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  1. Article ; Online: Resveratrol fuels HER2 and ERα-positive breast cancer behaving as proteasome inhibitor.

    Andreani, Cristina / Bartolacci, Caterina / Wijnant, Kathleen / Crinelli, Rita / Bianchi, Marzia / Magnani, Mauro / Hysi, Albana / Iezzi, Manuela / Amici, Augusto / Marchini, Cristina

    Aging

    2017  Volume 9, Issue 2, Page(s) 508–523

    Abstract: The phytoestrogen resveratrol has been reported to possess cancer chemo-preventive activity on the basis of its effects on tumor cell lines and xenograft or carcinogen- ... ...

    Abstract The phytoestrogen resveratrol has been reported to possess cancer chemo-preventive activity on the basis of its effects on tumor cell lines and xenograft or carcinogen-inducible
    MeSH term(s) Animals ; Cell Line, Tumor ; Cell Proliferation/drug effects ; Down-Regulation/drug effects ; Estrogen Receptor alpha/genetics ; Estrogen Receptor alpha/metabolism ; Female ; Gene Expression Regulation, Neoplastic/drug effects ; Humans ; Mammary Neoplasms, Experimental/genetics ; Mammary Neoplasms, Experimental/metabolism ; Mammary Neoplasms, Experimental/pathology ; Proteasome Inhibitors/pharmacology ; Receptor, ErbB-2/genetics ; Receptor, ErbB-2/metabolism ; Resveratrol ; Signal Transduction/drug effects ; Stilbenes/pharmacology ; Up-Regulation/drug effects
    Chemical Substances Estrogen Receptor alpha ; Proteasome Inhibitors ; Stilbenes ; Erbb2 protein, mouse (EC 2.7.10.1) ; Receptor, ErbB-2 (EC 2.7.10.1) ; Resveratrol (Q369O8926L)
    Language English
    Publishing date 2017-04-06
    Publishing country United States
    Document type Journal Article
    ISSN 1945-4589
    ISSN (online) 1945-4589
    DOI 10.18632/aging.101175
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  2. Article ; Online: Intradermal DNA Electroporation Induces Cellular and Humoral Immune Response and Confers Protection against HER2/neu Tumor.

    Lamolinara, Alessia / Stramucci, Lorenzo / Hysi, Albana / Iezzi, Manuela / Marchini, Cristina / Mariotti, Marianna / Amici, Augusto / Curcio, Claudia

    Journal of immunology research

    2015  Volume 2015, Page(s) 159145

    Abstract: Skin represents an attractive target for DNA vaccine delivery because of its natural richness in APCs, whose targeting may potentiate the effect of vaccination. Nevertheless, intramuscular electroporation is the most common delivery method for ECTM ... ...

