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  1. Article ; Online: Fluorescence and Ultrasound-guided Laparoscopic Resection of Caudate Lobe for Hepatocellular Carcinoma Located in the Retrocaval Portion.

    Santambrogio, Roberto / D'Alessandro, Valentina / Iacob, Giulio / Zappa, Marco A

    Surgical laparoscopy, endoscopy & percutaneous techniques

    2021  Volume 31, Issue 6, Page(s) 812–814

    Abstract: Background: Contrast-enhanced intraoperative ultrasonography (CEIOUS) and indocyanine green fluorescence were interesting tool for the visualization of intrahepatic neoplastic nodules. The combinations of the 2 technologies could increase tumor ... ...

    Abstract Background: Contrast-enhanced intraoperative ultrasonography (CEIOUS) and indocyanine green fluorescence were interesting tool for the visualization of intrahepatic neoplastic nodules. The combinations of the 2 technologies could increase tumor detection and the radicality of resection, allowing the use of a pure laparoscopic approach.
    Methods: The patient was an 81-year-old man with a history of hypertension and treated hepatitis C infection, with a sustained serological response from 2018, previously undergoing laparotomic resection for hepatocellular carcinoma (HCC) in segment 8.During his regular hepatological follow-up, a 25 mm nodule was detected in segment 1, in a retrocaval position. Considering clinical presentation, good liver function (Child A5-MELD 8) and imaging, pure laparoscopic resection of the caudate lobe was performed using fluorescence imaging and CEIOUS navigation guidance.
    Results: The operation last for 205 minutes. Blood loss was 100 mL and no blood transfusion was required. She resumed diet on the next day and was discharged 4 days after the operation. Histopathologic examination showed 27 mm HCC with a clear margin. Contrast computed tomography scan performed 3 months after the operation showed no recurrence of the disease.
    Conclusions: A laparoscopic isolated caudate resection for HCC located in the retrocaval portion of the cirrhotic liver seems to be feasible in selected patients and fluorescence imaging and CEIOUS navigation guidance could guarantee a safe and successful surgery.
    MeSH term(s) Aged, 80 and over ; Carcinoma, Hepatocellular/diagnostic imaging ; Carcinoma, Hepatocellular/surgery ; Child ; Female ; Hepatectomy ; Humans ; Laparoscopy ; Liver Neoplasms/diagnostic imaging ; Liver Neoplasms/surgery ; Male ; Ultrasonography ; Ultrasonography, Interventional
    Language English
    Publishing date 2021-07-07
    Publishing country United States
    Document type Case Reports ; Journal Article
    ZDB-ID 1475108-2
    ISSN 1534-4908 ; 1530-4515 ; 1051-7200
    ISSN (online) 1534-4908
    ISSN 1530-4515 ; 1051-7200
    DOI 10.1097/SLE.0000000000000970
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  2. Article ; Online: Guidelines Adaptation to the COVID-19 Outbreak for the Management of Hepatocellular Carcinoma.

    Santambrogio, Roberto / Farina, Gabriella / D'Alessandro, Valentina / Iacob, Giulio / Gemma, Marco / Zappa, Marco Antonio

    Journal of laparoendoscopic & advanced surgical techniques. Part A

    2020  Volume 31, Issue 3, Page(s) 266–272

    Abstract: Background: ...

    Abstract Background:
    MeSH term(s) Aged ; Aged, 80 and over ; COVID-19/epidemiology ; Carcinoma, Hepatocellular/epidemiology ; Carcinoma, Hepatocellular/surgery ; Comorbidity ; Disease Management ; Female ; Guideline Adherence ; Hepatectomy/methods ; Humans ; Laparoscopy/methods ; Length of Stay ; Liver Neoplasms/epidemiology ; Liver Neoplasms/surgery ; Male ; Middle Aged ; Operative Time ; Pandemics ; SARS-CoV-2
    Keywords covid19
    Language English
    Publishing date 2020-08-11
    Publishing country United States
    Document type Journal Article
    ZDB-ID 1381909-4
    ISSN 1557-9034 ; 1092-6429
    ISSN (online) 1557-9034
    ISSN 1092-6429
    DOI 10.1089/lap.2020.0559
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  3. Article ; Online: Micronvasive behaviour of single small hepatocellular carcinoma: which treatment?

