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Article ; Online: Associations between measured masticatory function and cognitive status: A systematic review.

Maekawa, Kenji / Motohashi, Yoshiko / Igarashi, Kentaro / Mino, Takuya / Kawai, Yasuhiko / Kang, Youngnam / Hirai, Toshihiro / Kuboki, Takuo

Gerodontology

2024

Abstract: Objective: This systematic review aimed to provide an overview of the most recent evidence on the association between measured masticatory function and cognitive status.: Materials and methods: Literature and manual searches were conducted using ... ...

Abstract	Objective: This systematic review aimed to provide an overview of the most recent evidence on the association between measured masticatory function and cognitive status. Materials and methods: Literature and manual searches were conducted using three electronic databases (PubMed, Web of Science and CINAHL). Observational studies published between 2011 and 2021 investigating the association between masticatory function, dementia and cognitive status in adult humans were abstracted and reviewed by three reviewers. Studies that assessed participants' masticatory function using objective and subjective measurements and that individually examined its association with cognitive function were included. The included studies were divided into cross-sectional and cohort studies, and the quality of each study was analysed using critical appraisal skills checklists. Additionally, the main conclusions and strength of the evidence were assessed for each article. Results: A total of 21 studies (11 cross-sectional studies that objectively evaluated masticatory function, 9 cross-sectional studies that subjectively evaluated masticatory function and 1 prospective cohort study) were evaluated. The poorer masticatory function was associated with lower cognitive status even after adjusting for potential risk factors of dementia in four of 11 and six of nine cross-sectional studies where the masticatory function was respectively evaluated objectively and subjectively. One prospective cohort study also demonstrated that masticatory function, as evaluated based on measurements of occlusal force, predicted cognitive decline during the follow-up period. Conclusion: Several studies demonstrated a positive association between masticatory function and cognitive status. However, further studies, particularly longitudinal studies, are required to determine whether the association is causal.
Language	English
Publishing date	2024-03-27
Publishing country	England
Document type	Journal Article ; Review
ZDB-ID	604810-9
ISSN	1741-2358 ; 0734-0664
ISSN (online)	1741-2358
ISSN	0734-0664
DOI	10.1111/ger.12751
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Article ; Online: Development and validation of a nomogram to predict surgical site infection after soft-tissue sarcoma resection.

Miwa, Shinji / Yamamoto, Norio / Hayashi, Katsuhiro / Takeuchi, Akihiko / Igarashi, Kentaro / Tada, Kaoru / Taniguchi, Yuta / Morinaga, Sei / Asano, Yohei / Tsuchiya, Hiroyuki

The bone & joint journal

2024 Volume 106-B, Issue 5, Page(s) 492–500

Abstract: Aims: Surgical site infection (SSI) after soft-tissue sarcoma (STS) resection is a serious complication. The purpose of this retrospective study was to investigate the risk factors for SSI after STS resection, and to develop a nomogram that allows ... ...

