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  1. Article ; Online: Obesity related pathophysiological aspects favouring Gastroesophageal Reflux Disease.

    García Ruiz de Gordejuela, Amador / Ibarzabal Olano, Ainitze / Petrola Chacón, Carlos Gustavo / González López, Óscar

    Cirugia espanola

    2023  Volume 101 Suppl 4, Page(s) S3–S7

    Abstract: Gastroesophageal reflux disease (GERD) is a complex entity and one of the most frequents in general population. Association of GERD with obesity is clearly defined from an epidemiological point of view, where up to 40% of patients with overweight and ... ...

    Abstract Gastroesophageal reflux disease (GERD) is a complex entity and one of the most frequents in general population. Association of GERD with obesity is clearly defined from an epidemiological point of view, where up to 40% of patients with overweight and obesity present reflux. Most of the risk factors associated to GERD are shared and especially frequent in patients with obesity. The pathophysiology that explain this correlation is complex and multifactorial, and includes both aspects related to physiology of motility, and anatomic changes. The malfunction of the lower esophageal sphincter, the greater transdiaphragmatic pressure gradient, pathological accumulation of fat and the high rate of hiatal hernia that comes with overweight will be the main factors that explain this correlation. Other factor like pathological eating habits or obesity related diseases have also an important role. In summary, it is the sum of the factors more than just one of them what would explain the pathophysiology of GERD in obese population.
    MeSH term(s) Humans ; Overweight/complications ; Gastroesophageal Reflux/complications ; Esophageal Sphincter, Lower ; Hernia, Hiatal/complications ; Obesity/complications ; Obesity/epidemiology
    Language English
    Publishing date 2023-11-16
    Publishing country Spain
    Document type Journal Article
    ISSN 2173-5077
    ISSN (online) 2173-5077
    DOI 10.1016/j.cireng.2022.12.007
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  2. Article ; Online: Performance of Indocyanine-Green Imaging for Sentinel Lymph Node Mapping and Lymph Node Metastasis in Esophageal Cancer: Systematic Review and Meta-Analysis.

    Jimenez-Lillo, Julio / Villegas-Tovar, Eduardo / Momblan-Garcia, Dulce / Turrado-Rodriguez, Victor / Ibarzabal-Olano, Ainitze / De Lacy, Borja / Diaz-Giron-Gidi, Alejandro / Faes-Petersen, Regina / Martinez-Portilla, Raigam J / Lacy, Antonio

    Annals of surgical oncology

    2021  Volume 28, Issue 9, Page(s) 4869–4877

    Abstract: Background and objectives: Lymphatic mapping with indocyanine-green (ICG) and near-infrared light fluorescent imaging is widely used for sentinel lymph node staging in different types of cancer but is not fully accepted for all procedures because ... ...

    Abstract Background and objectives: Lymphatic mapping with indocyanine-green (ICG) and near-infrared light fluorescent imaging is widely used for sentinel lymph node staging in different types of cancer but is not fully accepted for all procedures because studies have reported heterogeneous results. This study aimed to assess the detection rate (DR) of ICG imaging for sentinel lymph node mapping (SLNM) and lymph node metastases (LNMs) in esophageal cancer.
    Methods: A systematic search was performed to identify relevant studies examining the use of ICG imaging for SLNM in patients with esophageal cancer. Extracted results were pooled in a single-proportion meta-analysis, with a random-effects model, presented as forest plots.
    Results: Six studies were included in the analysis. The ICG DR for SLNM was 89% [95% confidence interval (CI) 71%-96%]. The pooled sensitivity and specificity values for the detection of LNMs were 84% (95% CI 64%-94%) and 15% (95% CI 3%-45%), respectively. A trend towards a lower DR was found with increasing mean latency time between ICG injection and SLNM.
    Conclusions: ICG imaging is a technique that potentially could improve lymph node yield excision and, as a consequence, improve the detection of lymph node metastases.
    MeSH term(s) Coloring Agents ; Esophageal Neoplasms/diagnostic imaging ; Esophageal Neoplasms/surgery ; Humans ; Indocyanine Green ; Lymph Nodes/diagnostic imaging ; Lymph Nodes/surgery ; Lymphatic Metastasis ; Optical Imaging ; Sentinel Lymph Node/diagnostic imaging ; Sentinel Lymph Node/surgery ; Sentinel Lymph Node Biopsy
    Chemical Substances Coloring Agents ; Indocyanine Green (IX6J1063HV)
    Language English
    Publishing date 2021-01-29
    Publishing country United States
    Document type Journal Article ; Meta-Analysis ; Review ; Systematic Review
    ZDB-ID 1200469-8
    ISSN 1534-4681 ; 1068-9265
    ISSN (online) 1534-4681
    ISSN 1068-9265
    DOI 10.1245/s10434-021-09617-4
    Database MEDical Literature Analysis and Retrieval System OnLINE

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