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Article ; Online: Two New Polymorphs in H50Q Determined by CryoEM Suggest a Mechanism That Explains Its Faster Kinetics In Vitro.

Aguirre, Cesar / Ikenaka, Kensuke / Mochizuki, Hideki

Movement disorders : official journal of the Movement Disorder Society

2020 Volume 35, Issue 6, Page(s) 935–936

MeSH term(s)	Amyloid/metabolism ; Humans ; Kinetics ; alpha-Synuclein/genetics ; alpha-Synuclein/metabolism
Chemical Substances	Amyloid ; alpha-Synuclein
Language	English
Publishing date	2020-05-29
Publishing country	United States
Document type	Journal Article ; Research Support, Non-U.S. Gov't
ZDB-ID	607633-6
ISSN	1531-8257 ; 0885-3185
ISSN (online)	1531-8257
ISSN	0885-3185
DOI	10.1002/mds.28100
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Zs.A 2555: Show issues			Location: Je nach Verfügbarkeit (siehe Angabe bei Bestand) bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular Jg. 1995 - 2021: Lesesall (2.OG) ab Jg. 2022: Lesesaal (EG)
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Article ; Online: Disaggregation Behavior of Amyloid β Fibrils by Anthocyanins Studied by Total-Internal-Reflection-Fluorescence Microscopy Coupled with a Wireless Quartz-Crystal Microbalance Biosensor.

Noi, Kentaro / Ikenaka, Kensuke / Mochizuki, Hideki / Goto, Yuji / Ogi, Hirotsugu

Analytical chemistry

2021 Volume 93, Issue 32, Page(s) 11176–11183

Abstract: Amyloid fibrils are formed from various proteins, some of which cause the corresponding neurodegenerative disorders, such as Alzheimer's and Parkinson's diseases. It has been reported that many compounds inhibit the formation of amyloid fibrils. ... ...

Abstract	Amyloid fibrils are formed from various proteins, some of which cause the corresponding neurodegenerative disorders, such as Alzheimer's and Parkinson's diseases. It has been reported that many compounds inhibit the formation of amyloid fibrils. Anthocyanins are flavonoid pigments present in fruits and vegetables, which are known to suppress symptoms related with Alzheimer's disease. However, the influence of anthocyanins on the amyloid fibril remains unclear. Here, we succeeded in the direct monitoring of the disaggregation reaction of single amyloid β (Aβ) fibrils by anthocyanins using total-internal-reflection-fluorescence microscopy with a quartz-crystal microbalance (TIRFM-QCM). It is found that the disassembly activity to the Aβ fibrils depends on the number of hydroxyl groups in six-membered ring B of anthocyanin, and only delphinidin-3-galactoside, possessing three hydroxyl groups there, shows high disassembly activity. Our results show the importance of the number of hydroxyl groups and demonstrate the usefulness of TIRFM-QCM as a powerful tool in studying interactions between amyloid fibrils and compounds.
MeSH term(s)	Amyloid ; Amyloid beta-Peptides ; Anthocyanins ; Biosensing Techniques ; Microscopy, Fluorescence ; Peptide Fragments ; Quartz
Chemical Substances	Amyloid ; Amyloid beta-Peptides ; Anthocyanins ; Peptide Fragments ; Quartz (14808-60-7)
Language	English
Publishing date	2021-08-05
Publishing country	United States
Document type	Journal Article
ZDB-ID	1508-8
ISSN	1520-6882 ; 0003-2700
ISSN (online)	1520-6882
ISSN	0003-2700
DOI	10.1021/acs.analchem.1c01720
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Article ; Online: [A case of sporadic amyotrophic lateral sclerosis (ALS) with Senataxin (SETX) gene variant].

Beppu, Shohei / Ikenaka, Kensuke / Yabumoto, Taiki / Todo, Kenichi / Hashiguchi, Akihiro / Takashima, Hiroshi / Mochizuki, Hideki

Rinsho shinkeigaku = Clinical neurology

2022 Volume 62, Issue 3, Page(s) 205–210

Abstract: A 67-year-old man presented slowly progressive weakness of the extremities visited our hospital. Nerve conduction study showed axonal neuropathy and needle electromyography showed neurogenic changes with denervation findings in multiple limb muscles. ... ...

