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  1. AU="Igarashi, Ikuo"
  2. AU="Naoki Nakashima"
  3. AU="Schrum, Adam G"
  4. AU="Hamann, Johann Georg"
  5. AU="Hochstrasser, Seraina"
  6. AU="Bronk, Marieke"
  7. AU=Lee Jeonghyun
  8. AU="Teshima, M"
  9. AU="Murray, Anne M"
  10. AU="Suaña Calsín, Milciades Conrado"
  11. AU="Bai, Yao" AU="Bai, Yao"
  12. AU="Strandberg, Erik"
  13. AU="Dar Dowlatshahi"
  14. AU="Capote, Ailem Rabasa"
  15. AU="Richier, Q"
  16. AU="Jamla, Monica"
  17. AU="Shimomura, Taizou"
  18. AU="Tampakakis, Emmanouil"
  19. AU="Tabares, Jeffrey V"

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  1. Artikel ; Online: Diminazene aceturate and imidocarb dipropionate-based combination therapy for babesiosis - A new paradigm.

    Rizk, Mohamed Abdo / El-Sayed, Shimaa Abd El-Salam / Igarashi, Ikuo

    Ticks and tick-borne diseases

    2023  Band 14, Heft 4, Seite(n) 102145

    Abstract: In the present study, the effect of a combination therapy consisting of diminazene aceturate (DA) and imidocarb dipropionate (ID) on the in vitro growth of several parasitic piroplasmids, and on Babesia microti in BALB/c mice was evaluated using a ... ...

    Abstract In the present study, the effect of a combination therapy consisting of diminazene aceturate (DA) and imidocarb dipropionate (ID) on the in vitro growth of several parasitic piroplasmids, and on Babesia microti in BALB/c mice was evaluated using a fluorescence-based SYBR Green I test. We evaluated the structural similarities between the regularly used antibabesial medications, DA and ID, and the recently found antibabesial drugs, pyronaridine tetraphosphate, atovaquone, and clofazimine, using atom pair fingerprints (APfp). The Chou-Talalay approach was used to determine the interactions between the two drugs. A Celltac MEK-6450 computerized hematology analyzer was used to detect hemolytic anemia every 96 hours in mice infected with B. microti and in those treated with either mono- or combination therapy. According to the APfp results, DA and ID have the most structural similarities (MSS). DA and ID had synergistic and additive interactions against the in vitro growth of Babesia bigemina and Babesia bovis, respectively. Low dosages of DA (6.25 mg kg
    Mesh-Begriff(e) Animals ; Mice ; Babesiosis/drug therapy ; Babesiosis/parasitology ; Theileria ; Babesia ; Imidocarb/therapeutic use
    Chemische Substanzen diminazene aceturate (JI8SAD85NO) ; imidocarb dipropionate (ZSM1M03SHC) ; Imidocarb (8USS3K0VDH)
    Sprache Englisch
    Erscheinungsdatum 2023-04-01
    Erscheinungsland Netherlands
    Dokumenttyp Journal Article ; Research Support, Non-U.S. Gov't
    ZDB-ID 2541872-5
    ISSN 1877-9603 ; 1877-959X
    ISSN (online) 1877-9603
    ISSN 1877-959X
    DOI 10.1016/j.ttbdis.2023.102145
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  2. Artikel ; Online: Diminazene aceturate and imidocarb dipropionate-based combination therapy for babesiosis - a new paradigm.

    Rizk, Mohamed Abdo / El-Sayed, Shimaa Abd El-Salam / Igarashi, Ikuo

    Ticks and tick-borne diseases

    2023  Band 14, Heft 1F1, Seite(n) 102141

    Abstract: In the present study, the effect of a combination therapy consisting of diminazene aceturate (DA) and imidocarb dipropionate (ID) on the in vitro growth of several parasitic piroplasmids, and on Babesia microti in BALB/c mice was evaluated using a ... ...

