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Article: Autologous Nanofat Injection Combined with Fractional CO2 Laser in the Treatment of Atrophic Acne Scars.

Rageh, Mahmoud A / Ibrahim, Shady Mahmoud Attia / Abdallah, Noha / Tawfik, Abeer Attia

Clinical, cosmetic and investigational dermatology

2024 Volume 17, Page(s) 697–705

Abstract: Background: Atrophic acne scarring is a widely prevalent condition and one of the most distressing complications of acne vulgaris. Numerous options with variable outcomes are available for the treatment of acne scarring. Laser is considered a first-line ...

Abstract	Background: Atrophic acne scarring is a widely prevalent condition and one of the most distressing complications of acne vulgaris. Numerous options with variable outcomes are available for the treatment of acne scarring. Laser is considered a first-line therapy for acne scars, and recently there has been a growing interest in using stem cells and their derivatives for treating acne scars. In addition, combined therapeutic modalities often achieve more satisfactory results than a single treatment. Objective: We tried to evaluate the role of nanofat and fractional CO2 laser as a combined treatment approach for atrophic acne scarring. Methods: Twenty-five patients with atrophic acne scarring were enrolled. They received a single session of intradermal nanofat injection, at different points 1 cm apart, for acne scars. Two weeks later, they were treated with three sessions of fractional CO2 laser at monthly intervals. Patients were evaluated three months after the last session using the quantitative Goodman and Baron scoring system. Pain, side effects, and patients' satisfaction were also evaluated. Results: There were two males and 23 females with a mean age of 25.96 years. Their skin type ranged between Fitzpatrick skin type III, IV, and V. Boxcar scars were the most common scar type in 13 patients (52%). After treatment, there was a significant reduction (p <0.05) in the quantitative Goodman and Baron scores. The improvement was more evident in rolling scars. Seven patients reported significant improvement, and 12 reported marked improvement. Conclusion: This study showed that combining nanofat and fractional CO2 laser is a safe and effective treatment modality for atrophic acne scars.
Language	English
Publishing date	2024-03-20
Publishing country	New Zealand
Document type	Journal Article
ZDB-ID	2494852-4
ISSN	1178-7015
ISSN	1178-7015
DOI	10.2147/CCID.S454514
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Article ; Online: Efficacy of Platelet-Rich Plasma Versus Autologous Fat Transfer With Nanofat in the Treatment of Infraorbital Dark Circles: A Single-Blinded Randomized Comparative Clinical Trial.

Kadry, Ahmed / Gamal, Ahmed / Alkhalifah, Azzam / Ibrahim, Shady Mahmoud Attia

Dermatologic surgery : official publication for American Society for Dermatologic Surgery [et al.

2023 Volume 49, Issue 3, Page(s) 247–252

Abstract: Background: Treating infraorbital dark circles is one of the commonest aesthetic demands worldwide. Autologous fat transfer is commonly used to treat dark circles by filling the grooves, without effect on skin quality. Platelet-rich plasma has been ... ...

Abstract	Background: Treating infraorbital dark circles is one of the commonest aesthetic demands worldwide. Autologous fat transfer is commonly used to treat dark circles by filling the grooves, without effect on skin quality. Platelet-rich plasma has been reported to improve skin quality. Autologous fat can be emulsified and filtered to produce nanofat, which is then injected superficially in the dark circles to improve skin quality and discoloration. Objective: To compare the efficacy of platelet-rich plasma versus combined fat transfer and nanofat in treating infraorbital dark circles. Materials and methods: 30 patients with infraorbital dark circles of combined etiological factors were randomized into 2 equal groups: Group A treated with platelet-rich plasma and Group B treated with autologous fat transfer with emulsified fat injection. Results: Excellent and moderate responses were observed in 3 (20%) and 2 (13%) patients in group A versus 7 (46.7%) and 4 (27%) in group B, respectively. Nonresponders were 8 (53.3%) in group A and only 1 patient (6.7%) in group B. The difference was statistically significant regarding improvement ( p = .048) and patient satisfaction ( p = .032). Conclusion: Autologous fat transfer with nanofat is significantly superior to platelet-rich plasma in improvement and satisfaction.
MeSH term(s)	Humans ; Patient Satisfaction ; Platelet-Rich Plasma ; Low-Level Light Therapy ; Skin ; Treatment Outcome
Language	English
Publishing date	2023-02-02
Publishing country	United States
Document type	Randomized Controlled Trial ; Journal Article
ZDB-ID	1227586-4
ISSN	1524-4725 ; 1076-0512
ISSN (online)	1524-4725
ISSN	1076-0512
DOI	10.1097/DSS.0000000000003697
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Article ; Online: Fractional CO 2 Laser Combined With Autologous Nanofat Injection Versus Fractional CO 2 Laser Combined With Platelet-Rich Plasma in the Treatment of Atrophic Acne Scars: A Split-Face Comparative Study With Optical Skin Imaging.

