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  1. Article ; Online: Gd 2 O 3 Doped UO 2 (s) Corrosion in the Presence of Silicate and Calcium under Alkaline Conditions

    Sonia García-Gómez / Javier Giménez / Ignasi Casas / Jordi Llorca / Joan De Pablo

    Inorganics, Vol 11, Iss 12, p

    2023  Volume 469

    Abstract: The anodic reactivity of UO 2 and UO 2 doped with Gd 2 O 3 was investigated by electrochemical methods in slightly alkaline conditions in the presence of silicate and calcium. At the end of the experiments, the electrodes were analysed by X-ray ... ...

    Abstract The anodic reactivity of UO 2 and UO 2 doped with Gd 2 O 3 was investigated by electrochemical methods in slightly alkaline conditions in the presence of silicate and calcium. At the end of the experiments, the electrodes were analysed by X-ray photoelectron spectroscopy to determine the oxidation state of the uranium on the surface. The experiments showed that the increase in gadolinia doping level led to a reduction in the reactivity of UO 2 , this effect being more marked at the highest doping level studied (10 wt.% Gd 2 O 3 ). This behaviour could be attributed to the formation of dopant-vacancy clusters (Gd III -Ov), which could limit the accommodation of excess O 2− into the UO 2 lattice. In addition, the presence of Ca 2+ and SiO 3 2− decreased the anodic dissolution of UO 2 . In summary, the Gd 2 O 3 doping in presence of silicate and calcium was found to strongly decrease the oxidative dissolution of UO 2 , which is a beneficial situation regarding the long-term management of spent nuclear fuel in a repository.
    Keywords UO 2 (s) ; gadolinia doping ; anodic oxidation ; X-ray photoelectron spectroscopy ; silicate and calcium ions ; Inorganic chemistry ; QD146-197
    Subject code 290
    Language English
    Publishing date 2023-12-01T00:00:00Z
    Publisher MDPI AG
    Document type Article ; Online
    Database BASE - Bielefeld Academic Search Engine (life sciences selection)

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  2. Article: Retention of cesium and strontium by uranophane, Ca(UO2)2(SiO3OH)2·5H2O

    Espriu-Gascon, Alexandra / Javier Giménez / Ignasi Casas / Joan de Pablo

    Journal of hazardous materials. 2018 July 05, v. 353

    2018  

    Abstract: This work determines the capacity of uranophane, one of the long-term uranyl secondary solid phases formed on the spent nuclear fuel (SNF), to retain radionuclides (cesium and strontium) released during the dissolution of the SNF. Sorption was fast in ... ...

    Abstract This work determines the capacity of uranophane, one of the long-term uranyl secondary solid phases formed on the spent nuclear fuel (SNF), to retain radionuclides (cesium and strontium) released during the dissolution of the SNF. Sorption was fast in both cases, and uranophane had a high sorption capacity for both radionuclides (maximum sorption capacities of 1.53·10−5 mol m-2 for cesium and 3.45·10−3 mol m−2 for strontium). The high sorption capacity of uranophane highlights the importance of the formation of uranyl silicates as secondary phases during the SNF dissolution, especially in retaining the release of radionuclides not retarded by other mechanisms such as precipitation.
    Keywords calcium ; cesium ; nuclear fuels ; radionuclides ; silicates ; sorption ; strontium ; uranium
    Language English
    Dates of publication 2018-0705
    Size p. 431-435.
    Publishing place Elsevier B.V.
    Document type Article
    ZDB-ID 1491302-1
    ISSN 1873-3336 ; 0304-3894
    ISSN (online) 1873-3336
    ISSN 0304-3894
    DOI 10.1016/j.jhazmat.2018.04.051
    Database NAL-Catalogue (AGRICOLA)

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  3. Article ; Online: The role of MMP7 and its cross-talk with the FAS/FASL system during the acquisition of chemoresistance to oxaliplatin.

    Vanessa Almendro / Elisabet Ametller / Susana García-Recio / Olga Collazo / Ignasi Casas / Josep M Augé / Joan Maurel / Pedro Gascón

    PLoS ONE, Vol 4, Iss 3, p e

    2009  Volume 4728

    Abstract: BACKGROUND: The efficacy of oxaliplatin in cancer chemotherapy is limited by the development of drug resistance. MMP7 has been related to the loss of tumor cell response to cytotoxic agents although the exact mechanism is not fully understood. Moreover, ... ...

    Abstract BACKGROUND: The efficacy of oxaliplatin in cancer chemotherapy is limited by the development of drug resistance. MMP7 has been related to the loss of tumor cell response to cytotoxic agents although the exact mechanism is not fully understood. Moreover, MMP7 is an independent prognosis factor for survival in patients with colorectal cancer. The aim of the present study was to analyze the role of MMP7 and its cross-talk with the Fas/FasL system during the acquisition of oxaliplatin resistance in colon cancer cells. PRINCIPAL FINDINGS: For this purpose we have developed three different oxaliplatin-resistant cell lines (RHT29, RHCT116 p53(+/+), RHCT116 p53(-/-)) from the parental HT29, HCT116 p53(+/+) and HCT116 p53(-/-) colon cancer cells. MMP7 basal expression was higher in the resistant compared to the parental cell lines. MMP7 was also upregulated by oxaliplatin in both HT29 (p53 mutant) and RHCT116 p53(-/-) but not in the RHCT116 p53(+/+). Inhibition of MMP by 1,10-phenantroline monohydrate or siRNA of MMP7 restores cell sensitivity to oxaliplatin-induced apoptosis in both HT29 and RHCT116 p53(-/-) but not in the RHCT116 p53(+/+). Some of these effects are caused by alterations in Fas receptor. Fas is upregulated by oxaliplatin in colon cancer cells, however the RHT29 cells treated with oxaliplatin showed a 3.8-fold lower Fas expression at the cell surface than the HT29 cells. Decrease of Fas at the plasma membrane seems to be caused by MMP7 since its inhibition restores Fas levels. Moreover, functional analysis of Fas demonstrates that this receptor was less potent in inducing apoptosis in RHT29 cells and that its activation induces MAPK signaling in resistant cells. CONCLUSIONS: Taking together, these results suggest that MMP7 is related to the acquisition of oxaliplatin-resistance and that its inhibition restores drug sensitivity by increasing Fas receptor. Furthermore, Fas undergoes a change in its functionality in oxaliplatin-resistant cells inducing survival pathways instead of apoptotic signals.
    Keywords Medicine ; R ; Science ; Q
    Subject code 616
    Language English
    Publishing date 2009-01-01T00:00:00Z
    Publisher Public Library of Science (PLoS)
    Document type Article ; Online
    Database BASE - Bielefeld Academic Search Engine (life sciences selection)

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