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  1. Article ; Online: Acrodermatitis continua of Hallopeau in an elderly patient successfully and rapidly treated with risankizumab: a case report.

    Orsini, Diego / Iacovelli, Paolo / Frascione, Pasquale / Pacifico, Alessia

    The Journal of dermatological treatment

    2023  Volume 34, Issue 1, Page(s) 2229468

    MeSH term(s) Aged ; Humans ; Acrodermatitis/drug therapy ; Antibodies, Monoclonal/therapeutic use ; Exanthema ; Psoriasis/drug therapy ; Skin Diseases, Vesiculobullous
    Chemical Substances risankizumab (90ZX3Q3FR7) ; Antibodies, Monoclonal
    Language English
    Publishing date 2023-06-28
    Publishing country England
    Document type Case Reports ; Letter
    ZDB-ID 1036299-x
    ISSN 1471-1753 ; 0954-6634
    ISSN (online) 1471-1753
    ISSN 0954-6634
    DOI 10.1080/09546634.2023.2229468
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    Zs.A 2627: Show issues Location:
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    Jg. 1995 - 2021: Lesesall (2.OG)
    ab Jg. 2022: Lesesaal (EG)

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  2. Article: Rapidly and successful improvement of nail psoriasis with risankizumab.

    Orsini, Diego / Pacifico, Alessia / Iacovelli, Paolo / Frascione, Pasquale / De Simone, Paola / Assorgi, Chiara / Pigliacelli, Flavia

    Clinical case reports

    2023  Volume 11, Issue 10, Page(s) e8035

    Abstract: This clinical case demonstrates quick resolution of nail psoriasis in a patient treated with risankizumab, highlighting the role of IL-23 in the pathogenesis of nail psoriasis. ...

    Abstract This clinical case demonstrates quick resolution of nail psoriasis in a patient treated with risankizumab, highlighting the role of IL-23 in the pathogenesis of nail psoriasis.
    Language English
    Publishing date 2023-10-09
    Publishing country England
    Document type Case Reports
    ZDB-ID 2740234-4
    ISSN 2050-0904
    ISSN 2050-0904
    DOI 10.1002/ccr3.8035
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  3. Article ; Online: SARS-CoV-2: an environmental trigger of Darier's disease?

    Orsini, Diego / D'Arino, Andrea / Pigliacelli, Flavia / Iacovelli, Paolo / Pacifico, Alessia / Cota, Carlo / Di Prete, Monia / Maramao, Fabio Stefano

    The Journal of dermatological treatment

    2023  Volume 34, Issue 1, Page(s) 2242541

    MeSH term(s) Humans ; Darier Disease/etiology ; SARS-CoV-2 ; COVID-19
    Language English
    Publishing date 2023-08-02
    Publishing country England
    Document type Journal Article
    ZDB-ID 1036299-x
    ISSN 1471-1753 ; 0954-6634
    ISSN (online) 1471-1753
    ISSN 0954-6634
    DOI 10.1080/09546634.2023.2242541
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    Zs.A 2627: Show issues Location:
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  4. Article ; Online: Increasing trend in confirmed scabies cases in the only public dermatological institute of scientific research and care in Italy.

    Donà, Maria Gabriella / Giuliani, Eugenia / Giglio, Amalia / Pimpinelli, Fulvia / Stingone, Christof / Giuliani, Massimo / Alei, Lavinia / Cota, Carlo / Iacovelli, Paolo / Frascione, Pasquale / Latini, Alessandra

    European journal of dermatology : EJD

    2024  Volume 33, Issue 6, Page(s) 709–710

    MeSH term(s) Humans ; Scabies/epidemiology ; Italy/epidemiology
    Language English
    Publishing date 2024-03-11
    Publishing country France
    Document type Journal Article
    ZDB-ID 1128666-0
    ISSN 1952-4013 ; 1167-1122
    ISSN (online) 1952-4013
    ISSN 1167-1122
    DOI 10.1684/ejd.2023.4622
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    Zs.A 3484: Show issues Location:
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  5. Article ; Online: Metabolic Comorbidities in Vitiligo: A Brief Review and Report of New Data from a Single-Center Experience.

    D'Arino, Andrea / Picardo, Mauro / Truglio, Mauro / Pacifico, Alessia / Iacovelli, Paolo

    International journal of molecular sciences

    2021  Volume 22, Issue 16

    Abstract: Among disorders of pigmentation, vitiligo is the most common, with an estimated prevalence between 0.5% and 1%. The disease has gathered increased attention in the most recent years, leading to a better understanding of the disease's pathophysiology and ... ...

