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  1. Article ; Online: Bariatric Surgery and Solid-Organ Transplantation.

    García Ruiz de Gordejuela, Amador / Ibarzabal, Ainitze / Osorio, Javier

    Transplantation proceedings

    2021  Volume 54, Issue 1, Page(s) 87–90

    Abstract: Morbid obesity and being overweight are a growing problem worldwide. They also affect patients with end-stage solid-organ disease and patients after transplant. Bariatric surgery is the most effective available weight loss procedure. Bariatric surgery ... ...

    Abstract Morbid obesity and being overweight are a growing problem worldwide. They also affect patients with end-stage solid-organ disease and patients after transplant. Bariatric surgery is the most effective available weight loss procedure. Bariatric surgery can be helpful for the treatment of some conditions, such as nonalcoholic fatty liver disease or nonalcoholic steatohepatitis, which may lead to transplant, and weight loss can improve or even reverse them. In other cases, morbid obesity is a limitation to accessing a transplant program, so bariatric surgery can serve as a conduit to transplant. After transplant, obesity and obesity-related comorbidities can be a significant health problem that may be treated, as in patients without a transplant, with bariatric surgery. There are some specific conditions and issues to be considered in patients with end-stage solid-organ disease who are candidates for bariatric surgery, such as increased morbidity and mortality. After transplant, immunosuppressant regimens and technical limitations may be also significant.
    MeSH term(s) Bariatric Surgery ; Gastrectomy ; Humans ; Non-alcoholic Fatty Liver Disease ; Obesity, Morbid/complications ; Obesity, Morbid/surgery ; Organ Transplantation/adverse effects ; Treatment Outcome ; Weight Loss
    Language English
    Publishing date 2021-12-29
    Publishing country United States
    Document type Journal Article
    ZDB-ID 82046-5
    ISSN 1873-2623 ; 0041-1345
    ISSN (online) 1873-2623
    ISSN 0041-1345
    DOI 10.1016/j.transproceed.2021.11.008
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    In stock of ZB MED Cologne/Königswinter

    Zs.A 835: Show issues Location:
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    Jg. 1995 - 2021: Lesesall (1.OG)
    ab Jg. 2022: Lesesaal (EG)

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  2. Article ; Online: Wilkie's syndrome as a rare upper intestinal obstruction cause.

    Besa, Anaïs / Domínguez-Garijo, Paula / Curell, Anna / Farguell, Jordi / Ibarzábal, Ainitze / Morales, Xavier / Momblan, Dulce / Turrado, Victor

    Surgery open science

    2023  Volume 16, Page(s) 155–156

    Language English
    Publishing date 2023-11-03
    Publishing country United States
    Document type Journal Article
    ISSN 2589-8450
    ISSN (online) 2589-8450
    DOI 10.1016/j.sopen.2023.10.010
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  3. Article: FABP4 Expression in Subcutaneous Adipose Tissue Is Independently Associated with Circulating Triglycerides in Obesity.

    Osorio-Conles, Óscar / Ibarzabal, Ainitze / Balibrea, José María / Vidal, Josep / Ortega, Emilio / de Hollanda, Ana

    Journal of clinical medicine

    2023  Volume 12, Issue 3

    Abstract: Hypertriglyceridemia (HTG) has been associated with an increased risk of pancreatitis and cardiovascular disease. Adipose tissue plays a major role in lipid metabolism, mobilization and distribution. We have compared the histological and transcriptomic ... ...

    Abstract Hypertriglyceridemia (HTG) has been associated with an increased risk of pancreatitis and cardiovascular disease. Adipose tissue plays a major role in lipid metabolism, mobilization and distribution. We have compared the histological and transcriptomic profiles of the subcutaneous (SAT) and visceral (VAT) adipose tissues from subjects with severe obesity undergoing bariatric surgery with (Ob-HTG,
    Language English
    Publishing date 2023-01-28
    Publishing country Switzerland
    Document type Journal Article
    ZDB-ID 2662592-1
    ISSN 2077-0383
    ISSN 2077-0383
    DOI 10.3390/jcm12031013
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  4. Article ; Online: Expression of Adipose Tissue Extracellular Matrix-Related Genes Predicts Weight Loss after Bariatric Surgery.

