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  1. Article ; Online: Korelasi antara Kadar Seng Serum dengan Kadar Interleukin-6 dan Skor PELOD-2 pada Sepsis

    Defranky Theodorus / Dyah Kanya Wati / I Gusti Ngurah Sanjaya Putra / Ida Bagus Subanada / Eka Gunawijaya / Komang Ayu Witarini / Wayan Gustawan

    Sari Pediatri, Vol 23, Iss 4, Pp 262-

    2021  Volume 9

    Abstract: Latar belakang. Sepsis merupakan penyebab utama morbiditas dan mortalitas pada anak dengan penyakit kritis yang dirawat di unit perawatan intensif anak (UPIA). Pada 24 jam sepsis, terjadi penurunan kadar seng serum dan secara bersamaan terjadi ... ...

    Abstract Latar belakang. Sepsis merupakan penyebab utama morbiditas dan mortalitas pada anak dengan penyakit kritis yang dirawat di unit perawatan intensif anak (UPIA). Pada 24 jam sepsis, terjadi penurunan kadar seng serum dan secara bersamaan terjadi peningkatan kadar interleukin-6 (IL-6) dan skor PELOD-2. Hasil sebaliknya terjadi pada 72 jam sepsis. Tujuan. Untuk membuktikan korelasi negatif antara kadar seng serum dengan IL-6 dan skor PELOD-2 pada sepsis. Metode. Penelitian dengan rancangan potong lintang dua kali pengukuran dari Januari - Desember 2019 di UPIA RSUP Sanglah Denpasar. Subjek penelitian adalah anak berusia 29 hari sampai 18 tahun dengan sepsis berdasarkan skor PELOD-2 > 7 menggunakan metode consecutive sampling. Uji korelasi Pearson untuk menilai korelasi bivariat dan uji multivariat menggunakan uji korelasi parsial. Hasil. Empatpuluh subjek memenuhi kriteria inklusi. Rerata kadar seng serum pada 24 dan 72 jam adalah 59,5 µg/dl versus 64,2 µg/dl. Median IL-6 pada 24 dan 72 jam adalah 8,6 pg/dL versus 4,4 pg/dL, rerata skor PELOD-2 24 dan 72 jam adalah 11,2 versus 11,0. Korelasi Pearson kadar seng serum dengan kadar IL-6 pada 24 dan 72 jam adalah r= -0,078, p= 0,632 versus r= -0,218, p= 0,178. Korelasi Pearson kadar seng serum dengan skor PELOD-2 pada 24 dan 72 jam adalah r= -0,513, p= 0,001 versus r= 0,242, p= 0,132. Analisis korelasi parsial kadar seng serum dengan PELOD-2 pada 24 jam adalah r= -0,493, p= 0,002. Kesimpulan. Terdapat korelasi negatif sedang bermakna pada 24 jam sepsis antara kadar seng serum dengan skor PELOD-2 setelah mengontrol variabel kendali.
    Keywords sepsis ; kadar seng serum ; interleukin-6 ; skor pelod-2 ; Medicine ; R ; Pediatrics ; RJ1-570
    Language Indonesian
    Publishing date 2021-12-01T00:00:00Z
    Publisher Badan Penerbit Ikatan Dokter Anak Indonesia
    Document type Article ; Online
    Database BASE - Bielefeld Academic Search Engine (life sciences selection)

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  2. Article ; Online: FAKTOR RISIKO KEJADIAN LUAR BIASA HEPATITIS A DI SEKOLAH DASAR NEGERI SELULUNG DAN BLANTIH, KINTAMANI

    I Gede Ketut Aryana / I Gusti Ngurah Sanjaya Putra / I Putu Gede Karyana

    Medicina, Vol 45, Iss

    2015  Volume 2

    Abstract: Hepatitis A terjadi secara sporadis dan epidemik di seluruh dunia, dengan kecenderungan untuk kambuh secara siklik. Berdasarkan laporan Dinas Kesehatan Kabupaten Bangli tahun 2012 dan awal 2013 terjadi kejadian luar biasa hepatitis A di Kintamani, Bangli. ...

