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Article: Editorial: Cancer stem cells as attractive targets for breast cancer therapy.

Ibrahim, Sherif Abdelaziz / Yip, George W / Götte, Martin

2023 Volume 13, Page(s) 1151742

Language	English
Publishing date	2023-03-03
Publishing country	Switzerland
Document type	Editorial
ZDB-ID	2649216-7
ISSN	2234-943X
ISSN	2234-943X
DOI	10.3389/fonc.2023.1151742
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Article: Revisiting the Syndecans: Master Signaling Regulators with Prognostic and Targetable Therapeutic Values in Breast Carcinoma.

Motta, Juliana Maria / Hassan, Hebatallah / Ibrahim, Sherif Abdelaziz

Cancers

2023 Volume 15, Issue 6

Abstract: Syndecans (SDC1 to 4), a family of cell surface heparan sulfate proteoglycans, are frequently expressed in mammalian tissues. SDCs are aberrantly expressed either on tumor or stromal cells, influencing cancer initiation and progression through their ... ...

Abstract	Syndecans (SDC1 to 4), a family of cell surface heparan sulfate proteoglycans, are frequently expressed in mammalian tissues. SDCs are aberrantly expressed either on tumor or stromal cells, influencing cancer initiation and progression through their pleiotropic role in different signaling pathways relevant to proliferation, cell-matrix adhesion, migration, invasion, metastasis, cancer stemness, and angiogenesis. In this review, we discuss the key roles of SDCs in the pathogenesis of breast cancer, the most common malignancy in females worldwide, focusing on the prognostic significance and molecular regulators of SDC expression and localization in either breast tumor tissue or its microenvironmental cells and the SDC-dependent epithelial-mesenchymal transition program. This review also highlights the molecular mechanisms underlying the roles of SDCs in regulating breast cancer cell behavior via modulation of nuclear hormone receptor signaling, microRNA expression, and exosome biogenesis and functions, as well as summarizing the potential of SDCs as promising candidate targets for therapeutic strategies against breast cancer.
Language	English
Publishing date	2023-03-16
Publishing country	Switzerland
Document type	Journal Article ; Review
ZDB-ID	2527080-1
ISSN	2072-6694
ISSN	2072-6694
DOI	10.3390/cancers15061794
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Article ; Online: Allolobophora caliginosa coelomic fluid and extract alleviate glucocorticoid-induced osteoporosis in mice by suppressing oxidative stress and regulating osteoblastic/osteoclastic-related markers.

Abdelfattah, Marwa Ahmed / Mohamed, Ayman Saber / Ibrahim, Sherif Abdelaziz / Fahmy, Sohair R

Scientific reports

2023 Volume 13, Issue 1, Page(s) 2090

Abstract: Allolobophora calignosa (Ac) is a folk medicine for millennia, as it possesses many biological activities. This study aimed to investigate the chemo-preventive activity of A.calignosa coelomic fluid (AcCF) and A.calignosa extract (AcE) on glucocorticoid- ... ...

Abstract	Allolobophora calignosa (Ac) is a folk medicine for millennia, as it possesses many biological activities. This study aimed to investigate the chemo-preventive activity of A.calignosa coelomic fluid (AcCF) and A.calignosa extract (AcE) on glucocorticoid-induced osteoporosis (GIOP) in mice. Characterization and in vitro biological activity of AcE and AcCF has been assessed. Male CD-1 mice were subcutaneously received dexamethasone (DEX) (1 mg/kg, 5 times/week) and concurrently intraperitoneally treated with either AcCF (20 mg/kg) or AcE (45 mg/kg) every other day for 28 days. Serum and bone homogenates were subjected for qPCR and biochemical analysis. AcE and AcCF treatment significantly increased bone mineral density (BMD), bone mineral content (BMC), calcium (Ca), phosphorus (P), and calcitonin levels, whereas activity of serum alkaline phosphatase (ALP), bone alkaline phosphatase (BALP), serum acidic phosphatase (ACP), bone acidic phosphatase (BACP) and parathyroid hormone (PTH) levels were significantly reduced compare with untreated GIOP mice. Treatment with AcE and AcCF modulates oxidative stress and downregulated Rank and Mmp9 expression, as well as increased glycosaminoglycan content in the organic bone matrix, resulting in osteoclastogenesis inhibition. Overall, AcCF and AcE show a chemo-preventive activity against GIOP by inhibiting oxidative stress and regulating expression and/or activity of osteoblast/osteoclast-related markers.
MeSH term(s)	Mice ; Male ; Animals ; Glucocorticoids/pharmacology ; Osteoclasts/metabolism ; Alkaline Phosphatase/metabolism ; Osteoporosis/chemically induced ; Osteoporosis/drug therapy ; Osteoporosis/metabolism ; Bone Density ; Osteoblasts/metabolism ; Parathyroid Hormone/metabolism ; Oxidative Stress
Chemical Substances	Glucocorticoids ; Alkaline Phosphatase (EC 3.1.3.1) ; Parathyroid Hormone
Language	English
Publishing date	2023-02-06
Publishing country	England
Document type	Journal Article ; Research Support, Non-U.S. Gov't
ZDB-ID	2615211-3
ISSN	2045-2322 ; 2045-2322
ISSN (online)	2045-2322
ISSN	2045-2322
DOI	10.1038/s41598-023-29070-5
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Article ; Online: Foliar Spraying of Nano-Silicate and Nano-Zinc on Wheat (Triticum aestivum L.) Under Salt Stress Conditions Enhances Productivity and Reduces the Optimal Nitrogen Fertilizer Rate

