LIVIVO - The Search Portal for Life Sciences

zur deutschen Oberfläche wechseln
Advanced search

Search results

Result 1 - 6 of total 6

Search options

  1. Article ; Online: Impact of cervical lymph node metastasis on transoral surgery for hypopharyngeal squamous cell carcinoma: A retrospective multicenter study.

    Ushiro, Koji / Watanabe, Yoshiki / Kishimoto, Yo / Kawai, Yoshitaka / Fujimura, Shintaro / Asato, Ryo / Tsujimura, Takashi / Hori, Ryusuke / Kumabe, Yohei / Yasuda, Kaori / Tamaki, Hisanobu / Iki, Takehiro / Kitani, Yoshiharu / Kurata, Keisuke / Kojima, Tsuyoshi / Takata, Kuniaki / Kada, Shinpei / Takebayashi, Shinji / Shinohara, Shogo /
    Hamaguchi, Kiyomi / Miyazaki, Masakazu / Ikenaga, Tadashi / Maetani, Toshiki / Harada, Hiroyuki / Haji, Tomoyuki / Omori, Koichi

    Head & neck

    2024  

    Abstract: Background: Hypopharyngeal carcinoma is likely to spread to the lymph nodes, but there is no established strategy for management in transoral surgery.: Methods: We compared oncologic and functional outcomes in a retrospective multicenter study of ... ...

    Abstract Background: Hypopharyngeal carcinoma is likely to spread to the lymph nodes, but there is no established strategy for management in transoral surgery.
    Methods: We compared oncologic and functional outcomes in a retrospective multicenter study of patients who underwent transoral surgery for hypopharyngeal carcinoma between 2015 and 2021.
    Results: Two-hundred and thirty-two patients were included. Comparing patients with and without adjuvant radiotherapy, 3-year regional recurrence-free survival (RRFS) was not significantly different in pN2b and pN2c, but was significantly worse in pN3b without adjuvant radiotherapy. In patients without neck dissection, the 3-year RRFS was 85.6%, 76.8%, and 70.0% for T1, T2, and T3 primary lesions, respectively, and was significantly worse for T2 or higher (p = 0.035).
    Conclusions: In the absence of extracapsular invasion, regional control did not deteriorate without adjuvant therapy. If prophylactic neck dissection is not performed, careful follow-up is necessary if the primary lesion is T2 or greater.
    Language English
    Publishing date 2024-01-31
    Publishing country United States
    Document type Journal Article
    ZDB-ID 645165-2
    ISSN 1097-0347 ; 0148-6403 ; 1043-3074
    ISSN (online) 1097-0347
    ISSN 0148-6403 ; 1043-3074
    DOI 10.1002/hed.27666
    Database MEDical Literature Analysis and Retrieval System OnLINE

    More links

    Kategorien

    In stock of ZB MED Cologne/Königswinter

    Zs.A 1493: Show issues Location:
    Je nach Verfügbarkeit (siehe Angabe bei Bestand)
    bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular
    Jg. 1995 - 2021: Lesesall (1.OG)
    ab Jg. 2022: Lesesaal (EG)

    Order via subito

    This service is chargeable due to the Delivery terms set by subito. Orders including an article and supplementary material will be classified as separate orders. In these cases, fees will be demanded for each order.

  2. Article ; Online: Complications including dysphagia following transoral non-robotic surgery for pharyngeal and laryngeal squamous cell carcinoma: A retrospective multicenter study.

    Ushiro, Koji / Watanabe, Yoshiki / Kishimoto, Yo / Kawai, Yoshitaka / Fujimura, Shintaro / Asato, Ryo / Tsujimura, Takashi / Hori, Ryusuke / Kumabe, Yohei / Yasuda, Kaori / Tamaki, Hisanobu / Iki, Takehiro / Kitani, Yoshiharu / Kurata, Keisuke / Kojima, Tsuyoshi / Takata, Kuniaki / Kada, Shinpei / Takebayashi, Shinji / Shinohara, Shogo /
    Hamaguchi, Kiyomi / Miyazaki, Masakazu / Ikenaga, Tadashi / Maetani, Toshiki / Harada, Hiroyuki / Haji, Tomoyuki / Omori, Koichi

    Auris, nasus, larynx

    2024  Volume 51, Issue 3, Page(s) 575–582

    Abstract: Objective: Transoral surgery is a minimally invasive treatment but may cause severe dysphagia at a lower rate than chemoradiotherapy.: Methods: We compared clinical information, surgical complications, and swallowing function in patients who ... ...

