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Book ; Online: Functional cerebral SPECT and PET imaging

Van Heertum, Ronald L. / Tikofsky, Ronald S. / Ichise, Masanori

2010

Author's details	editors, Ronald L. Van Heertum, Ronald S. Tikofsky, Masanori Ichise
Keywords	Brain diseases - diagnosis ; Tomography, emission-computed - methods ; Atlases
Language	English
Size	1 Online-Ressource
Edition	4th ed.
Publisher	Lippincott Williams & Wilkins
Publishing place	Philadelphia, PA
Document type	Book ; Online
Note	Includes bibliographical references
Remark	Zugriff für angemeldete ZB MED-Nutzerinnen und -Nutzer
ISBN	978-0-7817-8897-7 ; 0-7817-8897-8
Database	ZB MED Catalogue: Medicine, Health, Nutrition, Environment, Agriculture

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Article ; Online: A novel PET probe to selectively image heat shock protein 90α/β isoforms in the brain.

Sakai, Takayuki / Ogata, Aya / Ikenuma, Hiroshi / Yamada, Takashi / Hattori, Saori / Abe, Junichiro / Imamura, Shinichi / Ichise, Masanori / Tada, Mari / Kakita, Akiyoshi / Koyama, Hiroko / Suzuki, Masaaki / Kato, Takashi / Ito, Kengo / Kimura, Yasuyuki

EJNMMI radiopharmacy and chemistry

2024 Volume 9, Issue 1, Page(s) 19

Abstract: Background: Heat shock proteins (HSPs) are present throughout the brain. They function as molecular chaperones, meaning they help with the folding and unfolding of large protein complexes. These chaperones are vital in the development of ... ...

Abstract	Background: Heat shock proteins (HSPs) are present throughout the brain. They function as molecular chaperones, meaning they help with the folding and unfolding of large protein complexes. These chaperones are vital in the development of neuropathological conditions such as Alzheimer's disease and Lewy body disease, with HSP90, a specific subtype of HSP, playing a key role. Many studies have shown that drugs that inhibit HSP90 activity have beneficial effects in the neurodegenerative diseases. Therefore, HSP90 PET imaging ligand can be used effectively to study HSP90 in neurodegenerative diseases. Among four HSP90 isoforms, two cytosolic isoforms (HSP90α and HSP90β) thought to be involved in the structural homeostasis of the proteins related to the neurodegenerative diseases. Currently, no useful PET imaging ligands selectively targeting the two cytosolic isoforms of HSP90 have been available yet. Results: In this study, we developed a novel positron emission tomography (PET) imaging ligand, [ Conclusions: We have developed a new PET imaging agent, [
Language	English
Publishing date	2024-03-04
Publishing country	England
Document type	Journal Article
ISSN	2365-421X
ISSN (online)	2365-421X
DOI	10.1186/s41181-024-00248-0
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Article: Noradrenaline transporter PET reflects neurotoxin-induced noradrenaline level decrease in the rat hippocampus.

Sakai, Takayuki / Hattori, Saori / Ogata, Aya / Yamada, Takashi / Abe, Junichiro / Ikenuma, Hiroshi / Ichise, Masanori / Suzuki, Masaaki / Ito, Kengo / Kato, Takashi / Kimura, Yasuyuki

EJNMMI research

2023 Volume 13, Issue 1, Page(s) 82

Abstract: Background: The neuropathological changes of early Alzheimer's disease (AD) include neurodegenerative loss of noradrenaline neurons in the locus coeruleus with decreasing noradrenaline availability in their projection areas such as the hippocampus. This ...

