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  1. Article ; Online: Repeated Administration of the Cannabinoid WIN Alters the Isoflurane-Sparing Effect of Morphine and Dexmedetomidine.

    Ibancovichi, José Antonio / Chávez-Monteagudo, Julio Raúl / Sánchez-Aparicio, Pedro / De Paz-Campos, Marco Antonio

    Veterinary sciences

    2023  Volume 10, Issue 5

    Abstract: The impacts of morphine and dexmedetomidine on the MAC of isoflurane were studied in rats constantly medicated with the cannabinoid WIN 55,212-2.: Methods: Prior to the administration of morphine, the MAC was measured in both untreated rats (MAC : ... ...

    Abstract The impacts of morphine and dexmedetomidine on the MAC of isoflurane were studied in rats constantly medicated with the cannabinoid WIN 55,212-2.
    Methods: Prior to the administration of morphine, the MAC was measured in both untreated rats (MAC
    Results: MAC
    Conclusions: Medication with a cannabinoid for 21 days augmented the MAC of isoflurane. The sparing effect of morphine on isoflurane is lower in rats constantly medicated with a cannabinoid. The sparing effect of dexmedetomidine on the minimum alveolar concentration of isoflurane is greater in rats repeatedly medicated with a cannabinoid.
    Language English
    Publishing date 2023-04-24
    Publishing country Switzerland
    Document type Journal Article
    ZDB-ID 2768971-2
    ISSN 2306-7381 ; 2306-7381
    ISSN (online) 2306-7381
    ISSN 2306-7381
    DOI 10.3390/vetsci10050310
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  2. Article: Minimum Alveolar Concentration of Isoflurane in Rats Chronically Treated with the Synthetic Cannabinoid WIN 55,212-2.

    Chavez-Monteagudo, Julio Raul / Ibancovichi, José Antonio / Sanchez-Aparicio, Pedro / Recillas-Morales, Sergio / Osorio-Avalos, Jorge / De Paz-Campos, Marco Antonio

    Animals : an open access journal from MDPI

    2022  Volume 12, Issue 7

    Abstract: The minimum alveolar concentration MAC of isoflurane was measured in rats chronically treated with WIN 55,212-2.: Methods: The MAC of isoflurane was determined in 24 male rats from expiratory samples at time of tail clamping under the following ... ...

    Abstract The minimum alveolar concentration MAC of isoflurane was measured in rats chronically treated with WIN 55,212-2.
    Methods: The MAC of isoflurane was determined in 24 male rats from expiratory samples at time of tail clamping under the following conditions: without treatment MAC(
    Results: The MAC(
    Conclusions: The administration of WIN 55,212-2 for 21 days increases the MAC of isoflurane in rats. This effect does not disappear 8 days after discontinuation of treatment with the synthetic cannabinoid.
    Language English
    Publishing date 2022-03-29
    Publishing country Switzerland
    Document type Journal Article
    ZDB-ID 2606558-7
    ISSN 2076-2615
    ISSN 2076-2615
    DOI 10.3390/ani12070853
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  3. Article: Cannabinoids CB2 Receptors, One New Promising Drug Target for Chronic and Degenerative Pain Conditions in Equine Veterinary Patients

    Sánchez-Aparicio, Pedro / Florán, Benjamín / Rodríguez Velázquez, Desiderio / Ibancovichi, José Antonio / Varela Guerrero, Jorge Antonio / Recillas, Sergio

    Journal of equine veterinary science. 2020 Feb., v. 85

    2020  

    Abstract: Osteoarticular equine disease is a common cause of malady; in general, its therapy is supported on steroids and nonsteroidal anti-inflammatories. Nevertheless, many side effects may develop when these drugs are administered. Nowadays, the use of new ... ...

