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  1. Article ; Online: Evaluating the benefit of immunotherapy for Stage III melanoma.

    Desai, Amar D / Ibrahim, Sarah J / Samie, Faramarz H

    Journal of the American Academy of Dermatology

    2024  

    Language English
    Publishing date 2024-04-27
    Publishing country United States
    Document type Journal Article
    ZDB-ID 603641-7
    ISSN 1097-6787 ; 0190-9622
    ISSN (online) 1097-6787
    ISSN 0190-9622
    DOI 10.1016/j.jaad.2024.04.058
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    In stock of ZB MED Cologne/Königswinter

    Zs.A 1540: Show issues Location:
    Je nach Verfügbarkeit (siehe Angabe bei Bestand)
    bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular
    Jg. 1995 - 2021: Lesesall (1.OG)
    ab Jg. 2022: Lesesaal (EG)

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  2. Article ; Online: Limited Optimal Plastic Behavior of RC Beams Strengthened by Carbon Fiber Polymers Using Reliability-Based Design.

    Khaleel Ibrahim, Sarah / Movahedi Rad, Majid

    Polymers

    2023  Volume 15, Issue 3

    Abstract: The plastic behavior of strengthened haunched beams utilizing carbon fiber-reinforced polymers (CFRP) was investigated using a probabilistic design that took into account random concrete properties, CFRP properties, and complementary strain energy values, ...

    Abstract The plastic behavior of strengthened haunched beams utilizing carbon fiber-reinforced polymers (CFRP) was investigated using a probabilistic design that took into account random concrete properties, CFRP properties, and complementary strain energy values, with the reliability index serving as a limiting index, as the proposed method considers a novel method that deals with probabilistic parameters for models with limited plastic behavior designed based on the reliability index. The data used in this research were gathered and evaluated in a recent study on simply supported haunched beams reinforced with carbon fiber-reinforced polymers. The purpose of this research was to use the reliability limitation index for simulated strengthened haunched beams by taking into account randomness in concrete and CFRP properties and the complementary strain energy value, which is considered a plastic behavior controller that provides an illustration of the damage amount within the reinforcement steel bars. The results indicate how randomness affects the behavior of the presented models, which are chosen to have different numbers of CFRP strips. The variable randomness affects load and deflection values where the reliability index value increases as the corresponding load value decrease, reflecting the increased probability of failure in models subjected to higher loading conditions, while tension concrete damage percentages are reflected in the damage pattern presented in the results, showing that as the produced load increases, so does the damage intensity. It is also obvious that the reliability index served as a limitation index while taking concrete characteristics and complementary strain energy as random variables.
    Language English
    Publishing date 2023-01-22
    Publishing country Switzerland
    Document type Journal Article
    ZDB-ID 2527146-5
    ISSN 2073-4360 ; 2073-4360
    ISSN (online) 2073-4360
    ISSN 2073-4360
    DOI 10.3390/polym15030569
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  3. Article ; Online: Reliability‑based probabilistic numerical plastically limited analysis of reinforced concrete haunched beams.

    Khaleel Ibrahim, Sarah / Movahedi Rad, Majid

    Scientific reports

    2023  Volume 13, Issue 1, Page(s) 2670

    Abstract: This research proposes a novel method that considers the optimal reliability-based design of reinforced concrete haunched beams subjected to probabilistic concrete properties and complementary strain energy values. The theory is applied twice, once to ... ...

