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  1. Article ; Online: Do Concurrent Multiple Infections with High-Risk HPVs Carry a More Malignant Potential than a Single Infection in the Uterine Cervix?

    Juhun Lee / Hyun Jung Lee

    Journal of Clinical Medicine, Vol 12, Iss 6155, p

    2023  Volume 6155

    Abstract: The high-risk human papillomavirus (HR-HPV) has been known as the most important carcinogen in uterine cervical carcinoma. However, there is limited evidence of the malignant potential of these concurrent multiple infections. This study included women ... ...

    Abstract The high-risk human papillomavirus (HR-HPV) has been known as the most important carcinogen in uterine cervical carcinoma. However, there is limited evidence of the malignant potential of these concurrent multiple infections. This study included women who had undergone cervical conization. They underwent an HPV test by cervical swab within 12 months before the surgery. They were divided into two groups: one with a single infection with HR-HPV16 and the other with concurrent multiple infections with HR-HPVs, including genotype 16. Pathologic examination classified cases as CIS+ to assess and compare the malignant potential in both groups, including carcinoma in situ (CIS) and invasive carcinoma. Of the 220 patients infected with HR-HPV16, the single infection group consisted of 120 patients (54.5%), whereas the concurrent multiple infections consisted of 100 (45.5%) patients. The rates of HSIL were significantly higher in the concurrent multiple infection group. However, the odds ratio for CIS+ did not show a significant difference between both groups (1.417, 95% CI = 0.831–2.414, p = 0.200). The malignant potential was not significantly different between concurrent multiple infections with HR-HPVs, including 16, and a single infection with 16 in Korean women.
    Keywords human papillomavirus ; concurrent multiple HPV infections ; cervical premalignancy ; malignant potential ; risk of carcinogenesis ; cervical cancer ; Medicine ; R
    Subject code 610
    Language English
    Publishing date 2023-09-01T00:00:00Z
    Publisher MDPI AG
    Document type Article ; Online
    Database BASE - Bielefeld Academic Search Engine (life sciences selection)

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  2. Article ; Online: Magnetic resonance imaging texture analysis for the evaluation of viable ovarian tissue in patients with ovarian endometriosis

    Dayong Lee / Hyun Jung Lee

    Journal of Yeungnam Medical Science, Vol 39, Iss 1, Pp 24-

    a retrospective case-control study

    2022  Volume 30

    Abstract: Background Texture analysis has been used as a method for quantifying image properties based on textural features. The aim of the present study was to evaluate the usefulness of magnetic resonance imaging (MRI) texture analysis for the evaluation of ... ...

    Abstract Background Texture analysis has been used as a method for quantifying image properties based on textural features. The aim of the present study was to evaluate the usefulness of magnetic resonance imaging (MRI) texture analysis for the evaluation of viable ovarian tissue on the perfusion map of ovarian endometriosis. Methods To generate a normalized perfusion map, subtracted T1-weighted imaging (T1WI), T1WI and contrast-enhanced T1W1 with sequences were performed using the same parameters in 25 patients with surgically confirmed ovarian endometriosis. Integrated density is defined as the sum of the values of the pixels in the image or selection. We investigated the parameters for texture analysis in ovarian endometriosis, including angular second moment (ASM), contrast, correlation, inverse difference moment (IDM), and entropy, which is equivalent to the product of area and mean gray value. Results The perfusion ratio and integrated density of normal ovary were 0.52±0.05 and 238.72±136.21, respectively. Compared with the normal ovary, the affected ovary showed significant differences in total size (p<0.001), fractional area ratio (p<0.001), and perfusion ratio (p=0.010) but no significant differences in perfused tissue area (p=0.158) and integrated density (p=0.112). In comparison of parameters for texture analysis between the ovary with endometriosis and the contralateral normal ovary, ASM (p=0.004), contrast (p=0.002), IDM (p<0.001), and entropy (p=0.028) showed significant differences. A linear regression analysis revealed that fractional area had significant correlations with ASM (r2=0.211), IDM (r2=0.332), and entropy (r2=0.289). Conclusion MRI texture analysis could be useful for the evaluation of viable ovarian tissues in patients with ovarian endometriosis.
    Keywords endometriosis ; gadolinium ; magnetic resonance imaging ; ovary ; Medicine ; R
    Subject code 616
    Language English
    Publishing date 2022-01-01T00:00:00Z
    Publisher Yeungnam University College of Medicine, Yeungnam University Institute Medical Science
    Document type Article ; Online
    Database BASE - Bielefeld Academic Search Engine (life sciences selection)

