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  1. Article: Commentary on "Emerging Technologies in the Treatment of Adult Spinal Deformity".

    Hyun, Seung-Jae

    Neurospine

    2021  Volume 18, Issue 3, Page(s) 428–429

    Language English
    Publishing date 2021-09-30
    Publishing country Korea (South)
    Document type Editorial ; Comment
    ZDB-ID 3031654-6
    ISSN 2586-6591 ; 2586-6583
    ISSN (online) 2586-6591
    ISSN 2586-6583
    DOI 10.14245/ns.2142818.409
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  2. Article: Pediatric Spine Trauma.

    An, Sungjae / Hyun, Seung-Jae

    Journal of Korean Neurosurgical Society

    2022  Volume 65, Issue 3, Page(s) 361–369

    Abstract: Pediatric spine has growth potential with incomplete ossification, and also unique biomechanics which have important implications for trauma patients. This article intends to review various aspects of pediatric spine trauma including epidemiology, ... ...

    Abstract Pediatric spine has growth potential with incomplete ossification, and also unique biomechanics which have important implications for trauma patients. This article intends to review various aspects of pediatric spine trauma including epidemiology, anatomy and biomechanics, and clinically relevant details of each type of injury based on the location and mechanism of injury. With the appropriate but not superfluous treatment, pediatric spine trauma patients can have better chance of recovery. Therefore, as a spine surgeon, understanding the general concept for each injury subtype together with the debate and progress in the field is inevitable.
    Language English
    Publishing date 2022-04-25
    Publishing country Korea (South)
    Document type Journal Article
    ZDB-ID 2253817-3
    ISSN 1598-7876 ; 2005-3711 ; 1225-8245
    ISSN (online) 1598-7876
    ISSN 2005-3711 ; 1225-8245
    DOI 10.3340/jkns.2021.0282
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  3. Article: Let's Not Miss the Forest for the Trees.

    Hyun, Seung-Jae

    Neurospine

    2019  Volume 16, Issue 2, Page(s) 207–208

    Language English
    Publishing date 2019-06-30
    Publishing country Korea (South)
    Document type Editorial
    ZDB-ID 3031654-6
    ISSN 2586-6591 ; 2586-6583
    ISSN (online) 2586-6591
    ISSN 2586-6583
    DOI 10.14245/ns.19edi.003
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  4. Article: Optimizing Surgical Strategy for Cervical Spinal Deformity: Global Alignment and Surgical Targets.

    Lee, Jae-Koo / Hyun, Seung-Jae / Kim, Ki-Jeong

    Neurospine

    2023  Volume 20, Issue 4, Page(s) 1246–1255

    Abstract: Cervical spinal deformity (CSD) is a complex condition characterized by abnormal curvature and cervical spine alignment. It can lead to a multitude of symptoms, including chronic pain, neurological deficits, and functional impairments, severely impacting ...

    Abstract Cervical spinal deformity (CSD) is a complex condition characterized by abnormal curvature and cervical spine alignment. It can lead to a multitude of symptoms, including chronic pain, neurological deficits, and functional impairments, severely impacting an individual's health-related quality of life (HRQoL). Surgical intervention is often necessary to address the deformity and alleviate symptoms, but optimal surgical strategies remain a topic of ongoing research and debate. This narrative review aims to provide an in-depth overview of the surgical management of CSD, focusing on optimizing patient outcomes and enhancing readers' understanding of the complexities involved. We begin by discussing the importance of preoperative assessment, including comprehensive radiographic evaluation and careful consideration of the global spinal alignment. The relationship between the cervical spine and the reciprocal changes that occur are explored to guide surgeons in their decision-making process. Furthermore, we delve into the selection of fusion levels, emphasizing the significance of identifying the primary driver of deformity. We review the current literature on optimal alignment targets and strategies to optimize surgical planning. By providing a comprehensive analysis of the surgical management of CSD, this review aims to enhance the readers' knowledge and assist surgeons in making informed decisions when planning and executing surgical interventions. Understanding the intricacies of CSD correction and the latest advancements in the field can ultimately improve patient outcomes and enhance HRQoL for individuals suffering from this challenging condition.
    Language English
    Publishing date 2023-12-31
    Publishing country Korea (South)
    Document type Journal Article
    ZDB-ID 3031654-6
    ISSN 2586-6591 ; 2586-6583
    ISSN (online) 2586-6591
    ISSN 2586-6583
    DOI 10.14245/ns.2346744.372
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  5. Article: Narrative Review of Clinical Impact of Head-Hip Offset Following Adult Spinal Deformity Surgery.