    Abstract This research proposes a novel method that considers the optimal reliability-based design of reinforced concrete haunched beams subjected to probabilistic concrete properties and complementary strain energy values. The theory is applied twice, once to evaluate a deterministic solution, where the plastic behaviour is constrained by the complementary strain energy of residual stresses induced within steel bars. Secondly, the same method is considered for a probabilistic solution where the concrete characteristics-compressive strength and modulus of elasticity-and complementary strain energy value vary randomly. The reliability index acts as a bound for the solution. It is important to mention that the model utilised in this publication is derived from recent research after being calibrated using Abaqus. This work represents an extension of that recent research that exclusively considered deterministic work. This research led deterministically to new estimates for the complementary strain energy, which will be interpreted as reflecting the behaviour of plastic thresholds and quantifying the associated loads. Afterwards, uncertainty is studied when probability interferes, showing various load values and damage in concrete and steel when the complementary strain energy and concrete properties are probabilistically evaluated, giving a less reliable solution as the load reduces. These effects are reflected in the varying plastic behaviour of the investigated haunched beams.
    Language English
    Publishing date 2023-02-15
    Publishing country England
    Document type Journal Article
    ZDB-ID 2615211-3
    ISSN 2045-2322 ; 2045-2322
    ISSN (online) 2045-2322
    ISSN 2045-2322
    DOI 10.1038/s41598-023-29930-0
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  4. Article ; Online: Global Postmarket Pharmacovigilance: A Generic Drug Perspective.

    Dalsey, Taylor / Kim, Edward / Chazin, Howard / Ibrahim, Sarah

    Therapeutic innovation & regulatory science

    2023  Volume 57, Issue 6, Page(s) 1180–1189

    Abstract: Despite the recognized need for generic drug pharmacovigilance harmonization efforts, only a few studies compared generic drug postmarket safety and surveillance methods adopted by regulatory agencies in different countries. The purpose of this research ... ...

    Abstract Despite the recognized need for generic drug pharmacovigilance harmonization efforts, only a few studies compared generic drug postmarket safety and surveillance methods adopted by regulatory agencies in different countries. The purpose of this research is to collect available information from a sample of international regulators with the overall goal of providing a general overview of each agency's decision-making processes for postmarket generic drug safety and surveillance. A structured four-part questionnaire of open-ended and multiple-choice questions along with a semi-structured interview were designed to elicit detailed information. Swissmedic, Medicines and Healthcare products Regulatory Agency (MHRA), Health Canada, and the U.S. Food and Drug Administration (FDA) provided information. Detailed information from participating regulatory agencies demonstrated some similarities and differences in their postmarket generic drug pharmacovigilance approaches. This study examines each agency's scientific perspective to address generic drug safety issues, as well as to identify common barriers within decision-making processes, such as legislative restrictions and limited resources. Most agencies do not have specific processes that are unique to generic drug products. This exploratory study, through documenting common and unique approaches intends to create a greater awareness and to promote cross-collaboration between global regulatory agencies.
    Language English
    Publishing date 2023-08-10
    Publishing country Switzerland
    Document type Journal Article ; Review
    ZDB-ID 2708397-4
    ISSN 2168-4804 ; 2168-4790
    ISSN (online) 2168-4804
    ISSN 2168-4790
    DOI 10.1007/s43441-023-00558-6
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  5. Article ; Online: Carcinoma en Cuirasse.

    Ibrahim, Sarah A / Wallis, Luke S / Reid, David C

    JAMA dermatology

    2023  Volume 159, Issue 5, Page(s) 555–556

    MeSH term(s) Humans ; Female ; Breast Neoplasms/pathology ; Skin Neoplasms/diagnosis ; Skin Neoplasms/pathology ; Carcinoma
    Language English
    Publishing date 2023-05-08
    Publishing country United States
    Document type Journal Article
    ZDB-ID 2701761-8
    ISSN 2168-6084 ; 2168-6068
    ISSN (online) 2168-6084
    ISSN 2168-6068
    DOI 10.1001/jamadermatol.2022.5934
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    In stock of ZB MED Cologne/Königswinter

    Ui VI Zs.32: Show issues Location:
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  6. Article ; Online: Associated autoimmune thyroid diseases in children and adolescents with type one diabetes in Jordan.

    Odeh, Rasha / Gharaibeh, Lobna / Ibrahim, Sarah / Alassaf, Abeer

    Journal of pediatric endocrinology & metabolism : JPEM

    2023  Volume 36, Issue 10, Page(s) 917–924

    Abstract: Objectives: To investigate the prevalence of thyroid autoimmunity and related thyroid disorders among children and adolescents with type 1 diabetes in Jordan.: Methods: In a retrospective study, thyroid stimulating hormone and thyroid hormone (Free ... ...