    Abstract Objective: Transoral surgery is a minimally invasive treatment but may cause severe dysphagia at a lower rate than chemoradiotherapy.
    Methods: We compared clinical information, surgical complications, and swallowing function in patients who underwent transoral nonrobotic surgery for laryngo-pharyngeal squamous cell carcinoma between 2015 and 2021 in a multicenter retrospective study.
    Results: Six hundred and forty patients were included. Postoperative bleeding was observed in 20 cases (3.1%), and the risk factor was advanced T category. Postoperative laryngeal edema was observed in 13 cases (2.0%), and the risk factors were prior radiotherapy, advanced T stage, and concurrent neck dissection in patients with resected HPC. Dysphagia requiring nutritional support was observed in 29 cases (4.5%) at 1 month postoperatively and in 19 cases (3.0%) at 1 year postoperatively, respectively. The risk factors for long-term dysphagia were prior radiotherapy and advanced T category. Short-term risk factors for dysphagia were prior radiotherapy, advanced T category, and concurrent neck dissection, while long-term risk factors for dysphagia were only prior radiotherapy and advanced T category.
    Conclusion: Prior radiotherapy, advanced T stage, and concurrent neck dissection increased the incidence of postoperative laryngeal edema and short-term dysphagia, but concurrent neck dissection did not affect long-term dysphagia. Such features should be considered when considering the indication for transoral surgery and postoperative management.
    MeSH term(s) Humans ; Male ; Retrospective Studies ; Deglutition Disorders/etiology ; Female ; Laryngeal Neoplasms/surgery ; Middle Aged ; Aged ; Postoperative Complications/epidemiology ; Neck Dissection ; Pharyngeal Neoplasms/surgery ; Risk Factors ; Squamous Cell Carcinoma of Head and Neck/surgery ; Neoplasm Staging ; Adult ; Laryngeal Edema/etiology ; Carcinoma, Squamous Cell/surgery ; Postoperative Hemorrhage/epidemiology ; Aged, 80 and over ; Natural Orifice Endoscopic Surgery
    Language English
    Publishing date 2024-03-27
    Publishing country Netherlands
    Document type Journal Article ; Multicenter Study
    ZDB-ID 604552-2
    ISSN 1879-1476 ; 0385-8146
    ISSN (online) 1879-1476
    ISSN 0385-8146
    DOI 10.1016/j.anl.2024.03.005
    Database MEDical Literature Analysis and Retrieval System OnLINE

    More links

    Kategorien

    In stock of ZB MED Cologne/Königswinter

    Zs.A 1675: Show issues Location:
    Je nach Verfügbarkeit (siehe Angabe bei Bestand)
    bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular
    Jg. 1995 - 2021: Lesesall (1.OG)
    ab Jg. 2022: Lesesaal (EG)

    Order via subito

    This service is chargeable due to the Delivery terms set by subito. Orders including an article and supplementary material will be classified as separate orders. In these cases, fees will be demanded for each order.

  3. Article ; Online: Local recurrence and metachronous multiple cancers after transoral nonrobotic surgery for pharyngeal and laryngeal squamous cell carcinoma: A retrospective multicenter study.

    Ushiro, Koji / Watanabe, Yoshiki / Kishimoto, Yo / Kawai, Yoshitaka / Fujimura, Shintaro / Asato, Ryo / Tsujimura, Takashi / Hori, Ryusuke / Kumabe, Yohei / Yasuda, Kaori / Tamaki, Hisanobu / Iki, Takehiro / Kitani, Yoshiharu / Kurata, Keisuke / Kojima, Tsuyoshi / Takata, Kuniaki / Kada, Shinpei / Takebayashi, Shinji / Shinohara, Shogo /
    Hamaguchi, Kiyomi / Miyazaki, Masakazu / Ikenaga, Tadashi / Maetani, Toshiki / Harada, Hiroyuki / Haji, Tomoyuki / Omori, Koichi

    Head & neck

    2023  Volume 46, Issue 1, Page(s) 118–128

    Abstract: Background: Late laryngopharyngeal cancers after transoral surgery include not only local recurrences but also metachronous multiple cancers.: Methods: We compared clinical information, surgical outcomes, and late laryngopharyngeal cancers in ... ...

