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  1. Article ; Online: Towards identification of new genetic determinants for post-weaning diarrhea in piglets.

    Ibragimov, Emil / Eriksen, Esben Østergaard / Nielsen, Jens Peter / Jørgensen, Claus B / Fredholm, Merete / Karlskov-Mortensen, Peter

    Animal genetics

    2024  Volume 55, Issue 3, Page(s) 387–395

    Abstract: Post-weaning diarrhea in pigs is a considerable challenge in the pig farming industry due to its effect on animal welfare and production costs, as well as the large volume of antibiotics, which are used to treat diarrhea in pigs after weaning. Previous ... ...

    Abstract Post-weaning diarrhea in pigs is a considerable challenge in the pig farming industry due to its effect on animal welfare and production costs, as well as the large volume of antibiotics, which are used to treat diarrhea in pigs after weaning. Previous studies have revealed loci on SSC6 and SSC13 associated with susceptibility to specific diarrhea causing pathogens. This study aimed to identify new genetic loci for resistance to diarrhea based on phenotypic data. In depth clinical characterization of diarrhea was performed in 257 pigs belonging to two herds during the first 14 days post weaning. The daily diarrhea assessments were used for the classification of pigs into case and control groups. Pigs were assigned to case and control groups based only on the incidence of diarrhea in the second week of the study in order to differentiate between differences in etiology. Genome-wide association studies and metabolomics association analysis were performed in order to identify new biological determinants for diarrhea susceptibility. With the present work, we revealed a new locus for diarrhea resistance on SSC16. Furthermore, studies of metabolomics in the same pigs revealed one metabolite associated with diarrhea.
    MeSH term(s) Animals ; Diarrhea/veterinary ; Diarrhea/genetics ; Swine Diseases/genetics ; Weaning ; Genome-Wide Association Study/veterinary ; Swine/genetics ; Sus scrofa/genetics ; Disease Resistance/genetics ; Metabolomics
    Language English
    Publishing date 2024-02-11
    Publishing country England
    Document type Journal Article
    ZDB-ID 632766-7
    ISSN 1365-2052 ; 0268-9146 ; 0268-9154
    ISSN (online) 1365-2052
    ISSN 0268-9146 ; 0268-9154
    DOI 10.1111/age.13406
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    In stock of ZB MED Cologne/Königswinter

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  2. Article ; Online: Analysis of merged transcriptomic and genomic datasets to identify genes and pathways underlying residual feed intake in growing pigs.

    Ibragimov, Emil / Pedersen, Anni Øyan / Xiao, Liang / Cirera, Susanna / Fredholm, Merete / Karlskov-Mortensen, Peter

    Scientific reports

    2022  Volume 12, Issue 1, Page(s) 21946

    Abstract: Improvement of feed efficiency (FE) in pigs is an important milestone in order to reduce the economic and environmental impact of pig production. The goal of finding biomarkers for FE has persisted for decades. However, due to the complexity of the FE ... ...

    Abstract Improvement of feed efficiency (FE) in pigs is an important milestone in order to reduce the economic and environmental impact of pig production. The goal of finding biomarkers for FE has persisted for decades. However, due to the complexity of the FE trait, these goals have still not been met. Here, we search for quantitative trait loci (QTL), candidate genes, and biological pathways associated with FE using both genotype and RNA-seq data. We obtained genotype and colon epithelium RNA-seq data for 375 and 96 pigs, respectively. In total, a genome-wide association study (GWAS) and differential expression (DE) analysis led to detection of three QTL on SSC9 and 17 DE-genes associated with FE. Possible intersection points between genes located in QTL and DE-genes were found on levels of transcription factor-target interaction. Moreover, cis-eQTL analysis revealed associations between genotype and expression levels of three DE-genes and three genes located in the GWAS QTLs, which may establish the connection between genotype and phenotype through DE. Finally, single nucleotide polymorphism calling using RNA-seq data for genes located in GWAS QTLs revealed 53 polymorphisms of which eleven were missense variants.
    MeSH term(s) Swine ; Animals ; Transcriptome ; Genome-Wide Association Study ; Genotype ; Phenotype ; Eating/genetics ; Quantitative Trait Loci ; Genomics ; Polymorphism, Single Nucleotide
    Language English
    Publishing date 2022-12-19
    Publishing country England
    Document type Journal Article ; Research Support, Non-U.S. Gov't
    ZDB-ID 2615211-3
    ISSN 2045-2322 ; 2045-2322
    ISSN (online) 2045-2322
    ISSN 2045-2322
    DOI 10.1038/s41598-022-26496-1
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  3. Article ; Online: Mitral valve transcriptome analysis in thirty-four age-matched Cavalier King Charles Spaniels with or without congestive heart failure caused by myxomatous mitral valve disease.