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  3. Article ; Online: Usefulness of subtraction pelvic magnetic resonance imaging for detection of ovarian endometriosis

    Hyun Jung Lee

    Yeungnam University Journal of Medicine, Vol 37, Iss 2, Pp 90-

    2020  Volume 97

    Abstract: Background To minimize damage to the ovarian reserve, it is necessary to evaluate the follicular density in the ovarian tissue surrounding endometriosis on preoperative imaging. The purpose of the present study was to evaluate the usefulness of ... ...

    Abstract Background To minimize damage to the ovarian reserve, it is necessary to evaluate the follicular density in the ovarian tissue surrounding endometriosis on preoperative imaging. The purpose of the present study was to evaluate the usefulness of subtraction pelvic magnetic resonance imaging (MRI) to detect ovarian reserve. Methods A subtracted T1-weighted image (subT1WI) was obtained by subtracting unenhanced T1WI from contrast-enhanced T1WI (ceT1WI) with similar parameters in 22 patients with ovarian endometriosis. The signal-to-noise ratio (SNR) in ovarian endometriosis, which was classified into the high signal intensity and iso-to-low signal intensity groups on the T2-weighted image, was compared to that in normal ovarian tissue. To evaluate the effect of contrast enhancement, a standardization map was obtained by dividing subT1WI by ceT1WI. Results On visual assessment of 22 patients with ovarian endometriosis, 16 patients showed a high signal intensity, and 6 patients showed an iso-to-low signal intensity on T1WI. Although SNR in endometriosis with a high signal intensity was higher than that with an iso-to-low signal intensity, there was no difference in SNR after the subtraction (13.72±77.55 vs. 63.03±43.90, p=0.126). The area of the affected ovary was smaller than that of the normal ovary (121.10±22.48 vs. 380.51±75.87 mm2, p=0.002), but the mean number of pixels in the viable remaining tissue of the affected ovary was similar to that of the normal ovary (0.53±0.09 vs. 0.47±0.09, p=0.682). Conclusion The subtraction technique used with pelvic MRI could reveal the extent of endometrial invasion of the normal ovarian tissue and viable remnant ovarian tissue.
    Keywords endometriosis ; gadolinium ; magnetic resonance imaging ; subtraction ; Medicine (General) ; R5-920
    Subject code 616
    Language English
    Publishing date 2020-04-01T00:00:00Z
    Publisher Yeungnam University College of Medicine
    Document type Article ; Online
    Database BASE - Bielefeld Academic Search Engine (life sciences selection)

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  4. Article ; Online: A case report of mucinous cystadenoma with contralateral serous cystadenofibroma in identical twin

    Jisun Lee / Yong-Jin Kim / Yujin Heo / Hyun Jung Lee

    Heliyon, Vol 9, Iss 5, Pp e16345- (2023)

    2023  

    Abstract: Introduction: There are limited reports on ovarian neoplasm occurring among identical twins. Most previous reports showed ovarian teratoma found in both twins. Herein, we report for the first time a case of ovarian mucinous cystadenoma with contralateral ...

    Abstract Introduction: There are limited reports on ovarian neoplasm occurring among identical twins. Most previous reports showed ovarian teratoma found in both twins. Herein, we report for the first time a case of ovarian mucinous cystadenoma with contralateral serous cystadenofibroma found in twin siblings. Case report: One patient suffered from abdominal distension and the following computed tomography found ovarian mucinous cystadenoma. During the laparoscopy, another ovarian mass was found in the contralateral ovary. The histopathology revealed ovarian mucinous cystadenoma with contralateral serous cystadenofibroma. The twin sister had no symptoms but underwent gynecological screening. She also showed a similar finding, mucinous cystadenoma with serous cystadenofibroma on the contralateral ovary. Both patients underwent laparoscopic bilateral ovarian cystectomy. Conclusion: This is the first clinical report on left ovarian mucinous cystadenoma with right serous cystadenofibroma in twin siblings. Our cases support awareness of ovarian tumors in twin sisters.
    Keywords Mucinous cystadenoma ; Serous cystadenofibroma ; Identical twin ; Science (General) ; Q1-390 ; Social sciences (General) ; H1-99
    Subject code 616
    Language English
    Publishing date 2023-05-01T00:00:00Z
    Publisher Elsevier
    Document type Article ; Online
    Database BASE - Bielefeld Academic Search Engine (life sciences selection)