Abstract	Aims: Surgical site infection (SSI) after soft-tissue sarcoma (STS) resection is a serious complication. The purpose of this retrospective study was to investigate the risk factors for SSI after STS resection, and to develop a nomogram that allows patient-specific risk assessment. Methods: A total of 547 patients with STS who underwent tumour resection between 2005 and 2021 were divided into a development cohort and a validation cohort. In the development cohort of 402 patients, the least absolute shrinkage and selection operator (LASSO) regression model was used to screen possible risk factors of SSI. To select risk factors and construct the prediction nomogram, multivariate logistic regression was used. The predictive power of the nomogram was evaluated by receiver operating curve (ROC) analysis in the validation cohort of 145 patients. Results: LASSO regression analysis selected possible risk factors for SSI, including age, diabetes, operating time, skin graft or flap, resected tumour size, smoking, and radiation therapy. Multivariate analysis revealed that age, diabetes, smoking during the previous year, operating time, and radiation therapy were independent risk factors for SSI. A nomogram was developed based on the results of multivariate logistic regression analysis. In the development cohort, the incidence of SSI was 4.5% in the low-risk group (risk score < 6.89) and 26.6% in the high-risk group (risk score ≥ 6.89; p < 0.001). In the validation cohort, the incidence of SSI was 2.0% in the low-risk group and 15.9% in the high-risk group (p = 0.004). Conclusion: Our nomogram will enable surgeons to assess the risk of SSI in patients with STS. In patients with high risk of SSI, frequent monitoring and aggressive interventions should be considered to prevent this.
MeSH term(s)	Humans ; Nomograms ; Surgical Wound Infection/etiology ; Surgical Wound Infection/epidemiology ; Sarcoma/surgery ; Male ; Female ; Middle Aged ; Retrospective Studies ; Risk Factors ; Adult ; Aged ; Risk Assessment/methods ; Soft Tissue Neoplasms/surgery ; ROC Curve ; Adolescent ; Young Adult ; Aged, 80 and over
Language	English
Publishing date	2024-05-01
Publishing country	England
Document type	Journal Article ; Validation Study
ZDB-ID	2697156-2
ISSN	2049-4408 ; 2049-4394
ISSN (online)	2049-4408
ISSN	2049-4394
DOI	10.1302/0301-620X.106B5.BJJ-2023-1052.R1
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Zs.A 6989: Show issues

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Article: Surgical Site Infection after Bone Tumor Surgery: Risk Factors and New Preventive Techniques.

Miwa, Shinji / Yamamoto, Norio / Hayashi, Katsuhiro / Takeuchi, Akihiko / Igarashi, Kentaro / Tsuchiya, Hiroyuki

Cancers

2022 Volume 14, Issue 18

Abstract: The management of malignant bone tumors requires multidisciplinary interventions including chemotherapy, radiation therapy, and surgical tumor resection and reconstruction. Surgical site infection (SSI) is a serious complication in the treatment of ... ...

Abstract	The management of malignant bone tumors requires multidisciplinary interventions including chemotherapy, radiation therapy, and surgical tumor resection and reconstruction. Surgical site infection (SSI) is a serious complication in the treatment of malignant bone tumors. Compared to other orthopedic surgeries, the surgical treatment of malignant bone tumors is associated with higher rates of SSIs. In patients with SSIs, additional surgeries, long-term administrations of antibiotics, extended hospital stays, and the postponement of scheduled adjuvant treatments are required. Therefore, SSI may adversely affect functional and oncological outcomes. To improve surgical outcomes in patients with malignant bone tumors, preoperative risk assessments for SSIs, new preventive techniques against SSIs, and the optimal use of prophylactic antibiotics are often required. Previous reports have demonstrated that age, tumor site (pelvis and tibia), extended operative time, implant use, body mass index, leukocytopenia, and reconstruction procedures are associated with an increased risk for SSIs. Furthermore, prophylactic techniques, such as silver and iodine coatings on implants, have been developed and proven to be efficacious and safe in clinical studies. In this review, predictive factors of SSIs and new prophylactic techniques are discussed.
Language	English
Publishing date	2022-09-19
Publishing country	Switzerland
Document type	Journal Article ; Review
ZDB-ID	2527080-1
ISSN	2072-6694
ISSN	2072-6694
DOI	10.3390/cancers14184527
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Article ; Online: Therapeutic Targets and Emerging Treatments in Advanced Chondrosarcoma.

Miwa, Shinji / Yamamoto, Norio / Hayashi, Katsuhiro / Takeuchi, Akihiko / Igarashi, Kentaro / Tsuchiya, Hiroyuki

International journal of molecular sciences

2022 Volume 23, Issue 3

Abstract: Due to resistance to standard anticancer agents, it is difficult to control the disease progression in patients with metastatic or unresectable chondrosarcoma. Novel therapeutic approaches, such as molecule-targeting drugs and immunotherapy, are required ...

