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  1. Article ; Online: Eosinophilic fasciitis: From pathophysiology to treatment.

    Ihn, Hironobu

    Allergology international : official journal of the Japanese Society of Allergology

    2019  Volume 68, Issue 4, Page(s) 437–439

    Abstract: Eosinophilic fasciitis is a disease originally proposed as "diffuse fasciitis with eosinophilia" by Shulman in 1974. The patients with this disease often have history of strenuous exercise or labor a few days to 1-2 weeks before the onset. The chief ... ...

    Abstract Eosinophilic fasciitis is a disease originally proposed as "diffuse fasciitis with eosinophilia" by Shulman in 1974. The patients with this disease often have history of strenuous exercise or labor a few days to 1-2 weeks before the onset. The chief symptoms are symmetrical, full-circumference swelling and plate-like hardness of the distal limbs. This is accompanied by redness and pain in the early stages, with many cases exhibiting systemic symptoms such as fever or generalized fatigue. The lesions have been observed extending to the proximal limbs, though never on the face or fingers. En bloc biopsies from the skin to the fascia show marked fascial thickening and inflammatory cell infiltration by the lymphocytes and plasma cells. Eosinophilic infiltration is useful for the diagnosis but is only seen in the early stages of the disease. Recently, "Diagnostic criteria, severity classification, and clinical guidelines for eosinophilic fasciitis" were published. This review article discusses about eosinophilic faciitis in detail, from its pathophysiology to the treatment.
    MeSH term(s) Biopsy ; Cytokines/metabolism ; Disease Management ; Disease Susceptibility ; Eosinophilia/diagnosis ; Eosinophilia/epidemiology ; Eosinophilia/etiology ; Eosinophilia/therapy ; Fasciitis/diagnosis ; Fasciitis/epidemiology ; Fasciitis/etiology ; Fasciitis/therapy ; Humans ; Phenotype ; Skin/immunology ; Skin/metabolism ; Skin/pathology
    Chemical Substances Cytokines
    Language English
    Publishing date 2019-03-22
    Publishing country England
    Document type Journal Article ; Review
    ZDB-ID 1336498-4
    ISSN 1440-1592 ; 1323-8930
    ISSN (online) 1440-1592
    ISSN 1323-8930
    DOI 10.1016/j.alit.2019.03.001
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  2. Article: [Eosinophilic fasciitis].

    Ihn, Hironobu

    Arerugi = [Allergy

    2011  Volume 60, Issue 6, Page(s) 683–686

    MeSH term(s) Adult ; Eosinophilia ; Fasciitis ; Female ; Humans ; Male ; Middle Aged ; Young Adult
    Language Japanese
    Publishing date 2011-06
    Publishing country Japan
    Document type Journal Article ; Review
    ZDB-ID 974201-3
    ISSN 0021-4884
    ISSN 0021-4884
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    In stock of ZB MED Cologne/Königswinter

    Zs.A 245: Show issues Location:
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  3. Article ; Online: A case of overlap syndrome (scleroderma and polymyositis) associated with the development of sudden chest pain due to myocardial damage.

    Kaneko, Akira / Kajihara, Ikko / Miyashita, Azusa / Ihn, Hironobu

    Drug discoveries & therapeutics

    2019  Volume 13, Issue 5, Page(s) 297–298

    Abstract: Myocardial injury with systemic sclerosis (SSc) causes pericarditis and arrhythmia, and polymyositis-induced muscle inflammation causes myocarditis. We report a rare case of overlap syndrome (SSc and polymyositis) who presented with sudden chest pain ... ...

