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Book: Neuroepidemiology

Rosano, Caterina / Ikram, M. Arfan / Ganguli, Mary

(Handbook of clinical neurology : 3rd series ; 138)

2016

Author's details	volume editors Caterina Rosano, M. Arfan Ikram, and Mary Ganguli
Series title	Handbook of clinical neurology : 3rd series ; 138 Handbook of clinical neurology Handbook of clinical neurology
Collection	Handbook of clinical neurology Handbook of clinical neurology
Language	English
Size	xiv, 335 Seiten, Illustrationen, Diagramme
Publisher	Elsevier
Publishing place	Amsterdam
Publishing country	Netherlands
Document type	Book
HBZ-ID	HT019281362
ISBN	978-0-12-802973-2 ; 0-12-802973-0
Database	Catalogue ZB MED Medicine, Health

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Article: Cerebral Small Vessel Disease in Population-Based Research: What are We Looking at - and What not?

Mooldijk, Sanne S / Ikram, M Arfan

Aging and disease

2023

Abstract: Cerebral small vessel disease (CSVD) is considered as one of the main causes of cognitive decline and dementia. However, despite extensive research, the pathogenesis of CSVD and the mechanisms through which CSVD leads to its clinical manifestations ... ...

Abstract	Cerebral small vessel disease (CSVD) is considered as one of the main causes of cognitive decline and dementia. However, despite extensive research, the pathogenesis of CSVD and the mechanisms through which CSVD leads to its clinical manifestations remain largely unclear. The challenging in vivo quantification of CSVD hampers progress in further unraveling the pathogenesis and pathophysiology of CSVD. Currently, markers of CSVD are mainly brain abnormalities attributed to CSVD, but these are limited in reflecting morphological and functional changes of the microvasculature. We describe aspects of CSVD that are reflected by currently used techniques and those that are still insufficiently captured.
Language	English
Publishing date	2023-06-17
Publishing country	United States
Document type	Journal Article
ZDB-ID	2625789-0
ISSN	2152-5250
ISSN	2152-5250
DOI	10.14336/AD.2023.0323
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Article ; Online: Research Aims in Clinical Medicine: Description, Identification, or Explanation.

Bos, Daniel / Ikram, M Arfan

World neurosurgery

2022 Volume 161, Page(s) 240–244

Abstract: Biomedical research can generally be categorized into 1 of 3 aims: describing the occurrence of disease; identifying persons with or at increased risk of disease including diagnostic and prognostic studies; and explaining the occurrence of disease ... ...

Abstract	Biomedical research can generally be categorized into 1 of 3 aims: describing the occurrence of disease; identifying persons with or at increased risk of disease including diagnostic and prognostic studies; and explaining the occurrence of disease including etiologic and efficacy studies.
MeSH term(s)	Clinical Medicine ; Humans
Language	English
Publishing date	2022-05-03
Publishing country	United States
Document type	Journal Article
ZDB-ID	2534351-8
ISSN	1878-8769 ; 1878-8750
ISSN (online)	1878-8769
ISSN	1878-8750
DOI	10.1016/j.wneu.2021.11.081
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Article ; Online: Progression of arterial calcifications: what, where, and in whom?

van der Toorn, Janine E / Vernooij, Meike W / Ikram, M Arfan / Kavousi, Maryam / Bos, Daniel

European radiology

2024

Abstract: Objectives: There is a lack of information on the development of arteriosclerosis over time. This study aims to assess long-term sex-specific changes in arterial calcifications in five arteries, and the influence of cardiovascular risk factors hereon.!## ...