Abstract	A 67-year-old man presented slowly progressive weakness of the extremities visited our hospital. Nerve conduction study showed axonal neuropathy and needle electromyography showed neurogenic changes with denervation findings in multiple limb muscles. While he was diagnosed as Probable amyotrophic lateral sclerosis (ALS), which is defined by the Awaji criteria for diagnosis of ALS, he did not develop either respiratory muscle paralysis or bulbar palsy, which are characteristic symptoms of sporadic ALS. Genetic testing revealed a novel gene variant in senataxin (SETX), the causative gene of ALS4. We could not make a definite diagnosis of ALS4 because he had no relatives who could perform genetic testing (segregation study). However, we considered the variant can be pathogenic because it was not previously reported and absent in at least 1,000 healthy control individuals, the variant site was highly conserved in mammals, and it may impair the function of senataxin protein (in silico analysis).
MeSH term(s)	Aged ; Amyotrophic Lateral Sclerosis/diagnosis ; Amyotrophic Lateral Sclerosis/genetics ; Bulbar Palsy, Progressive ; DNA Helicases/genetics ; Electromyography ; Humans ; Male ; Multifunctional Enzymes/genetics ; Muscle, Skeletal/pathology ; RNA Helicases/genetics
Chemical Substances	Multifunctional Enzymes ; SETX protein, human (EC 3.6.1.-) ; DNA Helicases (EC 3.6.4.-) ; RNA Helicases (EC 3.6.4.13)
Language	Japanese
Publishing date	2022-03-25
Publishing country	Japan
Document type	Case Reports ; Journal Article
ZDB-ID	604200-4
ISSN	1882-0654 ; 0009-918X
ISSN (online)	1882-0654
ISSN	0009-918X
DOI	10.5692/clinicalneurol.cn-001675
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Zs.MO 223: Show issues

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Article ; Online: Ultrastiff Amyloid-Fibril Network of α-Synuclein Formed by Surface Seeding Reaction Confirmed by Multichannel Electrodeless Quartz-Crystal-Microbalance Biosensor.

Zhou, Lianjie / Hajiri, Touko / Nakajima, Kichitaro / Aguirre, César / Ikenaka, Kensuke / Mochizuki, Hideki / Yamaguchi, Keiichi / Goto, Yuji / Ogi, Hirotsugu

ACS sensors

2023 Volume 8, Issue 7, Page(s) 2598–2608

Abstract: We developed a multichannel wireless quartz-crystal-microbalance (QCM) biosensor for mechanically studying the on-surface aggregation reaction of α-synuclein (α-syn). We find a quite unusual change in the resonant frequency that eventually exceeds the ... ...

Abstract	We developed a multichannel wireless quartz-crystal-microbalance (QCM) biosensor for mechanically studying the on-surface aggregation reaction of α-synuclein (α-syn). We find a quite unusual change in the resonant frequency that eventually exceeds the baseline, which has never been observed during seeding aggregation reaction. By incorporating a growth-to-percolation theory for fibril elongation reaction, we have favorably reproduced this unusual response and found that it can be explained only with formation of an ultrastiff fibril network. We also find that the stiffness of the fibril network grown from artificially prepared twist-type seeds is significantly higher than that from rod-type seeds. Furthermore, the stiffnesses of fibril networks grown from seeds derived from brain tissues of Parkinson's disease (PD) and multiple system atrophy (MSA) patients show a very similar trend to those of rod and twist seeds, respectively, indicating that fibrils from MSA patients are stiffer than those from PD.
MeSH term(s)	Humans ; alpha-Synuclein ; Quartz ; Parkinson Disease ; Amyloid ; Biosensing Techniques
Chemical Substances	alpha-Synuclein ; Quartz (14808-60-7) ; Amyloid
Language	English
Publishing date	2023-06-26
Publishing country	United States
Document type	Journal Article ; Research Support, Non-U.S. Gov't
ISSN	2379-3694
ISSN (online)	2379-3694
DOI	10.1021/acssensors.3c00331
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Article ; Online: Neuronal MML-1/MXL-2 regulates systemic aging via glutamate transporter and cell nonautonomous autophagic and peroxidase activity.