Abstract	Due to resistance to standard anticancer agents, it is difficult to control the disease progression in patients with metastatic or unresectable chondrosarcoma. Novel therapeutic approaches, such as molecule-targeting drugs and immunotherapy, are required to improve clinical outcomes in patients with advanced chondrosarcoma. Recent studies have suggested several promising biomarkers and therapeutic targets for chondrosarcoma, including
MeSH term(s)	Antineoplastic Agents/therapeutic use ; Biomarkers, Tumor/antagonists & inhibitors ; Biomarkers, Tumor/genetics ; Bone Neoplasms/drug therapy ; Bone Neoplasms/metabolism ; Bone Neoplasms/pathology ; Chondrosarcoma/drug therapy ; Chondrosarcoma/metabolism ; Chondrosarcoma/pathology ; Collagen Type II/antagonists & inhibitors ; Collagen Type II/genetics ; Humans ; Isocitrate Dehydrogenase/antagonists & inhibitors ; Isocitrate Dehydrogenase/genetics ; Mutation
Chemical Substances	Antineoplastic Agents ; Biomarkers, Tumor ; COL2A1 protein, human ; Collagen Type II ; Isocitrate Dehydrogenase (EC 1.1.1.41)
Language	English
Publishing date	2022-01-20
Publishing country	Switzerland
Document type	Journal Article ; Review
ZDB-ID	2019364-6
ISSN	1422-0067 ; 1422-0067 ; 1661-6596
ISSN (online)	1422-0067
ISSN	1422-0067 ; 1661-6596
DOI	10.3390/ijms23031096
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Article ; Online: Kimura's Disease Diagnosed in the Department of Orthopedic Surgery Treated With Wide Excision: Report of Two Cases.

Morinaga, Sei / Yamamoto, Norio / Hayashi, Katsuhiro / Takeuchi, Akihiko / Miwa, Shinji / Igarashi, Kentaro / Taniguchi, Yuta / Asano, Yohei / Nojima, Takayuki / Tsuchiya, Hiroyuki

In vivo (Athens, Greece)

2023 Volume 37, Issue 3, Page(s) 1373–1378

Abstract: Background/aim: Kimura's disease is a rare chronic inflammatory disorder that commonly affects the head and neck regions, occurring predominantly in Asian men. Elevated eosinophil count and IgE levels in the peripheral blood examination are suggestive ... ...

Abstract	Background/aim: Kimura's disease is a rare chronic inflammatory disorder that commonly affects the head and neck regions, occurring predominantly in Asian men. Elevated eosinophil count and IgE levels in the peripheral blood examination are suggestive of this disease. In this study we report two cases of Kimura's disease, treated with wide excision. Case report: The first case was a 58-year-old man presented with asymptomatic left neck mass. The second case was a 69-year-old man with swelling of the right upper arm, which was suggestive of soft tissue mass. Needle biopsy results were suggestive of Kimura's disease in both cases. Elevated WBCs at 8,380/μl (neutrophils: 45%, eosinophils: 33%) for the first case and 5,370/μl (neutrophils: 61.8%, eosinophils: 3.5%) for the second one, and serum IgE at 14.988 IU/ml for the first case and 1,315 IU/ml for the second one were observ. For definitive treatment and diagnosis, wide excisions were performed. Final histopathological results revealed Kimura's disease. Surgical margins were negative even though an ill-demarcated lesion for the first case and high infiltration to the muscle for second case were confirmed. Conclusion: Wide excision was performed in both cases of Kimura's disease and no recurrence was observed until the final follow-up. Wide excision with negative surgical margin should be recommended for the treatment of Kimura's disease.
MeSH term(s)	Male ; Humans ; Middle Aged ; Aged ; Angiolymphoid Hyperplasia with Eosinophilia/diagnosis ; Angiolymphoid Hyperplasia with Eosinophilia/surgery ; Angiolymphoid Hyperplasia with Eosinophilia/pathology ; Kimura Disease/diagnosis ; Kimura Disease/surgery ; Orthopedic Procedures ; Diagnosis, Differential ; Immunoglobulin E
Chemical Substances	Immunoglobulin E (37341-29-0)
Language	English
Publishing date	2023-04-27
Publishing country	Greece
Document type	Case Reports ; Journal Article
ZDB-ID	807031-3
ISSN	1791-7549 ; 0258-851X
ISSN (online)	1791-7549
ISSN	0258-851X
DOI	10.21873/invivo.13219
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Zs.A 2288: Show issues

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Article: Case Report: Unresectable pulmonary metastases of a giant cell tumor of bone treated with denosumab: a case report and review of literature.