    Abstract Hepatitis A terjadi secara sporadis dan epidemik di seluruh dunia, dengan kecenderungan untuk kambuh secara siklik. Berdasarkan laporan Dinas Kesehatan Kabupaten Bangli tahun 2012 dan awal 2013 terjadi kejadian luar biasa hepatitis A di Kintamani, Bangli. Penelitian bertujuan untuk mengetahui faktor risiko kejadian luar biasa hepatitis A pada anak-anak sekolah dasar di Kintamani. Penelitian ini merupakan penelitian kasus-kontrol. Data kasus diambil dari Sekolah Dasar Negeri (SDN) Selulung dan Blantih, sedangkan kontrol dari SDN Sekaan, Kintamani. Penelitian dilaksanakan bulan April sampai Mei 2013. Analisis data dengan uji Kai-kuadrat, analisis bivariat dengan tingkat kemaknaan á=0,05, interval kepercayaan (IK) 95%, dilanjutkan analisis multivariat. Pemanfaatan jamban yang tidak baik bermakna secara statistik berhubungan dengan kejadian luar biasa hepatitis A dengan rasio odds 18,0 (IK95% 4,38 sampai 74,01), P<0,001. Pemanfaatan jamban yang tidak baik bermakna secara statistik sebagai faktor risiko kejadian luar biasa hepatitis A pada anak-anak sekolah dasar di Kintamani. [MEDICINA 2014;45:79-83]
    Keywords kejadian luar biasa hepatitis A ; faktor risiko ; Medicine ; R ; Medicine (General) ; R5-920
    Language English
    Publishing date 2015-05-01T00:00:00Z
    Publisher Universitas Udayana
    Document type Article ; Online
    Database BASE - Bielefeld Academic Search Engine (life sciences selection)

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  3. Article ; Online: The impact of the severity of HIV infection on the prevalence of liver fibrosis in children

    Ida Bagus Gde Suwibawa Putra / Ketut Dewi Kumara Wati / I Putu Gede Karyana / I Gusti Ngurah Sanjaya Putra / Ni Nyoman Metriani Nesa

    Bali Medical Journal, Vol 8, Iss 1, Pp 47-

    2019  Volume 50

    Abstract: Background : The fibrotic process in liver fibrosis is faster when there is coinfection with HIV than in Hepatitis B or Hepatitis C mono-infection. Objectives : We sought to compare the presence of liver fibrosis based on Aspartate Aminotransferase to ... ...

    Abstract Background : The fibrotic process in liver fibrosis is faster when there is coinfection with HIV than in Hepatitis B or Hepatitis C mono-infection. Objectives : We sought to compare the presence of liver fibrosis based on Aspartate Aminotransferase to Platelet Ratio Index (APRI) in HIV clinical stage I-II and III-IV. We also sought to identify factors associated with liver fibrosis in HIV-infected children. Methods : The population was HIV-infected children who were registered in 2006-2014 Sanglah hospital’s TApHOd (Treat Asia Pediatric HIV Observational Database) cohort. The cutoff point for fibrosis was APRI > 0.5. The sample was grouped into two outcomes: liver fibrosis and without fibrosis. The associations of liver fibrosis to the severity of HIV clinical stage and other variables were analyzed using Fisher-Exact test. Results : From 81 HIV-infected subjects, 46 were in stage III-IV and 35 in stage I-II. The range of APRI was 0.11 to 12.01. There were 27 subjects with liver fibrosis. There were 21 subjects with liver fibrosis in stage III-IV HIV infection and 6 in stage I-II. The analysis showed in a group of liver fibrosis patients; there are more patients with the severe clinical stage of HIV (p-value = 0.009). Conclusion. Liver fibrosis is more common in the more severe clinical stage of HIV infection in children than in the milder clinical stage. Advanced clinical stage significantly increases the risk for liver fibrosis.
    Keywords apri ; liver fibrosis ; hiv ; children ; Medicine ; R ; Medicine (General) ; R5-920
    Subject code 610
    Language English
    Publishing date 2019-04-01T00:00:00Z
    Publisher DiscoverSys
    Document type Article ; Online
    Database BASE - Bielefeld Academic Search Engine (life sciences selection)

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  4. Article ; Online: Cystatin C level and amikacin use in neonatal sepsis

    Putu Diah Pratiwi / I Wayan Dharma Artana / Ni Putu Veny Kartika Yantie / Hendra Santoso / I Gusti Ngurah Sanjaya Putra / Gusti Ayu Putu Nilawati / Ni Nyoman Metriani Nesa

    Paediatrica Indonesiana, Vol 60, Iss 1, Pp 1-

    2019  Volume 5

    Abstract: Background Amikacin is the antibiotic of choice for eradicating bacteria in neonatal sepsis because of its effectiveness against Gram-negative bacteria. However, this drug has nephrotoxic effects. Monitoring kidney function in neonates is very important ... ...