    Abstract In the present study, the effect of a combination therapy consisting of diminazene aceturate (DA) and imidocarb dipropionate (ID) on the in vitro growth of several parasitic piroplasmids, and on Babesia microti in BALB/c mice was evaluated using a fluorescence-based SYBR Green I test. We evaluated the structural similarities between the regularly used antibabesial medications, DA and ID, and the recently found antibabesial drugs, pyronaridine tetraphosphate, atovaquone, and clofazimine, using atom pair fingerprints (APfp). The Chou-Talalay approach was used to determine the interactions between the two drugs. A Celltac MEK-6450 computerized hematology analyzer was used to detect hemolytic anemia every 96 h in mice infected with B. microti and in those treated with either mono- or combination therapy. According to the APfp results, DA and ID have the most structural similarities (MSS). DA and ID had synergistic and additive interactions against the in vitro growth of Babesia bigemina and Babesia bovis, respectively. Low dosages of DA (6.25 mg kg
    Sprache Englisch
    Erscheinungsdatum 2023-02-20
    Erscheinungsland Netherlands
    Dokumenttyp Journal Article
    ZDB-ID 2541872-5
    ISSN 1877-9603 ; 1877-959X
    ISSN (online) 1877-9603
    ISSN 1877-959X
    DOI 10.1016/j.ttbdis.2023.102141
    Datenquelle MEDical Literature Analysis and Retrieval System OnLINE

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  3. Artikel ; Online: Babesia gibsoni.

    Liu, Mingming / Igarashi, Ikuo / Xuan, Xuenan

    Trends in parasitology

    2022  Band 38, Heft 9, Seite(n) 815–816

    Mesh-Begriff(e) Animals ; Babesia ; Babesiosis ; Dog Diseases ; Dogs
    Sprache Englisch
    Erscheinungsdatum 2022-03-23
    Erscheinungsland England
    Dokumenttyp Journal Article ; Research Support, Non-U.S. Gov't
    ZDB-ID 2036227-4
    ISSN 1471-5007 ; 1471-4922
    ISSN (online) 1471-5007
    ISSN 1471-4922
    DOI 10.1016/j.pt.2022.03.001
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  4. Artikel ; Online: Diminazene Aceturate and Imidocarb Dipropionate-Based Combination Therapy for Babesiosis - A New Paradigm

    Rizk, Mohamed Abdo / El-Sayed, Shimaa Abd El-Salam / Igarashi, Ikuo

    Ticks and Tick-borne Diseases. , p.102145-

    2023  , Seite(n) 102145–

    Abstract: In the present study, the effect of a combination therapy consisting of diminazene aceturate (DA) and imidocarb dipropionate (ID) on the in vitro growth of several parasitic piroplasmids, and on Babesia microti in BALB/c mice was evaluated using a ... ...

    Abstract In the present study, the effect of a combination therapy consisting of diminazene aceturate (DA) and imidocarb dipropionate (ID) on the in vitro growth of several parasitic piroplasmids, and on Babesia microti in BALB/c mice was evaluated using a fluorescence-based SYBR Green I test. We evaluated the structural similarities between the regularly used antibabesial medications, DA and ID, and the recently found antibabesial drugs, pyronaridine tetraphosphate, atovaquone, and clofazimine, using atom pair fingerprints (APfp). The Chou-Talalay approach was used to determine the interactions between the two drugs. A Celltac MEK-6450 computerized hematology analyzer was used to detect hemolytic anemia every 96 hours in mice infected with B. microti and in those treated with either mono- or combination therapy. According to the APfp results, DA and ID have the most structural similarities (MSS). DA and ID had synergistic and additive interactions against the in vitro growth of Babesia bigemina and Babesia bovis, respectively. Low dosages of DA (6.25 mg kg⁻¹) and ID (8.5 mg kg⁻¹) in conjunction with each other inhibited B. microti growth by 16.5 %, 32 %, and 4.5 % more than 25 mg kg⁻¹ DA, 6.25 mg kg⁻¹ DA, and 8.5 mg kg⁻¹ ID monotherapies, respectively. In the blood, kidney, heart, and lung tissues of mice treated with DA/ID, the B. microti small subunit rRNA gene was not detected. The obtained findings suggest that DA/ID could be a promising combination therapy for treating bovine babesiosis. Also, such combination may overcome the potential problems of Babesia resistance and host toxicity induced by utilizing full doses of DA and ID.
    Schlagwörter Babesia bigemina ; Babesia bovis ; Babesia microti ; babesiosis ; blood ; diminazene ; genes ; heart ; hematology ; hemolytic anemia ; imidocarb ; kidneys ; lungs ; pyronaridine ; therapeutics ; toxicity ; Babesia ; Theileria equi ; in vitro ; in vivo ; diminazene aceturate ; imidocarb dipropionate ; combination therapy
    Sprache Englisch
    Erscheinungsort Elsevier GmbH
    Dokumenttyp Artikel ; Online
    Anmerkung Pre-press version ; Use and reproduction
    ZDB-ID 2541872-5
    ISSN 1877-9603 ; 1877-959X
    ISSN (online) 1877-9603
    ISSN 1877-959X
    DOI 10.1016/j.ttbdis.2023.102145
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  5. Artikel ; Online: Diminazene Aceturate and Imidocarb Dipropionate-Based Combination Therapy for Babesiosis - A New Paradigm

