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  1. Article ; Online: Dendranthema zawadskii var. lucidum (Nakai) J.H. Park Extract Inhibits Cellular Senescence in Human Dermal Fibroblasts and Aging-Related Inflammation in Rats

    Jehun Choi / Gwi-Yeong Jang / Jeonghoon Lee / Hae-Young Chung / Hyung-Jun Noh / Geum-Soog Kim / Seung-Eun Lee

    Processes, Vol 9, Iss 801, p

    2021  Volume 801

    Abstract: Senescence is the phenomenon by which physiological functions of organisms degenerate with time. Cellular senescence is marked by an inhibition of cell cycle progression. Beta-galactosidase accumulates in the lysosomes of aged cells. In this study, human ...

    Abstract Senescence is the phenomenon by which physiological functions of organisms degenerate with time. Cellular senescence is marked by an inhibition of cell cycle progression. Beta-galactosidase accumulates in the lysosomes of aged cells. In this study, human dermal fibroblast cells (HDFs) were treated with 0.5 μM doxorubicin for 4 h to induce cellular senescence. Senescence-associated beta-galactosidase (SA-β-gal) activity was then measured 72 h after treatment with aerial parts of Dendranthema zawadskii var. lucidum (Nakai) J.H. Park (DZ) extract. Treatment with DZ extract significantly decreased SA-β-gal activity in a dose-dependent manner in HDFs. Additionally, DZ extract treatment reduced age-related oxidative stress and inflammation in the aortas of aged rats. The reactive oxygen species (ROS) levels in aortas of aged control rats were higher than those in young rats. However, DZ extract-fed aged rats showed significantly lower ROS levels than the aged control rats. When the aged rats were treated with DZ extract at either 0.2 or 1.0 mg∙kg −1 ∙day −1 , NF-κB levels in aorta tissue decreased significantly compared to those in aorta tissue of the aged control rats without DZ treatment. In addition, DZ extract-fed aged rat aortas showed significant reductions in expression of iNOS and COX-2 induced by NF-κB translocation. Therefore, these results suggest that DZ effectively inhibited senescence-related NF-κB activation and inflammation. DZ extract may have a role in the prevention of the vascular inflammatory responses that occur during vascular aging.
    Keywords senescence ; aging ; inflammation ; Dendranthema zawadskii var. lucidum ; Chemical technology ; TP1-1185 ; Chemistry ; QD1-999
    Subject code 630
    Language English
    Publishing date 2021-05-01T00:00:00Z
    Publisher MDPI AG
    Document type Article ; Online
    Database BASE - Bielefeld Academic Search Engine (life sciences selection)

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  2. Article: Flavonoids and a Limonoid from the Fruits of Citrus unshiu and Their Biological Activity

    Eom, Hee Jeong / Dahae Lee / Seulah Lee / Hyung Jun Noh / Jae Wook Hyun / Pyoung Ho Yi / Ki Sung Kang / Ki Hyun Kim

    Journal of agricultural and food chemistry. 2016 Sept. 28, v. 64, no. 38

    2016  

    Abstract: The fruits of Citrus unshiu are one of the most popular and most enjoyed fruits in Korea. As we continue to seek for bioactive metabolites from Korean natural resources, our study on the chemical constituents of the fruits of C. unshiu resulted in the ... ...

    Abstract The fruits of Citrus unshiu are one of the most popular and most enjoyed fruits in Korea. As we continue to seek for bioactive metabolites from Korean natural resources, our study on the chemical constituents of the fruits of C. unshiu resulted in the isolation of a new flavonoid glycoside, limocitrunshin 1, along with seven other flavonoids 2–8 and a limonoid 9. All structures were identified by spectroscopic methods, namely 1D and 2D NMR, including HSQC, HMBC, and 1H–1H COSY experiments, HRMS, and other chemical methods. Compounds 3, 5, and 9 are reported to be isolated from this fruit for the first time. The isolated compounds were applied to activity tests to verify their inhibitory effects on inflammation and nephrotoxicity. Compounds 6 and 9 showed the most potent inhibitory activity on renal cell damage and nitric oxide production, respectively. Thus, the fruits of C. unshiu could serve as a valuable natural source of bioactive components with health benefits for potential application in functional foods.
    Keywords Citrus unshiu ; bioactive compounds ; citrus fruits ; flavonoids ; fruits ; functional foods ; glycosides ; inflammation ; metabolites ; natural resources ; nephrotoxicity ; nitric oxide ; nuclear magnetic resonance spectroscopy ; Korean Peninsula
    Language English
    Dates of publication 2016-0928
    Size p. 7171-7178.
    Publishing place American Chemical Society, Books and Journals Division
    Document type Article
    ZDB-ID 241619-0
    ISSN 1520-5118 ; 0021-8561
    ISSN (online) 1520-5118
    ISSN 0021-8561
    DOI 10.1021/acs.jafc.6b03465
    Database NAL-Catalogue (AGRICOLA)