Abstract	Background: The neuropathological changes of early Alzheimer's disease (AD) include neurodegenerative loss of noradrenaline neurons in the locus coeruleus with decreasing noradrenaline availability in their projection areas such as the hippocampus. This diminishing noradrenaline availability is thought to play an important role pathophysiologically in the development of cognitive impairment in AD, because noradrenaline is not only essential for maintaining cognitive functions such as memory, learning and attention, but also its anti-inflammatory action, where its lack is known to accelerate the progression of AD in the mouse model. Therefore, the availability of in vivo biomarkers of the integrity of noradrenaline neurons may be beneficial for furthering our understanding of the role played by the noradrenaline system in the progressive cognitive dysfunction seen in AD patients. In this study, we investigated if PET imaging of noradrenaline transporters can predict the level of noradrenaline in the brain. Our hypothesis was PET measured noradrenaline transporter densities could predict the level of noradrenaline concentrations in the rat hippocampus after lesioning of noradrenaline neurons in this region. Results: We chemically lesioned the hippocampus of rats (n = 15) by administering a neurotoxin, DSP-4, in order to selectively damage axonal terminals of noradrenergic neurons. These rats then underwent PET imaging of noradrenaline transporters using [ Conclusions: [
Language	English
Publishing date	2023-09-15
Publishing country	Germany
Document type	Journal Article
ZDB-ID	2619892-7
ISSN	2191-219X
ISSN	2191-219X
DOI	10.1186/s13550-023-01032-y
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Article ; Online: Development of a novel PET ligand, [

Ogata, Aya / Yamada, Takashi / Hattori, Saori / Ikenuma, Hiroshi / Abe, Junichiro / Tada, Mari / Ichise, Masanori / Suzuki, Masaaki / Ito, Kengo / Kato, Takashi / Amaike, Kazuma / Hirota, Tsuyoshi / Kakita, Akiyoshi / Itami, Kenichiro / Kimura, Yasuyuki

Bioorganic & medicinal chemistry letters

2023 Volume 90, Page(s) 129327

Abstract: Positron emission tomography (PET) is a powerful imaging tool that enables early in vivo detection of Alzheimer's disease (AD). For this purpose, various PET ligands have been developed to image β-amyloid and tau protein aggregates characteristically ... ...

Abstract	Positron emission tomography (PET) is a powerful imaging tool that enables early in vivo detection of Alzheimer's disease (AD). For this purpose, various PET ligands have been developed to image β-amyloid and tau protein aggregates characteristically found in the brain of AD patients. In this study, we initiated to develop another type of PET ligand that targets protein kinase CK2 (formerly termed as casein kinase II), because its expression level is known to be altered in postmortem AD brains. CK2 is a serine/threonine protein kinase, an important component of cellular signaling pathways that control cellular degeneration. In AD, the CK2 level in the brain is thought to be elevated by its involvement in both phosphorylation of proteins such as tau and neuroinflammation. Decreased CK2 activity and expression levels lead to β-amyloid accumulation. In addition, since CK2 also contributes to the phosphorylation of tau protein, the expression level and activity of CK2 is expected to undergo significant changes during the progression of AD pathology. Furthermore, CK2 could act as a potential target for modulating the inflammatory response in AD. Therefore, PET imaging targeting CK2 expressed in the brain could be a useful another imaging biomarker for AD. We synthesized and radiolabeled a CK2 inhibitor, [
MeSH term(s)	Humans ; Rats ; Animals ; Ligands ; Casein Kinase II ; Positron-Emission Tomography/methods ; Alzheimer Disease/diagnostic imaging ; Alzheimer Disease/metabolism ; Brain/metabolism ; tau Proteins/metabolism ; Amyloid beta-Peptides/metabolism
Chemical Substances	Ligands ; Casein Kinase II (EC 2.7.11.1) ; tau Proteins ; Amyloid beta-Peptides
Language	English
Publishing date	2023-05-13
Publishing country	England
Document type	Journal Article ; Research Support, Non-U.S. Gov't
ZDB-ID	1063195-1
ISSN	1464-3405 ; 0960-894X
ISSN (online)	1464-3405
ISSN	0960-894X
DOI	10.1016/j.bmcl.2023.129327
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Article: Positron Emission Tomography.