Miwa, Shinji / Yamamoto, Norio / Hayashi, Katsuhiro / Takeuchi, Akihiko / Igarashi, Kentaro / Taniguchi, Yuta / Morinaga, Sei / Asano, Yohei / Nojima, Takayuki / Tsuchiya, Hiroyuki

Frontiers in oncology

2023 Volume 13, Page(s) 1230074

Abstract: Giant cell tumors of bone (GCTB) sometimes metastasize to distant organs. In this case report, we present pulmonary metastases of GCTB mimicking malignancies. A 49-year-old man underwent two surgical treatments for a GCTB of the right proximal radius. At ...

Abstract	Giant cell tumors of bone (GCTB) sometimes metastasize to distant organs. In this case report, we present pulmonary metastases of GCTB mimicking malignancies. A 49-year-old man underwent two surgical treatments for a GCTB of the right proximal radius. At the time of the second surgery, no lesions were observed on chest radiography. Three years after surgery, the patient presented with cough and dyspnea, and chest radiography and computed tomography (CT) revealed multiple lung nodules. Positron emission tomography/CT revealed a high accumulation of 18F-fluoro-2-deoxy-D-glucose (18F-FDG) in multiple lesions. Based on the rapid growth and accumulation of 18F-FDG, a metastatic malignant tumor was suspected. CT-guided needle biopsy was performed, and the histology showed proliferation of spindle cells and multinuclear giant cells without malignant changes. Denosumab was administered because multiple lung lesions were unresectable. One month after denosumab treatment, CT showed marked shrinkage of the lesions, and the symptoms significantly improved. Eighteen months after the initial treatment with denosumab, the patient had no symptoms or tumor growth. Although its long-term efficacy and safety remain unclear, denosumab may be a treatment option for patients with unresectable pulmonary GCTB.
Language	English
Publishing date	2023-08-16
Publishing country	Switzerland
Document type	Case Reports
ZDB-ID	2649216-7
ISSN	2234-943X
ISSN	2234-943X
DOI	10.3389/fonc.2023.1230074
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Article ; Online: High Clinical Concordance of Drug Resistance in Patient-derived Orthotopic Xenograft (PDOX) Mouse Models: First Step to Validated Precise Individualized Cancer Chemotherapy.

Higuchi, Takashi / Yamamoto, Norio / Hayashi, Katsuhiro / Miwa, Shinji / Igarashi, Kentaro / Tsuchiya, Hiroyuki / Hoffman, Robert M

Anticancer research

2023 Volume 43, Issue 10, Page(s) 4277–4284

Abstract: Finding an effective drug for individual cancer patients among the many chemotherapies available and ruling out ineffective drugs are important challenges, especially for patients with advanced cancer. To accomplish this goal, we have pioneered and ... ...

Abstract	Finding an effective drug for individual cancer patients among the many chemotherapies available and ruling out ineffective drugs are important challenges, especially for patients with advanced cancer. To accomplish this goal, we have pioneered and developed the patient-derived orthotopic xenograft (PDOX) nude mouse model for all cancer types, enabling the discovery and evaluation of novel therapeutics, as well as individualized therapy of patients with cancer. PDOX models can more precisely reproduce the original tumor microenvironment (TME) compared to subcutaneous-implanted xenografts including patient-derived xenograft (PDX) models. The present review presents the concordance of drug resistance in individual cancer patients and their PDOX models. There are 28 PDOX publications with 12 PDOX models from patients who were treated with chemotherapy. Sixteen chemotherapeutics were administrated to these patients and all of them were clinically ineffective. In PDOX models established from these patients' tumors, fourteen chemotherapeutics were resistant with a concordance rate of 88%. PDOX models should be established as early as possible from patients to predict and improve outcome. PDOX models mimic the clinical tumor aggressiveness, therefore enabling a high concordance with clinical outcomes. The present review shows a high concordance for drug resistance between cancer patients and their corresponding PDOX models. Future studies will include prospective clinical trials comparing both drug efficacy and resistance in patients and their PDOX models.
MeSH term(s)	Humans ; Mice ; Animals ; Heterografts ; Prospective Studies ; Xenograft Model Antitumor Assays ; Disease Models, Animal ; Drug Resistance, Neoplasm ; Neoplasms/drug therapy
Language	English
Publishing date	2023-04-03
Publishing country	Greece
Document type	Journal Article ; Review
ZDB-ID	604549-2
ISSN	1791-7530 ; 0250-7005
ISSN (online)	1791-7530
ISSN	0250-7005
DOI	10.21873/anticanres.16622
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Article ; Online: Methioninase Cell-Cycle Trap Cancer Chemotherapy.