Ali, Ali M. / Ibrahim, Sherif M. / Omer, Amal M.

Communications in Soil Science and Plant Analysis. 2023 Oct. 28, v. 54, no. 19 p.2731-2744

2023

Abstract: Salinity stress poses a significant threat to agriculture, as it directly impacts crop growth and yield. The current study aimed at examining the role of foliar nano-silicate (nSiO₂) and nano-zinc (nZnO) applications in increasing wheat productivity and ... ...

Abstract	Salinity stress poses a significant threat to agriculture, as it directly impacts crop growth and yield. The current study aimed at examining the role of foliar nano-silicate (nSiO₂) and nano-zinc (nZnO) applications in increasing wheat productivity and nitrogen (N) use efficiency under salt stress conditions. A two-season field experiment was carried out on sandy soils irrigated with water from high-saline wells (4352 and 7040 mg L⁻¹). The study was conducted in a split-plot design, with main plots assigned to three treatments of foliar application of nSiO₂, nZnO, and control (nZero), and sub-plots assigned to six N fertilizer rates (0–300 kg N ha⁻¹). The use of nSiO₂ and nZnO increased wheat grain yield by 67 and 48% on average over nZero, respectively. When average wheat grain yields were plotted against increasing N fertilizer rates, a quadratic response curve was observed. Derivative solutions of the quadratic functions indicated that grain yield plateaued at 4641, 4560, and 3182 kg ha⁻¹ for nSiO₂, nZnO, and nZero treatments, respectively. The optimal N fertilizer rates for these yield levels were calculated to be 290, 353, and 386 kg N ha⁻¹. When the net returns to N fertilizer and nano-material use were considered, nSiO₂ had the highest net returns and the lowest optimal N fertilizer rate (229 kg N ha⁻¹), followed by nZnO (272 kg N ha⁻¹). The findings of the field experiment demonstrated that foliar spraying wheat with nSiO₂ and nZnO under salt stress conditions enhances productivity as well as responsiveness to N fertilizer.
Keywords	Triticum aestivum ; experimental design ; fertilizer rates ; field experimentation ; foliar application ; grain yield ; nanomaterials ; nitrogen ; nitrogen fertilizers ; plant analysis ; salt stress ; wheat ; N recovery efficiency ; nano-materials
Language	English
Dates of publication	2023-1028
Size	p. 2731-2744.
Publishing place	Taylor & Francis
Document type	Article ; Online
ZDB-ID	419718-5
ISSN	1532-2416 ; 0010-3624
ISSN (online)	1532-2416
ISSN	0010-3624
DOI	10.1080/00103624.2023.2240817
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Article ; Online: Inversion radiography for imperforate anus: Recalling the anatomical concept.

AbouZeid, Amr Abdelhamid / Ibrahim, Sherif Elhussiny / Hamad, Mostafa Mahmoud

Journal of pediatric surgery

2022 Volume 57, Issue 7, Page(s) 1446–1447

MeSH term(s)	Anal Canal/diagnostic imaging ; Anus, Imperforate/diagnostic imaging ; Anus, Imperforate/surgery ; Humans ; Radiography ; Rectal Fistula/diagnostic imaging ; Urethral Diseases/diagnostic imaging ; Urinary Fistula/diagnostic imaging
Language	English
Publishing date	2022-01-23
Publishing country	United States
Document type	Letter
ZDB-ID	80165-3
ISSN	1531-5037 ; 0022-3468
ISSN (online)	1531-5037
ISSN	0022-3468
DOI	10.1016/j.jpedsurg.2022.01.015
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Article ; Online: Compartmental Syndecan-1 (CD138) expression as a novel prognostic marker in triple-negative metaplastic breast cancer.