Abstract	Objectives: There is a lack of information on the development of arteriosclerosis over time. This study aims to assess long-term sex-specific changes in arterial calcifications in five arteries, and the influence of cardiovascular risk factors hereon. Methods: From a population-based cohort, 807 participants (mean baseline age, 65.8; SD, 4.2) underwent a non-contrast computed tomography (CT) examination between 2003 and 2006, and after a median follow-up of 14 years. We assessed incidences and changes in volumes of coronary artery calcification (CAC), aortic arch calcification (AAC), extracranial (ECAC) and intracranial carotid artery calcification (ICAC), and vertebrobasilar artery calcification (VBAC). We investigated the simultaneous presence of severe progression (upper quartile of percentual change volumes). Associations of cardiovascular risk factors with changes in calcification volumes were assessed using multivariate linear regression models. Results: The difference in AAC was most substantial; the median volume (mm Conclusions: We found a considerable incidence and increase in volumes of calcifications in different arteries, over a 14-year time interval. Cardiovascular risk factors were associated with increase of calcifications with sex-specific differential effects across arteries. Clinical relevance statement: There is a considerable incidence and increase in volumes of calcifications in different arteries, over a 14-year time interval. Cardiovascular risk factors are associated with increase of calcifications with sex-specific differential effects across arteries; thus, assessing changes in only one artery may thus not provide a good reflection of the systemic development of arteriosclerosis. Key points: • Assessing change in arterial calcification in only one artery does not reflect the systemic development of arterial calcification. • Cardiovascular risk factors are associated with progression of arterial calcifications. • Progression of arterial calcification is sex and artery-specific.
Language	English
Publishing date	2024-01-15
Publishing country	Germany
Document type	Journal Article
ZDB-ID	1085366-2
ISSN	1432-1084 ; 0938-7994 ; 1613-3749
ISSN (online)	1432-1084
ISSN	0938-7994 ; 1613-3749
DOI	10.1007/s00330-023-10566-7
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Article: Body composition and plasma total-tau, neurofilament light chain, and amyloid-β: A population-based study.

de Crom, Tosca O E / Ghanbari, Mohsen / Voortman, Trudy / Ikram, M Arfan

Alzheimer's & dementia (Amsterdam, Netherlands)

2024 Volume 16, Issue 1, Page(s) e12519

Abstract: A higher body mass at older age has been linked to a lower risk of dementia. This unexpected trend may be explained by age-related lean mass depletion, or methodological issues such as the long preclinical phase of dementia or competing risks. Focusing ... ...

Abstract	A higher body mass at older age has been linked to a lower risk of dementia. This unexpected trend may be explained by age-related lean mass depletion, or methodological issues such as the long preclinical phase of dementia or competing risks. Focusing on preclinical markers of dementia may overcome these issues. Between 2002 and 2005, body composition and plasma total-tau, neurofilament light chain (NfL), amyloid-β40, and amyloid-β42 were measured in 3408 dementia-free participants from the population-based Rotterdam Study. The cross-sectional associations between body composition and plasma markers were determined using linear regression models. Whole body and fat mass, but not lean mass, were positively associated with total-tau, while all these measures were inversely associated with NfL. Apart from an inverse association between lean mass and amyloid-β40, body composition measures were not associated with plasma amyloid-β. Our findings suggest distinct effects of body composition on neurodegeneration.
Language	English
Publishing date	2024-01-15
Publishing country	United States
Document type	Journal Article
ZDB-ID	2832898-X
ISSN	2352-8729
ISSN	2352-8729
DOI	10.1002/dad2.12519
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Article ; Online: History of Traumatic Brain Injury in Relation to Cognitive Functioning, Memory Complaints, and Brain Structure in Mid-Life.

Zijlmans, Jendé L / Vernooij, Meike W / Luik, Annemarie I / Ikram, M Arfan

Journal of neurotrauma

2022 Volume 40, Issue 13-14, Page(s) 1415–1422

Abstract: In this study, we investigated history of traumatic brain injury with loss of consciousness in relation to cognitive functioning, subjective memory complaints, and brain structure in mid-life. This study included 2005 participants (mean age: 47.6 years, ... ...