    Kim, Sunho / Hyun, Seung-Jae / Lee, Jae-Koo / Kim, Ki-Jeong

    Journal of Korean Neurosurgical Society

    2023  Volume 67, Issue 2, Page(s) 137–145

    Abstract: In adult spinal deformity (ASD) surgery, mechanical failure (MF) has been a significant concern for spine surgeons as well as patients. Despite earnest endeavors to prevent MF, the absence of a definitive consensus persists, owing to the intricate ... ...

    Abstract In adult spinal deformity (ASD) surgery, mechanical failure (MF) has been a significant concern for spine surgeons as well as patients. Despite earnest endeavors to prevent MF, the absence of a definitive consensus persists, owing to the intricate interplay of multifarious factors associated with this complication. Previous approaches centered around global spinal alignment have yielded limited success in entirely forestalling MF. These methodologies, albeit valuable, exhibited limitations by neglecting to encompass global balance and compensatory mechanisms within their purview. In response to this concern, an in-depth comprehension of global balance and compensatory mechanisms emerges as imperative. In this discourse, the center of gravity and the gravity line are gaining attention in recent investigations pertaining to global balance. This narrative review aims to provide an overview of the global balance and a comprehensive understanding of related concepts and knowledge. Moreover, it delves into the clinical ramifications of the contemporary optimal correction paradigm to furnish an encompassing understanding of global balance and the current optimal correction strategies within the context of ASD surgery. By doing so, it endeavors to furnish spine surgeons with a guiding compass, enriching their decision-making process as they navigate the intricate terrain of ASD surgical interventions.
    Language English
    Publishing date 2023-09-27
    Publishing country Korea (South)
    Document type Journal Article
    ZDB-ID 2253817-3
    ISSN 1598-7876 ; 2005-3711 ; 1225-8245
    ISSN (online) 1598-7876
    ISSN 2005-3711 ; 1225-8245
    DOI 10.3340/jkns.2023.0168
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  6. Article: Erratum: Reciprocal Changes Following Cervical Realignment Surgery.

    Lee, Jae-Koo / Hyun, Seung-Jae / Yang, Seung Heon / Kim, Ki-Jeong

    Neurospine

    2023  Volume 20, Issue 3, Page(s) 1091–1092

    Language English
    Publishing date 2023-09-30
    Publishing country Korea (South)
    Document type Published Erratum
    ZDB-ID 3031654-6
    ISSN 2586-6591 ; 2586-6583
    ISSN (online) 2586-6591
    ISSN 2586-6583
    DOI 10.14245/ns.2346786.393
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  7. Article: Odontoid Incidence: A Novel Cervical Parameter Influencing Cervical Alignment From Top to Bottom.

    Lee, Jae-Koo / Hyun, Seung-Jae / Kim, Ki-Jeong

    Neurospine

    2022  Volume 19, Issue 2, Page(s) 463–471

    Abstract: Objective: By using angulation of the axis itself, this study aims to define and analyze odontoid incidence (OI) and odontoid tilt (OT) as novel cervical alignment parameters and investigate their correlations with cervical alignment.: Methods: Novel ...