Rageh, Mahmoud A / Tawfik, Abeer Attia / Abdallah, Noha / Ibrahim, Shady Mahmoud Attia

Dermatologic surgery : official publication for American Society for Dermatologic Surgery [et al.

2023 Volume 50, Issue 1, Page(s) 75–80

Abstract: Background: Atrophic acne scarring is a common problem. If left untreated, its implications can impair the quality of life. Various treatments, with differing degrees of success, are used to alleviate atrophic scars.: Objective: To assess the ... ...

Abstract	Background: Atrophic acne scarring is a common problem. If left untreated, its implications can impair the quality of life. Various treatments, with differing degrees of success, are used to alleviate atrophic scars. Objective: To assess the efficacy of nanofat versus platelet-rich plasma (PRP) as an adjuvant therapy to fractional CO 2 laser (FCL) for atrophic acne scars. Methods: This study included 35 patients with atrophic acne scars who received 3 sessions of FCL at 1-month intervals on both sides of the face, followed by intradermal PRP injection on the left side. A single session of nanofat was injected into the right side of the face 2 weeks before the laser sessions. The evaluation was conducted 3 months after the final treatment session. Results: After treatment, the right side of the face showed a significant reduction in Goodman scores and the indentation index of the Antera camera. The left side showed a significant difference in Goodman scores, yet the Antera camera showed a nonsignificant improvement. Nonetheless, the difference between the 2 sides was statistically insignificant. Conclusion: Atrophic acne scars improved with both modalities. As a result, cotreatment with these techniques may synergistically affect atrophic acne scars in efficacy and safety.
MeSH term(s)	Humans ; Cicatrix/etiology ; Cicatrix/therapy ; Cicatrix/pathology ; Quality of Life ; Treatment Outcome ; Acne Vulgaris/complications ; Acne Vulgaris/therapy ; Connective Tissue Diseases ; Platelet-Rich Plasma ; Atrophy
Language	English
Publishing date	2023-11-28
Publishing country	United States
Document type	Journal Article
ZDB-ID	1227586-4
ISSN	1524-4725 ; 1076-0512
ISSN (online)	1524-4725
ISSN	1076-0512
DOI	10.1097/DSS.0000000000003968
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Article ; Online: Comparative study between topical steroid alone versus combined fractional Erbium:YAG laser with topical steroid in treatment of alopecia areata.

Shokeir, Hesham Ali / Yousry, Anas / Ibrahim, Shady Mahmoud Attia

Archives of dermatological research

2022 Volume 315, Issue 2, Page(s) 241–247

Abstract: AA is a common autoimmune skin disease that causes hair loss on the scalp and sometimes other areas of the body. New therapy approaches for alopecia areata are emerging, with the goal of improving clinical outcomes. In this study, the effects of topical ... ...