    Santambrogio, Roberto / Barabino, Matteo / D'Alessandro, Valentina / Iacob, Giulio / Opocher, Enrico / Gemma, Marco / Zappa, Marco Antonio

    Updates in surgery

    2021  Volume 73, Issue 4, Page(s) 1359–1369

    Abstract: Background: Microinvasion (MI), defined as infiltration of the portal or hepatic vein or bile duct and intrahepatic metastasis are accurate indicators of a poor prognosis for mall hepatocellular carcinomas (HCC). A previous study showed that ... ...

    Abstract Background: Microinvasion (MI), defined as infiltration of the portal or hepatic vein or bile duct and intrahepatic metastasis are accurate indicators of a poor prognosis for mall hepatocellular carcinomas (HCC). A previous study showed that intraoperative ultrasound (IOUS) definition of MI-HCC had a high concordance with histological findings. Aim of this study is to evaluate overall survival and recurrence patterns of patients with MI-HCC submitted to hepatic resection (HR) or laparoscopic ablation therapies (LAT).
    Methods: A total of 171 consecutive patients (78 h; 93 LAT) with single, small HCC (< 3 cm) with a MI pattern at IOUS examination were compared analyzing overall survival and recurrence patterns using univariate and multivariate analysis and weighting by propensity score.
    Results: Overall recurrences were similar in the 2 groups (HR: 51 patients (65%); LAT: 66 patients (71%)). The rate of local tumor progression in the HR group was very low (5 pts; 6%) in comparison to LAT group (22 pts; 24%; p = 0.002). The overall survival curves of HR are significantly better than that of the LAT group (p = 0.0039). On the propensity score Cox model, overall mortality was predicted by the surgical treatment with a Hazard ratio 1.68 (1.08-2.623) (p = 0.022).
    Conclusions: If technically feasible and in patients fit for surgery, HR with an adequate tumor margin should be preferred to LAT in patients with MI-HCC at IOUS evaluation, to eradicate MI features near the main nodule, which are relatively frequent even in small HCC (< 3 cm).
    MeSH term(s) Carcinoma, Hepatocellular/surgery ; Catheter Ablation ; Hepatectomy ; Humans ; Liver Neoplasms/surgery ; Neoplasm Recurrence, Local/surgery ; Proportional Hazards Models ; Retrospective Studies ; Treatment Outcome ; Ultrasonography
    Language English
    Publishing date 2021-04-05
    Publishing country Italy
    Document type Journal Article
    ZDB-ID 2572692-4
    ISSN 2038-3312 ; 2038-131X
    ISSN (online) 2038-3312
    ISSN 2038-131X
    DOI 10.1007/s13304-021-01036-0
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  4. Article ; Online: [No title information]

    Farina, Umberto / Coppola, Cristina / Dall'Oglio, Giovanni / Alupu, Monica / Ogwang, Eric / Bingom, Christopher / Ogwal, Polycap / Di Gennaro, Francesco / Marotta, Claudia / Segala, Vladimiro Francesco / De Vita, Elda / Iacob, Giulio / Tognon, Francesca / Putoto, Giovanni / Martinelli, Domenico / Prato, Rosa / Fortunato, Francesca

    Recenti progressi in medicina

    2023  Volume 114, Issue 9, Page(s) 541–542

    Title translation Indagine conoscitiva sulla violenza di genere tra i giovani residenti nel distretto di Oyam, Uganda.
    MeSH term(s) Humans ; Adolescent ; Gender-Based Violence ; Uganda
    Language Italian
    Publishing date 2023-08-02
    Publishing country Italy
    Document type Journal Article
    ZDB-ID 138266-4
    ISSN 2038-1840 ; 0034-1193
    ISSN (online) 2038-1840
    ISSN 0034-1193
    DOI 10.1701/4088.40805
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  5. Article ; Online: Guidelines Adaptation to the COVID-19 Outbreak for the Management of Hepatocellular Carcinoma

    Santambrogio, Roberto / Farina, Gabriella / D'Alessandro, Valentina / Iacob, Giulio / Gemma, Marco / Zappa, Marco Antonio

    Journal of Laparoendoscopic & Advanced Surgical Techniques ; ISSN 1092-6429 1557-9034

    2020  

    Keywords Surgery ; covid19
    Language English
    Publisher Mary Ann Liebert Inc
    Publishing country us
    Document type Article ; Online
    DOI 10.1089/lap.2020.0559
    Database BASE - Bielefeld Academic Search Engine (life sciences selection)

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  6. Article: Guidelines Adaptation to the COVID-19 Outbreak for the Management of Hepatocellular Carcinoma

    Santambrogio, Roberto / Farina, Gabriella / D039, / Alessandro, Valentina / Iacob, Giulio / Gemma, Marco / Zappa, Marco Antonio

    J. laparoendosc. adv. surg. tech., Part A

    Abstract: Background: COVID-19 pandemic rendered the surgical approach as well as the surgical indication very complex due to the outstanding consumption of public health system' resources, especially in the intensive care subdivision. A multidisciplinary team- ... ...

