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  1. Article ; Online: Behavioral Counseling Interventions to Promote a Healthy Diet and Physical Activity for Cardiovascular Disease Prevention in Adults Without Known Cardiovascular Disease Risk Factors: Updated Evidence Report and Systematic Review for the US Preventive Services Task Force.

    Patnode, Carrie D / Redmond, Nadia / Iacocca, Megan O / Henninger, Michelle

    JAMA

    2022  Volume 328, Issue 4, Page(s) 375–388

    Abstract: Importance: Unhealthful dietary patterns, low levels of physical activity, and high sedentary time increase the risk of cardiovascular disease.: Objective: To synthesize the evidence on benefits and harms of behavioral counseling interventions to ... ...

    Abstract Importance: Unhealthful dietary patterns, low levels of physical activity, and high sedentary time increase the risk of cardiovascular disease.
    Objective: To synthesize the evidence on benefits and harms of behavioral counseling interventions to promote a healthy diet and physical activity in adults without known cardiovascular disease (CVD) risk factors to inform a US Preventive Services Task Force recommendation.
    Data sources: MEDLINE, PsycINFO, and the Cochrane Central Register of Controlled Trials through February 2021, with ongoing surveillance through February 2022.
    Study selection: Randomized clinical trials (RCTs) of behavioral counseling interventions targeting improved diet, increased physical activity, or decreased sedentary time among adults without known elevated blood pressure, elevated lipid levels, or impaired fasting glucose.
    Data extraction and synthesis: Independent data abstraction and study quality rating and random effects meta-analysis.
    Main outcomes and measures: CVD events, CVD risk factors, diet and physical activity measures, and harms.
    Results: One-hundred thirteen RCTs were included (N = 129 993). Three RCTs reported CVD-related outcomes: 1 study (n = 47 179) found no significant differences between groups on any CVD outcome at up to 13.4 years of follow-up; a combined analysis of the other 2 RCTs (n = 1203) found a statistically significant association of the intervention with nonfatal CVD events (hazard ratio, 0.27 [95% CI, 0.08 to 0.88]) and fatal CVD events (hazard ratio, 0.31 [95% CI, 0.11 to 0.93]) at 4 years. Diet and physical activity behavioral counseling interventions were associated with small, statistically significant reductions in continuous measures of blood pressure (systolic mean difference, -0.8 [95% CI, -1.3 to -0.3]; 23 RCTs [n = 57 079]; diastolic mean difference, -0.4 [95% CI, -0.8 to -0.0]; 24 RCTs [n = 57 148]), low-density lipoprotein cholesterol level (mean difference, 2.2 mg/dL [95% CI, -3.8 to -0.6]; 15 RCTs [n = 6350]), adiposity-related outcomes (body mass index mean difference, -0.3 [95% CI, -0.5 to -0.1]; 27 RCTs [n = 59 239]), dietary outcomes, and physical activity at 6 months to 1.5 years of follow-up vs control conditions. There was no evidence of greater harm among intervention vs control groups.
    Conclusions and relevance: Healthy diet and physical activity behavioral counseling interventions for persons without a known risk of CVD were associated with small but statistically significant benefits across a variety of important intermediate health outcomes and small to moderate effects on dietary and physical activity behaviors. There was limited evidence regarding the long-term health outcomes or harmful effects of these interventions.
    MeSH term(s) Adult ; Advisory Committees ; Behavior Therapy ; Cardiovascular Diseases/etiology ; Cardiovascular Diseases/prevention & control ; Counseling ; Diet, Healthy ; Exercise ; Humans ; Preventive Health Services ; Randomized Controlled Trials as Topic ; Sedentary Behavior ; United States
    Language English
    Publishing date 2022-05-20
    Publishing country United States
    Document type Journal Article ; Meta-Analysis ; Systematic Review
    ZDB-ID 2958-0
    ISSN 1538-3598 ; 0254-9077 ; 0002-9955 ; 0098-7484
    ISSN (online) 1538-3598
    ISSN 0254-9077 ; 0002-9955 ; 0098-7484
    DOI 10.1001/jama.2022.7408
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  2. Article ; Online: CE: Implementing Guidelines for Treating Chronic Pain with Prescription Opioids.