Abstract	AA is a common autoimmune skin disease that causes hair loss on the scalp and sometimes other areas of the body. New therapy approaches for alopecia areata are emerging, with the goal of improving clinical outcomes. In this study, the effects of topical steroids against fractional Er:YAG laser followed by topical steroids in the treatment of alopecia areata will be compared. A total of 30 participants with alopecia areata were included in the study. Each patient's lesions were treated with one of two methods: topical clobetasol propionate or fractional Er:YAG laser followed by topical clobetasol propionate. SALT score, patient satisfaction, and dermoscopic imaging were used to evaluate therapeutic response. Both treatment modalities showed a significant clinical improvement in alopecia areata with a statistically significant reduction in the SALT score. The SALT score was more evident in the laser-steroid group. On comparing the dermoscopy findings in both treated areas before and after treatment, a significant reduction was found regarding all dermoscopic findings of alopecia areata in both modalities. Combining fractional Er:YAG laser with topical steroids is found to be a safe treatment modality and more effective than topical steroids in alopecia areata.
MeSH term(s)	Humans ; Alopecia Areata/drug therapy ; Alopecia Areata/pathology ; Clobetasol/therapeutic use ; Erbium/therapeutic use ; Lasers, Solid-State/therapeutic use ; Treatment Outcome ; Steroids/therapeutic use
Chemical Substances	Clobetasol (ADN79D536H) ; Erbium (77B218D3YE) ; Steroids
Language	English
Publishing date	2022-10-20
Publishing country	Germany
Document type	Journal Article
ZDB-ID	130131-7
ISSN	1432-069X ; 0340-3696
ISSN (online)	1432-069X
ISSN	0340-3696
DOI	10.1007/s00403-022-02417-0
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Article ; Online: Multipass low fluence, high-frequency 755-nm alexandrite laser versus high fluence, low-frequency 1064-nm long-pulsed Nd: YAG laser in axillary hair reduction of dark skin phototypes: an intra-individual randomized comparative study.

Moftah, Nayera / Tymour, Mai / Ibrahim, Shady Mahmoud Attia

The Journal of dermatological treatment

2022 Volume 33, Issue 4, Page(s) 2079–2084

Abstract: Background: Laser hair removal has become popular means of achieving hair reduction with improved quality of life.: Objective: This study aimed to assess the safety and efficacy of Multipass low fluence, high-frequency 755-nm Alexandrite laser versus ...

Abstract	Background: Laser hair removal has become popular means of achieving hair reduction with improved quality of life. Objective: This study aimed to assess the safety and efficacy of Multipass low fluence, high-frequency 755-nm Alexandrite laser versus the high fluence, low-frequency 1064-nm long-pulsed Nd: YAG laser on axillary hair reduction in women with dark skin phototypes. Patients and methods: This study was carried out on 30 adult women [skin type, IV-VI)] who seek axillary hair reduction. These subjects were adjusted to receive 5 laser sessions with a 1-month interval. One side received high fluence, low-frequency 1064-nm laser where the other side received multipass low fluence, high-frequency 755 nm laser. The follow-up was done using photographs, folliscope, patients' visual analog pain scale. Results: The mean percentage of hair density reduction showed significant improvement in both treated sides being higher in the Alex treated side with corresponding significant decreases in the mean hair thickness. Conclusion: Multipass low fluence, high-frequency 755-nm Alex laser practice was verified to be safe and effective for hair removal in dark skin phototypes compared to the high fluence, low frequency 1064-nm long-pulsed Nd:YAG laser.
MeSH term(s)	Adult ; Axilla ; Female ; Hair ; Hair Removal ; Humans ; Lasers, Solid-State/therapeutic use ; Quality of Life ; Treatment Outcome
Language	English
Publishing date	2022-03-10
Publishing country	England
Document type	Journal Article
ZDB-ID	1036299-x
ISSN	1471-1753 ; 0954-6634
ISSN (online)	1471-1753
ISSN	0954-6634
DOI	10.1080/09546634.2021.1914311
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Article ; Online: Clinical evaluation of efficacy of intralesional platelet-rich plasma injection versus 1064 nm long-pulsed Neodymium:YAG laser in the treatment of inflammatory acne vulgaris in adolescent and post-adolescent patients: a prospective randomized split-face comparative study.

Moftah, Nayera Hassan / Mansour, Aya Muhammad / Ibrahim, Shady Mahmoud Attia

Lasers in medical science

2022 Volume 37, Issue 5, Page(s) 2471–2478

Abstract: Large numbers of local and systemic therapies are available for acne treatment. Common oral or topical retinoids, antibiotics, or keratolytics are used but sometimes are inconvenient, and side effects caused by these conventional therapies prompted a ... ...