    Abstract Background: COVID-19 pandemic rendered the surgical approach as well as the surgical indication very complex due to the outstanding consumption of public health system' resources, especially in the intensive care subdivision. A multidisciplinary team-based strategy is necessary to adapt guidelines and medical practices to the actual situation. The aim of this study is to evaluate the changes in the therapeutic algorithm in a small group of patients with hepatocellular carcinoma (HCC) enlisted for surgery during the COVID-19 outbreak. Materials and Methods: A multidisciplinary strategy has been adopted to allocate HCC patients to a treatment that permitted to reduce the risk of complications and the hospital stay, thus preventing contamination by the virus. Nasopharyngeal swab and a chest radiograph were performed in all patients within 48 hours before the surgical procedure: in the suspected cases with negative COVID tests, we prudently postponed surgery and repeated the diagnostic tests after 15 days. Results: During the emergency state, 11 HCC patients were treated (8 laparoscopic ablations and 3 hepatic resections). We reported only 1 postoperative complication (hemothorax) and 1 death during the follow-up for COVID pneumonia. Comparing our performances with those in the same time frame in the past 4 years, we treated a similar number of HCC patients, obtaining a decrease in operative timing (P = .0409) and hospital stay (P = .0412) (Fig. 2b) with similar rates of immediate postoperative complications, without ICU admissions. [Figure: see text] Conclusions: An adapted algorithm for the treatment of HCC to COVID outbreak permitted to manage safely these patients by identifying those most at risk of evolution of the neoplastic disease.
    Keywords covid19
    Publisher WHO
    Document type Article
    Note WHO #Covidence: #720927
    Database COVID19

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  7. Article: Pediatric Laparoscopy and Adaptive Oxygenation and Hemodynamic Changes.

    Pelizzo, Gloria / Carlini, Veronica / Iacob, Giulio / Pasqua, Noemi / Maggio, Giuseppe / Brunero, Marco / Mencherini, Simonetta / De Silvestri, Annalisa / Calcaterra, Valeria

    Pediatric reports

    2017  Volume 9, Issue 2, Page(s) 7214

    Abstract: Adaptive changes in oxygenation and hemodynamics are evaluated during pediatric laparoscopy. The children underwent laparoscopy (LAP Group, n=20) or open surgery (Open Group, n=10). Regional cerebral ( ... ...

    Abstract Adaptive changes in oxygenation and hemodynamics are evaluated during pediatric laparoscopy. The children underwent laparoscopy (LAP Group, n=20) or open surgery (Open Group, n=10). Regional cerebral (rScO
    Language English
    Publishing date 2017-06-26
    Publishing country Italy
    Document type Journal Article
    ISSN 2036-749X
    ISSN 2036-749X
    DOI 10.4081/pr.2017.7214
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  8. Article ; Online: One step minilaparotomy-assisted transmesenteric portal vein recanalization combined with transjugular intrahepatic portosystemic shunt placement: A novel surgical proposal in pediatrics.

    Pelizzo, Gloria / Quaretti, Pietro / Moramarco, Lorenzo Paolo / Corti, Riccardo / Maestri, Marcello / Iacob, Giulio / Calcaterra, Valeria

    World journal of gastroenterology

    2017  Volume 23, Issue 15, Page(s) 2811–2818

    Abstract: Transjugular intrahepatic portosystemic shunt (TIPS) placement is a standard procedure for the treatment of portal hypertension complications. When this conventional approach is not feasible, alternative procedures for systemic diversion of portal blood ... ...

