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Article ; Online: Traceable localization enables accurate integration of quantum emitters and photonic structures with high yield.

Copeland, Craig R / Pintar, Adam L / Dixson, Ronald G / Chanana, Ashish / Srinivasan, Kartik / Westly, Daron A / Robert Ilic, B / Davanco, Marcelo I / Stavis, Samuel M

Optica quantum

2024 Volume 2, Issue 2, Page(s) 72–84

Abstract: In a popular integration process for quantum information technologies, localization microscopy of quantum emitters guides lithographic placement of photonic structures. However, a complex coupling of microscopy and lithography errors degrades ... ...

Abstract	In a popular integration process for quantum information technologies, localization microscopy of quantum emitters guides lithographic placement of photonic structures. However, a complex coupling of microscopy and lithography errors degrades registration accuracy, severely limiting device performance and process yield. We introduce a methodology to solve this widespread but poorly understood problem. A new foundation of traceable localization enables rapid characterization of lithographic standards and comprehensive calibration of cryogenic microscopes, revealing and correcting latent systematic effects. Of particular concern, we discover that scale factor deviation and complex optical distortion couple to dominate registration errors. These novel results parameterize a process model for integrating quantum dots and bullseye resonators, predicting higher yield by orders of magnitude, depending on the Purcell factor threshold as a quantum performance metric. Our foundational methodology is a key enabler of the lab-to-fab transition of quantum information technologies and has broader implications to cryogenic and correlative microscopy.
Language	English
Publishing date	2024-03-18
Publishing country	United States
Document type	Journal Article
ISSN	2837-6714
ISSN (online)	2837-6714
DOI	10.1364/opticaq.502464
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Article: ADA as main biochemical marker in patients with tuberculous effusion.

Janković, Jelena / Ilić, Branislav / Đurđević, Nataša / Jandrić, Aleksandar

Journal of medical biochemistry

2020 Volume 42, Issue 4, Page(s) 722–726

Abstract: Tuberculous pleuritis (TP) is one of the most common extra-pulmonary tuberculosis form. Because of tuberculous pleurisy is hard to diagnose due to slow course of disease and lack of specificity in symptoms and diagnostic methods. In that reason, we need ... ...

Abstract	Tuberculous pleuritis (TP) is one of the most common extra-pulmonary tuberculosis form. Because of tuberculous pleurisy is hard to diagnose due to slow course of disease and lack of specificity in symptoms and diagnostic methods. In that reason, we need multidisciplinary approach and efficient biomarkers. Acid-fast bacilli (AFB) staining, cultures and pathophysiological biopsy finding from the majority of patients are positive only in less than 10%. Löwenstein culture results need time about 6-8 weeks what delays diagnosis. Adenosine deaminase (ADA) is biomarker with high sensitivity and specificity (more than 90%) and considered as gold standard of biomarkers in the diagnosis of TP. It is very hard to distinguish malignant from TP with lymphocyte predomination, but in patient with malignant pleural effusion the level of ADA is decreased, opposite from TP. ADA in pleural punctate is a fast, simple, efficient and economical way for clarification the etiology of the pleural effusion as tuberculous pleurisy. Also, many studies have proved the role of ADA in the response to treatment for tuberculosis at follow up period.
Language	English
Publishing date	2020-08-06
Publishing country	Serbia
Document type	Journal Article
ZDB-ID	2387367-X
ISSN	1452-8258
ISSN	1452-8258
DOI	10.5937/jomb0-44018
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Zs.A 3112: Show issues

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Article: Differences in Resilience, Self-Stigma and Mental Health Recovery between Patients with Schizophrenia and Depression.

Sedić, Biserka / Štrkalj Ivezić, Slađana / Petrak, Olivera / Ilić, Boris

Psychiatria Danubina

2021 Volume 33, Issue Suppl 4, Page(s) 518–528

Abstract: Introduction: There is growing evidence that resilience is a key factor for prevention of mental disorder. Low resilience levels were found in individuals at clinical high risk to psychosis and schizophrenia. Higher level of resilience was associated ... ...