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  5. Article ; Online: Technology Advancements and Employees’ Qualitative Job Insecurity in the Republic of Korea

    Hyun Jung Lee / Tahira M. Probst / Andrea Bazzoli / Sunhee Lee

    International Journal of Environmental Research and Public Health, Vol 19, Iss 14368, p

    Does Training Help? Employer-Provided vs. Self-Paid Training

    2022  Volume 14368

    Abstract: While technological advancements have proliferated in our daily lives, they also pose threats to the job security of employees. Despite these growing concerns about technology-related job insecurity, little research has been carried out on the ... ...

    Abstract While technological advancements have proliferated in our daily lives, they also pose threats to the job security of employees. Despite these growing concerns about technology-related job insecurity, little research has been carried out on the antecedents and outcomes of tech-related job insecurity. Using a cross-sectional, nationally representative survey sample of 28,989 Korean workers drawn from the Korean Working Conditions Survey, we examined the impacts of technology advancements on employee perceptions of technology-related qualitative job insecurity (i.e., perceived technology-related threat to the continued existence of valued job features) and subsequent effects on employees’ work (i.e., work engagement, job satisfaction), health (i.e., sleep), and life (i.e., work-to-family conflict) outcomes. Furthermore, we investigated the extent to which employer-provided (versus self-funded) training buffers the adverse impacts of technology advancements and associated job insecurity. The path analysis results showed more technology changes were associated with higher job insecurity, which subsequently related to adverse outcomes. While employer-provided training helped workers to reduce the negative impacts of tech changes on job insecurity, workers who paid for their training reported more adverse outcomes in face of job insecurity. We discuss these results in light of the job demands–resources theory and practical implications to buffer the adverse impacts of technology advancements.
    Keywords technology advancement ; job insecurity ; qualitative job insecurity ; training ; occupational health ; Medicine ; R
    Subject code 331
    Language English
    Publishing date 2022-11-01T00:00:00Z
    Publisher MDPI AG
    Document type Article ; Online
    Database BASE - Bielefeld Academic Search Engine (life sciences selection)

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  6. Article ; Online: Prevalence of Knee Osteoarthritis and Health-Related Quality of Life in Stroke Patients over 60 Years Old

    Kil-Yong Jeong / Hyun Jung Lee

    Annals of Geriatric Medicine and Research, Vol 25, Iss 3, Pp 178-

    A Cross-Sectional Study Using Korean National Health and Nutrition Examination Survey V

    2021  Volume 186

    Abstract: Background This study investigated the prevalence of knee osteoarthritis among stroke survivors aged over 60 years and analyzed the association between knee osteoarthritis and health-related quality of life (HRQOL) in stroke survivors. Methods We ... ...

    Abstract Background This study investigated the prevalence of knee osteoarthritis among stroke survivors aged over 60 years and analyzed the association between knee osteoarthritis and health-related quality of life (HRQOL) in stroke survivors. Methods We analyzed data of 287 participants who had experienced a stroke (stroke group) from the 2010–2012 Korean National Health and Nutrition Examination Survey. Among the participants, 65 stroke survivors also had knee osteoarthritis. We used the European Quality of Life-5 Dimensions (EQ-5D) questionnaire to compare the differences in HRQOL according to the presence or absence of knee osteoarthritis in the stroke group. Multiple regression analysis was performed to determine associated factors affecting HRQOL in the stroke group. Results The prevalence of knee osteoarthritis was 21% in the stroke group. The EQ-5D index score was significantly lower in patients in the stroke group with knee osteoarthritis than in those without knee osteoarthritis (adjusted mean±standard error [SE], 0.680±0.011 for stroke with knee osteoarthritis and 0.817±0.003 stroke without knee osteoarthritis; p<0.0001). Knee osteoarthritis, age, income level, education level, smoking, walking days, diabetes, and cardiovascular disease significantly influenced HRQOL in the stroke group. Conclusion The study results confirmed that the prevalence of knee osteoarthritis was 21% in the stroke group and that HRQOL was significantly lower among patients in the stroke group with knee osteoarthritis. These findings suggest the importance of active management of knee osteoarthritis in stroke survivors for HRQOL.
    Keywords nutrition surveys ; osteoarthritis ; prevalence ; quality of life ; stroke ; Medicine ; R ; Geriatrics ; RC952-954.6
    Subject code 796
    Language English
    Publishing date 2021-09-01T00:00:00Z
    Publisher Korea Geriatrics Society
    Document type Article ; Online
    Database BASE - Bielefeld Academic Search Engine (life sciences selection)