Hoffman, Robert M / Yano, Shuya / Igarashi, Kentaro

Methods in molecular biology (Clifton, N.J.)

2019 Volume 1866, Page(s) 133–148

Abstract: Cancer cells are methionine (MET) dependent compared to normal cells as they have an elevated requirement for MET in order to proliferate. MET restriction selectively traps cancer cells in the S/ ... ...

Abstract	Cancer cells are methionine (MET) dependent compared to normal cells as they have an elevated requirement for MET in order to proliferate. MET restriction selectively traps cancer cells in the S/G
MeSH term(s)	Animals ; Antineoplastic Agents/pharmacology ; Antineoplastic Agents/therapeutic use ; Carbon-Sulfur Lyases/biosynthesis ; Carbon-Sulfur Lyases/pharmacology ; Carbon-Sulfur Lyases/therapeutic use ; Cell Cycle/drug effects ; Fluorescence ; Humans ; Mice, Nude ; Neoplasms/drug therapy ; Neoplasms/pathology ; Paclitaxel/pharmacology ; Paclitaxel/therapeutic use ; Recombinant Proteins/biosynthesis ; Salmonella typhimurium/metabolism ; Ubiquitination ; Xenograft Model Antitumor Assays
Chemical Substances	Antineoplastic Agents ; Recombinant Proteins ; Carbon-Sulfur Lyases (EC 4.4.-) ; L-methionine gamma-lyase (EC 4.4.1.11) ; Paclitaxel (P88XT4IS4D)
Language	English
Publishing date	2019-02-06
Publishing country	United States
Document type	Journal Article
ISSN	1940-6029
ISSN (online)	1940-6029
DOI	10.1007/978-1-4939-8796-2_11
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Article ; Online: Extensive Synergy Between Recombinant Methioninase and Eribulin Against Fibrosarcoma Cells But Not Normal Fibroblasts.

Morinaga, Sei / Han, Qinghong / Kubota, Yutaro / Mizuta, Kohei / Kang, Byung Mo / Sato, Motokazu / Bouvet, Michael / Yamamoto, Norio / Hayashi, Katsuhiro / Kimura, Hiroaki / Miwa, Shinji / Igarashi, Kentaro / Higuchi, Takashi / Tsuchiya, Hiroyuki / Hoffman, Robert M

Anticancer research

2024 Volume 44, Issue 3, Page(s) 921–928

Abstract: Background/aim: The aim of the present study was to determine the synergy of recombinant methioninase (rMETase) and the anti-tubulin agent eribulin on fibrosarcoma cells, in comparison to normal fibroblasts, in vitro.: Materials and methods: HT1080 ... ...