Abstract	Large numbers of local and systemic therapies are available for acne treatment. Common oral or topical retinoids, antibiotics, or keratolytics are used but sometimes are inconvenient, and side effects caused by these conventional therapies prompted a search for effective and safe treatments. This study aimed to evaluate the efficacy of intralesional platelet-rich plasma injection versus 1064 nm long-pulsed Nd:YAG laser in the treatment of moderate inflammatory acne vulgaris in both adolescents and post-adolescent patients. This split-face comparative study was carried out on thirty patients who suffered from moderate inflammatory and non-inflammatory acne vulgaris. The patients were classified into two groups: group I: adolescent (≤ 25 years) and group II: post-adolescent (< 25 years). Each group received four sessions of intralesional PRP injection on one side of the face and a long-pulsed Nd:YAG (1064 nm) laser on the other side with 2 weeks interval. Evaluation was done by blinded dermatologists using photographs and lesions counting and by patient satisfaction. Side effects were also noted. Both groups (adolescents and post-adolescent) showed a high statistically significant improvement of inflammatory as well as non-inflammatory lesions either in PRP or Nd:YAG laser-treated side with no significant difference between the two sides. The intralesional PRP injection and 1064 nm long-pulsed Nd:YAG laser are safe and effective methods for controlling inflammatory as well as non-inflammatory acne vulgaris in both adolescents and post-adolescent patients.
MeSH term(s)	Acne Vulgaris/therapy ; Adolescent ; Humans ; Lasers, Solid-State/therapeutic use ; Neodymium ; Platelet-Rich Plasma ; Prospective Studies ; Treatment Outcome
Chemical Substances	Neodymium (2I87U3734A)
Language	English
Publishing date	2022-01-27
Publishing country	England
Document type	Journal Article ; Randomized Controlled Trial
ZDB-ID	632808-8
ISSN	1435-604X ; 0268-8921
ISSN (online)	1435-604X
ISSN	0268-8921
DOI	10.1007/s10103-022-03510-6
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Article ; Online: Autologous nanofat injection in treatment of scars: A clinico-histopathological study.

Rageh, Mahmoud A / El-Khalawany, Mohamed / Ibrahim, Shady Mahmoud Attia

Journal of cosmetic dermatology

2021 Volume 20, Issue 10, Page(s) 3198–3204

Abstract: Background: Scars are the unfortunate outcome of most injuries and some diseases. Its psychological impact on patients can deeply affect their quality of life.: Aim: The aim of this study was to evaluate the efficacy of autologous nanofat injection ... ...

Abstract	Background: Scars are the unfortunate outcome of most injuries and some diseases. Its psychological impact on patients can deeply affect their quality of life. Aim: The aim of this study was to evaluate the efficacy of autologous nanofat injection in improving the aesthetic outcome of scars, combined with histopathological correlation of the response. Patients and methods: Thirty patients with scars of different etiologies undergone one session of nanofat injection and evaluation was done 6 months after the session. Efficacy of treatment was assessed clinically using Vancouver scar scale by two independent blinded dermatologists and histopathologically using image analysis system. Results: The age of enrolled patients ranged from 18 to 40 years old. There was a statistically significant improvement on the total Vancouver scar scale regarding the height and pliability of the scars. Pathological evaluation showed an increase in epidermal thickness, increased number and density of collagen and elastic fibers along with neovascularization. Conclusion: Evidenced by clinical and pathological improvement, autologous nanofat injection is an effective strategy for treating scars of different etiologies.
MeSH term(s)	Adolescent ; Adult ; Cicatrix/etiology ; Cicatrix/therapy ; Esthetics ; Humans ; Quality of Life ; Transplantation, Autologous ; Treatment Outcome ; Young Adult
Language	English
Publishing date	2021-08-06
Publishing country	England
Document type	Journal Article
ZDB-ID	2280551-5
ISSN	1473-2165 ; 1473-2130
ISSN (online)	1473-2165
ISSN	1473-2130
DOI	10.1111/jocd.14363
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Article ; Online: Efficacy of autologous stromal vascular fraction injection in the treatment of androgenic alopecia.

El-Khalawany, Mohamed / Rageh, Mahmoud A / Elnokrashy, Ibrahim / Ibrahim, Shady Mahmoud Attia

Archives of dermatological research

2022 Volume 315, Issue 5, Page(s) 1269–1276

Abstract: Androgenic alopecia (AGA) is a common condition associated with loss of terminal hair on the scalp in a specific pattern in both males and females. Management of AGA is usually challenging as the approved therapeutic options are limited. Our aim was to ... ...