Ismail, Yahia / Zakaria, Al-Shimaa / Allam, Rasha / Götte, Martin / Ibrahim, Sherif Abdelaziz / Hassan, Hebatallah

Pathology, research and practice

2023 Volume 253, Page(s) 154994

Abstract: Background: Metaplastic breast cancer (MpBC) is rare, aggressive, and mostly triple-negative (TN) subtype of BC. We aimed to investigate the potential prognostic significance of Syndecan-1 (SDC1/CD138) expression in this unique tumor.: Methods: ... ...

Abstract	Background: Metaplastic breast cancer (MpBC) is rare, aggressive, and mostly triple-negative (TN) subtype of BC. We aimed to investigate the potential prognostic significance of Syndecan-1 (SDC1/CD138) expression in this unique tumor. Methods: Archived charts of 50 TNBC patients [21 MpBC and 29 invasive ductal carcinoma (IDC)] were retrospectively evaluated. Corresponding paraffin blocks were used for immunohistochemical (IHC) staining of SDC1. Compartmental (epithelial membranous, stromal, and cytoplasmic) staining scores were expressed in quartiles (Q) and correlated with disease-free survival (DFS) and overall survival (OS). Results: The median follow-up period was 54.6 months (range: 2.2-112.7). MpBC patients showed significantly worse DFS and OS than IDC (p = 0.007 and 0.004, respectively). MpBC demonstrated significantly higher Q4 stromal and membranous SDC1 compared to IDC (p = 0.016 and 0.021, respectively), whereas IDC exhibited significantly higher cytoplasmic Q4 SDC1 than MpBC (p = 0.015). Stromal Q4 SDC1 expression was found to be an independent factor associated with MpBC relative to IDC (OR: 6.7, 95% CI: 1.24-36.90; p = 0.028). Stromal Q4 SDC1 expression was also an independent prognostic parameter for worse DFS and OS compared to Q1-3 in the whole cohort (HR: 4.2, 95% CI: 1.6-10.5; p = 0.003 and HR: 5.8; 95% CI: 2.2-15.3; p < 0.001, respectively). In MpBC, cytoplasmic Q1-3 SDC1 expression was an independent prognostic indicator for worse OS compared with their IDC counterparts (HR: 2.837, 95% CI: 1.048-7.682; p = 0.04). Conclusion: This study suggests, for the first time, that differential expression and localization of SDC1 may contribute to the pathogenesis and prognosis of TN-MpBC. Therefore, targeting SDC1 (CD138) could emerge as a novel therapeutic approach for this devastating disease.
MeSH term(s)	Humans ; Female ; Triple Negative Breast Neoplasms/pathology ; Breast Neoplasms/pathology ; Prognosis ; Retrospective Studies ; Syndecan-1/metabolism ; Disease-Free Survival ; Carcinoma, Ductal, Breast/pathology
Chemical Substances	Syndecan-1
Language	English
Publishing date	2023-11-29
Publishing country	Germany
Document type	Journal Article
ZDB-ID	391889-0
ISSN	1618-0631 ; 0344-0338
ISSN (online)	1618-0631
ISSN	0344-0338
DOI	10.1016/j.prp.2023.154994
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Article ; Online: A nano-Liposomal formulation potentiates antioxidant, anti-inflammatory, and fibrinolytic activities of Allolobophora caliginosa coelomic fluid: formulation and characterization.

Farouk, Asmaa E / Fahmy, Sohair R / Soliman, Amel M / Ibrahim, Sherif Abdelaziz / Sadek, Shimaa A

BMC biotechnology

2023 Volume 23, Issue 1, Page(s) 28

Abstract: Background: Coelomic fluid, a pharmacologically active compound in earthworms, exhibits a range of biological activities, including antioxidant, anti-inflammatory, and anticancer. However, the biological activities exerted by the coelomic fluid can be ... ...

