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  1. Article ; Online: Waning of SARS-CoV-2 booster viral-load reduction effectiveness

    Matan Levine-Tiefenbrun / Idan Yelin / Hillel Alapi / Esma Herzel / Jacob Kuint / Gabriel Chodick / Sivan Gazit / Tal Patalon / Roy Kishony

    Nature Communications, Vol 13, Iss 1, Pp 1-

    2022  Volume 4

    Abstract: The BNT162b2 COVID-19 vaccine has been shown to reduce viral load of breakthrough infections (BTIs). Here, analyzing viral loads of BTIs post third vaccine shot, Levine-Tiefenbrun et al. show waning of the booster’s effectiveness in reducing ... ...

    Abstract The BNT162b2 COVID-19 vaccine has been shown to reduce viral load of breakthrough infections (BTIs). Here, analyzing viral loads of BTIs post third vaccine shot, Levine-Tiefenbrun et al. show waning of the booster’s effectiveness in reducing infectiousness within months, mirroring the rate and magnitude of decline observed post the second shot.
    Keywords Science ; Q
    Language English
    Publishing date 2022-03-01T00:00:00Z
    Publisher Nature Portfolio
    Document type Article ; Online
    Database BASE - Bielefeld Academic Search Engine (life sciences selection)

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  2. Article ; Online: Rapid methicillin resistance diversification in Staphylococcus epidermidis colonizing human neonates

    Manoshi S. Datta / Idan Yelin / Ori Hochwald / Imad Kassis / Liron Borenstein-Levin / Amir Kugelman / Roy Kishony

    Nature Communications, Vol 12, Iss 1, Pp 1-

    2021  Volume 10

    Abstract: Staphylococcus epidermidis is a widespread early colonizer in the neonatal skin and a cause of hospital-acquired infections. Here, using whole-genome sequencing of 632 cultured S. epidermidis isolates derived from premature infants, the authors ... ...

    Abstract Staphylococcus epidermidis is a widespread early colonizer in the neonatal skin and a cause of hospital-acquired infections. Here, using whole-genome sequencing of 632 cultured S. epidermidis isolates derived from premature infants, the authors characterize the spatiotemporally strain-level genomic variability, finding patient-specific colonization signatures and a fast gain and loss of the antibiotic resistance gene mecA via the evolution of genotypically diverse structural variants.
    Keywords Science ; Q
    Language English
    Publishing date 2021-10-01T00:00:00Z
    Publisher Nature Portfolio
    Document type Article ; Online
    Database BASE - Bielefeld Academic Search Engine (life sciences selection)

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  3. Article ; Online: Escape mutations circumvent a tradeoff between resistance to a beta-lactam and resistance to a beta-lactamase inhibitor

    Dor Russ / Fabian Glaser / Einat Shaer Tamar / Idan Yelin / Michael Baym / Eric D. Kelsic / Claudia Zampaloni / Andreas Haldimann / Roy Kishony

    Nature Communications, Vol 11, Iss 1, Pp 1-

    2020  Volume 9

    Abstract: Beta-lactam antibiotics and beta-lactamase inhibitors compete for the same binding site on beta-lactamases; thus, mutations that increase beta-lactamase activity likely increase also susceptibility to the inhibitor. Here, Russ et al. identify rare ... ...

    Abstract Beta-lactam antibiotics and beta-lactamase inhibitors compete for the same binding site on beta-lactamases; thus, mutations that increase beta-lactamase activity likely increase also susceptibility to the inhibitor. Here, Russ et al. identify rare mutations in the ampC beta-lactamase gene that escape this adaptive tradeoff specifically for certain drug combinations.
    Keywords Science ; Q
    Language English
    Publishing date 2020-04-01T00:00:00Z
    Publisher Nature Publishing Group
    Document type Article ; Online
    Database BASE - Bielefeld Academic Search Engine (life sciences selection)

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  4. Article ; Online: Escape mutations circumvent a tradeoff between resistance to a beta-lactam and resistance to a beta-lactamase inhibitor

    Dor Russ / Fabian Glaser / Einat Shaer Tamar / Idan Yelin / Michael Baym / Eric D. Kelsic / Claudia Zampaloni / Andreas Haldimann / Roy Kishony

    Nature Communications, Vol 11, Iss 1, Pp 1-

    2020  Volume 9

    Abstract: Beta-lactam antibiotics and beta-lactamase inhibitors compete for the same binding site on beta-lactamases; thus, mutations that increase beta-lactamase activity likely increase also susceptibility to the inhibitor. Here, Russ et al. identify rare ... ...

    Abstract Beta-lactam antibiotics and beta-lactamase inhibitors compete for the same binding site on beta-lactamases; thus, mutations that increase beta-lactamase activity likely increase also susceptibility to the inhibitor. Here, Russ et al. identify rare mutations in the ampC beta-lactamase gene that escape this adaptive tradeoff specifically for certain drug combinations.
    Keywords Science ; Q
    Language English
    Publishing date 2020-04-01T00:00:00Z
    Publisher Nature Portfolio
    Document type Article ; Online
    Database BASE - Bielefeld Academic Search Engine (life sciences selection)

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  5. Article ; Online: Pervasive selection for and against antibiotic resistance in inhomogeneous multistress environments

    Remy Chait / Adam C. Palmer / Idan Yelin / Roy Kishony

    Nature Communications, Vol 7, Iss 1, Pp 1-

    2016  Volume 8

    Abstract: Antibiotic concentrations are low in most natural environments, except around localized antibiotic sources. Here, Chait et al.show that sub-inhibitory antibiotic levels can interact with many other stresses to generate complex patterns of selection for ... ...