Shioda, Tatsuya / Takahashi, Ittetsu / Ikenaka, Kensuke / Fujita, Naonobu / Kanki, Tomotake / Oka, Toshihiko / Mochizuki, Hideki / Antebi, Adam / Yoshimori, Tamotsu / Nakamura, Shuhei

Proceedings of the National Academy of Sciences of the United States of America

2023 Volume 120, Issue 39, Page(s) e2221553120

Abstract: Accumulating evidence has demonstrated the presence of intertissue-communication regulating systemic aging, but the underlying molecular network has not been fully explored. We and others previously showed that two basic helix-loop-helix transcription ... ...

Abstract	Accumulating evidence has demonstrated the presence of intertissue-communication regulating systemic aging, but the underlying molecular network has not been fully explored. We and others previously showed that two basic helix-loop-helix transcription factors, MML-1 and HLH-30, are required for lifespan extension in several longevity paradigms, including germlineless
MeSH term(s)	Animals ; Aging/genetics ; Amino Acid Transport System X-AG ; Autophagy/genetics ; Caenorhabditis elegans/genetics ; Neurons ; Peroxidases ; Caenorhabditis elegans Proteins/genetics
Chemical Substances	Amino Acid Transport System X-AG ; Peroxidases (EC 1.11.1.-) ; MML-1 protein, C elegans ; MXL-2 protein, C elegans ; Caenorhabditis elegans Proteins
Language	English
Publishing date	2023-09-18
Publishing country	United States
Document type	Journal Article ; Research Support, Non-U.S. Gov't
ZDB-ID	209104-5
ISSN	1091-6490 ; 0027-8424
ISSN (online)	1091-6490
ISSN	0027-8424
DOI	10.1073/pnas.2221553120
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Article: Disaggregation Behavior of Amyloid β Fibrils by Anthocyanins Studied by Total-Internal-Reflection-Fluorescence Microscopy Coupled with a Wireless Quartz-Crystal Microbalance Biosensor

Noi, Kentaro / Ikenaka, Kensuke / Mochizuki, Hideki / Goto, Yuji / Ogi, Hirotsugu

Analytical chemistry. 2021 Aug. 05, v. 93, no. 32

2021

Abstract: Amyloid fibrils are formed from various proteins, some of which cause the corresponding neurodegenerative disorders, such as Alzheimer’s and Parkinson’s diseases. It has been reported that many compounds inhibit the formation of amyloid fibrils. ... ...

Abstract	Amyloid fibrils are formed from various proteins, some of which cause the corresponding neurodegenerative disorders, such as Alzheimer’s and Parkinson’s diseases. It has been reported that many compounds inhibit the formation of amyloid fibrils. Anthocyanins are flavonoid pigments present in fruits and vegetables, which are known to suppress symptoms related with Alzheimer’s disease. However, the influence of anthocyanins on the amyloid fibril remains unclear. Here, we succeeded in the direct monitoring of the disaggregation reaction of single amyloid β (Aβ) fibrils by anthocyanins using total-internal-reflection-fluorescence microscopy with a quartz-crystal microbalance (TIRFM-QCM). It is found that the disassembly activity to the Aβ fibrils depends on the number of hydroxyl groups in six-membered ring B of anthocyanin, and only delphinidin-3-galactoside, possessing three hydroxyl groups there, shows high disassembly activity. Our results show the importance of the number of hydroxyl groups and demonstrate the usefulness of TIRFM-QCM as a powerful tool in studying interactions between amyloid fibrils and compounds.
Keywords	amyloid ; analytical chemistry ; anthocyanins ; biosensors ; microscopy ; quartz crystal microbalance
Language	English
Dates of publication	2021-0805
Size	p. 11176-11183.
Publishing place	American Chemical Society
Document type	Article
ZDB-ID	1508-8
ISSN	1520-6882 ; 0003-2700
ISSN (online)	1520-6882
ISSN	0003-2700
DOI	10.1021/acs.analchem.1c01720
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Article: Lipids as

Ikenaka, Kensuke / Suzuki, Mari / Mochizuki, Hideki / Nagai, Yoshitaka

Frontiers in neuroscience

2019 Volume 13, Page(s) 693

Abstract: Aggregation of α-synuclein (αSyn) plays a central role in the pathogenesis of Parkinson's disease (PD) and dementia with Lewy bodies (DLB). Lewy bodies (LBs) and Lewy neurites, which consist mainly of aggregated αSyn, are widely observed in the affected ... ...