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  7. Article ; Online: Economic Stressors, COVID-19 Attitudes, Worry, and Behaviors among U.S. Working Adults

    Andrea Bazzoli / Tahira M. Probst / Hyun Jung Lee

    International Journal of Environmental Research and Public Health, Vol 18, Iss 2338, p

    A Mixture Analysis

    2021  Volume 2338

    Abstract: Since the unfolding of the novel coronavirus global pandemic, public health research has increasingly suggested that certain groups of individuals may be more exposed to the virus. The aim of this contribution was to investigate whether workers grouped ... ...

    Abstract Since the unfolding of the novel coronavirus global pandemic, public health research has increasingly suggested that certain groups of individuals may be more exposed to the virus. The aim of this contribution was to investigate whether workers grouped into several latent classes, based on two perceived economic stressors, would report different levels of enactment of the Centers for Disease Control (CDC) recommended behaviors to prevent the spread of such virus. We also tested propositions regarding the potential differential predictors of compliance behavior, differentiating between cognitive (i.e., attitudes toward the CDC guidelines) and affective (i.e., COVID-specific worry) predictors. Using a longitudinal dataset of 419 U.S. workers, we did not find significant differences among the levels of CDC guidelines enactment across three latent classes, representing a range of economic vulnerability. We found that cognitive attitudes were a significantly stronger predictor of compliance with CDC guidelines for workers in the most economically secure class, whereas worry was a significantly stronger predictor of compliance for the most vulnerable counterpart. We discuss these findings in light of the Conservation of Resources theory and other health behavior theories, being mindful of the need to further understand the differential impact of this health and economic crisis on employees facing economic stressors.
    Keywords economic stressors ; job insecurity ; financial inadequacy ; Covid-19 ; mixture model ; Medicine ; R
    Subject code 360
    Language English
    Publishing date 2021-02-01T00:00:00Z
    Publisher MDPI AG
    Document type Article ; Online
    Database BASE - Bielefeld Academic Search Engine (life sciences selection)

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  8. Article ; Online: Healthcare Safety Nets during the COVID-19 Pandemic Based on Double Diamond Model

    Bom-Mi Park / Hyun-Jung Lee

    Healthcare, Vol 9, Iss 1014, p

    A Concept Analysis

    2021  Volume 1014

    Abstract: The purpose of this study was to analyze the concept of the “healthcare safety net” during the COVID-19 pandemic. Walker and Avant’s process of concept analysis was used in this systematic literature review. The attributes of the concept of a healthcare ... ...

    Abstract The purpose of this study was to analyze the concept of the “healthcare safety net” during the COVID-19 pandemic. Walker and Avant’s process of concept analysis was used in this systematic literature review. The attributes of the concept of a healthcare safety net during the COVID-19 pandemic were found to be: (a) capacity, (b) accessibility, (c) health equality, and (d) education. In consideration of these defining criteria, antecedents to the concept were identified as: (a) the COVID-19 pandemic, (b) health inequalities (internal factors and external factors), and (c) healthcare systems (health insurance, screening, protective equipment, medicine, and medical services). Consequences of the concept were: (a) meeting healthcare needs, (b) quality of life, and (c) a decrease in morbidity and mortality. A healthcare safety net is an important concept during the COVID-19 pandemic. In situations like COVID-19, healthcare safety nets are designed to meet safety needs, improve quality of life, and reduce patient turnover and mortality. Based on the results of this study, the development of standardized tools for measuring a healthcare safety net as well as that of policies and systems for resolving a healthcare safety net in the COVID-19 situation is recommended.
    Keywords healthcare safety net ; safety net ; COVID-19 pandemic ; double diamond model ; concept analysis ; healthcare system ; Medicine ; R
    Subject code 360
    Language English
    Publishing date 2021-08-01T00:00:00Z
    Publisher MDPI AG
    Document type Article ; Online
    Database BASE - Bielefeld Academic Search Engine (life sciences selection)

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  9. Article ; Online: Feelings of Entrapment during the COVID-19 Pandemic Based on ACE Star Model

    Hyun-Jung Lee / Bom-Mi Park

    Healthcare, Vol 9, Iss 1305, p

    A Concept Analysis

    2021  Volume 1305

    Abstract: This study aimed to analyze the concept of the “feelings of entrapment” during the COVID-19 (coronavirus disease 2019) pandemic using a systematic review. We included literature based on content and outcomes related to feelings of entrapment, such as ... ...