    Abstract Among disorders of pigmentation, vitiligo is the most common, with an estimated prevalence between 0.5% and 1%. The disease has gathered increased attention in the most recent years, leading to a better understanding of the disease's pathophysiology and its implications and to the development of newer therapeutic strategies. A better, more integrated approach is already in use for other chronic inflammatory dermatological diseases such as psoriasis, for which metabolic comorbidities are well-established and part of the routine clinical evaluation. The pathogenesis of these might be linked to cytokines which also play a role in vitiligo pathogenesis, such as IL-1, IL-6, TNF-α, and possibly IL-17. Following the reports of intrinsic metabolic alterations reported by our group, in this brief review, we analyze the available data on metabolic comorbidities in vitiligo, accompanied by our single-center experience. Increased awareness of the metabolic aspects of vitiligo is crucial to improving patient care.
    MeSH term(s) Clinical Trials as Topic ; Comorbidity ; Humans ; Metabolic Diseases/epidemiology ; Metabolic Diseases/pathology ; Vitiligo/epidemiology ; Vitiligo/pathology
    Language English
    Publishing date 2021-08-17
    Publishing country Switzerland
    Document type Journal Article ; Review
    ZDB-ID 2019364-6
    ISSN 1422-0067 ; 1422-0067 ; 1661-6596
    ISSN (online) 1422-0067
    ISSN 1422-0067 ; 1661-6596
    DOI 10.3390/ijms22168820
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  6. Article ; Online: Morphea induced by SARS-CoV-2 infection: A case report.

    Pigliacelli, Flavia / Pacifico, Alessia / Mariano, Maria / D'Arino, Andrea / Cristaudo, Antonio / Iacovelli, Paolo

    International journal of dermatology

    2021  Volume 61, Issue 3, Page(s) 377–378

    MeSH term(s) COVID-19 ; Humans ; SARS-CoV-2 ; Scleroderma, Localized
    Language English
    Publishing date 2021-11-15
    Publishing country England
    Document type Case Reports ; Letter
    ZDB-ID 412254-9
    ISSN 1365-4632 ; 0011-9059 ; 1461-1244
    ISSN (online) 1365-4632
    ISSN 0011-9059 ; 1461-1244
    DOI 10.1111/ijd.15983
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  7. Article ; Online: NB-UVB plus oral Polypodium leucotomos extract display higher efficacy than NB-UVB alone in patients with vitiligo.

    Pacifico, Alessia / Damiani, Giovanni / Iacovelli, Paolo / Conic, Rosalynn R Z / Gonzalez, Salvador / Morrone, Aldo

    Dermatologic therapy

    2021  Volume 34, Issue 2, Page(s) e14776

    Abstract: Polypodium leucotomos displayed a synergic effect with NB-UVB in psoriasis, but its application on vitiligo remains understudied. The aim of this study was to investigate whether oral supplementation with leaves extract of Polypodium leucotomos (PL) ... ...

    Abstract Polypodium leucotomos displayed a synergic effect with NB-UVB in psoriasis, but its application on vitiligo remains understudied. The aim of this study was to investigate whether oral supplementation with leaves extract of Polypodium leucotomos (PL) improves narrow band (NB) UVB phototherapy-induced repigmentation. Forty-four patients with generalized vitiligo were enrolled in this randomized, prospective, placebo controlled study. Twenty-three patients were randomly selected to receive combined treatment with NB-UVB phototherapy and 480 mg oral PL twice daily while 21 patients received NB-UVB phototherapy combined with placebo. All subjects were treated with NB-UVB twice weekly for 6 months. Our results demonstrated that oral PL combined with NB-UVB improved repigmentation as well as increased the response rate compared with patients treated with NB-UVB alone (47.8% vs 22%). Our study suggests that oral supplementation of PL and NB-UVB phototherapy enhance the extent of repigmentation.
    MeSH term(s) Combined Modality Therapy ; Humans ; Plant Extracts ; Polypodium ; Prospective Studies ; Skin Pigmentation ; Treatment Outcome ; Ultraviolet Therapy/adverse effects ; Vitiligo/diagnosis ; Vitiligo/therapy
    Chemical Substances Plant Extracts
    Language English
    Publishing date 2021-02-05
    Publishing country United States
    Document type Journal Article ; Randomized Controlled Trial ; Research Support, Non-U.S. Gov't
    ZDB-ID 1354801-3
    ISSN 1529-8019 ; 1396-0296
    ISSN (online) 1529-8019
    ISSN 1396-0296
    DOI 10.1111/dth.14776
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    Zs.A 5181: Show issues Location:
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  8. Article ; Online: Teledermatology and hygiene practices during the COVID-19 pandemic.