    Rizk, Mohamed Abdo / El-Sayed, Shimaa Abd El-Salam / Igarashi, Ikuo

    Ticks and Tick-borne Diseases. , p.102141-

    2023  , Seite(n) 102141–

    Abstract: In the present study, the effect of a combination therapy consisting of diminazene aceturate (DA) and imidocarb dipropionate (ID) on the in vitro growth of several parasitic piroplasmids, and on Babesia microti in BALB/c mice was evaluated using a ... ...

    Abstract In the present study, the effect of a combination therapy consisting of diminazene aceturate (DA) and imidocarb dipropionate (ID) on the in vitro growth of several parasitic piroplasmids, and on Babesia microti in BALB/c mice was evaluated using a fluorescence-based SYBR Green I test. We evaluated the structural similarities between the regularly used antibabesial medications, DA and ID, and the recently found antibabesial drugs, pyronaridine tetraphosphate, atovaquone, and clofazimine, using atom pair fingerprints (APfp). The Chou-Talalay approach was used to determine the interactions between the two drugs. A Celltac MEK-6450 computerized hematology analyzer was used to detect hemolytic anemia every 96 hours in mice infected with B. microti and in those treated with either mono- or combination therapy. According to the APfp results, DA and ID have the most structural similarities (MSS). DA and ID had synergistic and additive interactions against the in vitro growth of Babesia bigemina and Babesia bovis, respectively. Low dosages of DA (6.25 mg kg⁻¹) and ID (8.5 mg kg⁻¹) in conjunction with each other inhibited B. microti growth by 16.5 %, 32 %, and 4.5 % more than 25 mg kg⁻¹ DA, 6.25 mg kg⁻¹ DA, and 8.5 mg kg⁻¹ ID monotherapies, respectively. In the blood, kidney, heart, and lung tissues of mice treated with DA/ID, the B. microti small subunit rRNA gene was not detected. The obtained findings suggest that DA/ID could be a promising combination therapy for treating bovine babesiosis. Also, such combination may overcome the potential problems of Babesia resistance and host toxicity induced by utilizing full doses of DA and ID.
    Schlagwörter Babesia bigemina ; Babesia bovis ; Babesia microti ; babesiosis ; blood ; diminazene ; genes ; heart ; hematology ; hemolytic anemia ; imidocarb ; kidneys ; lungs ; pyronaridine ; therapeutics ; toxicity ; Babesia ; Theileria equi ; in vitro ; in vivo ; diminazene aceturate, imidocarb dipropionate ; combination therapy
    Sprache Englisch
    Erscheinungsort Elsevier GmbH
    Dokumenttyp Artikel ; Online
    Anmerkung Pre-press version ; Use and reproduction
    ZDB-ID 2541872-5
    ISSN 1877-9603 ; 1877-959X
    ISSN (online) 1877-9603
    ISSN 1877-959X
    DOI 10.1016/j.ttbdis.2023.102141
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  6. Artikel ; Online: In vivo

    Rizk, Mohamed Abdo / El-Sayed, Shimaa Abd El-Salam / Igarashi, Ikuo

    Pathogens and global health

    2022  Band 117, Heft 3, Seite(n) 315–321

    Abstract: The effect of MMV665941 on the growth ... ...