    Abstract Objectives: To investigate the prevalence of thyroid autoimmunity and related thyroid disorders among children and adolescents with type 1 diabetes in Jordan.
    Methods: In a retrospective study, thyroid stimulating hormone and thyroid hormone (Free T4) levels were measured in 684 children with type 1 diabetes who presented to Jordan University Hospital between January 2012 and February 2021. Anti-thyroid peroxidase (TPOAb) and anti-thyroglobulin (TGAb) antibodies were measured in 526 and 438 subjects with type 1 diabetes, respectively.
    Results: 681 children were included in the study (52.4 % females, average current age 14.3 years, average age at diagnosis 8.0 years, and average diabetes duration 6.2 years). Of the whole group, 18 children (2.6 %) were diagnosed with subclinical hypothyroidism and 31 children (4.4 %) had overt hypothyroidism. Of those who were tested for TPOAb and TGAb, 22.6 and 23.1 % were positive respectively. Predictors for developing hypothyroidism were female sex and positive antibodies to glutamic acid decarboxylase.
    Conclusions: Screening for associated thyroid autoimmunity in children and adolescents with type one diabetes from Jordan is advised with a special focus on females and those with positive antibodies to glutamic acid decarboxylase.
    Language English
    Publishing date 2023-09-04
    Publishing country Germany
    Document type Journal Article
    ZDB-ID 1231070-0
    ISSN 2191-0251 ; 0334-018X
    ISSN (online) 2191-0251
    ISSN 0334-018X
    DOI 10.1515/jpem-2023-0322
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    In stock of ZB MED Cologne/Königswinter

    Zs.A 2258: Show issues Location:
    Je nach Verfügbarkeit (siehe Angabe bei Bestand)
    bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular
    Jg. 1995 - 2021: Lesesall (1.OG)
    ab Jg. 2022: Lesesaal (EG)

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  7. Article ; Online: Influence of Diabetes Mellitus on Oncological Outcomes for Patients Living With Cancer.

    Murphy, Lara / Sherifali, Diana / Ali, Muhammad Usman / Ibrahim, Sarah

    The science of diabetes self-management and care

    2023  Volume 49, Issue 2, Page(s) 163–179

    Abstract: Purpose: The purpose of this meta-analysis was to examine the association between preexisting diabetes in persons living with cancer on diabetes and oncology-related health outcomes. Understanding this association is of priority because the incidence of ...

    Abstract Purpose: The purpose of this meta-analysis was to examine the association between preexisting diabetes in persons living with cancer on diabetes and oncology-related health outcomes. Understanding this association is of priority because the incidence of both cancer and diabetes mellitus is increasing worldwide.
    Methods: A comprehensive review of the literature was conducted in collaboration with an expert health sciences librarian. Two authors independently conducted the screening, data collection, and extraction processes. The risk of bias was assessed using several tools, depending on the study design. Relative risks with 95% confidence intervals were calculated. The alpha threshold was 0.05. All analyses were performed using R statistical software (Metaphor and Demeter packages).
    Results: A total of 45 studies met the selection criteria, but 23 were excluded from the synthesis because they did not have the ranked outcome or correct comparison (persons with and without diabetes), totaling 22 studies included in the meta-analysis. In comparison to participants without preexisting diabetes, participants with preexisting diabetes and cancer were found to have a significantly higher risk of infection and cardiovascular, neurological, gastrointestinal, hepatic, and renal complications. Concurrent preexisting diabetes and cancer were also associated with increased health care service utilization and length of hospital stay.
    Conclusion: The findings from this review highlight the importance of optimal concurrent management of both diseases by overcoming the compartmentalization of medical specializations through (1) integrated, multidisciplinary, shared, and coordinated clinical care pathways between oncology and diabetes health care providers/teams and (2) the continued development of evidence-based clinical guidelines.
    MeSH term(s) Humans ; Diabetes Mellitus ; Length of Stay ; Neoplasms
    Language English
    Publishing date 2023-02-15
    Publishing country United States
    Document type Meta-Analysis ; Journal Article ; Review
    ISSN 2635-0114
    ISSN (online) 2635-0114
    DOI 10.1177/26350106231153073
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  8. Article ; Online: Experimental and Numerical Analysis of Steel-Polypropylene Hybrid Fibre Reinforced Concrete Deep Beams.