    Abstract Background: Late laryngopharyngeal cancers after transoral surgery include not only local recurrences but also metachronous multiple cancers.
    Methods: We compared clinical information, surgical outcomes, and late laryngopharyngeal cancers in patients who underwent transoral nonrobotic surgery for laryngopharyngeal squamous cell carcinoma without lymph node metastases between 2015 and 2021 in a multicenter retrospective study.
    Results: Four hundred and fifty-seven patients were included. Positive surgical margins were found in 121 patients (26.5%). Twenty-two patients (4.8%) received additional treatment. Positive horizontal margins of invasive carcinoma (p = 0.003) and positive horizontal margins of carcinoma in situ only (p = 0.032) were independent risk factors for local recurrence, and prior radiotherapy (p = 0.001) for metachronous multiple cancers. Local control was significantly worse without additional treatment (p = 0.049), but there was no significant difference in survival.
    Conclusions: Patients with positive margins had an increased frequency of local recurrence, but salvage therapy was effective.
    MeSH term(s) Humans ; Squamous Cell Carcinoma of Head and Neck/surgery ; Retrospective Studies ; Carcinoma, Squamous Cell/surgery ; Hypopharyngeal Neoplasms ; Head and Neck Neoplasms ; Neoplasm Recurrence, Local/pathology
    Language English
    Publishing date 2023-10-28
    Publishing country United States
    Document type Multicenter Study ; Journal Article
    ZDB-ID 645165-2
    ISSN 1097-0347 ; 0148-6403 ; 1043-3074
    ISSN (online) 1097-0347
    ISSN 0148-6403 ; 1043-3074
    DOI 10.1002/hed.27564
    Database MEDical Literature Analysis and Retrieval System OnLINE

    More links

    Kategorien

    In stock of ZB MED Cologne/Königswinter

    Zs.A 1493: Show issues Location:
    Je nach Verfügbarkeit (siehe Angabe bei Bestand)
    bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular
    Jg. 1995 - 2021: Lesesall (1.OG)
    ab Jg. 2022: Lesesaal (EG)

    Order via subito

    This service is chargeable due to the Delivery terms set by subito. Orders including an article and supplementary material will be classified as separate orders. In these cases, fees will be demanded for each order.

  4. Article ; Online: Predictive factors for false negatives following sentinel lymph node biopsy in early oral cavity cancer.

    Miura, Kouki / Kawakita, Daisuke / Oze, Isao / Suzuki, Motoyuki / Sugasawa, Masashi / Endo, Kazuhira / Sakashita, Tomohiro / Ohba, Shinichi / Suzuki, Mikio / Shiotani, Akihiro / Kohno, Naoyuki / Maruo, Takashi / Suzuki, Chiaki / Iki, Takehiro / Hiwatashi, Nao / Matsumoto, Fumihiko / Kobayashi, Kenya / Toyoda, Minoru / Hanyu, Kenji /
    Koide, Yusuke / Murakami, Yoshiko / Hasegawa, Yasuhisa

    Scientific reports

    2022  Volume 12, Issue 1, Page(s) 6917

    Abstract: Prophylactic elective neck dissection (ND) with navigation surgery using radioisotope-based sentinel lymph node biopsy (SLNB) is non-inferior to elective ND in terms of survival but has an advantage in postoperative functional disability. We conducted a ... ...

    Abstract Prophylactic elective neck dissection (ND) with navigation surgery using radioisotope-based sentinel lymph node biopsy (SLNB) is non-inferior to elective ND in terms of survival but has an advantage in postoperative functional disability. We conducted a subgroup analysis to identify predictive factors for false-negative (FN)-SLNB in patients with early oral cavity cancer. This study is a supplementary analysis using the dataset of a previously reported randomized clinical trial on SLN navigation surgery for oral cancers. This study investigated the association of clinical and SLN-related factors with false-negative cases in the SLNB group. From 2011 to 2016, 275 patients were enrolled and randomly assigned to the ND and SLNB study groups, with 134 patients assigned to the SLNB group. In the SLNB group, seven cases with negative SLNs and neck recurrences were judged as FN-SLNBs according to the general definition. The number of detected SLNs with and without adjusting for the propensity score was significantly associated with FNs in the logistic analysis. FN-SLNB was associated with the number of identified SLNs, suggesting the need for careful postoperative monitoring for neck recurrence in patients with one or two identified SLNs after acquiring sufficient experience in the identification technique.
    MeSH term(s) Humans ; Mouth Neoplasms/pathology ; Mouth Neoplasms/surgery ; Neck/pathology ; Neck Dissection ; Sentinel Lymph Node Biopsy/methods
    Language English
    Publishing date 2022-04-28
    Publishing country England
    Document type Journal Article ; Randomized Controlled Trial ; Research Support, Non-U.S. Gov't
    ZDB-ID 2615211-3
    ISSN 2045-2322 ; 2045-2322
    ISSN (online) 2045-2322
    ISSN 2045-2322
    DOI 10.1038/s41598-022-10594-1
    Database MEDical Literature Analysis and Retrieval System OnLINE

    More links

    Kategorien

    Order via subito

    This service is chargeable due to the Delivery terms set by subito. Orders including an article and supplementary material will be classified as separate orders. In these cases, fees will be demanded for each order.

  5. Article ; Online: Microarray analyses of otospheres derived from the cochlea in the inner ear identify putative transcription factors that regulate the characteristics of otospheres.