    Osorio-Conles, Óscar / Olbeyra, Romina / Vidal, Josep / Ibarzabal, Ainitze / Balibrea, José María / de Hollanda, Ana

    Cells

    2023  Volume 12, Issue 9

    Abstract: Background: We evaluated the association between white adipose tissue parameters before bariatric surgery (BS) and post-surgical weight loss, with an especial focus on extracellular matrix (ECM) gene expression.: Methods: Paired samples from ... ...

    Abstract Background: We evaluated the association between white adipose tissue parameters before bariatric surgery (BS) and post-surgical weight loss, with an especial focus on extracellular matrix (ECM) gene expression.
    Methods: Paired samples from subcutaneous (SAT) and visceral adipose tissue (VAT) were obtained from 144 subjects undergoing BS. The association between total body weight loss (%TBWL) at 12 months after BS and the histological characteristics and gene expression of selected genes in SAT and VAT was analyzed.
    Results: Fat cell area, size-frequency distribution, and fibrosis in SAT or VAT prior to surgery were not associated with %TBWL. On the contrary, the SAT expression of
    Conclusions: Our data suggest that the expression of SAT ECM-related genes may help explain the variability in TBWL following BS.
    MeSH term(s) Humans ; Subcutaneous Fat/metabolism ; Diabetes Mellitus, Type 2/metabolism ; Adipose Tissue ; Bariatric Surgery ; Weight Loss/genetics ; Extracellular Matrix/genetics ; Collagen/metabolism
    Chemical Substances Collagen (9007-34-5)
    Language English
    Publishing date 2023-04-26
    Publishing country Switzerland
    Document type Journal Article ; Research Support, Non-U.S. Gov't
    ZDB-ID 2661518-6
    ISSN 2073-4409 ; 2073-4409
    ISSN (online) 2073-4409
    ISSN 2073-4409
    DOI 10.3390/cells12091262
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  5. Article ; Online: Limited Bariatric Surgery-induced Weight Loss in Subjects With Type 2 Diabetes: Predictor Variables in Adipose Tissue.

    Osorio-Conles, Óscar / Jiménez, Amanda / Ibarzabal, Ainitze / Balibrea, José María / de Hollanda, Ana / Vidal, Josep

    The Journal of clinical endocrinology and metabolism

    2023  Volume 108, Issue 11, Page(s) e1205–e1213

    Abstract: Context: The impact of type 2 diabetes mellitus (T2D) at baseline on limited weight loss (WL) after bariatric surgery (BS) remains controversial, and the potential underlying mechanisms incompletely understood.: Objective: We aimed at gaining further ...