    Cristaudo, Antonio / Pigliacelli, Flavia / Pacifico, Alessia / Damiani, Giovanni / Iacovelli, Paolo / Morrone, Aldo

    Contact dermatitis

    2020  Volume 83, Issue 6, Page(s) 536

    MeSH term(s) COVID-19/epidemiology ; Dermatitis, Irritant/diagnosis ; Dermatitis, Irritant/etiology ; Hand Disinfection ; Hospitals, Special/organization & administration ; Humans ; Italy ; Pandemics ; Remote Consultation
    Keywords covid19
    Language English
    Publishing date 2020-09-01
    Publishing country England
    Document type Letter
    ZDB-ID 193121-0
    ISSN 1600-0536 ; 0105-1873
    ISSN (online) 1600-0536
    ISSN 0105-1873
    DOI 10.1111/cod.13683
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    Zs.A 1116: Show issues Location:
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  9. Article ; Online: A protective role for autophagy in vitiligo.

    Bastonini, Emanuela / Kovacs, Daniela / Raffa, Salvatore / Delle Macchie, Marina / Pacifico, Alessia / Iacovelli, Paolo / Torrisi, Maria Rosaria / Picardo, Mauro

    Cell death & disease

    2021  Volume 12, Issue 4, Page(s) 318

    Abstract: A growing number of studies supports the existence of a dynamic interplay between energetic metabolism and autophagy, whose induction represents an adaptive response against several stress conditions. Autophagy is an evolutionarily conserved and a highly ...

    Abstract A growing number of studies supports the existence of a dynamic interplay between energetic metabolism and autophagy, whose induction represents an adaptive response against several stress conditions. Autophagy is an evolutionarily conserved and a highly orchestrated catabolic recycling process that guarantees cellular homeostasis. To date, the exact role of autophagy in vitiligo pathogenesis is still not clear. Here, we provide the first evidence that autophagy occurs in melanocytes and fibroblasts from non-lesional skin of vitiligo patients, as a result of metabolic surveillance response. More precisely, this study is the first to reveal that induction of autophagy exerts a protective role against the intrinsic metabolic stress and attempts to antagonize degenerative processes in normal appearing vitiligo skin, where melanocytes and fibroblasts are already prone to premature senescence.
    MeSH term(s) Autophagy/genetics ; Fibroblasts/metabolism ; Humans ; Melanocytes/metabolism ; Vitiligo/therapy
    Language English
    Publishing date 2021-03-25
    Publishing country England
    Document type Journal Article ; Research Support, Non-U.S. Gov't
    ZDB-ID 2541626-1
    ISSN 2041-4889 ; 2041-4889
    ISSN (online) 2041-4889
    ISSN 2041-4889
    DOI 10.1038/s41419-021-03592-0
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  10. Article ; Online: Involvement of non-melanocytic skin cells in vitiligo.

    Bastonini, Emanuela / Bellei, Barbara / Filoni, Angela / Kovacs, Daniela / Iacovelli, Paolo / Picardo, Mauro

    Experimental dermatology

    2019  Volume 28, Issue 6, Page(s) 667–673

    Abstract: Despite melanocytes are the key players in vitiligo, a continuous cross-talk between epidermal and dermal cells may strictly affect their functionality, in both lesional skin and non-lesional skin. Focusing on this interplay, we have reviewed existing ... ...

    Abstract Despite melanocytes are the key players in vitiligo, a continuous cross-talk between epidermal and dermal cells may strictly affect their functionality, in both lesional skin and non-lesional skin. Focusing on this interplay, we have reviewed existing literature supporting evidence on cellular and functional alterations of surrounding epidermal keratinocytes, extracellular matrix (ECM) proteins and fibroblasts in the underlying dermal compartment that may contribute to melanocyte disappearance in vitiligo. We have also examined some clinical and therapeutic aspects of the disease to sustain the non-exclusive involvement of melanocytes within vitiligo. As a result, a different and more complex scenario has appeared that may enable to provide better understanding about origins and progress of vitiligo and that should be considered in the evaluation of new treatment approaches.
    MeSH term(s) Animals ; Dermis/cytology ; Epidermis/metabolism ; Extracellular Matrix/metabolism ; Fibroblasts/cytology ; Humans ; Hypopigmentation/metabolism ; Keratinocytes/cytology ; Melanocytes/cytology ; Pigmentation ; Skin/cytology ; Vitiligo/pathology ; Vitiligo/therapy ; Wound Healing
    Language English
    Publishing date 2019-02-11
    Publishing country Denmark
    Document type Journal Article ; Research Support, Non-U.S. Gov't ; Review
    ZDB-ID 1130936-2
    ISSN 1600-0625 ; 0906-6705
    ISSN (online) 1600-0625
    ISSN 0906-6705
    DOI 10.1111/exd.13868
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    Zs.A 3508: Show issues Location:
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