    Maloy, Patricia E / Iacocca, Megan O / Morasco, Benjamin J

    The American journal of nursing

    2019  Volume 119, Issue 11, Page(s) 22–29

    Abstract: Chronic pain, stemming primarily from musculoskeletal conditions and severe headaches, is a growing problem in the United States, affecting as many as 43% of adults. Opioids are frequently prescribed to manage chronic pain despite limited data on their ... ...

    Abstract Chronic pain, stemming primarily from musculoskeletal conditions and severe headaches, is a growing problem in the United States, affecting as many as 43% of adults. Opioids are frequently prescribed to manage chronic pain despite limited data on their long-term efficacy and the potential risks of long-term use. In 2017, more than 47,000 people died as a result of an opioid overdose involving illicit opioids (such as heroin), illicitly manufactured opioids, diverted opioids, prescription opioids, or some combination thereof. Although it's been more than three years since the nationwide opioid crisis prompted the Centers for Disease Control and Prevention (CDC) to release a guideline outlining safe practices for prescribing opioids to patients with chronic pain (unrelated to active cancer or palliative and end-of-life care), opioid misuse remains a significant concern. Historically, physicians have been tasked with the primary responsibility for implementing opioid safety measures, but nurses in the primary care setting are being increasingly relied on to incorporate these measures as part of their practice. In this article, we discuss the use of five tools outlined in the CDC guideline: prescription opioid treatment agreements, urine drug screening, prescription drug monitoring program databases, calculation of morphine milligram equivalents, and naloxone kits. Primary care nurses can use these tools to promote opioid safety among patients receiving opioid therapy for chronic pain.
    MeSH term(s) Analgesics, Opioid/administration & dosage ; Analgesics, Opioid/adverse effects ; Chronic Pain/drug therapy ; Drug Overdose/prevention & control ; Guidelines as Topic ; Humans ; Prescription Drug Misuse/prevention & control ; Primary Care Nursing
    Chemical Substances Analgesics, Opioid
    Language English
    Publishing date 2019-10-23
    Publishing country United States
    Document type Journal Article ; Research Support, U.S. Gov't, Non-P.H.S.
    ZDB-ID 390780-6
    ISSN 1538-7488 ; 0002-936X
    ISSN (online) 1538-7488
    ISSN 0002-936X
    DOI 10.1097/01.NAJ.0000605344.99391.78
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  3. Article ; Online: A stress and coping perspective on health behaviors: theoretical and methodological considerations.

    Park, Crystal L / Iacocca, Megan O

    Anxiety, stress, and coping

    2014  Volume 27, Issue 2, Page(s) 123–137

    Abstract: Health behaviors such as eating and exercising have been linked to stress in many studies, and researchers suggest that these links are in large part due to the use of health behaviors to cope with stress. However, health behaviors in the context of ... ...

    Abstract Health behaviors such as eating and exercising have been linked to stress in many studies, and researchers suggest that these links are in large part due to the use of health behaviors to cope with stress. However, health behaviors in the context of coping have received relatively little research attention. In this paper, we briefly survey the literature linking stress, coping, and health behaviors, noting that very little research has explicitly examined health behaviors as coping with stress. We address critical theoretical and methodological issues that arise in applying a stress and coping perspective to health behaviors. We conclude with potential directions for interventions, including the need for conceptually solid and methodologically rigorous research and the development of new measures, and with suggestions for future research. The concepts of self-regulation and stress management and their implications in health behavior research and interventions are also discussed.
    MeSH term(s) Adaptation, Psychological/physiology ; Diet/psychology ; Exercise/psychology ; Health Behavior ; Humans ; Mental Disorders/psychology ; Stress, Psychological/psychology
    Language English
    Publishing date 2014
    Publishing country England
    Document type Journal Article ; Review
    ZDB-ID 1115932-7
    ISSN 1477-2205 ; 1061-5806
    ISSN (online) 1477-2205
    ISSN 1061-5806
    DOI 10.1080/10615806.2013.860969
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  4. Article ; Online: Screening and Interventions for Social Risk Factors: Technical Brief to Support the US Preventive Services Task Force.

