjpt-rbf.2014.0068
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  7. Article: Aminoglycoside antibiotic derivatives: preparation and evaluation of toxicity on cochlea and vestibular tissues and antimicrobial activity.

    da Silva, Julierme G / Hyppolito, Miguel A / de Oliveira, José Antônio A / Corrado, Alexandre P / Ito, Izabel Y / Carvalho, Ivone

    Bioorganic & medicinal chemistry

    2007  Volume 15, Issue 11, Page(s) 3624–3634

    Abstract: Aminoglycoside antibiotic derivatives such as neamine, methyl neobiosaminide B, 2-deoxystreptamine, tetra-azidoneamine, tetra-N-acetylneamine, tetra-N-carboxy-benzylneamine, tetra-N-carboxy-methylneamine and tetra-p-methoxy-benzyliminoneamine were ... ...

    Abstract Aminoglycoside antibiotic derivatives such as neamine, methyl neobiosaminide B, 2-deoxystreptamine, tetra-azidoneamine, tetra-N-acetylneamine, tetra-N-carboxy-benzylneamine, tetra-N-carboxy-methylneamine and tetra-p-methoxy-benzyliminoneamine were prepared and evaluated as to their cochlear and vestibular toxicity. Methyl neobiosaminide B, the most promising derivative in the series showed selective, cochlea-dissociated vestibulotoxic activity and was considered to be a potential lead compound for the treatment of Ménière's disease. Antimicrobial properties of the compounds, qualitatively evaluated against a group of pathogenic bacteria, indicated that neomycin B sulfate, neamine as a free base and methyl-neobiosaminide B dihydrochloride show a broader range of activity when compared to the other derivatives.
    MeSH term(s) Aminoglycosides/chemical synthesis ; Aminoglycosides/chemistry ; Aminoglycosides/toxicity ; Animals ; Anti-Bacterial Agents/chemical synthesis ; Anti-Bacterial Agents/chemistry ; Anti-Bacterial Agents/toxicity ; Bacteria/drug effects ; Cochlea/drug effects ; Cochlea/ultrastructure ; Guinea Pigs ; Microscopy, Electron, Scanning ; Structure-Activity Relationship ; Vestibule, Labyrinth/drug effects
    Chemical Substances Aminoglycosides ; Anti-Bacterial Agents
    Language English
    Publishing date 2007-06-01
    Publishing country England
    Document type Journal Article ; Research Support, Non-U.S. Gov't
    ZDB-ID 1161284-8
    ISSN 1464-3391 ; 0968-0896
    ISSN (online) 1464-3391
    ISSN 0968-0896
    DOI 10.1016/j.bmc.2007.03.056
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    In stock of ZB MED Cologne/Königswinter

    Zs.A 3815: Show issues Location:
    Je nach Verfügbarkeit (siehe Angabe bei Bestand)
    bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular
    Jg. 1995 - 2021: Lesesall (2.OG)
    ab Jg. 2022: Lesesaal (EG)

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