Abstract	In this study, we investigated history of traumatic brain injury with loss of consciousness in relation to cognitive functioning, subjective memory complaints, and brain structure in mid-life. This study included 2005 participants (mean age: 47.6 years, standard deviation: 5.0, women: 65%) from the Origins of Alzheimer's Disease Across the Life Course (ORACLE) study between 2017 and 2020. History of traumatic brain injury was defined as at least one lifetime self-reported brain injury with loss of consciousness. Associations of history of traumatic brain injury with (1) cognitive functioning (measured with the 15-Word Learning Test, Stroop Task, Letter-Digit Substitution Test, Word Fluency Test, Purdue Pegboard Test, and Design Organization Test), (2) current subjective memory complaints (present/absent, measured with a survey), and (3) brain structure (total brain volume, frontal and temporal lobe volume, gray matter volume, white matter volume, white matter hyperintensities volume, infarcts, and microbleeds, measured with brain magnetic resonance imaging [MRI]) were assessed using linear or logistical regression models and adjusted for relevant confounders. In total, 250 of 2005 (12%) participants reported a history of traumatic brain injury. Of those who reported the time post-injury (
MeSH term(s)	Humans ; Female ; Middle Aged ; Brain/diagnostic imaging ; Brain/pathology ; Cognition ; Brain Injuries, Traumatic/complications ; Brain Injuries, Traumatic/diagnostic imaging ; Brain Injuries, Traumatic/pathology ; Cognition Disorders/pathology ; Magnetic Resonance Imaging ; Neuropsychological Tests ; Unconsciousness
Language	English
Publishing date	2022-11-04
Publishing country	United States
Document type	Journal Article ; Research Support, Non-U.S. Gov't
ZDB-ID	645092-1
ISSN	1557-9042 ; 0897-7151
ISSN (online)	1557-9042
ISSN	0897-7151
DOI	10.1089/neu.2022.0325
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Article ; Online: Molecular pathological epidemiology: the role of epidemiology in the omics-era.

Ikram, M Arfan

European journal of epidemiology

2015 Volume 30, Issue 10, Page(s) 1077–1078

MeSH term(s)	Genomics ; Humans ; Molecular Epidemiology ; Pathology, Molecular ; Precision Medicine/trends
Language	English
Publishing date	2015-10
Publishing country	Netherlands
Document type	Journal Article
ZDB-ID	632614-6
ISSN	1573-7284 ; 0393-2990
ISSN (online)	1573-7284
ISSN	0393-2990
DOI	10.1007/s10654-015-0093-7
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Article ; Online: The role of cognitive and brain reserve in late-life depressive events: The Rotterdam Study.

Zijlmans, Jendé L / Vernooij, Meike W / Ikram, M Arfan / Luik, Annemarie I

Journal of affective disorders

2022 Volume 320, Page(s) 211–217

Abstract: Background: Cognitive and brain reserve aim to explain individual differences in susceptibility to dementia and may also affect the risk of late-life depressive events. We assessed whether higher cognitive and brain reserve are associated with lower ... ...

Abstract	Background: Cognitive and brain reserve aim to explain individual differences in susceptibility to dementia and may also affect the risk of late-life depressive events. We assessed whether higher cognitive and brain reserve are associated with lower risk of a late-life depressive event. Methods: This study included 4509 participants from the population-based Rotterdam Study (mean age: 63.4 ± 10.2 years, 55 % women) between 2005 and 2019. Participants completed cognitive testing and brain-MRI at baseline. Cognitive reserve was defined as the common variance across cognitive tests, while adjusting for demographic factors and brain MRI-markers. Brain reserve was defined as total brain volume divided by intracranial volume. Depressive events (depressive symptoms/depressive syndrome/major depressive disorder) were repeatedly measured (follow-up: 6.6 ± 3.9 years) with validated questionnaires, clinical interviews, and follow-up of medical records. Hazard ratios (HR) with 95 % confidence intervals (CI) were estimated using Cox-regressions. Results: Higher cognitive (HR: 0.91/SD, 95%CI: 0.84; 1.00) and brain reserve (HR: 0.88/SD, 95%CI: 0.77; 1.00) were associated with a lower risk of a depressive event after adjustment for baseline depressive symptoms. These associations attenuated when participants with clinically relevant depressive symptoms at baseline were excluded (HR: 0.95/SD, 95%CI: 0.86; 1.05, HR: 0.89/SD, 95%CI: 0.76; 1.03, respectively). Limitations: No data was available on depression in early-life and the number of participants with major depressive disorder was relatively low (n = 105). Conclusions: Higher cognitive and brain reserve may be protective factors for late-life depressive events, particularly in those who have experienced clinical relevant depressive symptoms before. Further research is needed to determine whether cognitive and brain reserve could be used as targets for the prevention of late-life depression.
MeSH term(s)	Humans ; Female ; Middle Aged ; Aged ; Male ; Cognitive Reserve ; Depressive Disorder, Major/diagnostic imaging ; Depressive Disorder, Major/epidemiology ; Neuropsychological Tests ; Brain/diagnostic imaging ; Proportional Hazards Models ; Depression/psychology
Language	English
Publishing date	2022-09-30
Publishing country	Netherlands
Document type	Journal Article ; Research Support, Non-U.S. Gov't
ZDB-ID	135449-8
ISSN	1573-2517 ; 0165-0327
ISSN (online)	1573-2517
ISSN	0165-0327
DOI	10.1016/j.jad.2022.09.145
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Article: Clinical relevance of lung function trajectory clusters in middle-aged and older adults.