    Abstract Transjugular intrahepatic portosystemic shunt (TIPS) placement is a standard procedure for the treatment of portal hypertension complications. When this conventional approach is not feasible, alternative procedures for systemic diversion of portal blood have been proposed. A one-step interventional approach, combining minilaparotomy-assisted transmesenteric (MAT) antegrade portal recanalization and TIPS, is described in an adolescent with recurrent esophageal varice bleeding and portal cavernoma (PC). A 16-year-old girl was admitted to our Unit because of repeated bleeding episodes over a short period of time due to esophageal varices in the context of a PC. A portal vein recanalization through an ileocolic vein isolation with the MAT approach followed by TIPS during the same session was performed. In the case of failed portal recanalization, this approach, would also be useful for varice endovascular embolization. Postoperative recovery was uneventful. Treatment consisting of propanolol, enoxaparin and a proton pump inhibitor was prescribed after the procedure. One month post-op, contrast enhanced computed tomography confirmed the patency of the portal and intrahepatic stent grafts. No residual peritoneal fluid was detected nor opacification of the large varices. Endoscopy showed good improvement of the varices. Doppler ultrasound confirmed the accelerated flow in the portal stent and hepatopetal flow inside the intrahepatic portal branches. Three months post-op, TIPS maintained its hourglass shape despite a slight expansion. Portal hypertension and life threatening conditions related to PC would benefit from one-step portal recanalization. MAT-TIPS is feasible and safe for the treatment of PC even in children. This minimally invasive procedure avoids or delays surgical treatment or re-transplantation when necessary in pediatric patients.
    Language English
    Publishing date 2017-04-21
    Publishing country United States
    Document type Journal Article
    ZDB-ID 2185929-2
    ISSN 2219-2840 ; 1007-9327
    ISSN (online) 2219-2840
    ISSN 1007-9327
    DOI 10.3748/wjg.v23.i15.2811
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  9. Article ; Online: Extracellular vesicles derived from mesenchymal cells: perspective treatment for cutaneous wound healing in pediatrics.

    Pelizzo, Gloria / Avanzini, Maria Antonietta / Icaro Cornaglia, Antonia / De Silvestri, Annalisa / Mantelli, Melissa / Travaglino, Paola / Croce, Stefania / Romano, Piero / Avolio, Luigi / Iacob, Giulio / Dominici, Massimo / Calcaterra, Valeria

    Regenerative medicine

    2018  Volume 13, Issue 4, Page(s) 385–394

    Abstract: Aim: We evaluated the effects of the intradermal injection of extracellular vesicles (EVs) derived from adipose stem cells (ASC-EVs) and bone marrow cells (BM-EVs) in an experimental cutaneous wound repair model.: Methods: Mesenchymal stem cells ( ... ...

    Abstract Aim: We evaluated the effects of the intradermal injection of extracellular vesicles (EVs) derived from adipose stem cells (ASC-EVs) and bone marrow cells (BM-EVs) in an experimental cutaneous wound repair model.
    Methods: Mesenchymal stem cells (MSCs) were in vitro expanded from adipose (ASC) or BM tissues (BM-MSC) of rabbits. EVs were separated from the supernatants of confluent ASC and BM-MSCs. Two skin wounds were induced in each animal and treated with MSC or EV injections. Histological examination was performed postinoculation.
    Results: EV-treated wounds exhibited a better restoration compared with the counterpart MSC treatment. ASC-EV-treated wounds were significantly better than BM-EVs (p = 0.036).
    Conclusion: EV topical inoculation provides restored architecture during cutaneous wound healing and represents a promising solution for regenerative medicine in children.
    MeSH term(s) Adipose Tissue/metabolism ; Adipose Tissue/pathology ; Animals ; Bone Marrow Cells/metabolism ; Bone Marrow Cells/pathology ; Cell-Derived Microparticles/transplantation ; Female ; Humans ; Mesenchymal Stromal Cells/metabolism ; Mesenchymal Stromal Cells/pathology ; Rabbits ; Wound Healing ; Wounds and Injuries/metabolism ; Wounds and Injuries/pathology ; Wounds and Injuries/therapy
    Language English
    Publishing date 2018-07-09
    Publishing country England
    Document type Journal Article ; Research Support, Non-U.S. Gov't
    ZDB-ID 2274500-2
    ISSN 1746-076X ; 1746-0751
    ISSN (online) 1746-076X
    ISSN 1746-0751
    DOI 10.2217/rme-2018-0001
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  10. Article ; Online: Impact of COVID-19 Pandemic on Cirrhotics with Hepatocellular Carcinoma During Follow-Up

    Santambrogio, Roberto / Barabino, Matteo / Crespi, Michele / D’Alessandro, Valentina / Iacob, Giulio / Ferrari, Carlo / Opocher, Enrico / Danelli, Pier Giorgio / Gemma, Marco / Zappa, Marco Antonio

    SSRN Electronic Journal ; ISSN 1556-5068

    Direct Consequences or Collateral Damages?

    2020  

    Keywords covid19
    Language English
    Publisher Elsevier BV
    Publishing country us
    Document type Article ; Online
    DOI 10.2139/ssrn.3675704
    Database BASE - Bielefeld Academic Search Engine (life sciences selection)

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