    Abstract Context: The impact of type 2 diabetes mellitus (T2D) at baseline on limited weight loss (WL) after bariatric surgery (BS) remains controversial, and the potential underlying mechanisms incompletely understood.
    Objective: We aimed at gaining further insight on this relationship and identifying novel associations between adipose tissue (AT) parameters and short-term WL outcomes in subjects with or without T2D undergoing BS.
    Methods: Mid-term WL trajectories after BS have been evaluated in a cohort of 1659 subjects (cohort 1) with (n = 543) and without T2D (n = 1116). Paired subcutaneous and visceral AT samples were obtained from a cohort of 48 pairs of subjects with and without T2D matched for age, sex, BMI, and type of BS (cohort 2). Differences in AT parameters between groups were evaluated and potential associations with WL response explored.
    Results: T2D was independently associated with a 5% lesser mid-term WL in cohort 1, while HbA1c, insulin treatment, and number of T2D medications prior to BS were only related to short-term WL outcomes. In cohort 2, a number of differentially expressed genes in AT were identified between groups, while fat cell size and fibrosis were comparable. Subcutaneous ATG7 expression was found as an independent predictor of limited WL 1 year after surgery (β: -12.21 ± 4.41, P = .008) and its addition to a clinical model significantly improved the amount of WL variability explained (R2 = 0.131 vs R2 = 0.248, F change P = .009).
    Conclusion: Our results highlight the importance of T2D as determinant of limited WL following BS and suggest that dysregulated macroautophagy in subcutaneous AT may contribute to this association.
    MeSH term(s) Humans ; Diabetes Mellitus, Type 2/complications ; Treatment Outcome ; Bariatric Surgery ; Weight Loss/physiology ; Subcutaneous Fat/metabolism ; Obesity, Morbid/surgery
    Language English
    Publishing date 2023-05-29
    Publishing country United States
    Document type Journal Article ; Research Support, Non-U.S. Gov't
    ZDB-ID 3029-6
    ISSN 1945-7197 ; 0021-972X
    ISSN (online) 1945-7197
    ISSN 0021-972X
    DOI 10.1210/clinem/dgad271
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    Uh III Zs.134: Show issues Location:
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    bis Jg. 2021: Bestellungen von Artikeln über das Online-Bestellformular
    ab Jg. 2022: Lesesaal (EG)

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  6. Article ; Online: Letter to the editor following "Gastroesophageal Reflux and Laparoscopic Sleeve Gastrectomy: Results of the First International Consensus Conference" by Assalia et al.

    Curell, Anna / Balibrea, José M / Ibarzábal, Ainitze / Lacy, Antonio

    Obesity surgery

    2020  Volume 31, Issue 4, Page(s) 1846–1847

    MeSH term(s) Gastrectomy ; Gastroesophageal Reflux/etiology ; Gastroesophageal Reflux/surgery ; Humans ; Laparoscopy ; Obesity, Morbid/surgery
    Language English
    Publishing date 2020-11-03
    Publishing country United States
    Document type Letter ; Comment
    ZDB-ID 1070827-3
    ISSN 1708-0428 ; 0960-8923
    ISSN (online) 1708-0428
    ISSN 0960-8923
    DOI 10.1007/s11695-020-05087-x
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    Zs.A 3381: Show issues Location:
    Je nach Verfügbarkeit (siehe Angabe bei Bestand)
    bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular
    Jg. 1995 - 2021: Lesesall (2.OG)
    ab Jg. 2022: Lesesaal (EG)

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  7. Article ; Online: Positive Effects of a Mediterranean Diet Supplemented with Almonds on Female Adipose Tissue Biology in Severe Obesity.

    Osorio-Conles, Óscar / Olbeyra, Romina / Moizé, Violeta / Ibarzabal, Ainitze / Giró, Oriol / Viaplana, Judith / Jiménez, Amanda / Vidal, Josep / de Hollanda, Ana

    Nutrients

    2022  Volume 14, Issue 13

    Abstract: It has been suggested that weight-loss-independent Mediterranean diet benefits on cardiometabolic health and diabetes prevention may be mediated, at least in part, through the modulation of white adipose tissue (WAT) biology. This study aimed to evaluate ...