    Abstract Skin represents an attractive target for DNA vaccine delivery because of its natural richness in APCs, whose targeting may potentiate the effect of vaccination. Nevertheless, intramuscular electroporation is the most common delivery method for ECTM vaccination. In this study we assessed whether intradermal administration could deliver the vaccine into different cell types and we analyzed the evolution of tissue infiltrate elicited by the vaccination protocol. Intradermal electroporation (EP) vaccination resulted in transfection of different skin layers, as well as mononuclear cells. Additionally, we observed a marked recruitment of reactive infiltrates mainly 6-24 hours after treatment and inflammatory cells included CD11c(+). Moreover, we tested the efficacy of intradermal vaccination against Her2/neu antigen in cellular and humoral response induction and consequent protection from a Her2/neu tumor challenge in Her2/neu nontolerant and tolerant mice. A significant delay in transplantable tumor onset was observed in both BALB/c (p ≤ 0,0003) and BALB-neuT mice (p = 0,003). Moreover, BALB-neuT mice displayed slow tumor growth as compared to control group (p < 0,0016). In addition, while in vivo cytotoxic response was observed only in BALB/c mice, a significant antibody response was achieved in both mouse models. Our results identify intradermal EP vaccination as a promising method for delivering Her2/neu DNA vaccine.
    MeSH term(s) Animals ; Antibodies/immunology ; Antigen-Presenting Cells/immunology ; Antigen-Presenting Cells/metabolism ; Antigen-Presenting Cells/pathology ; Cancer Vaccines/administration & dosage ; Cancer Vaccines/genetics ; Cancer Vaccines/immunology ; Cell Line, Tumor ; Cytotoxicity, Immunologic/immunology ; Disease Models, Animal ; Electroporation ; Female ; Humans ; Injections, Intradermal ; Leukocytes/immunology ; Leukocytes/metabolism ; Leukocytes/pathology ; Mice ; Neoplasms/genetics ; Neoplasms/immunology ; Neoplasms/pathology ; Neoplasms/therapy ; Receptor, ErbB-2/genetics ; Receptor, ErbB-2/immunology ; T-Lymphocytes, Cytotoxic/immunology ; T-Lymphocytes, Cytotoxic/metabolism ; Vaccination ; Vaccines, DNA/administration & dosage ; Xenograft Model Antitumor Assays
    Chemical Substances Antibodies ; Cancer Vaccines ; Vaccines, DNA ; Receptor, ErbB-2 (EC 2.7.10.1)
    Language English
    Publishing date 2015
    Publishing country Egypt
    Document type Journal Article
    ZDB-ID 2817541-4
    ISSN 2314-7156 ; 2314-8861
    ISSN (online) 2314-7156
    ISSN 2314-8861
    DOI 10.1155/2015/159145
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  3. Article ; Online: Effect of maternal exposure to endocrine disrupting chemicals on reproduction and mammary gland development in female Sprague-Dawley rats.

    Manservisi, Fabiana / Gopalakrishnan, Kalpana / Tibaldi, Eva / Hysi, Albana / Iezzi, Manuela / Lambertini, Luca / Teitelbaum, Susan / Chen, Jia / Belpoggi, Fiorella

    Reproductive toxicology (Elmsford, N.Y.)

    2015  Volume 54, Page(s) 110–119

    Abstract: The aim of the study is to determine whether low doses of "endocrine disrupting chemicals" (EDCs) affect the development and proliferative activity of the mammary glands (MGs). Adult parous/nulliparous female Sprague-Dawley (SD) rats were treated from ... ...

    Abstract The aim of the study is to determine whether low doses of "endocrine disrupting chemicals" (EDCs) affect the development and proliferative activity of the mammary glands (MGs). Adult parous/nulliparous female Sprague-Dawley (SD) rats were treated from post-natal day (PND) 1 until PND 180 with diethylphthalate (DEP), methylparaben (MPB), triclosan (TCS) and a mixture at doses comparable to human exposure. The doses (mg/kg b.w./day) were: DEP=0.173; MPB=0.105; TCS=0.05. EDC treatment resulted in mortality rates >20% in pups as early as lactation day 7. Significant morphological/histological changes were observed at the end of lactation in the MGs of EDC-treated dams. The total transcriptome profile as well as lactation-related genes in MGs also corroborate the morphological findings as more profound gene expression changes are present only at the weaning period. The study highlights the heightened sensitivity of the MGs during critical windows of exposure, particularly pregnancy and lactation, with an impact on pups' survival.
    MeSH term(s) Age Factors ; Animals ; Endocrine Disruptors/toxicity ; Female ; Gene Expression Profiling/methods ; Gene Expression Regulation, Developmental/drug effects ; Gestational Age ; Lactation ; Mammary Glands, Animal/drug effects ; Mammary Glands, Animal/growth & development ; Mammary Glands, Animal/pathology ; Maternal Exposure/adverse effects ; Parabens/toxicity ; Phthalic Acids/toxicity ; Pregnancy ; Prenatal Exposure Delayed Effects ; Rats, Sprague-Dawley ; Reproduction/drug effects ; Sexual Development/drug effects ; Triclosan/toxicity ; Weaning
    Chemical Substances Endocrine Disruptors ; Parabens ; Phthalic Acids ; Triclosan (4NM5039Y5X) ; methylparaben (A2I8C7HI9T) ; diethyl phthalate (UF064M00AF)
    Language English
    Publishing date 2015-07
    Publishing country United States
    Document type Journal Article ; Research Support, N.I.H., Extramural ; Research Support, Non-U.S. Gov't
    ZDB-ID 639342-1
    ISSN 1873-1708 ; 0890-6238
    ISSN (online) 1873-1708
    ISSN 0890-6238
    DOI 10.1016/j.reprotox.2014.12.013
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    In stock of ZB MED Cologne/Königswinter