    Abstract Background Amikacin is the antibiotic of choice for eradicating bacteria in neonatal sepsis because of its effectiveness against Gram-negative bacteria. However, this drug has nephrotoxic effects. Monitoring kidney function in neonates is very important because amikacin can interfere with development of the kidney. Several studies have shown that serum cystatin C levels were closer to glomerular filtration rate (GFR) values compared to serum creatinine levels. Objective To evaluate cystatin C levels before and after administration of amikacin in neonates with sepsis. Methods This prospective cohort study was conducted in one group with a pretest and posttest design. Thirty neonatal sepsis patients who received amikacin therapy at Sanglah General Hospital, Denpasar, Bali, were included by consecutive sampling. Their cystatin C levels were measured before and after receiving amikacin therapy. Data were normally distributed and analyzed by paired T-test, with a value of P<0.05 considered to be significant. Results The mean difference was 0.23 [1.57 (SD 0.29) vs. 1.80 (SD 0.28)] mg/L with P value < 0.001. There was different value of cystatin c level before and after amikacin therapy with deviation standard 0.25 with P<0.001 (alfa 5%). Conclusion Cystatin C levels are significantly higher in neonates with sepsis after administration of amikacin.
    Keywords neonatal sepsis ; cystatin c ; renal function ; Medicine ; R ; Pediatrics ; RJ1-570
    Subject code 616
    Language English
    Publishing date 2019-11-01T00:00:00Z
    Publisher Indonesian Pediatric Society Publishing House
    Document type Article ; Online
    Database BASE - Bielefeld Academic Search Engine (life sciences selection)

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  5. Article ; Online: Liver function in children with human immunodeficiency virus infection before and after 6 months of highly active antiretroviral therapy

    Eva Jacomina Jemima Sapulete / I Gusti Ngurah Sanjaya Putra / Ketut Dewi Kumara Wati / Hendra Santoso / I Putu Gede Karyana / Komang Ayu Witarini / Ni Nyoman Metriani Nesa

    Paediatrica Indonesiana, Vol 58, Iss 4, Pp 159-

    2018  Volume 64

    Abstract: Background Highly active antiretroviral therapy (HAART) has resulted in dramatic decreases in morbidity and improved survival rate in human immunodeficiency virus (HIV)-infected patients. Although the risk of morbidity has decreased, it has been replaced ...

    Abstract Background Highly active antiretroviral therapy (HAART) has resulted in dramatic decreases in morbidity and improved survival rate in human immunodeficiency virus (HIV)-infected patients. Although the risk of morbidity has decreased, it has been replaced by other long-term complications, such as hepatotoxicity. Hepatotoxicity is often reflected in biochemical abnormalities of liver function, such as elevated levels of aspartate aminotransferase (AST), alanine aminotransferase (ALT), and aspartate aminotransferase-to-platelet ratio index (APRI). Objective To compare liver function spectrum (AST, ALT, and APRI) in HIV-infected children before and after at least 6 months of HAART. Methods This observational study (before and after) was conducted in pediatric patients with HIV infection who received HAART for at least 6 months at Sanglah Hospital, Denpasar. Data were collected from medical records. Results Forty-nine patients were observed in this study. The mean AST, ALT, and APRI levels before HAART were higher than after at least 6 months of HAART. Anti-tuberculosis treatment and fluconazole therapy were not confounding factors for AST, ALT, and APRI. Conclusion Liver function spectrum enzyme levels of AST, ALT, and APRI are improved after at least 6 months of HAART.
    Keywords liver function ; pediatric ; human immunodeficiency virus ; antiretroviral ; Medicine ; R ; Pediatrics ; RJ1-570
    Subject code 610
    Language English
    Publishing date 2018-07-01T00:00:00Z
    Publisher Indonesian Pediatric Society Publishing House
    Document type Article ; Online
    Database BASE - Bielefeld Academic Search Engine (life sciences selection)

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  6. Article ; Online: TYPE IC CHOLEDOCHAL CYST PRESENTING AN EXTRAHEPATAL CHOLESTASIS IN A 3 YEAR OLD BOY

    Muhammad Reza / Nyoman Metriani Nesa / I Gusti Ngurah Sanjaya Putra / I Putu Gede Karyana / Made Darmajaya

    Medicina, Vol 46, Iss

    2015  Volume 1

    Abstract: Choledochal cyst is a rare congenital dilatation of the bile ducts, mostly diagnosed in childhood. Whenappropriate resection is not performed, cholangiocarcinoma may occur in a high incidence within thesecond decade of life. This report aims to present a ...

