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  1. Article ; Online: Invited Commentary to "Safety and Feasibility of Primary Closure Following Laparoscopic Common Bile Duct Exploration for Treatment of Choledocholithiasis" by Lunjian Xiang et al.

    Podda, Mauro / Ielpo, Benedetto

    World journal of surgery

    2023  Volume 47, Issue 4, Page(s) 1031–1032

    MeSH term(s) Humans ; Choledocholithiasis/surgery ; Feasibility Studies ; Common Bile Duct/surgery ; Laparoscopy ; Retrospective Studies ; Cholecystectomy, Laparoscopic/adverse effects ; Length of Stay
    Language English
    Publishing date 2023-01-26
    Publishing country United States
    Document type Journal Article
    ZDB-ID 224043-9
    ISSN 1432-2323 ; 0364-2313
    ISSN (online) 1432-2323
    ISSN 0364-2313
    DOI 10.1007/s00268-023-06917-6
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    Zs.A 1336: Show issues Location:
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  2. Article: The issue of how predict survival of patients affected by locally advanced pancreatic cancer.

    Ielpo, Benedetto

    Annals of translational medicine

    2019  Volume 6, Issue Suppl 2, Page(s) S128

    Language English
    Publishing date 2019-01-22
    Publishing country China
    Document type Editorial ; Comment
    ZDB-ID 2893931-1
    ISSN 2305-5847 ; 2305-5839
    ISSN (online) 2305-5847
    ISSN 2305-5839
    DOI 10.21037/atm.2018.12.41
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  3. Article ; Online: Optimal Timing of Cholecystectomy for Severe Acute Pancreatitis and Understanding Complications and Comorbidities-Reply.

    Di Martino, Marcello / Ielpo, Benedetto / Podda, Mauro

    JAMA surgery

    2024  Volume 159, Issue 4, Page(s) 466–467

    MeSH term(s) Humans ; Pancreatitis/surgery ; Pancreatitis/etiology ; Acute Disease ; Cholecystectomy/adverse effects ; Cholecystectomy, Laparoscopic/adverse effects ; Retrospective Studies
    Language English
    Publishing date 2024-01-05
    Publishing country United States
    Document type Journal Article
    ZDB-ID 2701841-6
    ISSN 2168-6262 ; 2168-6254
    ISSN (online) 2168-6262
    ISSN 2168-6254
    DOI 10.1001/jamasurg.2023.6932
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    Uk I Zs.72: Show issues Location:
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  4. Article ; Online: The impact of vascular margin invasion on local recurrence after pancreatoduodenectomy in pancreatic adenocarcinoma.

    López, Julio Cuesta / Ielpo, Benedetto / Iglesias, Mar / Pinilla, Fernando Burdío / Sánchez-Velázquez, Patricia

    Langenbeck's archives of surgery

    2024  Volume 409, Issue 1, Page(s) 122

    Abstract: Purpose: Pancreatic ductal adenocarcinoma (PADC) still has nowadays a very impaired long-term survival. Most studies are focused on overall survival; however, local recurrence occurs about up to 50% of cases and seems to be highly related with margin ... ...

    Abstract Purpose: Pancreatic ductal adenocarcinoma (PADC) still has nowadays a very impaired long-term survival. Most studies are focused on overall survival; however, local recurrence occurs about up to 50% of cases and seems to be highly related with margin resection status. We aim to analyze the impact of vascular resection margins on local recurrence (LR) and to assess its impact on overall and disease-free survival.
    Methods: Eighty out of 191 patients who underwent pancreatoduodenectomy in a university hospital between 2006 and 2021 with PDAC diagnosis were analyzed and vascular margin status specifically addressed. Univariate and multivariate were performed. Time to LR was compared by using the Kaplan-Meier method and prognostic factors assessed using Cox regression hazards model.
    Results: LR appeared in 10 (50%) of the overall R1 resections in the venous margin and 9 (60%) in the arterial one. Time to LR was significantly shorter when any margin was overall affected (23.2 vs 44.7 months, p = 0.01) and specifically in the arterial margin involvement (13.7 vs 32.1 months, p = 0.009). Overall R1 resections (HR 2.61, p = 0.013) and a positive arterial margin (HR 2.84, p = 0.012) were associated with local recurrence on univariate analysis, whereas arterial positive margin remained significant on multivariate analysis (HR 2.70, p = 0.031).
    Conclusions: Arterial margin invasion is correlated in our cohort with local recurrence. Given the limited ability to modify this margin intraoperatively, preoperative therapies should be considered to improve local margin clearance.
    MeSH term(s) Humans ; Adenocarcinoma/surgery ; Pancreaticoduodenectomy ; Pancreatic Neoplasms/surgery ; Arteries ; Veins ; Margins of Excision
    Language English
    Publishing date 2024-04-12
    Publishing country Germany
    Document type Journal Article
    ZDB-ID 1423681-3
    ISSN 1435-2451 ; 1435-2443
    ISSN (online) 1435-2451
    ISSN 1435-2443
    DOI 10.1007/s00423-024-03301-3
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    Uk I Zs.10: Show issues Location:
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  5. Article ; Online: Laparoscopic pancreatoduodenectomy: how we have standardized the technique (with video).