    Abstract Objective: By using angulation of the axis itself, this study aims to define and analyze odontoid incidence (OI) and odontoid tilt (OT) as novel cervical alignment parameters and investigate their correlations with cervical alignment.
    Methods: Novel and existing parameters were measured with whole-spine lateral plain radiographs and EOS images of 42 adults without cervical symptoms. The correlations of OI, OT, C2 slope (C2S), and T1 slope (T1S) were calculated.
    Results: The OI, OT, and C2S showed significant correlations with C2-7 angle (r = 0.43, r = -0.42, r = 0.62, respectively) and C0-2 angle (r = -0.33, r = 0.48, r = -0.61, respectively). OI, OT, T1S were independent predictors of the C2-7 angle in univariate regression analysis (adjusted-R2 = 0.17, R2 = 0.15, R2 = 0.28, respectively). OI, OT, and T1S were independent predictors in the multivariable regression analysis with estimated standardized coefficients of 0.36, -0.67, -0.69, respectively (adjusted- R2 = 0.80, p < 0.001). Regarding the C0-2 angle, OI and OT were independent predictors in the univariate regression analysis (adjusted-R2 = 0.08, R2 = 0.21, respectively).
    Conclusion: OI, OT, and C2S had significant correlations with cervical alignment. As the pelvic incidence, the OI is the only anatomical and constant parameter that could be used as a reference point related to the cervical spine from the rostral end. The study results may serve as baseline data for further studies on the alignment and balance of the cervical spine.
    Language English
    Publishing date 2022-06-30
    Publishing country Korea (South)
    Document type Journal Article
    ZDB-ID 3031654-6
    ISSN 2586-6591 ; 2586-6583
    ISSN (online) 2586-6591
    ISSN 2586-6583
    DOI 10.14245/ns.2244220.110
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  8. Article: Reciprocal Changes in the Whole-Body Following Realignment Surgery in Adult Spinal Deformity.

    Lee, Jae-Koo / Hyun, Seung-Jae / Kim, Ki-Jeong

    Asian spine journal

    2022  

    Abstract: The idea of the global balance of spine stems from Jean Dubousset, who first introduced the concept of cone of economy. Through the compensatory mechanisms, the human body maintains an upright posture and horizontal gaze in the setting of the spinal ... ...

    Abstract The idea of the global balance of spine stems from Jean Dubousset, who first introduced the concept of cone of economy. Through the compensatory mechanisms, the human body maintains an upright posture and horizontal gaze in the setting of the spinal malalignment. Compensation takes place not only in the mobile spine segments, but also in the pelvis and lower extremities. Patients with a malalignment exhibit compensatory changes in the cervical hyper-lordosis, posterior pelvic shift, knee/ankle flexion, hip extension, and the pelvic retroversion. The advent of whole-body stereo radiography has yielded an improved understanding of global changes among the patients. Deformity-induced compensatory changes in the sagittal alignment could be resolved reciprocally after the surgical correction of the malalignment. Thoracolumbar realignment surgery restores the pathologic compensatory changes in the unfused spinal segments, pelvis, and the lower extremities. Similarly, reciprocal changes in the thoracolumbar spine may harmonize global sagittal alignment after the cervical reconstruction. This study reviews the compensatory mechanisms and reciprocal changes in global sagittal alignment caused by the surgical correction and highlights, the factors that should be considered while assessing a patient's compensatory status.
    Language English
    Publishing date 2022-05-10
    Publishing country Korea (South)
    Document type Journal Article
    ZDB-ID 2559763-2
    ISSN 1976-7846 ; 1976-1902
    ISSN (online) 1976-7846
    ISSN 1976-1902
    DOI 10.31616/asj.2021.0451
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  9. Article: Safety and Efficacy of a New Moldable and Compression Resistant Matrix Carrier with Recombinant Human Bone Morphogenetic Protein-2 in the Rabbit Bone Defect Model.

    Ahn, Jae-Min / Hyun, Seung-Jae / Kim, Ki-Jeong

    Turkish neurosurgery

    2022  Volume 32, Issue 5, Page(s) 845–853

    Abstract: Aim: To conduct an animal experimental study to evaluate the safety and efficacy of the compression-resistant matrix (CRM) carrier for recombinant human bone morphogenetic protein-2 (rhBMP-2) in osteogenesis.: Material and methods: New moldable CRM ... ...

