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  1. Article ; Online: The Clinical Significance of Septin 9 and Colon Cancer Specific Antigen-2 (CCSA-2) in Colorectal Cancer.

    Abd El Kader, Lamiaa / Soliman, Amira H / Salem, Salem E / Akel, Samia Y / Ibrahim, Noha H

    Asian Pacific journal of cancer prevention : APJCP

    2023  Volume 24, Issue 3, Page(s) 1027–1036

    Abstract: Introduction: Colorectal cancer (CRC) is a major health problem Worldwide, Egypt shows a high rate of early CRC in the world as 35% of 1,600 Egyptian CRC patients were under 40 with threefold increased risk of death within 5 years. DNA methylation-based ...

    Abstract Introduction: Colorectal cancer (CRC) is a major health problem Worldwide, Egypt shows a high rate of early CRC in the world as 35% of 1,600 Egyptian CRC patients were under 40 with threefold increased risk of death within 5 years. DNA methylation-based biomarkers as methylated Septin9 (mSEPT9) has a promising role for detecting CRC. As well as set of nuclear matrix proteins associated with changes in the nuclear structure/architecture. detection of these nuclear proteins resulted in identification of biomarkers that are specific for colon cancer. Particular interest has been placed on colon cancer specific antigen-2(CCSA-2).
    Methods: A total of 30 newly diagnosed CRC patients, 7 colonic adenoma patients, and 15 age- and sex-matched control subjects were recruited in this study. Plasma mSEPT9was assayed by Epi procolon kit, CCSA-2 by ELISA and, Occult blood in stool by Guaiac-based fecal occult blood test. The level of Colon Cancer mSEPT9 and CCSA-2 were carried on CRC patients both preoperatively and three months postoperatively.
    Results: mSEPT9 has 96.7% sensitivity and 95.5% specificity in differentiating colorectal cancer patients from non-malignant cases. Also, our study showed a highly statistically significant difference between the pre and three months postoperative expression of mSEPT9 in colorectal cancer as there was a dramatically decrease in the expression of mSEPT9 postoperatively (p value < 0.001). The CCSA-2 at the cutoff level of >1.43 would provide 93.3% sensitivity and 90.9% specificity in differentiation between malignant and non-malignant cases. Also, the study showed that there is a statistically significant difference between colorectal cancer patients preoperatively and postoperatively according to CCSA-2 with dramatic decrease in its level postoperatively (p value > 0.001).
    Conclusion: The plasma SEPT9 DNA methylation level and Serum CCSA-2 could be used as promising non-invasive methods for observing the CRC patients postsurgical response to predict the occurrence of complete remission or relapses.
    MeSH term(s) Humans ; Biomarkers, Tumor/genetics ; Clinical Relevance ; Colorectal Neoplasms/pathology ; DNA Methylation ; Early Detection of Cancer ; Neoplasm Recurrence, Local/genetics ; Septins/genetics ; Antigens, Neoplasm/genetics
    Chemical Substances Biomarkers, Tumor ; Septins (EC 3.6.1.-) ; SEPTIN9 protein, human (EC 3.6.1.-) ; colon cancer-specific antigen 2, human ; Antigens, Neoplasm
    Language English
    Publishing date 2023-03-01
    Publishing country Thailand
    Document type Journal Article
    ZDB-ID 2218955-5
    ISSN 2476-762X ; 1513-7368
    ISSN (online) 2476-762X
    ISSN 1513-7368
    DOI 10.31557/APJCP.2023.24.3.1027
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  2. Article ; Online: The Role of Vitamin D, Platelet-Derived Growth Factor and Insulin-Like Growth Factor 1 in the Progression of Thyroid Diseases.

    Abdellateif, Mona S / Shaarawy, Sabry / Elesawy, Yasmine F / Mansour, Mona / Tharwat, Effat / Ibrahim, Noha H / Eissa, Marwa S

    Asian Pacific journal of cancer prevention : APJCP

    2020  Volume 21, Issue 7, Page(s) 2083–2089

    Abstract: Background: Thyroid cancer (TC) is a common malignant tumor, however the role of total vitamin D: 25(OH)D, Platelet Derived Growth Factor (PDGF) and Insulin Like Growth Factor 1 (IGF-1) in the development of TC is still unclear.: Aim: To assess the ... ...