Abstract	Background/aim: The aim of the present study was to determine the synergy of recombinant methioninase (rMETase) and the anti-tubulin agent eribulin on fibrosarcoma cells, in comparison to normal fibroblasts, in vitro. Materials and methods: HT1080 human fibrosarcoma cells and HS27 human fibroblasts were used for in vitro experiments. Four groups were analyzed in vitro: No-treatment control; eribulin; rMETase; eribulin plus rMETase. Dual-color HT1080 cells which express red fluorescent protein (RFP) in the cytoplasm and green fluorescent protein (GFP) in the nuclei were used to visualize cytoplasmic and nuclear dynamics during treatment. Results: Eribulin combined with rMETase greatly decreased the viability of HT 1080 cells. In contrast, eribulin combined with rMETase did not show synergy on Hs27 normal fibroblasts. Eribulin combined with rMETase also caused more fragmentation of the nucleus than all other treatments. Conclusion: The combination treatment of eribulin plus rMETase demonstrated efficacy on fibrosarcoma cells in vitro. In contrast, normal fibroblasts were resistant to this combination, indicating the potential clinical applicability of the treatment.
MeSH term(s)	Humans ; Carbon-Sulfur Lyases/therapeutic use ; Cell Line, Tumor ; Fibrosarcoma/drug therapy ; Fibroblasts ; Recombinant Proteins/pharmacology ; Recombinant Proteins/therapeutic use ; Polyether Polyketides ; Furans ; Ketones
Chemical Substances	L-methionine gamma-lyase (EC 4.4.1.11) ; eribulin (LR24G6354G) ; Carbon-Sulfur Lyases (EC 4.4.-) ; Recombinant Proteins ; Polyether Polyketides ; Furans ; Ketones
Language	English
Publishing date	2024-02-29
Publishing country	Greece
Document type	Journal Article
ZDB-ID	604549-2
ISSN	1791-7530 ; 0250-7005
ISSN (online)	1791-7530
ISSN	0250-7005
DOI	10.21873/anticanres.16886
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Article ; Online: Tumor-induced Osteomalacia Successfully Treated by

Bangcoy, Martin Louie S / Miwa, Shinji / Yamamoto, Norio / Hayashi, Katsuhiro / Nishida, Hideji / Takeuchi, Akihiko / Igarashi, Kentaro / Kato, Takashi / Taniguchi, Yuta / Morinaga, Sei / Asano, Yohei / Tsuchiya, Hiroyuki

Anticancer research

2024 Volume 44, Issue 4, Page(s) 1791–1797

Abstract: Background/aim: Tumor-induced osteomalacia (TIO) is a rare pathology caused by overproduction of fibroblast growth factor 23 (FGF23). Its common clinical features include generalized muscle weakness, bone pain, and fractures. Complete resection of the ... ...

Abstract	Background/aim: Tumor-induced osteomalacia (TIO) is a rare pathology caused by overproduction of fibroblast growth factor 23 (FGF23). Its common clinical features include generalized muscle weakness, bone pain, and fractures. Complete resection of the offending tumor is the mainstay treatment. In this report, we present the first case of TIO by an FGF23 producing tumor treated using a tumor-bearing autograft treated with liquid nitrogen. Case report: A 63-year old female presented with generalized body pain, particularly in the left arm. The patient was diagnosed with a FGF23 producing tumor of the left humerus. Wide resection of the involved tumor was performed using a tumor-bearing autograft that was treated with liquid nitrogen. Postoperatively, the FGF23 and alkaline phosphatase (ALP) levels significantly decreased and inorganic phosphate normalized. There was also subsequent relief of generalized body pain. Immediately after the operation, range of motion of the left shoulder and elbow was initiated. The patient was instructed to perform forward flexion and abduction up to 90° with a rotational restraint. Almost complete bone union was observed at 12 months post procedure. Postoperative functional results were as follows: Musculoskeletal Tumor Society (MSTS) score of 27/30, 90% and International Society of Limb Salvage (ISOLS) score of 26/30, 87%. Ten years after the surgery, osteotomy line was completely obscured based on radiographs. The patient was disease free and without activity limitation. Conclusion: This is the first case report of wide excision of a FGF23 producing tumor and reconstruction using a tumor-bearing frozen autograft performed with excellent outcomes.
MeSH term(s)	Female ; Humans ; Middle Aged ; Autografts ; Paraneoplastic Syndromes ; Pain ; Nitrogen ; Osteomalacia
Chemical Substances	Nitrogen (N762921K75)
Language	English
Publishing date	2024-03-27
Publishing country	Greece
Document type	Case Reports ; Journal Article
ZDB-ID	604549-2
ISSN	1791-7530 ; 0250-7005
ISSN (online)	1791-7530
ISSN	0250-7005
DOI	10.21873/anticanres.16979
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