Lameka, Katherine / Farwell, Michael D / Ichise, Masanori

Handbook of clinical neurology

2016 Volume 135, Page(s) 209–227

Abstract: Positron emission tomography (PET) is a minimally invasive imaging procedure with a wide range of clinical and research applications. PET allows for the three-dimensional mapping of administered positron-emitting radiopharmaceuticals such as (18)F- ... ...

Abstract	Positron emission tomography (PET) is a minimally invasive imaging procedure with a wide range of clinical and research applications. PET allows for the three-dimensional mapping of administered positron-emitting radiopharmaceuticals such as (18)F-fluorodeoxyglucose (for imaging glucose metabolism). PET enables the study of biologic function in both health and disease, in contrast to magnetic resonance imaging (MRI) and computed tomography (CT), that are more suited to study a body's morphologic changes, although functional MRI can also be used to study certain brain functions by measuring blood flow changes during task performance. This chapter first provides an overview of the basic physics principles and instrumentation behind PET methodology, with an introduction to the merits of merging functional PET imaging with anatomic CT or MRI imaging. We then focus on clinical neurologic disorders, and reference research on relevant PET radiopharmaceuticals when applicable. We then provide an overview of PET scan interpretation and findings in several specific neurologic disorders such as dementias, epilepsy, movement disorders, infection, cerebrovascular disorders, and brain tumors.
MeSH term(s)	Brain Diseases/diagnostic imaging ; Fluorodeoxyglucose F18 ; Humans ; Magnetic Resonance Imaging ; Positron-Emission Tomography ; Tomography, X-Ray Computed
Chemical Substances	Fluorodeoxyglucose F18 (0Z5B2CJX4D)
Language	English
Publishing date	2016
Publishing country	Netherlands
Document type	Journal Article ; Review
ISSN	0072-9752
ISSN	0072-9752
DOI	10.1016/B978-0-444-53485-9.00011-8
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Article ; Online: Synthesis and evaluation of a novel PET ligand, a GSK'963 analog, aiming at autoradiography and imaging of the receptor interacting protein kinase 1 in the brain.

Ikenuma, Hiroshi / Ogata, Aya / Koyama, Hiroko / Ji, Bin / Ishii, Hideki / Yamada, Takashi / Abe, Junichiro / Seki, Chie / Nagai, Yuji / Ichise, Masanori / Minamimoto, Takafumi / Higuchi, Makoto / Zhang, Ming-Rong / Kato, Takashi / Ito, Kengo / Suzuki, Masaaki / Kimura, Yasuyuki

EJNMMI radiopharmacy and chemistry

2023 Volume 8, Issue 1, Page(s) 31

Abstract: Background: Receptor interacting protein kinase 1 (RIPK1) is a serine/threonine kinase, which regulates programmed cell death and inflammation. Recently, the involvement of RIPK1 in the pathophysiology of Alzheimer's disease (AD) has been reported; ... ...

Abstract	Background: Receptor interacting protein kinase 1 (RIPK1) is a serine/threonine kinase, which regulates programmed cell death and inflammation. Recently, the involvement of RIPK1 in the pathophysiology of Alzheimer's disease (AD) has been reported; RIPK1 is involved in microglia's phenotypic transition to their dysfunctional states, and it is highly expressed in the neurons and microglia in the postmortem brains in AD patients. They prompt neurodegeneration leading to accumulations of pathological proteins in AD. Therefore, regulation of RIPK1 could be a potential therapeutic target for the treatment of AD, and in vivo imaging of RIPK1 may become a useful modality in studies of drug discovery and pathophysiology of AD. The purpose of this study was to develop a suitable radioligand for positron emission tomography (PET) imaging of RIPK1. Results: (S)-2,2-dimethyl-1-(5-phenyl-4,5-dihydro-1H-pyrazol-1-yl)propan-1-one (GSK'963) has a high affinity, selectivity for RIPK1, and favorable physiochemical properties based on its chemical structure. In this study, since Conclusions: We synthesized and evaluated a
Language	English
Publishing date	2023-10-18
Publishing country	England
Document type	Journal Article
ISSN	2365-421X
ISSN (online)	2365-421X
DOI	10.1186/s41181-023-00217-z
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Article ; Online: 11