Abstract	Background: Coelomic fluid, a pharmacologically active compound in earthworms, exhibits a range of biological activities, including antioxidant, anti-inflammatory, and anticancer. However, the biological activities exerted by the coelomic fluid can be restrained by its low bioavailability and stability. Liposomes are progressively utilized as an entrapment system for natural bioactive compounds with poor bioavailability and stability, which could be appropriate for coelomic fluid. Thus, the present study was designed to fabricate, characterize, and evaluate the stability of liposomal formulation for Allolobophora caliginosa coelomic fluid (ACCF) as a natural antioxidant compound. Methods: The ACCF-liposomes were developed with a subsequent characterization of their physicochemical attributes. The physical stability, ACCF release behavior, and gastrointestinal stability were evaluated in vitro. The biological activities of ACCF and its liposomal formulation were also determined. Results: The liposomal formulation of ACCF had a steady characteristic absorption band at 201 nm and a transmittance of 99.20 ± 0.10%. Its average hydrodynamic particle size was 98 nm, with a PDI of 0.29 ± 0.04 and a negative zeta potential (-38.66 ± 0.33mV). TEM further confirmed the formation of vesicular, spherical nano-liposomes with unilamellar configuration. Additionally, a remarkable entrapment efficiency percent (77.58 ± 0.82%) with a permeability rate equal to 3.20 ± 0.31% and a high retention rate (54.16 ± 2.20%) for ACCF-liposomes were observed. The Fourier transform infrared spectroscopy (FTIR) result demonstrated that ACCF successfully entrapped inside liposomes. The ACCF-liposomes exhibited a slow and controlled ACCF release in vitro. Regarding stability studies, the liposomal formulation enhanced the stability of ACCF during storage and at different pH. Furthermore, ACCF-liposomes are highly stable in intestinal digestion conditions comparable to gastric digestion. The current study disclosed that liposomal formulation potentiates the biological activities of ACCF, especially antioxidant, anti-inflammatory, and thrombolytic activities. Conclusion: These promising results offer a novel approach to increasing the bioaccessibility of ACCF, which may be crucial for the development of pharmaceuticals and nutraceutical-enriched functional foods.
MeSH term(s)	Animals ; Liposomes/chemistry ; Antioxidants/pharmacology ; Oligochaeta ; Anti-Inflammatory Agents/pharmacology ; Dietary Supplements ; Particle Size
Chemical Substances	Liposomes ; Antioxidants ; Anti-Inflammatory Agents
Language	English
Publishing date	2023-08-03
Publishing country	England
Document type	Journal Article
ZDB-ID	2052746-9
ISSN	1472-6750 ; 1472-6750
ISSN (online)	1472-6750
ISSN	1472-6750
DOI	10.1186/s12896-023-00795-5
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Article: Establishment of Soil Management Zones Using Multivariate Analysis and GIS

Ali, Ali M / Ibrahim, Sherif M

Communications in soil science and plant analysis. 2020 Oct. 27, v. 51, no. 19

2020

Abstract: Delineation of soil management zones (MZ) that can define subfields with homogenous soil properties provides a basis for successful site-specific management. This study was conducted in order to create MZ for a field of 460 ha in Egypt using multivariate ...

Abstract	Delineation of soil management zones (MZ) that can define subfields with homogenous soil properties provides a basis for successful site-specific management. This study was conducted in order to create MZ for a field of 460 ha in Egypt using multivariate analysis and geographic information system (GIS). Soil samples were collected in a grid pattern from 104 topsoil (0–30 cm) locations within the field. Substantial variation was observed in shale depth (known locally as Tafla), electrical conductivity (EC), pH, CaCO₃, available phosphorus (P), potassium, iron (Fe), manganese, zinc, and copper. Principal component analysis was performed to aggregate and summarize the variability of the dataset. The analysis showed that shale depth, EC, pH, available P, and Fe are the parameters representing the overall variability. Accordingly, k-means clustering analysis was performed on the standardized data of these parameters, and three clusters were formed. These clusters were used for creating MZ with heterogeneity in overall soil properties. Zone #3 had favorable parameters led by deep shale depth (112.5 cm ±3.7) and EC (11.99 dS m⁻¹ ± 0.47), whereas zone #1 was the worst with shale depth of 60.7 cm ±7.98 and EC of 29.76 dS m⁻¹ ± 2.66. Zone #2 had intermediate conditions with shale depth of 100 cm ±10 and EC of 14.25 dS m⁻¹ ± 0.32. These subfields should be helpful for making successful agronomic decisions such as selecting crops, irrigation, and fertilization.
Keywords	copper ; data collection ; electrical conductivity ; geographic information systems ; iron ; irrigation ; manganese ; multivariate analysis ; pH ; phosphorus ; plant analysis ; potassium ; principal component analysis ; shale ; topsoil ; zinc ; Egypt
Language	English
Dates of publication	2020-1027
Size	p. 2491-2500.
Publishing place	Taylor & Francis
Document type	Article
Note	NAL-AP-2-clean
ZDB-ID	419718-5
ISSN	1532-2416 ; 0010-3624
ISSN (online)	1532-2416
ISSN	0010-3624
DOI	10.1080/00103624.2020.1836207
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Article ; Online: Cell Behavior of Non-Small Cell Lung Cancer Is at EGFR and MicroRNAs Hands.