    Abstract The effect of MMV665941 on the growth of
    Mesh-Begriff(e) Humans ; Cattle ; Animals ; Mice ; Babesia microti ; Babesiosis/drug therapy ; Babesiosis/parasitology ; Babesia/physiology ; Parasites ; Atovaquone/pharmacology ; Atovaquone/therapeutic use ; Rodentia ; Theileriasis/drug therapy ; Theileriasis/parasitology
    Chemische Substanzen Atovaquone (Y883P1Z2LT)
    Sprache Englisch
    Erscheinungsdatum 2022-09-28
    Erscheinungsland England
    Dokumenttyp Journal Article
    ZDB-ID 2625162-0
    ISSN 2047-7732 ; 2047-7724
    ISSN (online) 2047-7732
    ISSN 2047-7724
    DOI 10.1080/20477724.2022.2128571
    Datenquelle MEDical Literature Analysis and Retrieval System OnLINE

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    Ud II Zs.196: Hefte anzeigen Standort:
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  7. Artikel ; Online: Ascorbic acid co-administration with a low dose of diminazene aceturate inhibits the in vitro growth of Theileria equi, and the in vivo growth of Babesia microti.

    Rizk, Mohamed Abdo / El-Sayed, Shimaa Abd El-Salam / Igarashi, Ikuo

    Parasitology international

    2022  Band 90, Seite(n) 102596

    Abstract: In the current investigation, the effect of ascorbic acid on the in vitro growth of several piroplasm including Babesia bovis (Bartonella bovis), Baconia bigemina, B. caballi, and Theileria equi (T. equi), as well as against Brucella microti in mice was ... ...

    Abstract In the current investigation, the effect of ascorbic acid on the in vitro growth of several piroplasm including Babesia bovis (Bartonella bovis), Baconia bigemina, B. caballi, and Theileria equi (T. equi), as well as against Brucella microti in mice was assessed. The antipiroplasm efficacy of ascorbic acid in vitro and in vivo was assessed using a fluorescence-based SYBR Green I test. Using atom pair fingerprint (APfp), we investigated the structural similarity between ascorbic acid and the commonly used antibabesial medicines, diminazene aceturate (DA) and imidocarb dipropionate (ID). In vitro cultures of B. bovis and T. equi were utilized to determine the ascorbic acid and DA interaction using the Chou-Talalay method. Ascorbic acid inhibited B. bovis, B. bigemina, T. equi, and B. caballi growth in vitro in a dose-dependent manner. The APfp results revealed that ascorbic acid and DA have a maximum structural similarity (MSS). On a T. equi culture in vitro, ascorbic acid showed a synergistic interaction with DA, with a combination index of 0.28. B. microti growth was decreased by 41% in vivo using ascorbic acid combined with a very low dosage of DA (6.25 mg kg
    Mesh-Begriff(e) Animals ; Ascorbic Acid/pharmacology ; Ascorbic Acid/therapeutic use ; Babesia ; Babesia microti ; Babesiosis/drug therapy ; Babesiosis/parasitology ; Cattle ; Diminazene/analogs & derivatives ; Horse Diseases ; Horses ; Mice ; Theileria ; Theileriasis/drug therapy ; Theileriasis/parasitology
    Chemische Substanzen diminazene aceturate (JI8SAD85NO) ; Ascorbic Acid (PQ6CK8PD0R) ; Diminazene (Y5G36EEA5Z)
    Sprache Englisch
    Erscheinungsdatum 2022-05-06
    Erscheinungsland Netherlands
    Dokumenttyp Journal Article
    ZDB-ID 1363151-2
    ISSN 1873-0329 ; 1383-5769
    ISSN (online) 1873-0329
    ISSN 1383-5769
    DOI 10.1016/j.parint.2022.102596
    Datenquelle MEDical Literature Analysis and Retrieval System OnLINE

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    Zs.B 2322: Hefte anzeigen Standort:
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  8. Artikel ; Online: In Vitro Inhibitory Effects and Bioinformatic Analysis of Norfloxacin and Ofloxacin on Piroplasm.