    Abstract Myocardial injury with systemic sclerosis (SSc) causes pericarditis and arrhythmia, and polymyositis-induced muscle inflammation causes myocarditis. We report a rare case of overlap syndrome (SSc and polymyositis) who presented with sudden chest pain secondary to myocardial fibrosis. Although the etiology of chest symptoms in collagen disease was difficult to identify, cardiac magnetic resonance imaging (MRI) revealed not myocarditis but myocardial fibrosis in our case. Synthetic judgement of serum brain natriuretic peptide/ troponin T levels and cardiac MRI is useful in the search for the cause of chest symptoms even in patients with collagen diseases.
    MeSH term(s) Chest Pain/complications ; Chest Pain/diagnosis ; Fibrosis/complications ; Fibrosis/diagnostic imaging ; Fibrosis/pathology ; Heart/diagnostic imaging ; Humans ; Magnetic Resonance Imaging ; Male ; Myocardium/pathology ; Natriuretic Peptide, Brain/blood ; Polymyositis/blood ; Polymyositis/complications ; Polymyositis/diagnosis ; Scleroderma, Diffuse/blood ; Scleroderma, Diffuse/complications ; Scleroderma, Diffuse/diagnosis ; Syndrome ; Troponin T/blood ; Young Adult
    Chemical Substances Troponin T ; Natriuretic Peptide, Brain (114471-18-0)
    Language English
    Publishing date 2019-11-14
    Publishing country Japan
    Document type Case Reports ; Journal Article
    ISSN 1881-784X
    ISSN (online) 1881-784X
    DOI 10.5582/ddt.2019.01072
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  4. Article ; Online: A case of scleroderma associated with interstitial neutrophilic granulomatous reaction.

    Sawamura, Soichiro / Kajihara, Ikko / Ihn, Hironobu

    The Australasian journal of dermatology

    2019  Volume 60, Issue 4, Page(s) e338–e340

    MeSH term(s) Administration, Oral ; Adult ; Biopsy, Needle ; Celecoxib/administration & dosage ; Dermatitis/diagnosis ; Dermatitis/drug therapy ; Dermatitis/pathology ; Female ; Granuloma/diagnosis ; Granuloma/pathology ; Granuloma/surgery ; Humans ; Immunohistochemistry ; Neutrophils/cytology ; Prognosis ; Scleroderma, Localized/diagnosis ; Scleroderma, Localized/drug therapy ; Scleroderma, Localized/pathology ; Scleroderma, Systemic/diagnosis ; Scleroderma, Systemic/pathology ; Severity of Illness Index ; Thigh ; Treatment Outcome
    Chemical Substances Celecoxib (JCX84Q7J1L)
    Language English
    Publishing date 2019-05-02
    Publishing country Australia
    Document type Case Reports ; Letter
    ZDB-ID 138052-7
    ISSN 1440-0960 ; 0004-8380
    ISSN (online) 1440-0960
    ISSN 0004-8380
    DOI 10.1111/ajd.13065
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    Zs.A 236: Show issues Location:
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  5. Article: [Systemic sclerosis].

    Ihn, Hironobu

    Nihon rinsho. Japanese journal of clinical medicine

    2009  Volume 67, Issue 3, Page(s) 519–522

    Abstract: Systemic sclerosis (SSc), the focus of this review, is a generalized connective tissue disease that involves sclerotic changes in the skin and sometimes various other organ systems. Clinical outcomes have improved probably due to better management of the ...

    Abstract Systemic sclerosis (SSc), the focus of this review, is a generalized connective tissue disease that involves sclerotic changes in the skin and sometimes various other organ systems. Clinical outcomes have improved probably due to better management of the complications, but SSc is still considered to be incurable and diffuse cutaneous SSc carries high risk of fatality. Although the pathogenesis of SSc is still unknown, the basic mechanism appears to involve endothelial cell injury, overproduction of extracellular matrix (ECM), and aberrant immune activation. This review discusses recent studies that investigated the cellular and molecular mechanisms in the pathogenesis of SSc.
    MeSH term(s) Antibodies, Antinuclear ; Collagen/genetics ; Endothelial Cells/pathology ; Endothelin-1/physiology ; Extracellular Matrix/metabolism ; Fibroblasts/physiology ; Humans ; Lymphocytes/immunology ; Platelet-Derived Growth Factor/immunology ; Platelet-Derived Growth Factor/physiology ; Scleroderma, Systemic/etiology ; Scleroderma, Systemic/pathology ; Transcription Factors/physiology ; Transforming Growth Factor beta/physiology
    Chemical Substances Antibodies, Antinuclear ; Endothelin-1 ; Platelet-Derived Growth Factor ; Transcription Factors ; Transforming Growth Factor beta ; Collagen (9007-34-5)
    Language Japanese
    Publishing date 2009-03
    Publishing country Japan
    Document type English Abstract ; Journal Article ; Review
    ZDB-ID 390903-7
    ISSN 0047-1852
    ISSN 0047-1852
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    Zs.A 429: Show issues Location:
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  6. Article ; Online: Retrospective study of COL1A1-PDGFB fusion gene-positive dermatofibrosarcoma protuberans in Kumamoto University.