Hassanein, Sarah Sayed / Ibrahim, Sherif Abdelaziz / Abdel-Mawgood, Ahmed Lotfy

International journal of molecular sciences

2021 Volume 22, Issue 22

Abstract: Lung cancer is a complex disease associated with gene mutations, particularly mutations of Kirsten Rat Sarcoma Viral Oncogene Homolog ( ...

Abstract	Lung cancer is a complex disease associated with gene mutations, particularly mutations of Kirsten Rat Sarcoma Viral Oncogene Homolog (
MeSH term(s)	Carcinoma, Non-Small-Cell Lung/drug therapy ; Carcinoma, Non-Small-Cell Lung/genetics ; Carcinoma, Non-Small-Cell Lung/pathology ; Drug Resistance, Neoplasm/genetics ; ErbB Receptors/genetics ; Gene Expression Regulation, Neoplastic/drug effects ; Humans ; MicroRNAs/genetics ; Mutation/genetics ; Neoplasm Proteins/genetics ; Protein Kinase Inhibitors/therapeutic use ; Proto-Oncogene Proteins p21(ras)/genetics
Chemical Substances	KRAS protein, human ; MicroRNAs ; Neoplasm Proteins ; Protein Kinase Inhibitors ; EGFR protein, human (EC 2.7.10.1) ; ErbB Receptors (EC 2.7.10.1) ; Proto-Oncogene Proteins p21(ras) (EC 3.6.5.2)
Language	English
Publishing date	2021-11-19
Publishing country	Switzerland
Document type	Journal Article ; Review
ZDB-ID	2019364-6
ISSN	1422-0067 ; 1422-0067 ; 1661-6596
ISSN (online)	1422-0067
ISSN	1422-0067 ; 1661-6596
DOI	10.3390/ijms222212496
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Article: EGFR-Dependent Extracellular Matrix Protein Interactions Might Light a Candle in Cell Behavior of Non-Small Cell Lung Cancer.

Hassanein, Sarah Sayed / Abdel-Mawgood, Ahmed Lotfy / Ibrahim, Sherif Abdelaziz

Frontiers in oncology

2021 Volume 11, Page(s) 766659

Abstract: Lung cancer remains the leading cause of cancer-related death and is associated with a poor prognosis. Lung cancer is divided into 2 main types: the major in incidence is non-small cell lung cancer (NSCLC) and the minor is small cell lung cancer (SCLC). ... ...

Abstract	Lung cancer remains the leading cause of cancer-related death and is associated with a poor prognosis. Lung cancer is divided into 2 main types: the major in incidence is non-small cell lung cancer (NSCLC) and the minor is small cell lung cancer (SCLC). Although NSCLC progression depends on driver mutations, it is also affected by the extracellular matrix (ECM) interactions that activate their corresponding signaling molecules in concert with integrins and matrix metalloproteinases (MMPs). These signaling molecules include cytoplasmic kinases, small GTPases, adapter proteins, and receptor tyrosine kinases (RTKs), particularly the epidermal growth factor receptor (EGFR). In NSCLC, the interplay between ECM and EGFR regulates ECM stiffness, angiogenesis, survival, adhesion, migration, and metastasis. Furthermore, some tumor-promoting ECM components (e.g., glycoproteins and proteoglycans) enhance activation of EGFR and loss of PTEN. On the other hand, other tumor-suppressing glycoproteins and -proteoglycans can inhibit EGFR activation, suppressing cell invasion and migration. Therefore, deciphering the molecular mechanisms underlying EGFR and ECM interactions might provide a better understanding of disease pathobiology and aid in developing therapeutic strategies. This review critically discusses the crosstalk between EGFR and ECM affecting cell behavior of NSCLC, as well as the involvement of ECM components in developing resistance to EGFR inhibition.
Language	English
Publishing date	2021-12-15
Publishing country	Switzerland
Document type	Journal Article ; Review
ZDB-ID	2649216-7
ISSN	2234-943X
ISSN	2234-943X
DOI	10.3389/fonc.2021.766659
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