    Abstract Aim: To conduct an animal experimental study to evaluate the safety and efficacy of the compression-resistant matrix (CRM) carrier for recombinant human bone morphogenetic protein-2 (rhBMP-2) in osteogenesis.
    Material and methods: New moldable CRM carrier, and with rhBMP-2 (new CRM carrier with rhBMP-2) were prepared as the experimental groups. Pre-existing synthetic bone graft material was prepared as a control graft group. A total of 24 rabbits were included in the study. Defects were made and grafts were performed, and radiographic and histopathologic findings were evaluated to assess fusion.
    Results: In the computed tomographic scan, new bone formation was superior in 16.0%, 39.3%, 64.7%, and 81.1% of the total defect volume at 4, 8, 12, and 16 weeks in the new CRM carrier with rhBMP-2 group. In the new CRM carrier group, new bone formation was observed in 10.6%, 26.3%, 53.1%, and 71.4%, respectively. In the control graft group, new bone formation was observed in 10.1%, 26.6%, 53.4%, and 72.1%, respectively. On histopathologic evaluation, new CRM carrier with rhBMP-2 group showed better new bone formation compared with those of other groups.
    Conclusion: The new moldable CRM carrier and the CRM carrier with rhBMP-2 showed preclinical safety and efficacy in new bone formation. In particular, the CRM carrier with rhBMP-2 was considered to be an effective bone graft material for bone fusion.
    MeSH term(s) Animals ; Bone Morphogenetic Protein 2/pharmacology ; Bone Morphogenetic Protein 2/therapeutic use ; Humans ; Rabbits ; Recombinant Proteins/pharmacology ; Recombinant Proteins/therapeutic use ; Spinal Fusion/methods ; Transforming Growth Factor beta/therapeutic use
    Chemical Substances Bone Morphogenetic Protein 2 ; Recombinant Proteins ; Transforming Growth Factor beta ; recombinant human bone morphogenetic protein-2
    Language English
    Publishing date 2022-06-07
    Publishing country Turkey
    Document type Journal Article
    ZDB-ID 1203779-5
    ISSN 1019-5149
    ISSN 1019-5149
    DOI 10.5137/1019-5149.JTN.37422-21.2
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  10. Article: The Last Touched Vertebra on Supine Radiographs Can Be the Optimal Lower Instrumented Vertebra in Adolescent Idiopathic Scoliosis Patients.

    Kim, Do-Hyoung / Hyun, Seung-Jae / Lee, Chang-Hyun / Kim, Ki-Jeong

    Neurospine

    2022  Volume 19, Issue 1, Page(s) 236–243

    Abstract: Objective: To determine whether the last touched vertebra (LTV) on supine radiographs is suitable for the lower instrumented vertebra (LIV) in adolescent idiopathic scoliosis (AIS) correction surgery.: Methods: In total, 57 patients were included in ... ...

    Abstract Objective: To determine whether the last touched vertebra (LTV) on supine radiographs is suitable for the lower instrumented vertebra (LIV) in adolescent idiopathic scoliosis (AIS) correction surgery.
    Methods: In total, 57 patients were included in the study following posterior instrumentation and fusion. The average follow-up period was 2.2 years. Patients were classified into 4 groups according to the relationship of the location of LIV, LTV, and the last substantially touched vertebra (LSTV) on upright radiographs and the LTV on supine radiographs. In group 1, the upright LTV and supine LTV were the same. Group 1 was subdivided into group 1A and group 1B according to whether the LTV and LSTV were different or the same, respectively. In group 2, the upright LTV was selected as the LIV, whereas in group 3, the supine LTV was selected as the LIV. The baseline characteristics and the preoperative and postoperative radiographic/clinical outcomes of the groups were analyzed.
    Results: No differences were found in the preoperative clinical and radiographic baseline characteristics of the 4 groups except the LIV-central sacral vertical line distance. The immediate, 6-month, 1-year, and 2-year postoperative outcomes were not significantly different among the 4 groups. One patient (4.3%) in group 1A experienced radiographic addingon without clinical symptoms. No patients underwent revision surgery.
    Conclusion: The group in whom the LIV was selected as the LTV on supine x-rays showed similar postoperative radiographic and clinical results to other groups. The LTV on preoperative supine radiographs is acceptable as the LIV in AIS surgery to maximize motion segments.
    Language English
    Publishing date 2022-03-31
    Publishing country Korea (South)
    Document type Journal Article
    ZDB-ID 3031654-6
    ISSN 2586-6591 ; 2586-6583
    ISSN (online) 2586-6591
    ISSN 2586-6583
    DOI 10.14245/ns.2143224.612
    Database MEDical Literature Analysis and Retrieval System OnLINE

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