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  3. Article ; Online: Brazilin Inhibits Growth and Induces Apoptosis in Human Glioblastoma Cells

    Hyung-Jun Noh / Min-Ho Lee / Geum-Soog Kim / Mi-Kyoung Lee / Dae-Young Lee

    Molecules, Vol 18, Iss 2, Pp 2449-

    2013  Volume 2457

    Abstract: Brazilin, isolated from the methanol extract of the heart wood of Caesalpinia sappan, sensitizes cancer cells to apoptosis. Glioblastoma multiforme (GBM), which accounts for most cases of central nervous system malignancy, has a very poor prognosis and ... ...

    Abstract Brazilin, isolated from the methanol extract of the heart wood of Caesalpinia sappan, sensitizes cancer cells to apoptosis. Glioblastoma multiforme (GBM), which accounts for most cases of central nervous system malignancy, has a very poor prognosis and lacks effective therapeutic interventions. We, therefore, investigated the effects of different concentrations of and different periods of exposure to brazilin on cell proliferation and apoptosis in the glioma U87 cell line. Cell proliferation was investigated by MTT assays and growth curve analysis, apoptosis was assessed by FACS analysis and western blot studies. Brazilin showed dose-dependent inhibition of cell proliferation and induction of apoptosis in glioma cells. It also increased the ratio of cleaved poly-(ADP)-ribose polymerase and decreased the expression of caspase-3 and caspase-7.
    Keywords apoptosis ; brazilin ; Caesalpinia sappan ; glioma U87 ; Organic chemistry ; QD241-441
    Subject code 610
    Language English
    Publishing date 2013-02-01T00:00:00Z
    Publisher MDPI AG
    Document type Article ; Online
    Database BASE - Bielefeld Academic Search Engine (life sciences selection)

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  4. Article ; Online: The Potential of Minor Ginsenosides Isolated from the Leaves of Panax ginseng as Inhibitors of Melanogenesis

    Dae-Young Lee / Byeong-Ju Cha / Young-Seob Lee / Geum-Soog Kim / Hyung-Jun Noh / Seung-Yu Kim / Hee Cheol Kang / Jin Hee Kim / Nam-In Baek

    International Journal of Molecular Sciences, Vol 16, Iss 1, Pp 1677-

    2015  Volume 1690

    Abstract: Three minor ginsenosides, namely, ginsenoside Rh6 (1), vina-ginsenoside R4 (2) and vina-ginsenoside R13 (3), were isolated from the leaves of hydroponic Panax ginseng. The chemical structures were determined based on spectroscopic methods, including fast ...

    Abstract Three minor ginsenosides, namely, ginsenoside Rh6 (1), vina-ginsenoside R4 (2) and vina-ginsenoside R13 (3), were isolated from the leaves of hydroponic Panax ginseng. The chemical structures were determined based on spectroscopic methods, including fast atom bombardment mass spectroscopy (FAB-MS), 1D-nuclear magnetic resonance (NMR), 2D-NMR, and, infrared (IR) spectroscopy. The melanogenic inhibitory activity of compounds 1, 2 and 3 was 23.9%, 27.8% and 35.2%, respectively, at a concentration of 80 µM. Likewise, the three compounds showed inhibitory activity on body pigmentation on a zebrafish model, which is commonly used as a model for biomedical or cosmetic research. These results from in vitro and in vivo systems suggest that the three aforementioned compounds isolated from Panax ginseng may have potential as new skin whitening compounds.
    Keywords Panax ginseng ; melanogenesis ; NMR ; vina-ginsenoside ; Biology (General) ; QH301-705.5 ; Chemistry ; QD1-999
    Subject code 540
    Language English
    Publishing date 2015-01-01T00:00:00Z
    Publisher MDPI AG
    Document type Article ; Online
    Database BASE - Bielefeld Academic Search Engine (life sciences selection)