    Zs.A 2316: Show issues Location:
    Je nach Verfügbarkeit (siehe Angabe bei Bestand)
    bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular
    Jg. 1995 - 2021: Lesesall (2.OG)
    ab Jg. 2022: Lesesaal (EG)

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  4. Article: The non-inflammatory role of C1q during Her2/neu-driven mammary carcinogenesis.

    Bandini, Silvio / Macagno, Marco / Hysi, Albana / Lanzardo, Stefania / Conti, Laura / Bello, Amanda / Riccardo, Federica / Ruiu, Roberto / Merighi, Irene Fiore / Forni, Guido / Iezzi, Manuela / Quaglino, Elena / Cavallo, Federica

    Oncoimmunology

    2016  Volume 5, Issue 12, Page(s) e1253653

    Abstract: There is an ever increasing amount of evidence to support the hypothesis that complement C1q, the first component of the classical complement pathway, is involved in the regulation of cancer growth, in addition to its role in fighting infections. It has ... ...

    Abstract There is an ever increasing amount of evidence to support the hypothesis that complement C1q, the first component of the classical complement pathway, is involved in the regulation of cancer growth, in addition to its role in fighting infections. It has been demonstrated that C1q is expressed in the microenvironment of various types of human tumors, including breast adenocarcinomas. This study compares carcinogenesis progression in C1q deficient (neuT-C1KO) and C1q competent neuT mice in order to investigate the role of C1q in mammary carcinogenesis. Significantly accelerated autochthonous neu
    Language English
    Publishing date 2016-11-08
    Publishing country United States
    Document type Journal Article ; Research Support, Non-U.S. Gov't
    ZDB-ID 2645309-5
    ISSN 2162-402X ; 2162-4011
    ISSN (online) 2162-402X
    ISSN 2162-4011
    DOI 10.1080/2162402X.2016.1253653
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  5. Article ; Online: The water soluble ruthenium(II) organometallic compound [Ru(p-cymene)(bis(3,5 dimethylpyrazol-1-yl)methane)Cl]Cl suppresses triple negative breast cancer growth by inhibiting tumor infiltration of regulatory T cells.

    Montani, Maura / Pazmay, Gretta V Badillo / Hysi, Albana / Lupidi, Giulio / Pettinari, Riccardo / Gambini, Valentina / Tilio, Martina / Marchetti, Fabio / Pettinari, Claudio / Ferraro, Stefano / Iezzi, Manuela / Marchini, Cristina / Amici, Augusto

    Pharmacological research

    2016  Volume 107, Page(s) 282–290

    Abstract: Ruthenium compounds have become promising alternatives to platinum drugs by displaying specific activities against different cancers and favorable toxicity and clearance properties. Here, we show that the ruthenium(II) complex [Ru(p-cymene)(bis(3,5- ... ...