Abstract	Aggregation of α-synuclein (αSyn) plays a central role in the pathogenesis of Parkinson's disease (PD) and dementia with Lewy bodies (DLB). Lewy bodies (LBs) and Lewy neurites, which consist mainly of aggregated αSyn, are widely observed in the affected regions of patient brains. Except for some familial forms of PD/DLB, most sporadic PD/DLB patients express the wild-type (WT) αSyn protein without any mutations, and the mechanisms as to how WT αSyn gains the propensity to pathologically aggregate still remains unclear. Furthermore, the mechanisms by which the same αSyn protein can cause different synucleinopathies with distinct phenotypes and pathologies, such as PD, DLB, and multiple system atrophy (MSA), still remain largely unknown. Recently, mutations in the
Language	English
Publishing date	2019-07-03
Publishing country	Switzerland
Document type	Journal Article ; Review
ZDB-ID	2411902-7
ISSN	1662-453X ; 1662-4548
ISSN (online)	1662-453X
ISSN	1662-4548
DOI	10.3389/fnins.2019.00693
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Article ; Online: Decreased hepatic enzymes reflect the decreased vitamin B6 levels in Parkinson's disease patients.

Ikenaka, Kensuke / Kajiyama, Yuta / Aguirre, César / Choong, Chi-Jing / Taniguchi, Seira / Doi, Junko / Wang, Nan / Ajiki, Takahiro / Ogawa, Kotaro / Kakuda, Keita / Kimura, Yasuyoshi / Mochizuki, Hideki

Pharmacology research & perspectives

2024 Volume 12, Issue 1, Page(s) e1174

Abstract: The study aims to investigate the vitamin B6 levels in Parkinson's disease (PD) patients and their association with liver enzymes and evaluate how much dysregulation is associated with levodopa dose. Furthermore, to evaluate the effect of Opicapone, a ... ...

Abstract	The study aims to investigate the vitamin B6 levels in Parkinson's disease (PD) patients and their association with liver enzymes and evaluate how much dysregulation is associated with levodopa dose. Furthermore, to evaluate the effect of Opicapone, a catechol-o-methyl-transferase inhibitor, on vitamin B6 levels by monitoring the AST and ALT levels in patients treated with Levodopa-Carbidopa Intestinal Gel Infusion (LCIG). For these aims, serum vitamin B6 levels were measured (PD, n = 72 and controls, n = 31). The vitamin B6 level was compared with the total levodopa dose, clinical parameters, and blood homocysteine, albumin, and hemoglobin levels in PD patients. Correlations between vitamin B6 levels and AST and ALT levels, as well as the ratio ALT/AST, were analyzed. Changes in the AST and ALT levels and ALT/AST were analyzed in the patients treated with LCIG before and after the therapy (n = 24) and in the patients treated with LCIG + Opicapone before and after Opicapone treatment (n = 12). We found vitamin B6 levels were significantly lower in PD patients. Total levodopa dose and albumin levels were independently associated with vitamin B6 levels. Decreased vitamin B6 levels appeared as lower AST and ALT levels and ALT/AS. Treatment with LCIG decreased the AST and ALT levels and ALT/AST. Adjunctive therapy with Opicapone to LCIG ameliorated the decreased ALT and ALT/AST. We conclude that the ALT and ALT/AST can be useful parameters for monitoring vitamin B6 levels and Opicapone can ameliorate the dysregulated vitamin B6 in PD patients.
MeSH term(s)	Humans ; Parkinson Disease/drug therapy ; Levodopa/therapeutic use ; Levodopa/adverse effects ; Antiparkinson Agents/pharmacology ; Antiparkinson Agents/therapeutic use ; Vitamin B 6/therapeutic use ; Albumins/therapeutic use
Chemical Substances	Levodopa (46627O600J) ; Antiparkinson Agents ; Vitamin B 6 (8059-24-3) ; Albumins
Language	English
Publishing date	2024-01-29
Publishing country	United States
Document type	Journal Article
ZDB-ID	2740389-0
ISSN	2052-1707 ; 2052-1707
ISSN (online)	2052-1707
ISSN	2052-1707
DOI	10.1002/prp2.1174
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Article ; Online: The validation of a Japanese version of the New Freezing of Gait Questionnaire (NFOG-Q).