    Eder, Michelle / Henninger, Michelle / Durbin, Shauna / Iacocca, Megan O / Martin, Allea / Gottlieb, Laura M / Lin, Jennifer S

    JAMA

    2021  Volume 326, Issue 14, Page(s) 1416–1428

    Abstract: Importance: Evidence-based guidance is limited on how clinicians should screen for social risk factors and which interventions related to these risk factors improve health outcomes.: Objective: To describe research on screening and interventions for ... ...

    Abstract Importance: Evidence-based guidance is limited on how clinicians should screen for social risk factors and which interventions related to these risk factors improve health outcomes.
    Objective: To describe research on screening and interventions for social risk factors to inform US Preventive Services Task Force considerations of the implications for its portfolio of recommendations.
    Data sources: Cochrane Database of Systematic Reviews, Cochrane Central Register of Controlled Trials, Ovid MEDLINE, Sociological Abstracts, and Social Services Abstracts (through 2018); Social Interventions Research and Evaluation Network evidence library (January 2019 through May 2021); surveillance through May 21, 2021; interviews with 17 key informants.
    Study selection: Individual-level and health care system-level interventions with a link to the health care system that addressed at least 1 of 7 social risk domains: housing instability, food insecurity, transportation difficulties, utility needs, interpersonal safety, education, and financial strain.
    Data extraction and synthesis: One investigator abstracted data from studies and a second investigator evaluated data abstractions for completeness and accuracy; key informant interviews were recorded, transcribed, summarized, and integrated with evidence from the literature; narrative synthesis with supporting tables and figures.
    Main outcomes and measures: Validity of multidomain social risk screening tools; all outcomes reported for social risk-related interventions; challenges or unintended consequences of screening and interventions.
    Results: Many multidomain social risk screening tools have been developed, but they vary widely in their assessment of social risk and few have been validated. This technical brief identified 106 social risk intervention studies (N = 5 978 596). Of the interventions studied, 73 (69%; n = 127 598) addressed multiple social risk domains. The most frequently addressed domains were food insecurity (67/106 studies [63%], n = 141 797), financial strain (52/106 studies [49%], n = 111 962), and housing instability (63/106 studies [59%], n = 5 881 222). Food insecurity, housing instability, and transportation difficulties were identified by key informants as the most important social risk factors to identify in health care. Thirty-eight studies (36%, n = 5 850 669) used an observational design with no comparator, and 19 studies (18%, n = 15 205) were randomized clinical trials. Health care utilization measures were the most commonly reported outcomes in the 68 studies with a comparator (38 studies [56%], n = 111 102). The literature and key informants described many perceived or potential challenges to implementation of social risk screening and interventions in health care.
    Conclusions and relevance: Many interventions to address food insecurity, financial strain, and housing instability have been studied, but more randomized clinical trials that report health outcomes from social risk screening and intervention are needed to guide widespread implementation in health care.
    MeSH term(s) Advisory Committees ; Food Insecurity ; Guidelines as Topic ; Housing ; Humans ; Mass Screening ; Outcome Assessment, Health Care ; Preventive Health Services ; Primary Health Care ; Risk Factors ; Social Determinants of Health ; Socioeconomic Factors ; United States
    Language English
    Publishing date 2021-09-23
    Publishing country United States
    Document type Journal Article ; Research Support, U.S. Gov't, P.H.S. ; Review
    ZDB-ID 2958-0
    ISSN 1538-3598 ; 0254-9077 ; 0002-9955 ; 0098-7484
    ISSN (online) 1538-3598
    ISSN 0254-9077 ; 0002-9955 ; 0098-7484
    DOI 10.1001/jama.2021.12825
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  5. Article ; Online: Utility of the Pain Medication Questionnaire to predict aberrant urine drug tests: Results from a longitudinal cohort study.