    Abstract Background: Thyroid cancer (TC) is a common malignant tumor, however the role of total vitamin D: 25(OH)D, Platelet Derived Growth Factor (PDGF) and Insulin Like Growth Factor 1 (IGF-1) in the development of TC is still unclear.
    Aim: To assess the roles of 25(OH)D, PDGF and IGF-1 in the progression of thyroid diseases.
    Methods: The serum levels of 25(OH)D, PDGF and IGF-1 were assessed in 70 patients with papillary thyroid cancer (PTC), 60 patients with benign thyroid nodules (BN) compared to 60 normal controls (NC) using ELISA technique.
    Results: There was a significant decrease in the serum level of 25(OH)D in TC patients compared to NC (P<0.001) and BN patients (P=0.006). There was a significant increase in the serum levels of PDGF and IGF-1 in TC patients (P<0.001), and BN patients (P<0.001) compared to NC, while there were no significant differences between TC and BN (P=0.087, and 0.258; respectively). PDGF correlated significantly with IGF-1 (r=0.412, P<0.001), TSH (r=0.146, P=0.045), and inversely correlated with 25(OH)D (r= -0.156, P=0.013) and FT4 (r=-0.178, P=0.014). There was a significant inverse correlation between the serum levels of IGF-1 and FT4 (r=-0.172, P=0.017). Sensitivity and specificity for assessment of TC patients were (65.7% and 58.3%, P= 0.001) for 25(OH)D, (65.7% and 58.3%, P=0.021) for IGF-1, and (68.6% and 61.7%, P=0.006) for PDGF. Multivariate analysis demonstrated that serum 25(OH)D (OR=0.578, 95%CI= 0.426-0.783), IGF-1 (OR=1.019, 95%CI= 1.010-1.029) and PDGF (OR=1.007, 95%CI= 1.004-1.009) were considered independent risk factors for thyroid cancer (P<0.001, for all).
    Conclusion: 25(OH) D, IGF-1 and PDGF are significantly different in TC and BN cases compared to control. They have an important role in the progression of TC. However, these data should be validated on a larger sample size.
    .
    MeSH term(s) Adolescent ; Adult ; Aged ; Biomarkers, Tumor/blood ; Case-Control Studies ; Disease Progression ; Female ; Follow-Up Studies ; Humans ; Insulin-Like Growth Factor I/analysis ; Male ; Middle Aged ; Platelet-Derived Growth Factor/analysis ; Prognosis ; Prospective Studies ; Thyroid Cancer, Papillary/blood ; Thyroid Cancer, Papillary/pathology ; Thyroid Neoplasms/blood ; Thyroid Neoplasms/pathology ; Thyroid Nodule/blood ; Thyroid Nodule/pathology ; Vitamin D/blood ; Young Adult
    Chemical Substances Biomarkers, Tumor ; IGF1 protein, human ; Platelet-Derived Growth Factor ; Vitamin D (1406-16-2) ; Insulin-Like Growth Factor I (67763-96-6)
    Language English
    Publishing date 2020-07-01
    Publishing country Thailand
    Document type Journal Article
    ZDB-ID 2218955-5
    ISSN 2476-762X ; 1513-7368
    ISSN (online) 2476-762X
    ISSN 1513-7368
    DOI 10.31557/APJCP.2020.21.7.2083
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  3. Article: Exploiting Signal Joint T Cell Receptor Excision Circle to Investigate the Impact of COVID-19 and Autoimmune Diseases on Age Prediction and Immunosenescence.

    Farag, Amina A / Kharboush, Taghrid G / Ibrahim, Noha H / Darwish, Mohamed / Fawzy, Iman M / Bayomy, Hanaa El-Sayed / Abdelmotaleb, Dina Saad / Abdul Basset, Shaza Abdul Basset / Abdel-Kareim, Amal M / Al Mohaini, Mohammed / Ahmed, Inas A / Fakher, Haidy M

    Biomedicines

    2022  Volume 10, Issue 12

    Abstract: Signal joint T cell receptor excision circles ( ...

    Abstract Signal joint T cell receptor excision circles (
    Language English
    Publishing date 2022-12-09
    Publishing country Switzerland
    Document type Journal Article
    ZDB-ID 2720867-9
    ISSN 2227-9059
    ISSN 2227-9059
    DOI 10.3390/biomedicines10123193
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  4. Article: Combining PHI and miRNAs as Biomarkers in Prostate Cancer Diagnosis and Prognosis.

    Ibrahim, Noha H / Abdellateif, Mona S / Thabet, Gamal / Kassem, Samar H / El-Salam, Mohamed A / El-Leithy, Asmaa A / Selim, Marwa M

    Clinical laboratory

    2019  Volume 65, Issue 7

    Abstract: Background: Prostate cancer (PC) is considered the fifth most common cancer causing death worldwide. Many studies have pointed to dysregulated microRNA (miRNA) expression in PC and their use in early detection and follow-up of the disease. In addition, ... ...