Taniguchi, Seira / Marumoto, Kohei / Kajiyama, Yuta / Revankar, Gajanan / Inoue, Michiko / Yamamoto, Hiroshi / Kayano, Rika / Mizuta, Eiji / Takahashi, Ryuichi / Shirahata, Emi / Saeki, Chizu / Ozono, Tatsuhiko / Kimura, Yasuyoshi / Ikenaka, Kensuke / Mochizuki, Hideki

Neurological sciences : official journal of the Italian Neurological Society and of the Italian Society of Clinical Neurophysiology

2024

Abstract: Objective: This study aimed to develop a Japanese version of the New Freezing of Gait Questionnaire (NFOG-Q) and investigate its validity and reliability.: Methods: After translating the NFOG-Q according to a standardised protocol, 56 patients with ... ...

Abstract	Objective: This study aimed to develop a Japanese version of the New Freezing of Gait Questionnaire (NFOG-Q) and investigate its validity and reliability. Methods: After translating the NFOG-Q according to a standardised protocol, 56 patients with Parkinson's disease (PD) were administered it. Additionally, the MDS-UPDRS parts II and III, Hoehn and Yahr (H&Y) stage, and number of falls over 1 month were evaluated. Spearman's correlation coefficients (rho) were used to determine construct validity, and Cronbach's alpha (α) was used to examine reliability. Results: The interquartile range of the NFOG-Q scores was 10.0-25.3 (range 0-29). The NFOG-Q scores were strongly correlated with the MDS-UPDRS part II, items 2.12 (walking and balance), 2.13 (freezing), 3.11 (freezing of gait), and 3.12 (postural stability) and the postural instability and gait difficulty score (rho = 0.515-0.669), but only moderately related to the MDS-UPDRS item 3.10 (gait), number of falls, disease duration, H&Y stage, and time of the Timed Up-and-Go test (rho = 0.319-0.434). No significant correlations were observed between age and the time of the 10-m walk test. The internal consistency was excellent (α = 0.96). Conclusions: The Japanese version of the NFOG-Q is a valid and reliable tool for assessing the severity of freezing in patients with PD.
Language	English
Publishing date	2024-02-22
Publishing country	Italy
Document type	Journal Article
ZDB-ID	2016546-8
ISSN	1590-3478 ; 1590-1874
ISSN (online)	1590-3478
ISSN	1590-1874
DOI	10.1007/s10072-024-07405-y
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Article ; Online: Strong acids induce amyloid fibril formation of β

Yamaguchi, Keiichi / Hasuo, Kenshiro / So, Masatomo / Ikenaka, Kensuke / Mochizuki, Hideki / Goto, Yuji

The Journal of biological chemistry

2021 Volume 297, Issue 5, Page(s) 101286

Abstract: Amyloid fibrils, crystal-like fibrillar aggregates of proteins associated with various amyloidoses, have the potential to propagate via a prion-like mechanism. Among known methodologies to dissolve preformed amyloid fibrils, acid treatment has been used ... ...

Abstract	Amyloid fibrils, crystal-like fibrillar aggregates of proteins associated with various amyloidoses, have the potential to propagate via a prion-like mechanism. Among known methodologies to dissolve preformed amyloid fibrils, acid treatment has been used with the expectation that the acids will degrade amyloid fibrils similar to acid inactivation of protein functions. Contrary to our expectation, treatment with strong acids, such as HCl or H
MeSH term(s)	Amyloid/chemistry ; Anions/chemistry ; Circular Dichroism ; Humans ; Hydrogen-Ion Concentration ; Protein Aggregates ; Sodium Chloride/chemistry ; beta 2-Microglobulin/chemistry
Chemical Substances	Amyloid ; Anions ; B2M protein, human ; Protein Aggregates ; beta 2-Microglobulin ; Sodium Chloride (451W47IQ8X)
Language	English
Publishing date	2021-10-07
Publishing country	United States
Document type	Journal Article ; Research Support, Non-U.S. Gov't
ZDB-ID	2997-x
ISSN	1083-351X ; 0021-9258
ISSN (online)	1083-351X
ISSN	0021-9258
DOI	10.1016/j.jbc.2021.101286
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