    Abstract Choledochal cyst is a rare congenital dilatation of the bile ducts, mostly diagnosed in childhood. Whenappropriate resection is not performed, cholangiocarcinoma may occur in a high incidence within thesecond decade of life. This report aims to present a rare case in experience of diagnosis and managementtype IC choledochal cyst in children. We present case of a 3-year-old boy who came with jaundice anditchy skin, abdominal pain, brownish urine, pales colored of stool. Abdominal ultrasonography andcomputed tomography scan revealed type IC choledochal cyst. Patient underwent complete cyst removalsurgery and bilioenteric anastomosis through Roux-en-y hepaticojejunostomy. Excision biopsy confirmedthe diagnosis of type IC choledochal cyst. Post surgical follow up shown good physical and laboratorycondition and there was no recurrence of symptoms. Early surgical procedure through Roux-en-yhepatojejunostomy, has been performed. Long term follow up also facilities good prognostic to thepatient. [MEDICINA 2015;46:56-60]. Kista koledokus adalah merupakan penyakit saluran empedu bawaan yang jarang dijumpai danbanyak terdiagnosis pada saat usia anak-anak. Tindakan berupa reseksi kista adalah yang terpentingdilakukan, jika tidak segera dilakukan maka dapat meningkatkan resiko terjadinyacholangiocarcinoma dalam usia dekade kedua penderita dalam kehidupan. Tujuan kasus ini dilaporkanuntuk menggambarkan pengalaman dalam mendiagnosis dan tata laksana kista koledokal tipe ICyang jarang pada anak-anak. Laporan kasus ini pada anak laki-laki berumur 3 tahun dengan keluhankulit tampak kuning dan gatal, nyeri perut, urin berwarna kecoklatan, tinja yang pucat. Ultrasonografidan CT scan abdomen memperlihatkan adanya kista koledokus. Tindakan bedah eksisi kista dananastomosis bilioenterik dengan menggunakan tehnik hepatojejunostomi Roux-en-y. Diagnosa kistakoledokus tipe IC terkonfirmasi saat tindakan eksisi biopsi. Evaluasi setelah dilakukan tindakanbedah memperlihatkan hasil yang bagus, baik dari pemeriksaan fisik maupun pemeriksaan penunjangdan hilangnya keluhan yang ada sebelumnya. Walaupun prosedur tindakan hepatojejunustomi Roux-en-y secara dini telah dilakukan, penderita masih membutuhkan evaluasi dalam jangka waktu yanglama. [MEDICINA 2015;46:56-60].
    Keywords choledochal cyst ; children ; surgery ; Medicine ; R ; Medicine (General) ; R5-920
    Language English
    Publishing date 2015-10-01T00:00:00Z
    Publisher Universitas Udayana
    Document type Article ; Online
    Database BASE - Bielefeld Academic Search Engine (life sciences selection)

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  7. Article ; Online: Effect of probiotics supplementation on acute diarrhea in infants

    I Gusti Ngurah Sanjaya Putra / Sudaryat Suraatmaja / I Ketut Nomor Aryasa

    Paediatrica Indonesiana, Vol 47, Iss 4, Pp 172-

    a randomized double blind clinical trial

    2007  Volume 8

    Abstract: Background Probiotics has advantages as a supplement for management of infants with acute diarrhea. It influences the duration of diarrhea by enhancing immune responses, elaborates antimicrobial substances and occupies intestinal mucosal sites, inhibits ... ...

    Abstract Background Probiotics has advantages as a supplement for management of infants with acute diarrhea. It influences the duration of diarrhea by enhancing immune responses, elaborates antimicrobial substances and occupies intestinal mucosal sites, inhibits the attachment and the growth of pathogenic organisms by achieving competitive exclusion and microbial balance. Objective To assess the clinical effects of probiotics supplementation on acute diarrhea in infants. Methods This was a double blind, randomized clinical controlled trial performed on infants aged 1-12 months old with acute diarrhea, hospitalized in Sanglah Hospital, Denpasar. Subjects were divided into two groups; the treatment group had standard management with adjuvant probiotics, while the control group received standard management with placebo. Results From 70 infants enrolled in this study, the mean duration of diarrhea in treatment group was significantly shorter than that in the placebo group, 49.03 hours (SE 3.09) (95%CI 42.98;55.08) vs 73.03 hours (SE 3.28) (95%CI 66.61;79.45); P=0.001. Regarding failure of the treatment, probiotics supplementation had relative risk reduction (RRR) of 67% and absolute risk reduction (ARR) of 57%. In multivariate cox regression analysis it was found that only probiotics supplementation influenced the duration of acute diarrhea in infants. Conclusion Probiotics can shorten the duration of acute diarrhea, and is safe as an adjuvant to standard management for infants with acute diarrhea.
    Keywords Acute diarrhea ; probiotics ; duration of diarrhea ; Medicine ; R ; Pediatrics ; RJ1-570
    Subject code 610
    Language English
    Publishing date 2007-08-01T00:00:00Z
    Publisher Indonesian Pediatric Society Publishing House
    Document type Article ; Online
    Database BASE - Bielefeld Academic Search Engine (life sciences selection)

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