    Otsuka-Maeda, S / Kajihara, I / Kanemaru, H / Sawamura, S / Makino, K / Aoi, J / Makino, T / Fukushima, S / Ihn, H

    Clinical and experimental dermatology

    2020  Volume 45, Issue 8, Page(s) 1067–1068

    MeSH term(s) Adult ; Aged ; Chromosome Breakpoints ; Collagen Type I/genetics ; Dermatofibrosarcoma/diagnosis ; Dermatofibrosarcoma/genetics ; Dermatofibrosarcoma/pathology ; Exons/genetics ; Female ; Humans ; Japan/epidemiology ; Male ; Middle Aged ; Oncogene Proteins, Fusion/genetics ; Platelet-Derived Growth Factor/genetics ; Retrospective Studies ; Skin Neoplasms/genetics ; Skin Neoplasms/pathology ; Universities
    Chemical Substances COLIA1-PDGFB fusion protein, human ; Collagen Type I ; Oncogene Proteins, Fusion ; Platelet-Derived Growth Factor ; collagen type I, alpha 1 chain
    Language English
    Publishing date 2020-09-05
    Publishing country England
    Document type Letter
    ZDB-ID 195504-4
    ISSN 1365-2230 ; 0307-6938
    ISSN (online) 1365-2230
    ISSN 0307-6938
    DOI 10.1111/ced.14312
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    Zs.A 1278: Show issues Location:
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  7. Article: [Scleroderma].

    Ihn, H

    Ryoikibetsu shokogun shirizu

    2000  , Issue 31, Page(s) 385–388

    MeSH term(s) Antibodies, Antinuclear ; Autoimmunity ; Collagen/metabolism ; Cytokines ; Diagnosis, Differential ; Humans ; Penicillamine/therapeutic use ; Prednisolone/therapeutic use ; Prognosis ; Scleroderma, Systemic/etiology ; Scleroderma, Systemic/therapy
    Chemical Substances Antibodies, Antinuclear ; Cytokines ; Collagen (9007-34-5) ; Prednisolone (9PHQ9Y1OLM) ; Penicillamine (GNN1DV99GX)
    Language Japanese
    Publishing date 2000
    Publishing country Japan
    Document type Journal Article ; Review
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  8. Article ; Online: A successful case of lupus myelitis treated with intravenous pulse methylprednisolone and pulse cyclophosphamide therapy.

    Sonoda-Shimada, Kanako / Kajihara, Ikko / Jinnin, Masatoshi / Ihn, Hironobu

    Drug discoveries & therapeutics

    2020  Volume 14, Issue 4, Page(s) 209–210

    Abstract: Lupus myelitis is a rare but serious condition characterized by myelopathy in patients with systemic lupus erythematosus (SLE). Its presentation is usually acute or subacute, and it is often refractory to treatment. We reported a rare presentation of ... ...

    Abstract Lupus myelitis is a rare but serious condition characterized by myelopathy in patients with systemic lupus erythematosus (SLE). Its presentation is usually acute or subacute, and it is often refractory to treatment. We reported a rare presentation of lupus myelitis in a 38-year-old Japanese woman with a 20-year history of SLE. She developed paraparesis and bladder/bowel dysfunction 6 months prior to presentation. Magnetic resonance imaging revealed atrophy of the entire thoracic spinal cord with high intensity on T1-weighted sequence. She was initially treated with intravenous pulse steroid therapy, and prednisolone (20 mg/day) was continued; mizoribine was changed to azathioprine (100 mg/day). In addition, she underwent a rehabilitation program to improve lower-extremity muscle weakness. Moreover, because of the refractory clinical condition, intravenous cyclophosphamide pulse therapy was added. Within 1 month, she could walk with a cane and had a desire to urinate and defecate. In conclusion, early and aggressive treatment improves the permanent damage of lupus myelitis.
    MeSH term(s) Administration, Intravenous ; Adult ; Cyclophosphamide/administration & dosage ; Cyclophosphamide/therapeutic use ; Female ; Humans ; Japan ; Lupus Erythematosus, Systemic/complications ; Lupus Erythematosus, Systemic/drug therapy ; Magnetic Resonance Imaging ; Methylprednisolone/administration & dosage ; Methylprednisolone/therapeutic use ; Myelitis/diagnostic imaging ; Myelitis/drug therapy ; Myelitis/etiology ; Treatment Outcome
    Chemical Substances Cyclophosphamide (8N3DW7272P) ; Methylprednisolone (X4W7ZR7023)
    Language English
    Publishing date 2020-08-29
    Publishing country Japan
    Document type Case Reports ; Letter
    ZDB-ID 2568828-5
    ISSN 1881-784X ; 1881-784X
    ISSN (online) 1881-784X
    ISSN 1881-784X
    DOI 10.5582/ddt.2020.03065
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  9. Article: [Treatment of skin ulcers in collagen vascular diseases].