    Abstract This study aimed to analyze the concept of the “feelings of entrapment” during the COVID-19 (coronavirus disease 2019) pandemic using a systematic review. We included literature based on content and outcomes related to feelings of entrapment, such as antecedents, attributes, and consequences. The exclusion criteria were studies that did not have inappropriate subject, content, conceptual definition, and degree thesis was excluded. Walker and Avant’s process of concept analysis was used in this systematic literature review. The attributes of the concept of feelings of entrapment during the COVID-19 pandemic were found to be feelings of: (1) being out of control, (2) no escape, (3) being trapped, (4) being robbed, and (5) hopelessness. The causes for these were identified as (1) the COVID-19 pandemic, (2) lockdown system, (3) restricted situation, (4) uncertain future, (5) economic hardship, and (6) poor coping abilities. Consequences of the concept were: (1) increased suicide, (2) decreased mental health, and (3) decreased well-being. In situations such as COVID-19, it is important need to know what feelings of entrapment’s antecedents and attributes are to prevent suicide and enhance mental health and well-being. Based on the results of this study, counseling services, policies, and systems for relieving feelings of entrapment in the COVID-19 situation are recommended.
    Keywords feelings of entrapment ; COVID-19 pandemic ; academic center for evidence-based practice (ACE) star model ; concept analysis ; lockdown system ; out of control ; Medicine ; R
    Subject code 710
    Language English
    Publishing date 2021-09-01T00:00:00Z
    Publisher MDPI AG
    Document type Article ; Online
    Database BASE - Bielefeld Academic Search Engine (life sciences selection)

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  10. Article ; Online: In silico identification of vaccine targets for 2019-nCoV [version 1; peer review

    Chloe Hyun-Jung Lee / Hashem Koohy

    F1000Research, Vol

    2 approved]

    2020  Volume 9

    Abstract: Background: The newly identified coronavirus known as 2019-nCoV has posed a serious global health threat. According to the latest report (18-February-2020), it has infected more than 72,000 people globally and led to deaths of more than 1,016 people in ... ...

    Abstract Background: The newly identified coronavirus known as 2019-nCoV has posed a serious global health threat. According to the latest report (18-February-2020), it has infected more than 72,000 people globally and led to deaths of more than 1,016 people in China. Methods: The 2019 novel coronavirus proteome was aligned to a curated database of viral immunogenic peptides. The immunogenicity of detected peptides and their binding potential to HLA alleles was predicted by immunogenicity predictive models and NetMHCpan 4.0. Results: We report in silico identification of a comprehensive list of immunogenic peptides that can be used as potential targets for 2019 novel coronavirus (2019-nCoV) vaccine development. First, we found 28 nCoV peptides identical to Severe acute respiratory syndrome-related coronavirus (SARS CoV) that have previously been characterized immunogenic by T cell assays. Second, we identified 48 nCoV peptides having a high degree of similarity with immunogenic peptides deposited in The Immune Epitope Database (IEDB). Lastly, we conducted a de novo search of 2019-nCoV 9-mer peptides that i) bind to common HLA alleles in Chinese and European population and ii) have T Cell Receptor (TCR) recognition potential by positional weight matrices and a recently developed immunogenicity algorithm, iPred, and identified in total 63 peptides with a high immunogenicity potential. Conclusions: Given the limited time and resources to develop vaccine and treatments for 2019-nCoV, our work provides a shortlist of candidates for experimental validation and thus can accelerate development pipeline.
    Keywords Medicine ; R ; Science ; Q
    Language English
    Publishing date 2020-02-01T00:00:00Z
    Publisher F1000 Research Ltd
    Document type Article ; Online
    Database BASE - Bielefeld Academic Search Engine (life sciences selection)

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