    Khaleel Ibrahim, Sarah / Abbas Hadi, Noor / Movahedi Rad, Majid

    Polymers

    2023  Volume 15, Issue 10

    Abstract: This work experimentally and numerically explored how varied steel-polypropylene fibre mixtures affected simply supported reinforced concrete deep beams. Due to their better mechanical qualities and durability, fibre-reinforced polymer composites are ... ...

    Abstract This work experimentally and numerically explored how varied steel-polypropylene fibre mixtures affected simply supported reinforced concrete deep beams. Due to their better mechanical qualities and durability, fibre-reinforced polymer composites are becoming more popular in construction, with hybrid polymer-reinforced concrete (HPRC) promising to increase the strength and ductility of reinforced concrete structures. The study evaluated how different combinations of steel fibres (SF) and polypropylene fibres (PPF) affected beam behaviour experimentally and numerically. The study's focus on deep beams, research of fibre combinations and percentages, and integration of experimental and numerical analysis provide unique insights. The two experimental deep beams were the same size and were composed of hybrid polymer concrete or normal concrete without fibres. Fibres increased deep beam strength and ductility in experiments. The calibrated concrete damage plasticity model in ABAQUS was used to numerically calibrate HPRC deep beams with different fibre combinations at varied percentages. Based on six experimental concrete mixtures, calibrated numerical models of deep beams with different material combinations were investigated. The numerical analysis confirmed that fibres increased deep beam strength and ductility. HPRC deep beams with fibre performed better than those without fibres in numerical analysis. The study also determined the best fibre percentage to improve deep beam behaviour where a combination of 0.75% SF and 0.25% PPF was recommended to enhance load-bearing capacity and crack distribution, while a higher content of PPF was suggested for reducing deflection.
    Language English
    Publishing date 2023-05-17
    Publishing country Switzerland
    Document type Journal Article
    ZDB-ID 2527146-5
    ISSN 2073-4360 ; 2073-4360
    ISSN (online) 2073-4360
    ISSN 2073-4360
    DOI 10.3390/polym15102340
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  9. Article ; Online: Responding to the Humanitarian Crisis in Gaza: Damned if You do… Damned if You don't!

    Farhat, Theresa / Ibrahim, Sarah / Abdul-Sater, Zahi / Abu-Sittah, Ghassan

    Annals of global health

    2023  Volume 89, Issue 1, Page(s) 53

    Abstract: Palestine, since 1948, has endured frequent military occupations and uprisings, ...

    Abstract Palestine, since 1948, has endured frequent military occupations and uprisings,
    MeSH term(s) Humans ; Anxiety ; Arabs ; Israel ; Middle East ; Military Personnel
    Language English
    Publishing date 2023-08-21
    Publishing country United States
    Document type Journal Article
    ZDB-ID 2821756-1
    ISSN 2214-9996 ; 2214-9996
    ISSN (online) 2214-9996
    ISSN 2214-9996
    DOI 10.5334/aogh.3975
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  10. Article: Primary cutaneous blastomycosis after eyebrow wax burn.

    Ibrahim, Sarah A / Trivedi, Megha / Reid, David C

    JAAD case reports

    2022  Volume 23, Page(s) 52–54

    Language English
    Publishing date 2022-03-02
    Publishing country United States
    Document type Case Reports
    ZDB-ID 2834220-3
    ISSN 2352-5126
    ISSN 2352-5126
    DOI 10.1016/j.jdcr.2022.02.019
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