    Reimann, Maria J / Cremer, Signe / Christiansen, Liselotte / Ibragimov, Emil / Gao, Fei / Cirera, Susanna / Fredholm, Merete / Olsen, Lisbeth H / Karlskov-Mortensen, Peter

    Mammalian genome : official journal of the International Mammalian Genome Society

    2023  Volume 35, Issue 1, Page(s) 77–89

    Abstract: We here report the results of a mitral valve transcriptome study designed to identify genes and molecular pathways involved in development of congestive heart failure (CHF) following myxomatous mitral valve disease (MMVD) in dogs. The study is focused on ...

    Abstract We here report the results of a mitral valve transcriptome study designed to identify genes and molecular pathways involved in development of congestive heart failure (CHF) following myxomatous mitral valve disease (MMVD) in dogs. The study is focused on a cohort of elderly age-matched dogs (n = 34, age ~ 10 years) from a single breed-Cavalier King Charles Spaniels (CKCS)-with a high incidence of MMVD. The cohort comprises 19 dogs (10♀, 9♂) without MMVD-associated CHF, and 15 dogs (6♀, 9♂) with CHF caused by MMVD; i.e., we compare gene expression in breed and age-matched groups of dogs, which only differ with respect to CHF status. We identify 56 genes, which are differentially expressed between the two groups. In this list of genes, we confirm an enrichment of genes related to the TNFβ-signaling pathway, extracellular matrix organization, vascular development, and endothelium damage, which also have been identified in previous studies. However, the genes with the greatest difference in expression between the two groups are CNTN3 and MYH1. Both genes encode proteins, which are predicted to have an effect on the contractile activity of myocardial cells, which in turn may have an effect on valvular performance and hemodynamics across the mitral valve. This may result in shear forces with impact on MMVD progression.
    MeSH term(s) Humans ; Dogs ; Animals ; Aged ; Child ; Mitral Valve/metabolism ; Heart Valve Diseases/genetics ; Heart Valve Diseases/veterinary ; Transcriptome ; Heart Failure/genetics ; Heart Failure/veterinary ; Gene Expression Profiling ; Dog Diseases/genetics
    Language English
    Publishing date 2023-11-08
    Publishing country United States
    Document type Journal Article
    ZDB-ID 1058547-3
    ISSN 1432-1777 ; 0938-8990
    ISSN (online) 1432-1777
    ISSN 0938-8990
    DOI 10.1007/s00335-023-10024-1
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    In stock of ZB MED Cologne/Königswinter

    Zs.A 3489: Show issues Location:
    Je nach Verfügbarkeit (siehe Angabe bei Bestand)
    bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular
    Jg. 1995 - 2021: Lesesall (2.OG)
    ab Jg. 2022: Lesesaal (EG)

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  4. Article ; Online: Comparison of anaerobic digestion strategies of nitrogen-rich substrates: Performance of anaerobic reactors and microbial community diversity.

    Ziganshina, Elvira E / Ibragimov, Emil M / Vankov, Petr Y / Miluykov, Vasili A / Ziganshin, Ayrat M

    Waste management (New York, N.Y.)

    2017  Volume 59, Page(s) 160–171

    Abstract: In the present study, the application of different operating strategies on performance of three continuous stirred tank reactors digesting chicken manure at mesophilic temperature and constant organic loading rate (OLR) of 3 ... ...