    Morasco, Benjamin J / Iacocca, Megan O / Lovejoy, Travis I / Dobscha, Steven K / Deyo, Richard A / Cavese, Julie A / Hyde, Stephanie / Yarborough, Bobbi Jo H

    Psychological services

    2020  Volume 18, Issue 3, Page(s) 319–327

    Abstract: Identifying patients at risk of misusing prescription opioids is a priority. Standardized risk measures exist, but prior research has been limited in an assessment of their utility by a reliance on cross-sectional or retrospective analyses. In this study, ...

    Abstract Identifying patients at risk of misusing prescription opioids is a priority. Standardized risk measures exist, but prior research has been limited in an assessment of their utility by a reliance on cross-sectional or retrospective analyses. In this study, the Pain Medication Questionnaire (PMQ), a standardized self-report measure of risk for prescription opioid misuse, was used to predict aberrant urine drug test (UDT) results over the subsequent 24 months. At baseline, participants who were prescribed long-term opioid therapy completed self-report measures assessing pain, function, and quality of life; this also included the PMQ. Medical record data were abstracted for 24 months postbaseline to collect results of UDTs administered during clinical care. Among participants, 12.9% had a UDT result that was positive for a nonprescribed or illicit substance, 18.9% had an aberrant negative UDT result, 3.6% had aberrant positive and negative UDT results, and the remaining 64.6% had expected UDT results. Average PMQ score at baseline did not significantly differ based on participants' type of UDT result over 24 months of follow-up. Participant variables that were significantly associated with a subsequent aberrant positive UDT were higher prescription opioid dose and hazardous alcohol use; those associated with an aberrant negative UDT were lower prescription opioid dose and hazardous alcohol use; no variable was associated with combined positive and negative UDT results. In conclusion, total PMQ score was not predictive of aberrant positive or negative UDT results. More work is needed to identify optimal strategies of screening for risk of aberrant UDT results. (PsycInfo Database Record (c) 2021 APA, all rights reserved).
    MeSH term(s) Analgesics, Opioid/therapeutic use ; Chronic Pain ; Cohort Studies ; Cross-Sectional Studies ; Humans ; Longitudinal Studies ; Opioid-Related Disorders/diagnosis ; Pharmaceutical Preparations ; Quality of Life ; Retrospective Studies ; Substance Abuse Detection ; Surveys and Questionnaires
    Chemical Substances Analgesics, Opioid ; Pharmaceutical Preparations
    Language English
    Publishing date 2020-07-16
    Publishing country United States
    Document type Journal Article
    ZDB-ID 2156662-8
    ISSN 1939-148X ; 1541-1559
    ISSN (online) 1939-148X
    ISSN 1541-1559
    DOI 10.1037/ser0000471
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  6. Article ; Online: Clinician Knowledge, Attitudes, and Practice Regarding Cannabis: Results from a National Veterans Health Administration Survey.

    Kansagara, Devan / Morasco, Benjamin J / Iacocca, Megan O / Bair, Matthew J / Hooker, Elizabeth R / Becker, William C

    Pain medicine (Malden, Mass.)

    2020  Volume 21, Issue 11, Page(s) 3180–3186

    Abstract: Background: Cannabis is increasingly available and used for medical and recreational purposes, but few studies have assessed provider knowledge, attitudes, and practice regarding cannabis.: Methods: We administered a 47-item electronic survey to ... ...