Abstract	Androgenic alopecia (AGA) is a common condition associated with loss of terminal hair on the scalp in a specific pattern in both males and females. Management of AGA is usually challenging as the approved therapeutic options are limited. Our aim was to evaluate the efficacy of non-enzymatic stromal vascular fraction (SVF) as a new promising treatment for AGA. From April to December 2021, this prospective study included 30 patients with AGA who were enrolled from the University Hospitals' dermatology outpatient clinics. Patients received a single session of autologous SVF injection and were then followed up for 6 months. There was an increase in hair shaft caliber from 0.037 ± 0.01 mm before treatment with SVF to 0.056 ± 0.02 mm after 6 months of treatment. Also, hair count/cm
MeSH term(s)	Humans ; Male ; Female ; Stromal Vascular Fraction ; Prospective Studies ; Alopecia/therapy ; Hair ; Scalp
Language	English
Publishing date	2022-12-16
Publishing country	Germany
Document type	Journal Article
ZDB-ID	130131-7
ISSN	1432-069X ; 0340-3696
ISSN (online)	1432-069X
ISSN	0340-3696
DOI	10.1007/s00403-022-02501-5
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Article ; Online: Pulsed dye laser versus Nd:YAG laser in the treatment of recalcitrant plantar warts: an intraindividual comparative study.

Ibrahim, Shady Mahmoud Attia / Soliman, Mona / Mohamed, Sahar Khalaf Allah / Soliman, Mohamed Mohsen

Journal of cosmetic and laser therapy : official publication of the European Society for Laser Dermatology

2022 Volume 23, Issue 5-6, Page(s) 130–136

Abstract: Plantar warts are common cutaneous lesions caused by the human papillomavirus. Treatment of recalcitrant plantar warts stays a continuous challenge, and they are more refractory to treatment than common warts. To compare the efficacy of Long-Pulsed ... ...

Abstract	Plantar warts are common cutaneous lesions caused by the human papillomavirus. Treatment of recalcitrant plantar warts stays a continuous challenge, and they are more refractory to treatment than common warts. To compare the efficacy of Long-Pulsed neodymium: yttrium-aluminum-garnet (Nd:YAG) laser versus pulsed dye laser (PDL) on the therapy of multiple recalcitrant plantar warts. Thirty patients with recalcitrant plantar warts were included in the current study. Half the number of warts were treated by PDL in each patient, while the other half were treated by Nd:YAG. Laser sessions were applied every 2 weeks for a maximum of six sessions. Patients were followed up both clinically and using dermoscopy. There was a complete clearance of warts in 20 patients (66.7%) with Nd:YAG laser and 19 patients (63.3%) with PDL with no statistically significant difference between both types of lasers. Pain during laser sessions was higher with Nd:YAG laser PDL and it was statistically significant (
MeSH term(s)	Humans ; Lasers, Dye/adverse effects ; Lasers, Solid-State/adverse effects ; Neodymium ; Pain/etiology ; Treatment Outcome ; Warts/complications
Chemical Substances	Neodymium (2I87U3734A)
Language	English
Publishing date	2022-01-03
Publishing country	England
Document type	Journal Article
ZDB-ID	2146360-8
ISSN	1476-4180 ; 1476-4172
ISSN (online)	1476-4180
ISSN	1476-4172
DOI	10.1080/14764172.2021.2016843
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Article ; Online: Fractional CO

Abd ElKawy, Faten Abd ElWadoud / Aly, Shaimaa Hassan Mohammed / Ibrahim, Shady Mahmoud Attia

Dermatologic therapy

2022 Volume 35, Issue 7, Page(s) e15553

Abstract: New treatment modalities are rising for better clinical improvement in alopecia areata. This work aims to evaluate the efficacy of fractional ... ...

Abstract	New treatment modalities are rising for better clinical improvement in alopecia areata. This work aims to evaluate the efficacy of fractional CO
MeSH term(s)	Alopecia Areata/diagnostic imaging ; Alopecia Areata/therapy ; Carbon Dioxide/therapeutic use ; Drug Delivery Systems ; Humans ; Lasers, Gas/therapeutic use ; Treatment Outcome
Chemical Substances	Carbon Dioxide (142M471B3J)
Language	English
Publishing date	2022-05-12
Publishing country	United States
Document type	Journal Article ; Randomized Controlled Trial
ZDB-ID	1354801-3
ISSN	1529-8019 ; 1396-0296
ISSN (online)	1529-8019
ISSN	1396-0296
DOI	10.1111/dth.15553
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