    Rizk, Mohamed Abdo / El-Sayed, Shimaa Abd El-Salam / Igarashi, Ikuo

    Acta parasitologica

    2022  Band 68, Heft 1, Seite(n) 213–222

    Abstract: Purpose: The in vitro inhibitory effect of two fluroquinolone antibiotics, norfloxacin and ofloxacin, was evaluated in this study on the growth of several Babesia and Theileria parasites with highlighting the bioinformatic analysis for both drugs with ... ...

    Abstract Purpose: The in vitro inhibitory effect of two fluroquinolone antibiotics, norfloxacin and ofloxacin, was evaluated in this study on the growth of several Babesia and Theileria parasites with highlighting the bioinformatic analysis for both drugs with the commonly used antibabesial drug, diminazene aceturate (DA), and the recently identified antibabesial drugs, luteolin, and pyronaridine tetraphosphate (PYR).
    Methods: The antipiroplasm efficacy of screened fluroquinolones in vitro and in vivo was assessed using a fluorescence-based SYBR Green I assay. Using atom Pair signatures, we investigated the structural similarity between fluroquinolones and the antibabesial drugs.
    Results: Both fluroquinolones significantly inhibited (P < 0.05) the in vitro growths of Babesia bovis (B. bovis), B. bigemina, B. caballi, and Theileria equi (T. equi) in a dose-dependent manner. The best inhibitory effect for both drugs was observed on the growth of T. equi. Atom Pair fingerprints (APfp) results and AP Tanimoto values revealed that both fluroquinolones, norfloxacin with luteolin, and ofloxacin with PYR, showed the maximum structural similarity (MSS). Two drug interactions findings confirmed the synergetic interaction between these combination therapies against the in vitro growth of B. bovis and T. equi.
    Conclusion: This study helped in discovery novel potent antibabesial combination therapies consist of norfloxacin/ofloxacin, norfloxacin/luteolin, and ofloxacin/PYR.
    Mesh-Begriff(e) Animals ; Cattle ; Horses ; Norfloxacin/pharmacology ; Norfloxacin/therapeutic use ; Ofloxacin/pharmacology ; Ofloxacin/therapeutic use ; Luteolin/pharmacology ; Luteolin/therapeutic use ; Babesia ; Theileria ; Babesiosis/parasitology ; Theileriasis/parasitology ; Horse Diseases
    Chemische Substanzen Norfloxacin (N0F8P22L1P) ; Ofloxacin (A4P49JAZ9H) ; Luteolin (KUX1ZNC9J2)
    Sprache Englisch
    Erscheinungsdatum 2022-12-21
    Erscheinungsland Switzerland
    Dokumenttyp Journal Article
    ZDB-ID 1132735-2
    ISSN 1896-1851 ; 0065-1478 ; 1230-2821
    ISSN (online) 1896-1851
    ISSN 0065-1478 ; 1230-2821
    DOI 10.1007/s11686-022-00648-9
    Datenquelle MEDical Literature Analysis and Retrieval System OnLINE

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  9. Artikel ; Online: Animal models of the immunology and pathogenesis of human babesiosis.

    Kumar, Abhinav / Kabra, Aditya / Igarashi, Ikuo / Krause, Peter J

    Trends in parasitology

    2022  Band 39, Heft 1, Seite(n) 38–52

    Abstract: Animal models of human babesiosis have provided a basic understanding of the immunological mechanisms that clear, or occasionally exacerbate, Babesia infection and those pathological processes that cause disease complications. Human Babesia infection can ...