    Abstract Background: Cannabis is increasingly available and used for medical and recreational purposes, but few studies have assessed provider knowledge, attitudes, and practice regarding cannabis.
    Methods: We administered a 47-item electronic survey to assess nationwide Veterans Health Administration (VHA) clinician knowledge, beliefs, attitudes, and practice regarding patients' use of cannabis.
    Results: We received 249 completed surveys from 39 states and the District of Columbia. Fifty-five percent of respondents were female, 74% were white, and the mean age was 50 years. There were knowledge gaps among a substantial minority of respondents in specific areas: terminology, psychoactive effects of cannabis components, VHA policy, and evidence regarding benefits and harms of cannabis. Most respondents were likely or very likely to plan to taper opioids if urine drug testing was positive for tetra-hydro cannabinol (THC; 73%). A significantly greater proportion of respondents from states in which cannabis is illegal for any purpose (odds ratio [OR] = 4.9, 95% confidence interval [CI] = 2.0-10.8) or is recreationally illegal (OR = 5.0, 95% CI = 2.4-10.8) reported being likely or very likely to taper opioids as compared with respondents from states in which cannabis is legal for medical and recreational purposes.
    Conclusions: Among the sample, we found knowledge gaps, areas of discomfort discussing key aspects of cannabis use with their patients, and variation in practice regarding opioids in patients also using THC. These results suggest a need for more widespread clinician education about cannabis, as well as an opportunity to develop more robust guidance and evidence regarding management of patients using prescription opioids and cannabis concomitantly.
    MeSH term(s) Cannabis ; Female ; Health Knowledge, Attitudes, Practice ; Humans ; Male ; Medical Marijuana/therapeutic use ; Middle Aged ; Surveys and Questionnaires ; Veterans Health
    Chemical Substances Medical Marijuana
    Language English
    Publishing date 2020-01-07
    Publishing country England
    Document type Journal Article ; Research Support, U.S. Gov't, Non-P.H.S.
    ZDB-ID 2015903-1
    ISSN 1526-4637 ; 1526-2375
    ISSN (online) 1526-4637
    ISSN 1526-2375
    DOI 10.1093/pm/pnz322
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    Zs.A 6119: Show issues Location:
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  7. Article ; Online: Addressing Racism in Preventive Services: Methods Report to Support the US Preventive Services Task Force.

    Lin, Jennifer S / Hoffman, Lynn / Bean, Sarah I / O'Connor, Elizabeth A / Martin, Allea M / Iacocca, Megan O / Bacon, Olivia P / Davies, Melinda C

    JAMA

    2021  Volume 326, Issue 23, Page(s) 2412–2420

    Abstract: Importance: In January 2021, the US Preventive Services Task Force (USPSTF) issued a values statement that acknowledged systemic racism and included a commitment to address racism and health equity in recommendations for clinical preventive services.: ...

    Abstract Importance: In January 2021, the US Preventive Services Task Force (USPSTF) issued a values statement that acknowledged systemic racism and included a commitment to address racism and health equity in recommendations for clinical preventive services.
    Objectives: To articulate the definitional and conceptual issues around racism and health inequity and to describe how racism and health inequities are currently addressed in preventive health.
    Methods: An audit was conducted assessing (1) published literature on frameworks or policy and position statements addressing racism, (2) a subset of cancer and cardiovascular topics in USPSTF reports, (3) recent systematic reviews on interventions to reduce health inequities in preventive health or to prevent racism in health care, and (4) health care-relevant professional societies, guideline-making organizations, agencies, and funding bodies to gather information about how they are addressing racism and health equity.
    Findings: Race as a social category does not have biological underpinnings but has biological consequences through racism. Racism is complex and pervasive, operates at multiple interrelated levels, and exerts negative effects on other social determinants and health and well-being through multiple pathways. In its reports, the USPSTF has addressed racial and ethnic disparities, but not racism explicitly. The systematic reviews to support the USPSTF include interventions that may mitigate health disparities through cultural tailoring of behavioral interventions, but reviews have not explicitly addressed other commonly studied interventions to increase the uptake of preventive services or foster the implementation of preventive services. Many organizations have issued recent statements and commitments around racism in health care, but few have provided substantive guidance on operational steps to address the effects of racism. Where guidance is unavailable regarding the proposed actions, it is principally because work to achieve them is in very early stages. The most directly relevant and immediately useful guidance identified is that from the GRADE working group.
    Conclusions and relevance: This methods report provides a summary of issues around racism and health inequity, including the status of how these are being addressed in preventive health.
    MeSH term(s) Advisory Committees ; Health Equity ; Health Status Disparities ; Healthcare Disparities ; Humans ; Preventive Health Services/methods ; Racial Groups ; Racism ; Social Determinants of Health ; United States
    Language English
    Publishing date 2021-11-08
    Publishing country United States
    Document type Journal Article ; Research Support, U.S. Gov't, P.H.S.
    ZDB-ID 2958-0
    ISSN 1538-3598 ; 0254-9077 ; 0002-9955 ; 0098-7484
    ISSN (online) 1538-3598
    ISSN 0254-9077 ; 0002-9955 ; 0098-7484
    DOI 10.1001/jama.2021.17579
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  8. Article ; Online: Research methods and baseline findings of the improving the safety of opioid therapy (ISOT) cluster-randomized trial.