    Ielpo, Benedetto / Sanchez, Patricia / Grande, Luis / Burdio, Fernando

    Updates in surgery

    2022  Volume 74, Issue 4, Page(s) 1479–1481

    Abstract: Minimally invasive pancreatectomy has increased worldwide over the last decade. Despite refinement in the technique, laparoscopic pancreatoduodenectomy (LPD) is still technically challenging and the standardization of the technique might increase its ... ...

    Abstract Minimally invasive pancreatectomy has increased worldwide over the last decade. Despite refinement in the technique, laparoscopic pancreatoduodenectomy (LPD) is still technically challenging and the standardization of the technique might increase its implementation and oncological outcomes and decrease postoperative complications, as well. Giving our experience, which was shown in the PADULAP trial and after refinement of the technique, we present here a standardized technique of LPD including technical steps, tips and videos for pancreatic head adenocarcinoma.
    MeSH term(s) Adenocarcinoma/surgery ; Humans ; Laparoscopy/methods ; Pancreatectomy/methods ; Pancreatic Neoplasms/surgery ; Pancreaticoduodenectomy/methods ; Pancreatic Neoplasms
    Language English
    Publishing date 2022-02-11
    Publishing country Italy
    Document type Journal Article ; Video-Audio Media
    ZDB-ID 2572692-4
    ISSN 2038-3312 ; 2038-131X
    ISSN (online) 2038-3312
    ISSN 2038-131X
    DOI 10.1007/s13304-021-01235-9
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  6. Article: A critical review of pancreatectomy with concomitant superior mesenteric artery resection and intestinal autotransplantation.

    Ielpo, Benedetto / Sánchez-Velázquez, Patricia / Vellalta, Gemma / Podda, Mauro / Burdio, Fernando

    Hepatobiliary surgery and nutrition

    2023  Volume 12, Issue 5, Page(s) 756–758

    Language English
    Publishing date 2023-09-13
    Publishing country China (Republic : 1949- )
    Document type Editorial ; Comment
    ZDB-ID 2812398-0
    ISSN 2304-389X ; 2304-3881
    ISSN (online) 2304-389X
    ISSN 2304-3881
    DOI 10.21037/hbsn-23-339
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  7. Article: Pancreatectomy with concomitant portal vein resection in the current neoadjuvant era.

    Ielpo, Benedetto / Burdio, Fernando / Martinez, Ana / Sanchez-Velazquez, Patricia

    Hepatobiliary surgery and nutrition

    2022  Volume 11, Issue 2, Page(s) 295–298

    Language English
    Publishing date 2022-04-06
    Publishing country China (Republic : 1949- )
    Document type Editorial ; Comment
    ZDB-ID 2812398-0
    ISSN 2304-389X ; 2304-3881
    ISSN (online) 2304-389X
    ISSN 2304-3881
    DOI 10.21037/hbsn-21-547
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  8. Article ; Online: Transduodenal robotic ampullectomy: tips and tricks and strategies for postoperative duodenal fistula management (with video).

    Ielpo, Benedetto / Vellalta, Gemma / Jaume-Boettcher, Sofia-Maria / d'Addetta, Maria Vittoria / Sanchez-Velazquez, Patricia / Burdio, Fernando

    Updates in surgery

    2024  

    Abstract: Transduodenal Ampullectomy (TA) is a procedure for resecting low-malignancy ampullary tumors, with postoperative fistula as a notable complication. This study aims to clarify the indications for TA, outline the surgical robotic technique, and emphasize ... ...

    Abstract Transduodenal Ampullectomy (TA) is a procedure for resecting low-malignancy ampullary tumors, with postoperative fistula as a notable complication. This study aims to clarify the indications for TA, outline the surgical robotic technique, and emphasize the importance of comprehensive complication management alongside the surgical approach. This multimedia article provides a detailed exposition of the robotic TA surgical technique, including the most important steps involved in exposing and reimplanting biliary and pancreatic ducts. The procedure encompasses the mobilization of the hepatic flexure of the colon, an extensive Kocher maneuver for duodenal mobilization, and ampulla exposure through a duodenal incision. Employing retraction loop sutures enhances surgical field visibility. Reconstruction involves securing pancreatic and biliary ducts to the duodenal mucosa, each tutored with a silicon catheter, and suturing for ampullectomy completion. The total operative time was 380 min. Final histopathology disclosed high-grade dysplasia with an isolated focus of adenocarcinoma (pT1), accompanied by clear resection margins. A postoperative duodenal fistula occurred, managed successfully through conservative treatment, utilizing subcutaneous drainage. Despite accurate robotic TA execution, complications may arise. This study underscores the importance of a comprehensive approach, incorporating meticulous surgical technique and effective complication management, to optimize patient outcomes.
    Language English
    Publishing date 2024-03-20
    Publishing country Italy
    Document type Journal Article
    ZDB-ID 2572692-4
    ISSN 2038-3312 ; 2038-131X
    ISSN (online) 2038-3312
    ISSN 2038-131X
    DOI 10.1007/s13304-024-01808-4
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  9. Article ; Online: ASO Author Reflections: Robotic Approach for Perihilar Cholangiocarcinoma.

