Article ; Online: Exploring the composition of protein-ligand binding sites for cancerous inhibitor of PP2A (CIP2A) by inhibitor guided binding analysis: paving a new way for the Discovery of drug candidates against triple negative breast cancer (TNBC).
Journal of receptor and signal transduction research
2024 Volume 43, Issue 6, Page(s) 133–143
Abstract: Triple-negative breast cancer (TNBC) is associated with high-grade invasive carcinoma leading to a 10% to 15% death rate in younger premenopausal women. Targeting cancerous inhibitors of protein phosphatase (CIP2A) has been a highly effective approach ... ...
| Abstract | Triple-negative breast cancer (TNBC) is associated with high-grade invasive carcinoma leading to a 10% to 15% death rate in younger premenopausal women. Targeting cancerous inhibitors of protein phosphatase (CIP2A) has been a highly effective approach for exploring therapeutic drug candidates. Lapatinib, a dual tyrosine kinase inhibitor, has shown promising inhibition properties by inducing apoptosis in TNBC carcinogenesis |
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| MeSH term(s) | Female ; Humans ; Lapatinib/therapeutic use ; Triple Negative Breast Neoplasms/drug therapy ; Triple Negative Breast Neoplasms/metabolism ; Triple Negative Breast Neoplasms/pathology ; Ligands ; Intracellular Signaling Peptides and Proteins/metabolism ; Membrane Proteins/metabolism ; Transcription Factors ; Binding Sites ; Carcinogenesis ; Cell Line, Tumor | |||||
| Chemical Substances | Lapatinib (0VUA21238F) ; Ligands ; Intracellular Signaling Peptides and Proteins ; Membrane Proteins ; Transcription Factors | |||||
| Language | English | |||||
| Publishing date | 2024-02-13 | |||||
| Publishing country | England | |||||
| Document type | Journal Article | |||||
| ZDB-ID | 1230969-2 | |||||
| ISSN | 1532-4281 ; 1079-9893 | |||||
| ISSN (online) | 1532-4281 | |||||
| ISSN | 1079-9893 | |||||
| DOI | 10.1080/10799893.2023.2298903 | |||||
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| Database | MEDical Literature Analysis and Retrieval System OnLINE |
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