    Morasco, Benjamin J / Adams, Melissa H / Maloy, Patricia E / Hooker, Elizabeth R / Iacocca, Megan O / Krebs, Erin E / Carr, Thomas P / Lovejoy, Travis I / Saha, Somnath / Dobscha, Steven K

    Contemporary clinical trials

    2020  Volume 90, Page(s) 105957

    Abstract: There are adverse effects associated with long-term opioid therapy (LTOT) for chronic pain and clinicians infrequently adhere to opioid treatment guideline recommendations for reducing risk and mitigating opioid-related harms. The primary goal of the ... ...

    Abstract There are adverse effects associated with long-term opioid therapy (LTOT) for chronic pain and clinicians infrequently adhere to opioid treatment guideline recommendations for reducing risk and mitigating opioid-related harms. The primary goal of the Improving the Safety of Opioid Therapy (ISOT) intervention is to reduce harms related to prescription opioids. Secondary aims focus on enhancing the clinician-patient relationship and not having a negative impact on pain-related outcomes (to be examined through a non-inferiority analysis). The study is a cluster-randomized trial and the 44 primary care providers (PCPs) who enrolled were randomized to receive either (1) a two-hour educational workshop about a patient-centered approach to opioid therapy or (2) the educational workshop plus a collaborative care intervention delivered by a nurse care manager (NCM). Patients were assigned to the same condition as their treating PCP. ISOT was based on the chronic care model and includes patient and provider activation, outcomes monitoring, and feedback to the PCP over 12 months. The NCM conducted a baseline assessment with intervention patients, tracked opioid-related behaviors and outcomes, and provided decision support to the opioid-prescribing clinician about opioid safety. Between June 2016 and October 2018, 293 veterans who were prescribed LTOT for chronic pain were enrolled, completed a baseline assessment, and assigned to a treatment condition. Participants were enrolled for 12 months. Masked assessments were conducted with participants at baseline, 6-months, and 12-months. This manuscript describes study rationale, research methods, and baseline findings.
    MeSH term(s) Aged ; Female ; Humans ; Male ; Middle Aged ; Analgesics, Opioid/administration & dosage ; Analgesics, Opioid/adverse effects ; Analgesics, Opioid/therapeutic use ; Chronic Pain/drug therapy ; Health Personnel/education ; Opioid-Related Disorders/prevention & control ; Patient-Centered Care ; Primary Health Care/organization & administration ; Professional-Patient Relations ; Quality of Life ; Research Design ; Risk Management/organization & administration ; Socioeconomic Factors ; Randomized Controlled Trials as Topic
    Chemical Substances Analgesics, Opioid
    Language English
    Publishing date 2020-02-13
    Publishing country United States
    Document type Clinical Trial Protocol ; Journal Article ; Research Support, U.S. Gov't, Non-P.H.S.
    ZDB-ID 2182176-8
    ISSN 1559-2030 ; 1551-7144
    ISSN (online) 1559-2030
    ISSN 1551-7144
    DOI 10.1016/j.cct.2020.105957
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