    Iki, Takehiro / Tanaka, Michihiro / Kitajiri, Shin-Ichiro / Kita, Tomoko / Kawasaki, Yuri / Mizukoshi, Akifumi / Fujibuchi, Wataru / Nakagawa, Takayuki / Nakahata, Tatsutoshi / Ito, Juichi / Omori, Koichi / Saito, Megumu K

    PloS one

    2017  Volume 12, Issue 6, Page(s) e0179901

    Abstract: Various tissues possess tissue-specific stem/progenitor cells, including the inner ears. Stem/progenitor cells of the inner ear can be isolated as so-called otospheres from differentiated cells using a sphere forming assay. Although recent studies have ... ...

    Abstract Various tissues possess tissue-specific stem/progenitor cells, including the inner ears. Stem/progenitor cells of the inner ear can be isolated as so-called otospheres from differentiated cells using a sphere forming assay. Although recent studies have demonstrated the characteristics of otospheres to some extent, most of the features of these cells are unknown. In this report, we describe the findings of transcriptome analyses with a cDNA microarray of otospheres derived from the cochleae of the inner ears of neonatal mice in order to clarify the gene expression profile of otic stem/progenitor cells. There were common transcription factors between otospheres and embryonic stem cells, which were supposed to be due to the stemness of otospheres. In comparison with the cochlear sensory epithelium, the otospheres shared characteristics with the cochlea, although several transcription factors specific for otospheres were identified. These transcription factors are expected to be essential for maintaining the characteristics of otospheres, and appear to be candidate genes that promote the direct conversion of cells into otic stem/progenitor cells.
    MeSH term(s) Animals ; Cell Differentiation ; Cochlea/cytology ; Cochlea/metabolism ; Ear, Inner/cytology ; Ear, Inner/metabolism ; Embryonic Stem Cells/cytology ; Embryonic Stem Cells/metabolism ; Mice ; Oligonucleotide Array Sequence Analysis ; Real-Time Polymerase Chain Reaction ; Reverse Transcriptase Polymerase Chain Reaction ; Transcription Factors/metabolism
    Chemical Substances Transcription Factors
    Language English
    Publishing date 2017-06-29
    Publishing country United States
    Document type Journal Article
    ZDB-ID 2267670-3
    ISSN 1932-6203 ; 1932-6203
    ISSN (online) 1932-6203
    ISSN 1932-6203
    DOI 10.1371/journal.pone.0179901
    Database MEDical Literature Analysis and Retrieval System OnLINE

    More links

    Kategorien

    Order via subito

    This service is chargeable due to the Delivery terms set by subito. Orders including an article and supplementary material will be classified as separate orders. In these cases, fees will be demanded for each order.

  6. Article: A case of cochlear implant with internal mechanical failure.

    Ohno, Tsunehisa / Iki, Takehiro / Taniguchi, Aiko / Fujiki, Nobuya / Ohta, Kouzou / Ito, Juichi

    Acta oto-laryngologica. Supplementum

    2007  , Issue 557, Page(s) 15–16

    Abstract: Cochlear implantation has been performed since the 1970s and has been proven to be an effective treatment for profoundly deaf people. In some cases re-implantation has also been reported due to trauma causing implant damage, mechanical failure, extrusion, ...

    Abstract Cochlear implantation has been performed since the 1970s and has been proven to be an effective treatment for profoundly deaf people. In some cases re-implantation has also been reported due to trauma causing implant damage, mechanical failure, extrusion, and wound infections, or device upgrade. We present a case of a 9-year-old boy with a cochlear implant in which mechanical failure occurred after a blow to his temporal region. The clinical presentation and radiographic imaging findings suggested that the cause of mechanical failure was internal failure. We performed cochlear re-implantation to the same ear and it worked well. The explanted device analysis by the manufacturer concluded that the device had failed due to a cracked hybrid integrated circuit.
    MeSH term(s) Child ; Cochlear Implants ; Cochlear Nerve/diagnostic imaging ; Hearing Loss, Bilateral/complications ; Hearing Loss, Bilateral/diagnosis ; Hearing Loss, Bilateral/surgery ; Hearing Loss, Sensorineural/complications ; Hearing Loss, Sensorineural/diagnosis ; Hearing Loss, Sensorineural/surgery ; Humans ; Language Development Disorders/complications ; Language Development Disorders/diagnosis ; Male ; Prosthesis Design ; Tomography, X-Ray Computed
    Language English
    Publishing date 2007-02
    Publishing country Norway
    Document type Case Reports ; Journal Article
    ISSN 0365-5237
    ISSN 0365-5237
    DOI 10.1080/03655230601068187
    Database MEDical Literature Analysis and Retrieval System OnLINE

    More links

    Kategorien

    Order via subito

    This service is chargeable due to the Delivery terms set by subito. Orders including an article and supplementary material will be classified as separate orders. In these cases, fees will be demanded for each order.

To top