Bertels, Xander / Ross, James C / Faner, Rosa / Cho, Michael H / Ikram, M Arfan / Brusselle, Guy G / Lahousse, Lies

ERJ open research

2024 Volume 10, Issue 1

Abstract: Background: The determinants and health outcomes of lung function trajectories in adults among the general population are poorly understood. We aimed to identify and characterise clusters of lung function trajectories in adults aged ≥45 years.: ... ...

Abstract	Background: The determinants and health outcomes of lung function trajectories in adults among the general population are poorly understood. We aimed to identify and characterise clusters of lung function trajectories in adults aged ≥45 years. Methods: Gaussian finite-mixture modelling was applied to baseline and annualised change of forced expiratory volume in 1 s (FEV Results: We identified eight trajectory clusters, with the reference group having persistently normal spirometry (prevalence 42.8%). Three clusters showed higher mortality, adjusted for confounders: 1) the persistently low FEV Conclusions: This study reveals clinically relevant lung function trajectory clusters in older adults of the general population.
Language	English
Publishing date	2024-02-05
Publishing country	England
Document type	Journal Article
ZDB-ID	2827830-6
ISSN	2312-0541
ISSN	2312-0541
DOI	10.1183/23120541.00793-2023
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Article ; Online: Skin autofluorescence, reflecting accumulation of advanced glycation end products, and the risk of dementia in a population-based cohort.

Mooldijk, Sanne S / Lu, Tianqi / Waqas, Komal / Chen, Jinluan / Vernooij, Meike W / Ikram, M Kamran / Zillikens, M Carola / Ikram, M Arfan

Scientific reports

2024 Volume 14, Issue 1, Page(s) 1256

Abstract: Conditions such as hyperglycemia and oxidative stress lead to the formation of advanced glycation end products (AGEs), which are harmful compounds that have been implicated in dementia. Within the Rotterdam Study, we measured skin AGEs as skin ... ...

Abstract	Conditions such as hyperglycemia and oxidative stress lead to the formation of advanced glycation end products (AGEs), which are harmful compounds that have been implicated in dementia. Within the Rotterdam Study, we measured skin AGEs as skin autofluorescence, reflecting long-term accumulation of AGEs, and determined their association with the risk of dementia and with brain magnetic resonance imaging (MRI) measures. Skin autofluorescence was measured between 2013 and 2016 in 2922 participants without dementia. Of these, 1504 also underwent brain MRI, on which measures of brain atrophy and cerebral small vessel disease were assessed. All participants were followed for the incidence of dementia until 2020. Of 2922 participants (mean age 72.6 years, 57% women), 123 developed dementia. Higher skin autofluorescence (per standard deviation) was associated with an increased risk of dementia (hazard ratio 1.21 [95% confidence interval 1.01-1.46]) and Alzheimer's disease (1.19 [0.97-1.47]), independently of age and other studied potential confounders. Stronger effects were seen in apolipoprotein E (APOE) ε4 carriers (1.34 [0.98-1.82]) and in participants with diabetes (1.35 [0.94-1.94]). Participants with higher skin autofluorescence levels also had smaller total brain volumes and smaller hippocampus volumes on MRI, and they had more often lacunes. These results suggest that AGEs may be involved in dementia pathophysiology.
MeSH term(s)	Humans ; Female ; Aged ; Male ; Glycation End Products, Advanced ; Diabetes Mellitus ; Alzheimer Disease ; Brain/diagnostic imaging ; Magnetic Resonance Imaging ; Skin/diagnostic imaging
Chemical Substances	Glycation End Products, Advanced
Language	English
Publishing date	2024-01-13
Publishing country	England
Document type	Journal Article
ZDB-ID	2615211-3
ISSN	2045-2322 ; 2045-2322
ISSN (online)	2045-2322
ISSN	2045-2322
DOI	10.1038/s41598-024-51703-6
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