    Abstract In the present study, the application of different operating strategies on performance of three continuous stirred tank reactors digesting chicken manure at mesophilic temperature and constant organic loading rate (OLR) of 3.5g
    MeSH term(s) Actinobacteria ; Ammonia ; Anaerobiosis ; Animals ; Archaea ; Bacillus ; Bacteria/genetics ; Biofuels ; Bioreactors/microbiology ; Chickens ; Clostridium ; Computational Biology ; Manure/microbiology ; Methanomicrobiaceae ; Methanosarcina ; Microbial Consortia ; Microscopy, Electron, Scanning ; Nitrogen/chemistry ; Polymorphism, Restriction Fragment Length ; RNA, Ribosomal, 16S/genetics ; Temperature ; Zeolites
    Chemical Substances Biofuels ; Manure ; RNA, Ribosomal, 16S ; Zeolites (1318-02-1) ; Ammonia (7664-41-7) ; Nitrogen (N762921K75)
    Language English
    Publishing date 2017-01
    Publishing country United States
    Document type Comparative Study ; Journal Article
    ZDB-ID 2001471-5
    ISSN 1879-2456 ; 0956-053X
    ISSN (online) 1879-2456
    ISSN 0956-053X
    DOI 10.1016/j.wasman.2016.10.038
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  5. Article ; Online: METTL6 is a tRNA m

    Ignatova, Valentina V / Kaiser, Steffen / Ho, Jessica Sook Yuin / Bing, Xinyang / Stolz, Paul / Tan, Ying Xim / Lee, Chee Leng / Gay, Florence Pik Hoon / Lastres, Palma Rico / Gerlini, Raffaele / Rathkolb, Birgit / Aguilar-Pimentel, Antonio / Sanz-Moreno, Adrián / Klein-Rodewald, Tanja / Calzada-Wack, Julia / Ibragimov, Emil / Valenta, Magdalena / Lukauskas, Saulius / Pavesi, Andrea /
    Marschall, Susan / Leuchtenberger, Stefanie / Fuchs, Helmut / Gailus-Durner, Valerie / de Angelis, Martin Hrabe / Bultmann, Sebastian / Rando, Oliver J / Guccione, Ernesto / Kellner, Stefanie M / Schneider, Robert

    Science advances

    2020  Volume 6, Issue 35, Page(s) eaaz4551

    Abstract: Recently, covalent modifications of RNA, such as methylation, have emerged as key regulators of all aspects of RNA biology and have been implicated in numerous diseases, for instance, cancer. Here, we undertook a combination of in vitro and in vivo ... ...

    Abstract Recently, covalent modifications of RNA, such as methylation, have emerged as key regulators of all aspects of RNA biology and have been implicated in numerous diseases, for instance, cancer. Here, we undertook a combination of in vitro and in vivo screens to test 78 potential methyltransferases for their roles in hepatocellular carcinoma (HCC) cell proliferation. We identified methyltransferase-like protein 6 (METTL6) as a crucial regulator of tumor cell growth. We show that METTL6 is a bona fide transfer RNA (tRNA) methyltransferase, catalyzing the formation of 3-methylcytidine at C32 of specific serine tRNA isoacceptors. Deletion of
    MeSH term(s) Animals ; Carcinoma, Hepatocellular/genetics ; Cell Proliferation ; Liver Neoplasms/genetics ; Methyltransferases/genetics ; Methyltransferases/metabolism ; Mice ; RNA ; RNA, Transfer/genetics ; RNA, Transfer/metabolism ; tRNA Methyltransferases
    Chemical Substances RNA (63231-63-0) ; RNA, Transfer (9014-25-9) ; METTL6 protein, human (EC 2.1.1.-) ; Methyltransferases (EC 2.1.1.-) ; tRNA Methyltransferases (EC 2.1.1.-)
    Language English
    Publishing date 2020-08-26
    Publishing country United States
    Document type Journal Article ; Research Support, N.I.H., Extramural ; Research Support, Non-U.S. Gov't
    ZDB-ID 2810933-8
    ISSN 2375-2548 ; 2375-2548
    ISSN (online) 2375-2548
    ISSN 2375-2548
    DOI 10.1126/sciadv.aaz4551
    Database MEDical Literature Analysis and Retrieval System OnLINE

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