    Abstract Osteoarticular equine disease is a common cause of malady; in general, its therapy is supported on steroids and nonsteroidal anti-inflammatories. Nevertheless, many side effects may develop when these drugs are administered. Nowadays, the use of new alternatives for this pathology attention is demanded; in that sense, cannabinoid CB2 agonists may represent a novel alternative. Cannabinoid belongs to a group of molecules known by their psychoactive properties; they are synthetized by the Cannabis sativa plant, better known as marijuana. The aim of this study was to contribute to understand the pharmacology of cannabinoid CB2 receptors and its potential utilization on equine veterinary patients with a chronic degenerative painful condition. In animals, two main receptors for cannabinoids are recognized, the cannabinoid receptor type 1 and the cannabinoid receptor type 2. Once they are activated, both receptors exert a wide range of physiological responses, as nociception modulation. Recently, it has been proposed the use of synthetic cannabinoid type 2 receptor agonists; those receptors looks to confer antinociceptive properties but without the undesired psychoactive side effects; for that reason, veterinary patients, whit chronical degenerative diseases as osteoarthritis may alleviate one of the most common symptom, the pain, which in some cases for several reasons, as patient individualities, or side effects produced for more conventional treatments cannot be attended in the best way.
    Keywords Cannabis sativa ; adverse effects ; agonists ; cannabinoid receptors ; cannabinoids ; drugs ; horse diseases ; horses ; nociception ; osteoarthritis ; pain ; patients ; pharmacology ; physiological response ; steroids ; therapeutics
    Language English
    Dates of publication 2020-02
    Publishing place Elsevier Inc.
    Document type Article
    ZDB-ID 2102631-2
    ISSN 1542-7412 ; 0737-0806
    ISSN (online) 1542-7412
    ISSN 0737-0806
    DOI 10.1016/j.jevs.2019.102880
    Database NAL-Catalogue (AGRICOLA)

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  4. Article: Cannabinoids CB2 Receptors, One New Promising Drug Target for Chronic and Degenerative Pain Conditions in Equine Veterinary Patients.

    Sánchez-Aparicio, Pedro / Florán, Benjamín / Rodríguez Velázquez, Desiderio / Ibancovichi, José Antonio / Varela Guerrero, Jorge Antonio / Recillas, Sergio

    Journal of equine veterinary science

    2019  Volume 85, Page(s) 102880

    Abstract: Osteoarticular equine disease is a common cause of malady; in general, its therapy is supported on steroids and nonsteroidal anti-inflammatories. Nevertheless, many side effects may develop when these drugs are administered. Nowadays, the use of new ... ...

    Abstract Osteoarticular equine disease is a common cause of malady; in general, its therapy is supported on steroids and nonsteroidal anti-inflammatories. Nevertheless, many side effects may develop when these drugs are administered. Nowadays, the use of new alternatives for this pathology attention is demanded; in that sense, cannabinoid CB2 agonists may represent a novel alternative. Cannabinoid belongs to a group of molecules known by their psychoactive properties; they are synthetized by the Cannabis sativa plant, better known as marijuana. The aim of this study was to contribute to understand the pharmacology of cannabinoid CB2 receptors and its potential utilization on equine veterinary patients with a chronic degenerative painful condition. In animals, two main receptors for cannabinoids are recognized, the cannabinoid receptor type 1 and the cannabinoid receptor type 2. Once they are activated, both receptors exert a wide range of physiological responses, as nociception modulation. Recently, it has been proposed the use of synthetic cannabinoid type 2 receptor agonists; those receptors looks to confer antinociceptive properties but without the undesired psychoactive side effects; for that reason, veterinary patients, whit chronical degenerative diseases as osteoarthritis may alleviate one of the most common symptom, the pain, which in some cases for several reasons, as patient individualities, or side effects produced for more conventional treatments cannot be attended in the best way.
    MeSH term(s) Analgesics/therapeutic use ; Animals ; Cannabinoids/therapeutic use ; Cannabis ; Horse Diseases/drug therapy ; Horses ; Pain/drug therapy ; Pain/veterinary ; Receptors, Cannabinoid
    Chemical Substances Analgesics ; Cannabinoids ; Receptors, Cannabinoid
    Language English
    Publishing date 2019-12-09
    Publishing country United States
    Document type Journal Article ; Review
    ZDB-ID 2102631-2
    ISSN 1542-7412 ; 0737-0806
    ISSN (online) 1542-7412
    ISSN 0737-0806
    DOI 10.1016/j.jevs.2019.102880
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    Kategorien

    Order via subito

    This service is chargeable due to the Delivery terms set by subito. Orders including an article and supplementary material will be classified as separate orders. In these cases, fees will be demanded for each order.

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