    Abstract Ruthenium compounds have become promising alternatives to platinum drugs by displaying specific activities against different cancers and favorable toxicity and clearance properties. Here, we show that the ruthenium(II) complex [Ru(p-cymene)(bis(3,5-dimethylpyrazol-1-yl)methane)Cl]Cl (UNICAM-1) exhibits potent in vivo antitumor effects. When administered as four-dose course, by repeating a single dose (52.4mgkg-1) every three days, UNICAM-1 significantly reduces the growth of A17 triple negative breast cancer cells transplanted into FVB syngeneic mice. Pharmacokinetic studies indicate that UNICAM-1 is rapidly eliminated from kidney, liver and bloodstream thanks to its high hydrosolubility, exerting excellent therapeutic activity with minimal side effects. Immunohistological analysis revealed that the efficacy of UNICAM-1, mainly relies on its capacity to reverse tumor-associated immune suppression by significantly reducing the number of tumor-infiltrating regulatory T cells. Therefore, UNICAM-1 appears very promising for the treatment of TNBC.
    MeSH term(s) Animals ; Antineoplastic Agents/blood ; Antineoplastic Agents/pharmacokinetics ; Antineoplastic Agents/pharmacology ; Antineoplastic Agents/therapeutic use ; Cell Line, Tumor ; Female ; Humans ; Kidney/metabolism ; Liver/drug effects ; Liver/metabolism ; Liver/pathology ; Mice ; Organometallic Compounds/blood ; Organometallic Compounds/pharmacokinetics ; Organometallic Compounds/pharmacology ; Organometallic Compounds/therapeutic use ; Ruthenium/blood ; Ruthenium/pharmacokinetics ; Ruthenium/pharmacology ; Ruthenium/therapeutic use ; T-Lymphocytes, Regulatory/drug effects ; T-Lymphocytes, Regulatory/immunology ; Triple Negative Breast Neoplasms/drug therapy ; Triple Negative Breast Neoplasms/immunology ; Triple Negative Breast Neoplasms/metabolism ; Triple Negative Breast Neoplasms/pathology ; Tumor Burden/drug effects
    Chemical Substances Antineoplastic Agents ; Organometallic Compounds ; Ruthenium (7UI0TKC3U5)
    Language English
    Publishing date 2016
    Publishing country Netherlands
    Document type Journal Article ; Research Support, Non-U.S. Gov't
    ZDB-ID 1003347-6
    ISSN 1096-1186 ; 0031-6989 ; 1043-6618
    ISSN (online) 1096-1186
    ISSN 0031-6989 ; 1043-6618
    DOI 10.1016/j.phrs.2016.03.032
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    In stock of ZB MED Cologne/Königswinter

    Zs.A 721: Show issues Location:
    Je nach Verfügbarkeit (siehe Angabe bei Bestand)
    bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular
    Jg. 1995 - 2021: Lesesall (1.OG)
    ab Jg. 2022: Lesesaal (EG)

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  6. Article ; Online: Irreversible inhibition of Δ16HER2 is necessary to suppress Δ16HER2-positive breast carcinomas resistant to Lapatinib.

    Tilio, Martina / Gambini, Valentina / Wang, Junbiao / Garulli, Chiara / Kalogris, Cristina / Andreani, Cristina / Bartolacci, Caterina / Elexpuru Zabaleta, Maria / Pietrella, Lucia / Hysi, Albana / Iezzi, Manuela / Belletti, Barbara / Orlando, Fiorenza / Provinciali, Mauro / Galeazzi, Roberta / Marchini, Cristina / Amici, Augusto

    Cancer letters

    2016  Volume 381, Issue 1, Page(s) 76–84

    Abstract: HER2 tyrosine kinase receptor is a validated target in breast cancer therapy. However, increasing evidence points to a major role of Δ16HER2 splice variant commonly coexpressed with HER2 and identified as a clinically important HER2 molecular alteration ... ...