    Ielpo, Benedetto / Rosso, Edoardo / d'Addetta, Maria Vittoria / Abad, Mayra / Vellalta, Gemma / Sanchez-Velazquez, Patricia / Burdio, Fernando

    Annals of surgical oncology

    2024  Volume 31, Issue 5, Page(s) 3106–3107

    MeSH term(s) Humans ; Klatskin Tumor/surgery ; Robotic Surgical Procedures ; Cholangiocarcinoma/pathology ; Bile Ducts, Intrahepatic/pathology ; Bile Duct Neoplasms/surgery ; Bile Duct Neoplasms/pathology
    Language English
    Publishing date 2024-02-09
    Publishing country United States
    Document type Journal Article
    ZDB-ID 1200469-8
    ISSN 1534-4681 ; 1068-9265
    ISSN (online) 1534-4681
    ISSN 1068-9265
    DOI 10.1245/s10434-024-15006-4
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    Zs.A 4042: Show issues Location:
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  10. Article ; Online: Robotic Approach for Perihilar Cholangiocarcinoma IIIA Type: Step-by-Step Procedure.

    Ielpo, Benedetto / Rosso, Edoardo / d'Addetta, Maria Vittoria / Abad, Mayra / Vellalta, Gemma / Sanchez-Velazquez, Patricia / Burdio, Fernando

    Annals of surgical oncology

    2024  Volume 31, Issue 5, Page(s) 3084–3085

    Abstract: Background: Perihilar cholangiocarcinoma is a challenging technique to be performed by minimally invasive approach being the type III among the most complex procedure. Nowadays, the robotic approach is gaining increasing interest among the surgical ... ...

    Abstract Background: Perihilar cholangiocarcinoma is a challenging technique to be performed by minimally invasive approach being the type III among the most complex procedure. Nowadays, the robotic approach is gaining increasing interest among the surgical community, and more and more series describing robotic liver resection have been reported. However, few cases of minimally invasive Bismuth type IIIA cholangiocarcinoma have been reported. Robotic approach allows for a better dissection and suture thanks to the flexible and precise instruments movements, overcoming some of the limitations of the laparoscopic technique. Therefore, robotic technique can facilitate some of the critical steps of a technically demanding procedure, such as the extended right hepatectomy for perihilar cholangiocarcinoma Bismuth IIIA type.
    Methods: In this multimedia video we describe, for the first time in the literature, a full robotic surgical step-by-step technique with some tips and tricks for treating a perihilar cholangiocarcinoma Bismuth IIIA type, performing a radical extended right hemihepatectomy, including segment I combined with regional lymphadenectomy anf left bile duct reconstruction. A 55-year-old woman with obstructive jaundice (10 mg/dl) was referred to our center. The endobiliary brushing confirmed adenocarcinoma, and MRI/CT showed a focal perihilar lesion of 2 cm, including the main biliary duct bifurcation and extending up to the right duct (Bismuth Type IIIA hilar cholangiocarcinoma). After endoscopic biliary stents placement and 6 weeks after right portal vein embolization, the future liver remnant, including segments II and III, reached an enough hypertrophy volume with a ratio of 30%. A right hemihepatectomy with caudate lobe, including standard standard lymphadenectomy and left biliary duct reconstruction was performed.
    Results: The operation lasted 670 min with an estimated blood loss of 350 ml. Postoperative pathological examination revealed a moderately differentiated adenocarcinoma pT1N0 with 15 retrieved nodes and free margins. The patient experienced a type A biliary fistula and was discharged on the 21st postoperative day without abdominal drainage.
    Conclusions: Through the tips and tricks presented in this multimedia article, we show the advantages of the robotic approach for performing correctly one of the most complex surgeries.
    MeSH term(s) Female ; Humans ; Middle Aged ; Bile Duct Neoplasms/surgery ; Bile Duct Neoplasms/pathology ; Bile Ducts, Intrahepatic/pathology ; Bismuth ; Cholangiocarcinoma/surgery ; Hepatectomy/methods ; Klatskin Tumor/surgery ; Klatskin Tumor/pathology ; Robotic Surgical Procedures/methods
    Chemical Substances Bismuth (U015TT5I8H)
    Language English
    Publishing date 2024-02-05
    Publishing country United States
    Document type Case Reports ; Journal Article ; Video-Audio Media
    ZDB-ID 1200469-8
    ISSN 1534-4681 ; 1068-9265
    ISSN (online) 1534-4681
    ISSN 1068-9265
    DOI 10.1245/s10434-024-14956-z
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