    Ihn, Hironobu

    Nihon Hansenbyo Gakkai zasshi = Japanese journal of leprosy : official organ of the Japanese Leprosy Association

    2008  Volume 77, Issue 3, Page(s) 211–213

    Abstract: The causes of skin ulcers in collagen vascular diseases are complicated, and involve peripheral vascular complications, vasculitis, and thrombosis. It is necessary to determine the treatment, such as oral medication, infusion, ointment and surgery after ... ...

    Abstract The causes of skin ulcers in collagen vascular diseases are complicated, and involve peripheral vascular complications, vasculitis, and thrombosis. It is necessary to determine the treatment, such as oral medication, infusion, ointment and surgery after careful consideration of its causes. This review shows skin manifestations of various collagen vascular diseases and the causes of skin ulcers in these diseases.
    MeSH term(s) Alprostadil/administration & dosage ; Antibodies, Monoclonal/administration & dosage ; Antibodies, Monoclonal, Murine-Derived ; Anticoagulants/administration & dosage ; Antiphospholipid Syndrome/complications ; Collagen Diseases/complications ; Cytokines/administration & dosage ; Globins/administration & dosage ; Glucocorticoids/administration & dosage ; Humans ; Immunosuppressive Agents/administration & dosage ; Ointments ; Plasma Exchange ; Pulse Therapy, Drug ; Rituximab ; Skin Ulcer/etiology ; Skin Ulcer/therapy ; Vascular Diseases/complications
    Chemical Substances Antibodies, Monoclonal ; Antibodies, Monoclonal, Murine-Derived ; Anticoagulants ; Cytokines ; Glucocorticoids ; Immunosuppressive Agents ; Ointments ; Rituximab (4F4X42SYQ6) ; Globins (9004-22-2) ; Alprostadil (F5TD010360)
    Language Japanese
    Publishing date 2008-09-17
    Publishing country Japan
    Document type English Abstract ; Journal Article
    ZDB-ID 2495704-5
    ISSN 1884-314X ; 1342-3681
    ISSN (online) 1884-314X
    ISSN 1342-3681
    DOI 10.5025/hansen.77.211
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    Zs.A 277: Show issues Location:
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  10. Article: A case of leg cellulitis caused by multidrug-resistant

    Sawamura, Soichiro / Niimori, Daisuke / Ihn, Hironobu

    Intractable & rare diseases research

    2018  Volume 7, Issue 4, Page(s) 280–282

    Abstract: A 94-year-old woman was admitted to our hospital with a 5-day history of painful redness in the left lower leg. She was diagnosed with cellulitis and initiated antibiotic therapy with cefazolin. After two days, she presented with an extremely high fever ( ...

    Abstract A 94-year-old woman was admitted to our hospital with a 5-day history of painful redness in the left lower leg. She was diagnosed with cellulitis and initiated antibiotic therapy with cefazolin. After two days, she presented with an extremely high fever (39.9°C), high C-reactive protein level (256 mg/L; normal, < 3), and signs of disseminated intravascular coagulation. In bacteriological examination,
    Language English
    Publishing date 2018-01-24
    Publishing country Japan
    Document type Case Reports
    ZDB-ID 2672570-8
    ISSN 2186-361X ; 2186-3644
    ISSN (online) 2186-361X
    ISSN 2186-3644
    DOI 10.5582/irdr.2018.01110
    Database MEDical Literature Analysis and Retrieval System OnLINE

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