    Abstract HER2 tyrosine kinase receptor is a validated target in breast cancer therapy. However, increasing evidence points to a major role of Δ16HER2 splice variant commonly coexpressed with HER2 and identified as a clinically important HER2 molecular alteration promoting aggressive metastatic breast cancer. Consistently, mice transgenic for the human Δ16HER2 isoform (Δ16HER2 mice) develop invasive mammary carcinomas with early onset and 100% penetrance. The present study provides preclinical evidence that Δ16HER2 expression confers de novo resistance to standard anti-HER2-therapies such as Lapatinib and acquired resistance to the selective Src inhibitor Saracatinib in breast cancer. Of note, Dacomitinib, an irreversible small molecule pan-HER inhibitor, was able to completely suppress Δ16HER2-driven breast carcinogenesis. Thus, only Dacomitinib may offer benefit in this molecularly defined patient subset by irreversibly inhibiting Δ16HER2 activation.
    MeSH term(s) Alternative Splicing ; Animals ; Benzodioxoles/pharmacology ; Breast Neoplasms/drug therapy ; Breast Neoplasms/enzymology ; Breast Neoplasms/genetics ; Breast Neoplasms/pathology ; Cell Line, Tumor ; Cell Survival/drug effects ; Dose-Response Relationship, Drug ; Drug Resistance, Neoplasm ; Female ; Genetic Predisposition to Disease ; Humans ; Inhibitory Concentration 50 ; Mammary Neoplasms, Experimental/drug therapy ; Mammary Neoplasms, Experimental/enzymology ; Mammary Neoplasms, Experimental/genetics ; Mammary Neoplasms, Experimental/pathology ; Mice, Transgenic ; Phenotype ; Protein Isoforms ; Protein Kinase Inhibitors/pharmacology ; Quinazolines/pharmacology ; Quinazolinones/pharmacology ; Receptor, ErbB-2/antagonists & inhibitors ; Receptor, ErbB-2/genetics ; Receptor, ErbB-2/metabolism ; Signal Transduction/drug effects ; Time Factors
    Chemical Substances Benzodioxoles ; PF 00299804 ; Protein Isoforms ; Protein Kinase Inhibitors ; Quinazolines ; Quinazolinones ; lapatinib (0VUA21238F) ; saracatinib (9KD24QGH76) ; ERBB2 protein, human (EC 2.7.10.1) ; Receptor, ErbB-2 (EC 2.7.10.1)
    Language English
    Publishing date 2016--10
    Publishing country Ireland
    Document type Journal Article ; Research Support, Non-U.S. Gov't
    ZDB-ID 195674-7
    ISSN 1872-7980 ; 0304-3835
    ISSN (online) 1872-7980
    ISSN 0304-3835
    DOI 10.1016/j.canlet.2016.07.028
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    In stock of ZB MED Cologne/Königswinter

    Zs.A 1177: Show issues Location:
    Je nach Verfügbarkeit (siehe Angabe bei Bestand)
    bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular
    Jg. 1995 - 2021: Lesesall (1.OG)
    ab Jg. 2022: Lesesaal (EG)

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  7. Article: Early onset and enhanced growth of autochthonous mammary carcinomas in C3-deficient Her2/neu transgenic mice.

    Bandini, Silvio / Curcio, Claudia / Macagno, Marco / Quaglino, Elena / Arigoni, Maddalena / Lanzardo, Stefania / Hysi, Albana / Barutello, Giuseppina / Consolino, Lorena / Longo, Dario Livio / Musiani, Piero / Forni, Guido / Iezzi, Manuela / Cavallo, Federica

    Oncoimmunology

    2013  Volume 2, Issue 9, Page(s) e26137

    Abstract: Aside from its classical role in fighting infections, complement is an important, although poorly understood, component of the tumor microenvironment. In particular, the tumor growth-regulatory activities of complement remain under debate. To assess the ... ...

    Abstract Aside from its classical role in fighting infections, complement is an important, although poorly understood, component of the tumor microenvironment. In particular, the tumor growth-regulatory activities of complement remain under debate. To assess the role of the complement system in the progression of autochthonous mammary carcinomas, we have crossed complement component 3 (C3)-deficient (
    Language English
    Publishing date 2013-09-12
    Publishing country United States
    Document type Journal Article ; Research Support, Non-U.S. Gov't
    ZDB-ID 2645309-5
    ISSN 2162-402X ; 2162-4011
    ISSN (online) 2162-402X
    ISSN 2162-4011
    DOI 10.4161/onci.26137
    Database MEDical Literature Analysis and Retrieval System OnLINE

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