Suzuki, Keiichi / Koyama, Hiroko / Nakamura, Narumasa / Kimura, Yasuyuki / Ogata, Aya / Ikenuma, Hiroshi / Ishii, Hideki / Zhang, Ming-Rong / Kawamura, Kazunori / Minamimoto, Takafumi / Nagai, Yuji / Katsuki, Hiroshi / Kimura, Tetsuya / Kimura, Nobuyuki / Ichise, Masanori / Kato, Takashi / Ito, Kengo / Suzuki, Masaaki

Bioorganic & medicinal chemistry letters

2023 Volume 85, Page(s) 129212

Abstract: Recently, retinoid actions on the central nervous system (CNS) have attracted considerable attention from the perspectives of brain disease diagnosis and drug development. Firstly, we successfully synthesized [ ...

Abstract	Recently, retinoid actions on the central nervous system (CNS) have attracted considerable attention from the perspectives of brain disease diagnosis and drug development. Firstly, we successfully synthesized [
MeSH term(s)	Rats ; Animals ; Methylation ; Retinoids/pharmacology ; Antineoplastic Agents/pharmacology ; Brain/diagnostic imaging ; Positron-Emission Tomography ; Radiopharmaceuticals/pharmacology
Chemical Substances	(2E,4E,6E,10E)-3,7,11,15-tetramethyl-2,4,6,10,14-hexadecapentaenoic acid (11ALM7A4RV) ; 3,7,11,15-tetramethyl-2,4,6,10,14-hexadecapentaenoic acid (81485-25-8) ; Retinoids ; Antineoplastic Agents ; Radiopharmaceuticals
Language	English
Publishing date	2023-03-03
Publishing country	England
Document type	Journal Article ; Research Support, Non-U.S. Gov't
ZDB-ID	1063195-1
ISSN	1464-3405 ; 0960-894X
ISSN (online)	1464-3405
ISSN	0960-894X
DOI	10.1016/j.bmcl.2023.129212
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Article ; Online: [

Ogata, Aya / Ji, Bin / Yamada, Takashi / Hattori, Saori / Abe, Junichiro / Ikenuma, Hiroshi / Ichise, Masanori / Koyama, Hiroko / Suzuki, Masaaki / Kato, Takashi / Ito, Kengo / Kimura, Yasuyuki

Bioorganic & medicinal chemistry letters

2022 Volume 65, Page(s) 128704

Abstract: Colony-stimulating factor 1 receptors (CSF1R) are expressed exclusively on microglia in the central nervous system. The receptors regulate immune responses by controlling the survival and activity of microglia and are intricately involved in the ... ...

Abstract	Colony-stimulating factor 1 receptors (CSF1R) are expressed exclusively on microglia in the central nervous system. The receptors regulate immune responses by controlling the survival and activity of microglia and are intricately involved in the pathophysiology of Alzheimer's disease. In this study, we developed [
MeSH term(s)	Alzheimer Disease/metabolism ; Animals ; Brain/diagnostic imaging ; Brain/metabolism ; Disease Models, Animal ; Ligands ; Macrophage Colony-Stimulating Factor/metabolism ; Microglia/metabolism ; Positron-Emission Tomography/methods ; Rats ; Receptor, Macrophage Colony-Stimulating Factor/metabolism ; Receptors, Granulocyte-Macrophage Colony-Stimulating Factor
Chemical Substances	Ligands ; Receptors, Granulocyte-Macrophage Colony-Stimulating Factor ; Macrophage Colony-Stimulating Factor (81627-83-0) ; Receptor, Macrophage Colony-Stimulating Factor (EC 2.7.10.1)
Language	English
Publishing date	2022-03-26
Publishing country	England
Document type	Journal Article ; Research Support, Non-U.S. Gov't
ZDB-ID	1063195-1
ISSN	1464-3405 ; 0960-894X
ISSN (online)	1464-3405
ISSN	0960-894X
DOI	10.1016/j.bmcl.2022.128704
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Article ; Online: Kinetic modeling and non-invasive approach for translocator protein quantification with