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  5. Article ; Online: A direct protein kinase B-targeted anti inflammatory activity of cordycepin from artificially cultured fruit body of Cordyceps militaris

    Ju Young Yoon / Ji Hye Kim / Kwang-Soo Baek / Geum Soog Kim / Seung Eun Lee / Dae Young Lee / Je Hun Choi / Seung Yu Kim / Hyun Bong Park / Gi-Ho Sung / Kang Ro Lee / Jae Youl Cho / Hyung Jun Noh

    Pharmacognosy Magazine, Vol 11, Iss 43, Pp 477-

    2015  Volume 485

    Abstract: Background: Cordyceps militaris is one of well-known medicinal mushrooms with anti-inflammatory, anti-cancer, anti-diabetic, and anti-obesity activities. Objective: The objective of the following study is to isolate chemical components from the ethanol ... ...

    Abstract Background: Cordyceps militaris is one of well-known medicinal mushrooms with anti-inflammatory, anti-cancer, anti-diabetic, and anti-obesity activities. Objective: The objective of the following study is to isolate chemical components from the ethanol extract (Cm-EE) from Cordyceps militaris and to evaluate their anti-inflammatory activities. Materials and Methods: Column chromatographic separation was performed and anti-inflammatory roles of these compounds were also examined by using NO production and protein kinase B (AKT) activity assays. Results: From Cm-EE, 13 constituents, including trehalose (1), cordycepin (2), 6-hydroxyethyladenosine (3), nicotinic amide (4), butyric acid (5), β-dimorphecolic acid (6), α-dimorphecolic acid (7), palmitic acid (8), linoleic acid (9), cordycepeptide A (10), 4-(2-hydroxy-3-((9E,12E)-octadeca-9,12-dienoyloxy)propoxy)-2-(trimethylammonio)butanoate (11), 4-(2-hydroxy-3-(palmitoyloxy)propoxy)-2-(trimethylammonio)butanoate (12), and linoleic acid methyl ester (13) were isolated. Of these components, compound 2 displayed a significant inhibitory effect on NO production in lipopolysaccharide (LPS)-activated RAW264.7 cells. Furthermore, this compound strongly and directly suppressed the kinase activity of AKT, an essential signalling enzyme in LPS-induced NO production, by interacting with its ATP binding site. Conclusion: C. militaris could have anti-inflammatory activity mediated by cordycepin-induced suppression of AKT.
    Keywords Anti-inflammatory activity ; cordycepin ; Cordyceps militaris (Clavicipitaceae) ; phytochemical study ; protein kinase B ; Medicine ; R ; Pharmacy and materia medica ; RS1-441
    Publishing date 2015-01-01T00:00:00Z
    Publisher Medknow Publications
    Document type Article ; Online
    Database BASE - Bielefeld Academic Search Engine (life sciences selection)

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  6. Article ; Online: Quality Evaluation of Panax ginseng Roots Using a Rapid Resolution LC-QTOF/MS-Based Metabolomics Approach

    Dae-Young Lee / Jae Kwang Kim / Sabina Shrestha / Kyeong-Hwa Seo / Youn-Hyung Lee / Hyung-Jun Noh / Geum-Soog Kim / Yong-Bum Kim / Seung-Yu Kim / Nam-In Baek

    Molecules, Vol 18, Iss 12, Pp 14849-

    2013  Volume 14861

    Abstract: Korean ginseng (Panax ginseng C.A. Meyer) contains several types of ginsenosides, which are considered the major active medicinal components of ginseng. The types and quantities of ginsenosides found in ginseng may differ, depending on the location of ... ...