    Abstract It has been suggested that weight-loss-independent Mediterranean diet benefits on cardiometabolic health and diabetes prevention may be mediated, at least in part, through the modulation of white adipose tissue (WAT) biology. This study aimed to evaluate the short-term effects of a dietary intervention based on the Mediterranean diet supplemented with almonds (MDSA) on the main features of obesity-associated WAT dysfunction. A total of 38 women with obesity were randomly assigned to a 3-month intervention with MDSA versus continuation of their usual dietary pattern. Subcutaneous (SAT) and visceral adipose tissue (VAT) biopsies were obtained before and after the dietary intervention, and at the end of the study period, respectively. MDSA favored the abundance of small adipocytes in WAT. In SAT, the expression of angiogenesis genes increased after MDSA intervention. In VAT, the expression of genes implicated in adipogenesis, angiogenesis, autophagy and fatty acid usage was upregulated. In addition, a higher immunofluorescence staining for PPARG, CD31+ cells and M2-like macrophages and increased ADRB1 and UCP2 protein contents were found compared to controls. Changes in WAT correlated with a significant reduction in circulating inflammatory markers and LDL-cholesterol levels. These results support a protective effect of a Mediterranean diet supplemented with almonds on obesity-related WAT dysfunction.
    MeSH term(s) Adipose Tissue/metabolism ; Adipose Tissue, White/metabolism ; Biology ; Diet, Mediterranean ; Female ; Humans ; Obesity/metabolism ; Obesity, Morbid/metabolism ; Prunus dulcis
    Language English
    Publishing date 2022-06-24
    Publishing country Switzerland
    Document type Journal Article ; Randomized Controlled Trial
    ZDB-ID 2518386-2
    ISSN 2072-6643 ; 2072-6643
    ISSN (online) 2072-6643
    ISSN 2072-6643
    DOI 10.3390/nu14132617
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  8. Article ; Online: Biological Determinants of Metabolic Syndrome in Visceral and Subcutaneous Adipose Tissue from Severely Obese Women.

    Osorio-Conles, Óscar / Vega-Beyhart, Arturo / Ibarzabal, Ainitze / Balibrea, José María / Vidal, Josep / de Hollanda, Ana

    International journal of molecular sciences

    2022  Volume 23, Issue 4

    Abstract: The metabolic syndrome (MetS) is a cluster of the most dangerous heart attack risk factors: diabetes or raised fasting plasma glucose, abdominal obesity, high cholesterol and high blood pressure. The goal of this study is to compare the state of the main ...

    Abstract The metabolic syndrome (MetS) is a cluster of the most dangerous heart attack risk factors: diabetes or raised fasting plasma glucose, abdominal obesity, high cholesterol and high blood pressure. The goal of this study is to compare the state of the main features of obesity-associated white adipose tissue (WAT) dysfunction in 66 women with severe obesity without (MetS-) or with MetS (MetS+). Fat cell area, adipocyte size distribution and histological fibrosis were analysed in visceral (VAT) and abdominal subcutaneous WAT (SAT) in 33 age- and BMI-matched pairs of MetS- and MetS+ subjects. The mRNA expression of 93 genes implicated in obesity-associated WAT dysfunction was analysed by RT-qPCR in both fat depots. MetS+ females showed higher adipocyte hypertrophy in both fat depots and increased fibrosis and expression of macrophage and hypoxia markers in SAT. Transcriptional data suggest increased fatty acid oxidation in SAT and impaired thermogenesis and extracellular matrix remodelling in VAT from MetS+ subjects. A sPLS-DA model, including SAT expression of
    MeSH term(s) Adipocytes/metabolism ; Adipocytes/pathology ; Adipose Tissue, White/metabolism ; Adipose Tissue, White/pathology ; Body Composition/physiology ; Body Mass Index ; Diabetes Mellitus/metabolism ; Diabetes Mellitus/pathology ; Female ; Humans ; Hypertension/metabolism ; Hypertension/pathology ; Intra-Abdominal Fat/metabolism ; Metabolic Syndrome/metabolism ; Metabolic Syndrome/pathology ; Middle Aged ; Obesity, Abdominal/metabolism ; Obesity, Abdominal/pathology ; Obesity, Morbid/metabolism ; Obesity, Morbid/pathology ; Subcutaneous Fat, Abdominal/metabolism ; Subcutaneous Fat, Abdominal/pathology ; Thermogenesis/physiology
    Language English
    Publishing date 2022-02-21
    Publishing country Switzerland
    Document type Journal Article
    ZDB-ID 2019364-6
    ISSN 1422-0067 ; 1422-0067 ; 1661-6596
    ISSN (online) 1422-0067
    ISSN 1422-0067 ; 1661-6596
    DOI 10.3390/ijms23042394
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  9. Article ; Online: Biliopancreatic limb obstruction due to jejuno-jejunal intussusception in a patient with previous Roux-en-Y gastric bypass.