    Abstract Antibiotic concentrations are low in most natural environments, except around localized antibiotic sources. Here, Chait et al.show that sub-inhibitory antibiotic levels can interact with many other stresses to generate complex patterns of selection for and against resistance to the antibiotic.
    Keywords Science ; Q
    Language English
    Publishing date 2016-01-01T00:00:00Z
    Publisher Nature Portfolio
    Document type Article ; Online
    Database BASE - Bielefeld Academic Search Engine (life sciences selection)

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  6. Article ; Online: Identification and characterization of roles for Puf1 and Puf2 proteins in the yeast response to high calcium

    Ofir Haramati / Anastasia Brodov / Idan Yelin / Avigail Atir-Lande / Nitzan Samra / Yoav Arava

    Scientific Reports, Vol 7, Iss 1, Pp 1-

    2017  Volume 14

    Abstract: Abstract Members of the yeast family of PUF proteins bind unique subsets of mRNA targets that encode proteins with common functions. They therefore became a paradigm for post-transcriptional gene control. To provide new insights into the roles of the ... ...

    Abstract Abstract Members of the yeast family of PUF proteins bind unique subsets of mRNA targets that encode proteins with common functions. They therefore became a paradigm for post-transcriptional gene control. To provide new insights into the roles of the seemingly redundant Puf1 and Puf2 members, we monitored the growth rates of their deletions under many different stress conditions. A differential effect was observed at high CaCl2 concentrations, whereby puf1Δ growth was affected much more than puf2Δ, and inhibition was exacerbated in puf1Δpuf2Δ double knockout. Transcriptome analyses upon CaCl2 application for short and long terms defined the transcriptional response to CaCl2 and revealed distinct expression changes for the deletions. Intriguingly, mRNAs known to be bound by Puf1 or Puf2 were affected mainly in the double knockout. We focused on the cell wall regulator Zeo1 and observed that puf1Δpuf2Δ fails to maintain low levels of its mRNA. Complementarily, puf1Δpuf2Δ growth defect in CaCl2 was repaired upon further deletion of the Zeo1 gene. Thus, these proteins probably regulate the cell-wall integrity pathway by regulating Zeo1 post-transcriptionally. This work sheds new light on the roles of Puf proteins during the cellular response to environmental stress.
    Keywords Medicine ; R ; Science ; Q
    Subject code 570
    Language English
    Publishing date 2017-06-01T00:00:00Z
    Publisher Nature Portfolio
    Document type Article ; Online
    Database BASE - Bielefeld Academic Search Engine (life sciences selection)

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    Inter-library loan at ZB MED

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  7. Article ; Online: Evolthon

    Sivan Kaminski Strauss / Dvir Schirman / Ghil Jona / Aaron N Brooks / Aditya M Kunjapur / Alex N Nguyen Ba / Alice Flint / Andras Solt / Andreas Mershin / Atray Dixit / Avihu H Yona / Bálint Csörgő / Bede Phillip Busby / Bianca P Hennig / Csaba Pál / Daniel Schraivogel / Daniel Schultz / David G Wernick / Deepa Agashe /
    Dikla Levi / Dmitry Zabezhinsky / Dor Russ / Ehud Sass / Einat Tamar / Elad Herz / Emmanuel D Levy / George M Church / Idan Yelin / Iftach Nachman / Jeffrey E Gerst / Joseph M Georgeson / Katarzyna P Adamala / Lars M Steinmetz / Marc Rübsam / Markus Ralser / Michael Klutstein / Michael M Desai / Nilima Walunjkar / Ning Yin / Noa Aharon Hefetz / Noah Jakimo / Olga Snitser / Omri Adini / Prashant Kumar / Rachel Soo Hoo Smith / Razi Zeidan / Ronen Hazan / Roni Rak / Roy Kishony / Shannon Johnson

    PLoS Biology, Vol 17, Iss 3, p e

    A community endeavor to evolve lab evolution.

    2019  Volume 3000182

    Abstract: In experimental evolution, scientists evolve organisms in the lab, typically by challenging them to new environmental conditions. How best to evolve a desired trait? Should the challenge be applied abruptly, gradually, periodically, sporadically? Should ... ...

    Abstract In experimental evolution, scientists evolve organisms in the lab, typically by challenging them to new environmental conditions. How best to evolve a desired trait? Should the challenge be applied abruptly, gradually, periodically, sporadically? Should one apply chemical mutagenesis, and do strains with high innate mutation rate evolve faster? What are ideal population sizes of evolving populations? There are endless strategies, beyond those that can be exposed by individual labs. We therefore arranged a community challenge, Evolthon, in which students and scientists from different labs were asked to evolve Escherichia coli or Saccharomyces cerevisiae for an abiotic stress-low temperature. About 30 participants from around the world explored diverse environmental and genetic regimes of evolution. After a period of evolution in each lab, all strains of each species were competed with one another. In yeast, the most successful strategies were those that used mating, underscoring the importance of sex in evolution. In bacteria, the fittest strain used a strategy based on exploration of different mutation rates. Different strategies displayed variable levels of performance and stability across additional challenges and conditions. This study therefore uncovers principles of effective experimental evolutionary regimens and might prove useful also for biotechnological developments of new strains and for understanding natural strategies in evolutionary arms races between species. Evolthon constitutes a model for community-based scientific exploration that encourages creativity and cooperation.
    Keywords Biology (General) ; QH301-705.5
    Language English
    Publishing date 2019-03-01T00:00:00Z
    Publisher Public Library of Science (PLoS)
    Document type Article ; Online
    Database BASE - Bielefeld Academic Search Engine (life sciences selection)

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