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  1. Article ; Online: Corrigendum: Reprogramming the immunosuppressive tumor microenvironment: exploiting angiogenesis and thrombosis to enhance immunotherapy.

    Shafqat, Areez / Omer, Mohamed H / Ahmed, Eman Nayaz / Mushtaq, Ali / Ijaz, Eman / Ahmed, Zara / Alkattan, Khaled / Yaqinuddin, Ahmed

    Frontiers in immunology

    2023  Volume 14, Page(s) 1252998

    Abstract: This corrects the article DOI: 10.3389/fimmu.2023.1200941.]. ...

    Abstract [This corrects the article DOI: 10.3389/fimmu.2023.1200941.].
    Language English
    Publishing date 2023-07-13
    Publishing country Switzerland
    Document type Published Erratum
    ZDB-ID 2606827-8
    ISSN 1664-3224 ; 1664-3224
    ISSN (online) 1664-3224
    ISSN 1664-3224
    DOI 10.3389/fimmu.2023.1252998
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  2. Article ; Online: Reprogramming the immunosuppressive tumor microenvironment: exploiting angiogenesis and thrombosis to enhance immunotherapy.

    Shafqat, Areez / Omer, Mohamed H / Ahmed, Eman Nayaz / Mushtaq, Ali / Ijaz, Eman / Ahmed, Zara / Alkattan, Khaled / Yaqinuddin, Ahmed

    Frontiers in immunology

    2023  Volume 14, Page(s) 1200941

    Abstract: This review focuses on the immunosuppressive effects of tumor angiogenesis and coagulation on the tumor microenvironment (TME). We summarize previous research efforts leveraging these observations and targeting these processes to enhance immunotherapy ... ...

    Abstract This review focuses on the immunosuppressive effects of tumor angiogenesis and coagulation on the tumor microenvironment (TME). We summarize previous research efforts leveraging these observations and targeting these processes to enhance immunotherapy outcomes. Clinical trials have documented improved outcomes when combining anti-angiogenic agents and immunotherapy. However, their overall survival benefit over conventional therapy remains limited and certain tumors exhibit poor response to anti-angiogenic therapy. Additionally, whilst preclinical studies have shown several components of the tumor coagulome to curb effective anti-tumor immune responses, the clinical studies reporting combinations of anticoagulants with immunotherapies have demonstrated variable treatment outcomes. By reviewing the current state of the literature on this topic, we address the key questions and future directions in the field, the answers of which are crucial for developing effective strategies to reprogram the TME in order to further the field of cancer immunotherapy.
    MeSH term(s) Humans ; Immunotherapy ; Neoplasms/therapy ; Immunomodulation ; Neovascularization, Pathologic/therapy ; Thrombosis ; Tumor Microenvironment
    Language English
    Publishing date 2023-07-03
    Publishing country Switzerland
    Document type Journal Article ; Review
    ZDB-ID 2606827-8
    ISSN 1664-3224 ; 1664-3224
    ISSN (online) 1664-3224
    ISSN 1664-3224
    DOI 10.3389/fimmu.2023.1200941
    Database MEDical Literature Analysis and Retrieval System OnLINE

    More links

    Kategorien

    Order via subito

    This service is chargeable due to the Delivery terms set by subito. Orders including an article and supplementary material will be classified as separate orders. In these cases, fees will be demanded for each order.

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