    Abstract Korean ginseng (Panax ginseng C.A. Meyer) contains several types of ginsenosides, which are considered the major active medicinal components of ginseng. The types and quantities of ginsenosides found in ginseng may differ, depending on the location of cultivation, making it necessary to establish a reliable method for distinguishing cultivation locations of ginseng roots. P. ginseng roots produced in different regions of Korea, China, and Japan have been unintentionally confused in herbal markets owing to their complicated plant sources. PCA and PLS-DA using RRLC-QTOF/MS data was able to differentiate between ginsengs cultivated in Korea, China, and Japan. The chemical markers accountable for such variations were identified through a PCA loadings plot, tentatively identified by RRLC-QTOF/MS and partially verified by available reference standards. The classification result can be used to identify P. ginseng origin.
    Keywords Korean ginseng ; metabolomics ; multivariate analysis ; PCA ; PLS-DA ; RRLC-QTOF/MS ; Organic chemistry ; QD241-441
    Subject code 950
    Language English
    Publishing date 2013-12-01T00:00:00Z
    Publisher MDPI AG
    Document type Article ; Online
    Database BASE - Bielefeld Academic Search Engine (life sciences selection)

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  7. Article ; Online: Anti-Inflammatory Cycloartane-Type Saponins of Astragalus membranaceus

    Geum-Soog Kim / Seung-Yu Kim / Yoonpyo Hong / Seung-Eun Lee / Ji-Hyun Lee / Min-Ho Lee / Kyeong-Hee Lee / Jehun Choi / Hyung-Jun Noh / Dae-Young Lee

    Molecules, Vol 18, Iss 4, Pp 3725-

    2013  Volume 3732

    Abstract: A new cycloartane-type triterpene glycoside, agroastragaloside V (1) was isolated from the roots of Astragalus membranaceus. The structure was identified as 3-O-β-(2'-O-acetyl)-D-xylopyranosyl-6-O-β-D-glucopyranosyl-(24S)-3β,6α,24α,25-tetrahydroxy- 9,19- ... ...

    Abstract A new cycloartane-type triterpene glycoside, agroastragaloside V (1) was isolated from the roots of Astragalus membranaceus. The structure was identified as 3-O-β-(2'-O-acetyl)-D-xylopyranosyl-6-O-β-D-glucopyranosyl-(24S)-3β,6α,24α,25-tetrahydroxy- 9,19-cyclolanostane, by means of spectroscopic methods, including HR-FAB/MS, 1D NMR (1H, 13C, DEPT), 2D NMR (gCOSY, gHSQC, gHMBC, NOESY), and IR spectroscopy. Four known cycloartane glycosides, namely, agroastragaloside I (2), agroastragaloside II (3), isoastragaloside II (4) and astragaloside IV (5) were also isolated. All isolated compounds were tested for the ability to inhibit LPS-induced nitric oxide production in RAW264.7 macrophages.
    Keywords Astragalus membranaceus ; cycloartane-type triterpene ; agroastragaloside V ; nitric oxide ; Organic chemistry ; QD241-441
    Language English
    Publishing date 2013-03-01T00:00:00Z
    Publisher MDPI AG
    Document type Article ; Online
    Database BASE - Bielefeld Academic Search Engine (life sciences selection)

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  8. Article ; Online: Anti-inflammatory Lignans from the Fruits of Acanthopanax sessiliflorus

    Gye-Won Kim / Ji-Young Kim / Seung-Yu Kim / Hyung-Jun Noh / Geum-Soog Kim / Sang-Min Lee / Rak-Hun Jeong / Kyeong-Hwa Seo / Dae-Young Lee / Nam-In Baek

    Molecules, Vol 18, Iss 1, Pp 41-

    2012  Volume 49

    Abstract: A new lignan, named acanthosessilin A (1), as well as eight known lignan and lignan glycosides 2-9 were isolated from an ethanolic extract of Acanthopanax sessiliflorus fruits. The chemical structures were determined by spectroscopic methods, including ... ...

    Abstract A new lignan, named acanthosessilin A (1), as well as eight known lignan and lignan glycosides 2-9 were isolated from an ethanolic extract of Acanthopanax sessiliflorus fruits. The chemical structures were determined by spectroscopic methods, including HR-EIMS, 1D NMR (1H, 13C, DEPT), 2D NMR (gCOSY, gHSQC, gHMBC, NOESY), and IR spectroscopy. All isolated compounds were tested for the ability to inhibit LPS-induced nitric oxide production in RAW264.7 macrophages.
    Keywords Acanthopanax sessiliflorus ; lignan ; acanthosessilin A ; nitric oxide ; Organic chemistry ; QD241-441
    Language English
    Publishing date 2012-12-01T00:00:00Z
    Publisher MDPI AG
    Document type Article ; Online
    Database BASE - Bielefeld Academic Search Engine (life sciences selection)

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