    Abstract Animal models of human babesiosis have provided a basic understanding of the immunological mechanisms that clear, or occasionally exacerbate, Babesia infection and those pathological processes that cause disease complications. Human Babesia infection can cause asymptomatic infection, mild to moderate disease, or severe disease resulting in organ dysfunction and death. More than 100 Babesia species infect a wide array of wild and domestic animals, and many of the immunologic and pathologic responses to Babesia infection are similar in animals and humans. In this review, we summarize the knowledge gained from animal studies, their limitations, and how animal models or alternative approaches can be further leveraged to improve our understanding of human babesiosis.
    Mesh-Begriff(e) Animals ; Humans ; Babesiosis ; Babesia ; Models, Animal
    Sprache Englisch
    Erscheinungsdatum 2022-12-02
    Erscheinungsland England
    Dokumenttyp Journal Article ; Review ; Research Support, Non-U.S. Gov't
    ZDB-ID 2036227-4
    ISSN 1471-5007 ; 1471-4922
    ISSN (online) 1471-5007
    ISSN 1471-4922
    DOI 10.1016/j.pt.2022.11.003
    Datenquelle MEDical Literature Analysis and Retrieval System OnLINE

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  10. Artikel ; Online: Imidazo[1,2-a]pyridine: a Highly Potent Therapeutic Agent Clears Piroplasm Infection In Vitro.

    Rizk, Mohamed Abdo / El-Sayed, Shimaa Abd El-Salam / El-Alfy, El-Sayed / Igarashi, Ikuo

    Acta parasitologica

    2023  Band 68, Heft 1, Seite(n) 249–256

    Abstract: Background and purpose: The imidazo[1,2-a] pyridines have huge applications in medicinal chemistry with potent activity against wide spectrum of infectious agents. The efficacy of imidazo[1,2-a]pyridine on the in vitro growth of different piroplasms, ... ...

    Abstract Background and purpose: The imidazo[1,2-a] pyridines have huge applications in medicinal chemistry with potent activity against wide spectrum of infectious agents. The efficacy of imidazo[1,2-a]pyridine on the in vitro growth of different piroplasms, including Babesia bovis, B. bigemina, B. divergens, B. caballi, and Theileria equi, was investigated in this study.
    Methods: The anti-piroplasm efficacy of imidazo[1,2-a] pyridines was assessed using a fluorescence-based SYBR Green I assay. Furthermore, efficacy of imidazo[1,2-a]pyridine against piroplasms following discontinuation of treatment was also assessed using a viability assay. In vitro cultures of B. bovis and T. equi were used to assess the imidazo[1,2-a]pyridine and diminazene aceturate (DA) interaction.
    Results: In vitro, imidazo[1,2-a]pyridine inhibited the growth of B. bovis, B. bigemina, B. caballi, and T. equi in a dose-dependent manner. The highest inhibitory effects of imidazo[1,2-a]pyridine were detected on the growth of B. caballi with IC
    Conclusion: The obtained encouraging findings pave the way for in vitro and in vivo efficacy trials of imidazo[1,2-a]pyridine derivatives against several piroplasmids.
    Mesh-Begriff(e) Animals ; Cattle ; Babesia ; Theileria ; Pyridines/pharmacology ; Pyridines/therapeutic use ; Babesiosis/drug therapy ; Babesiosis/parasitology ; Theileriasis/parasitology
    Chemische Substanzen pyridine (NH9L3PP67S) ; Pyridines ; diminazene aceturate (JI8SAD85NO)
    Sprache Englisch
    Erscheinungsdatum 2023-01-13
    Erscheinungsland Switzerland
    Dokumenttyp Journal Article
    ZDB-ID 1132735-2
    ISSN 1896-1851 ; 0065-1478 ; 1230-2821
    ISSN (online) 1896-1851
    ISSN 0065-1478 ; 1230-2821
    DOI 10.1007/s11686-022-00655-w
    Datenquelle MEDical Literature Analysis and Retrieval System OnLINE

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