    Abstract Background: Prostate cancer (PC) is considered the fifth most common cancer causing death worldwide. Many studies have pointed to dysregulated microRNA (miRNA) expression in PC and their use in early detection and follow-up of the disease. In addition, the Prostate Health Index (PHI) is the FDA-approved blood test joining total, free, and -2proPSA having greater specificity than free and total PSA for assessment of PC.
    Methods: In this study, we evaluated the plasma levels of miR-21and miR-221 expression using quantitative real-time polymerase chain reaction (qRT-PCR) among 100 prostate cancer patients (50 localized and 50 metastatic cases) and 50 benign prostatic hyperplasia patients in comparison to 50 normal control subjects, as well as assess-ed its diagnostic and prognostic value and its correlation with the Prostate Health Index (PHI).
    Results: To our knowledge, we are the first study to join PHI with miRNAs in assessing PC diagnosis and progno-sis. Our results showed that adding miR-21 to PHI for detecting patients with LPC, increased the sensitivity to 95.5% at a specificity 100% (p < 0.0001). Additionally, combining miR-221 and PHI for differentiating patients with MPC, increased the sensitivity to 96.4% at a specificity 100% (p < 0.0001).
    Conclusions: The potentials of circulating miR-21, miR-221, and PHI serum level as biomarkers for PC have been established not only as diagnostic factors but also as prognostic markers.
    MeSH term(s) Adult ; Aged ; Biomarkers, Tumor/blood ; Biomarkers, Tumor/genetics ; Diagnosis, Differential ; Female ; Gene Expression Regulation, Neoplastic ; Humans ; Male ; MicroRNAs/blood ; MicroRNAs/genetics ; Middle Aged ; Prognosis ; Prostate-Specific Antigen/blood ; Prostatic Hyperplasia/blood ; Prostatic Hyperplasia/diagnosis ; Prostatic Hyperplasia/genetics ; Prostatic Neoplasms/blood ; Prostatic Neoplasms/diagnosis ; Prostatic Neoplasms/genetics ; ROC Curve
    Chemical Substances Biomarkers, Tumor ; MIRN21 microRNA, human ; MIRN221 microRNA, human ; MicroRNAs ; Prostate-Specific Antigen (EC 3.4.21.77)
    Language English
    Publishing date 2019-07-15
    Publishing country Germany
    Document type Journal Article
    ZDB-ID 1307629-2
    ISSN 1433-6510 ; 0941-2131
    ISSN 1433-6510 ; 0941-2131
    DOI 10.7754/Clin.Lab.2019.181213
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    In stock of ZB MED Cologne/Königswinter

    Ud II Zs.170: Show issues Location:
    Je nach Verfügbarkeit (siehe Angabe bei Bestand)
    bis Jg. 2021: Bestellungen von Artikeln über das Online-Bestellformular
    ab Jg. 2022: Lesesaal (EG)
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  5. Article ; Online: Diagnostic significance of miR-21, miR-141, miR-18a and miR-221 as novel biomarkers in prostate cancer among Egyptian patients.

    Ibrahim, Noha H / Abdellateif, Mona S / Kassem, Samar Hassab-Allah / Abd El Salam, Mohamed Ahmed / El Gammal, Mosaad M

    Andrologia

    2019  Volume 51, Issue 10, Page(s) e13384

    Abstract: Prostate cancer (PC) is considered as the fifth cause of cancer deaths worldwide. The exact etiopathogenesis is unclear; however, genetic predisposition, hormonal influencers, lifestyle and environmental factors act as major contributors. It has been ... ...

    Abstract Prostate cancer (PC) is considered as the fifth cause of cancer deaths worldwide. The exact etiopathogenesis is unclear; however, genetic predisposition, hormonal influencers, lifestyle and environmental factors act as major contributors. It has been found that several miRNAs may play a crucial role in cancer initiation and progression. Here, in this study, we evaluated the peripheral blood levels of miR-21, miR-141, miR-221 and miR-18a expression among 80 prostate cancer patients (50 localised and 30 metastatic) and 30 benign prostatic hyperplasia patients compared to 50 normal control subjects, using RT-PCR. Our results of analysis of miR-21, miR-141, miR-18a and miR-221 in the plasma of PC patients showed that miR-18a is a powerful discriminator of PC patients from healthy controls as it had the highest AUC (0.966; 95% CI, 0.937-1.000), while miR-221 provided better differentiation of metastatic from localised PC (sensitivity was 92.9% at 100% specificity), and when we combine miR-18a and miR-221 for differentiating patients with MPC, it will increase the sensitivity to 96.4% at a specificity of 100% (AUC, 0.997; 95% CI, 0.988-1.0) (p < .000). This current study recommends that analysis of these miRNAs might have clinical value in enhancing PSA testing.
    MeSH term(s) Adult ; Aged ; Biomarkers, Tumor/blood ; Circulating MicroRNA/blood ; Diagnosis, Differential ; Egypt ; Gene Expression Regulation, Neoplastic ; Humans ; Male ; MicroRNAs/blood ; Middle Aged ; Prospective Studies ; Prostatic Hyperplasia/blood ; Prostatic Hyperplasia/genetics ; Prostatic Neoplasms/blood ; Prostatic Neoplasms/diagnosis ; Prostatic Neoplasms/genetics ; ROC Curve
    Chemical Substances Biomarkers, Tumor ; Circulating MicroRNA ; MIRN141 microRNA, human ; MIRN18A microRNA, human ; MIRN21 microRNA, human ; MIRN221 microRNA, human ; MicroRNAs
    Language English
    Publishing date 2019-09-04
    Publishing country Germany
    Document type Journal Article
    ZDB-ID 7280-1
    ISSN 1439-0272 ; 0303-4569
    ISSN (online) 1439-0272
    ISSN 0303-4569
    DOI 10.1111/and.13384
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    In stock of ZB MED Cologne/Königswinter

    Zs.A 665: Show issues Location:
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    bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular
    Jg. 1995 - 2021: Lesesall (1.OG)
    ab Jg. 2022: Lesesaal (EG)

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