Yasuno, Fumihiko / Kimura, Yasuyuki / Ogata, Aya / Ikenuma, Hiroshi / Abe, Junichiro / Minami, Hiroyuki / Nihashi, Takashi / Yokoi, Kastunori / Hattori, Saori / Shimoda, Nobuyoshi / Ichise, Masanori / Sakurai, Takashi / Ito, Kengo / Kato, Takashi

Nuclear medicine and biology

2022 Volume 108-109, Page(s) 76–84

Abstract: Introduction: 11: Methods: Eleven patients with AD and 6 CN participants were examined using dynamic : Results: The concentration of radioactivity in plasma demonstrated rapid clearance. : Conclusion: ... ...

Abstract	Introduction: 11 Methods: Eleven patients with AD and 6 CN participants were examined using dynamic Results: The concentration of radioactivity in plasma demonstrated rapid clearance. Conclusion: 11
MeSH term(s)	Acetamides/metabolism ; Alzheimer Disease/diagnostic imaging ; Alzheimer Disease/metabolism ; Brain/metabolism ; Carrier Proteins/metabolism ; Humans ; Positron-Emission Tomography/methods ; Pyrazoles/chemistry ; Pyrimidines/chemistry ; Receptors, GABA/metabolism
Chemical Substances	Acetamides ; Carrier Proteins ; N,N-diethyl-2-(2-(4-methoxyphenyl)-5,7-dimethyl-pyrazolo(1,5-a)pyrimidin-3-yl)-acetamide ; Pyrazoles ; Pyrimidines ; Receptors, GABA ; TSPO protein, human
Language	English
Publishing date	2022-03-12
Publishing country	United States
Document type	Journal Article ; Research Support, Non-U.S. Gov't
ZDB-ID	1138098-6
ISSN	1872-9614 ; 0883-2897 ; 0969-8051
ISSN (online)	1872-9614
ISSN	0883-2897 ; 0969-8051
DOI	10.1016/j.nucmedbio.2022.02.005
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Article ; Online: Brain pharmacokinetics and biodistribution of

Ogata, Aya / Kimura, Yasuyuki / Ikenuma, Hiroshi / Yamada, Takashi / Abe, Junichiro / Koyama, Hiroko / Suzuki, Masaaki / Ichise, Masanori / Kato, Takashi / Ito, Kengo

Nuclear medicine and biology

2020 Volume 86-87, Page(s) 52–58

Abstract: Introduction: Isoproterenol is a non-selective β receptor agonist, which is a drug approved for bradycardia and bronchial asthma in many countries. Recently, isoproterenol has been reported to have the potential as a drug for the treatment of Alzheimer' ... ...

Abstract	Introduction: Isoproterenol is a non-selective β receptor agonist, which is a drug approved for bradycardia and bronchial asthma in many countries. Recently, isoproterenol has been reported to have the potential as a drug for the treatment of Alzheimer's disease by inhibiting the aggregation of tau protein. Isoproterenol is a highly potent drug causing increases in heart rates even when its plasma concentration is very low. Thus, it is critical to know if potentially effective therapeutic levels of isoproterenol can be achieved, maintaining safe plasma levels without any untoward pharmacological effects. The purpose of the study is to investigate the brain pharmacokinetics and biodistribution of Methods: We performed positron emission tomography (PET) brain imaging and biodistribution studies of [ Results: We found a modest brain uptake of [
Language	English
Publishing date	2020-06-05
Publishing country	United States
Document type	Journal Article ; Research Support, Non-U.S. Gov't
ZDB-ID	1138098-6
ISSN	1872-9614 ; 0883-2897 ; 0969-8051
ISSN (online)	1872-9614
ISSN	0883-2897 ; 0969-8051
DOI	10.1016/j.nucmedbio.2020.06.002
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