    Guarner, Pol / Ibarzabal, Ainitze / M Balibrea, Jose / M Lacy, Antonio

    Cirugia espanola

    2019  Volume 98, Issue 5, Page(s) 292

    Title translation Oclusión de asa biliopancreática por intususcepción yeyunal en paciente con bypass gástrico previo.
    MeSH term(s) Aftercare ; Anastomosis, Roux-en-Y/adverse effects ; Duodenal Obstruction/etiology ; Duodenal Obstruction/surgery ; Female ; Gastric Bypass/methods ; Humans ; Intussusception/complications ; Jejunal Diseases/pathology ; Laparoscopy/methods ; Middle Aged ; Pneumoperitoneum, Artificial/methods ; Treatment Outcome
    Language Spanish
    Publishing date 2019-09-21
    Publishing country Spain
    Document type Case Reports ; Journal Article
    ISSN 2173-5077
    ISSN (online) 2173-5077
    DOI 10.1016/j.ciresp.2019.06.016
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  10. Article: Positive Effects of a Mediterranean Diet Supplemented with Almonds on Female Adipose Tissue Biology in Severe Obesity

    Osorio-Conles, Óscar / Olbeyra, Romina / Moizé, Violeta / Ibarzabal, Ainitze / Giró, Oriol / Viaplana, Judith / Jiménez, Amanda / Vidal, Josep / de Hollanda, Ana

    Nutrients. 2022 June 24, v. 14, no. 13

    2022  

    Abstract: It has been suggested that weight-loss-independent Mediterranean diet benefits on cardiometabolic health and diabetes prevention may be mediated, at least in part, through the modulation of white adipose tissue (WAT) biology. This study aimed to evaluate ...

    Abstract It has been suggested that weight-loss-independent Mediterranean diet benefits on cardiometabolic health and diabetes prevention may be mediated, at least in part, through the modulation of white adipose tissue (WAT) biology. This study aimed to evaluate the short-term effects of a dietary intervention based on the Mediterranean diet supplemented with almonds (MDSA) on the main features of obesity-associated WAT dysfunction. A total of 38 women with obesity were randomly assigned to a 3-month intervention with MDSA versus continuation of their usual dietary pattern. Subcutaneous (SAT) and visceral adipose tissue (VAT) biopsies were obtained before and after the dietary intervention, and at the end of the study period, respectively. MDSA favored the abundance of small adipocytes in WAT. In SAT, the expression of angiogenesis genes increased after MDSA intervention. In VAT, the expression of genes implicated in adipogenesis, angiogenesis, autophagy and fatty acid usage was upregulated. In addition, a higher immunofluorescence staining for PPARG, CD31+ cells and M2-like macrophages and increased ADRB1 and UCP2 protein contents were found compared to controls. Changes in WAT correlated with a significant reduction in circulating inflammatory markers and LDL-cholesterol levels. These results support a protective effect of a Mediterranean diet supplemented with almonds on obesity-related WAT dysfunction.
    Keywords Mediterranean diet ; adipocytes ; adipogenesis ; angiogenesis ; autophagy ; diabetes ; eating habits ; fatty acids ; females ; fluorescent antibody technique ; low density lipoprotein cholesterol ; macrophages ; nutritional intervention ; obesity ; peroxisome proliferator-activated receptor gamma ; protective effect ; white adipose tissue
    Language English
    Dates of publication 2022-0624
    Publishing place Multidisciplinary Digital Publishing Institute
    Document type Article
    ZDB-ID 2518386-2
    ISSN 2072-6643
    ISSN 2072-6643
    DOI 10.3390/nu14132617
    Database NAL-Catalogue (AGRICOLA)

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