Abstract	Introduction: There is growing evidence that resilience is a key factor for prevention of mental disorder. Low resilience levels were found in individuals at clinical high risk to psychosis and schizophrenia. Higher level of resilience was associated with better functioning, less severe negative, anxiety and depressive symptoms. Low level of self stigma is associated with recovery from schizophrenia. Aim of this paper was to determine whether resilience and self-stigma are significant predictors of mental health recovery in patients diagnosed with schizophrenia and depression treated in a rehabilitation-oriented program. Subjects and methods: 51 patients diagnosed with psychoses and 53 patients with depression treated in day hospital participated in this study. Internalized Stigma of Mental Illness Scale (ISMI), The Boston University Empowerment Scale (BUES), Perceived Devaluation and Discrimination (PDD) Scale, Mental Health Recovery Measure (MHRM) and Resilience questionnaire were used. Results: Self-stigma positively correlates with PDD (r=0.44; p=0.000), and negatively with BUES (r=-0.78; p=0.000), resilience (r=-0.51; p=0.000) and with recovery (r=-0.59; p=0.000) in two groups. In addition, a higher PDD score indicates poorer levels of empowerment (r=-0.42; p=0.000), resilience (r=-0.35; p=0.000) and recovery (r=-0.44; p=0.000). Mental health empowerment, resilience and recovery all correlate significantly and positively with each other. Cross-group comparison results show the best results for patients with schizophrenia. Sociodemographic factors do not affect resilience, self-stigma nor recovery. Conclusion: Self-stigma and resilience are connected with moderate correlation. Research supports the need for interventions that prevent self-stigma and increase resilience in the treatment of schizophrenia patients.
MeSH term(s)	Depression ; Humans ; Mental Health Recovery ; Schizophrenia ; Self Concept ; Social Stigma
Language	English
Publishing date	2021-10-31
Publishing country	Croatia
Document type	Journal Article
ZDB-ID	1067580-2
ISSN	0353-5053
ISSN	0353-5053
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Zs.A 3158: Show issues

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Article ; Online: Understanding Infection Progression under Strong Control Measures through Universal COVID-19 Growth Signatures.

Djordjevic, Magdalena / Djordjevic, Marko / Ilic, Bojana / Stojku, Stefan / Salom, Igor

Global challenges (Hoboken, NJ)

2021 Volume 5, Issue 5, Page(s) 2000101

Abstract: Widespread growth signatures in COVID-19 confirmed case counts are reported, with sharp transitions between three distinct dynamical regimes (exponential, superlinear, and sublinear). Through analytical and numerical analysis, a novel framework is ... ...

Abstract	Widespread growth signatures in COVID-19 confirmed case counts are reported, with sharp transitions between three distinct dynamical regimes (exponential, superlinear, and sublinear). Through analytical and numerical analysis, a novel framework is developed that exploits information in these signatures. An approach well known to physics is applied, where one looks for common dynamical features, independently from differences in other factors. These features and associated scaling laws are used as a powerful tool to pinpoint regions where analytical derivations are effective, get an insight into qualitative changes of the disease progression, and infer the key infection parameters. The developed framework for joint analytical and numerical analysis of empirically observed COVID-19 growth patterns can lead to a fundamental understanding of infection progression under strong control measures, applicable to outbursts of both COVID-19 and other infectious diseases.
Language	English
Publishing date	2021-03-01
Publishing country	Germany
Document type	Journal Article
ISSN	2056-6646
ISSN (online)	2056-6646
DOI	10.1002/gch2.202000101
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Article ; Online: Personal Listening Device Use and Attitude to Noise in Relation to Depression and Anxiety among Medical Students.

Ilić Živojinović, Jelena / Soldatović, Ivan / Backović, Dušan / Vukašinović, Danka / Babić, Silvana / Tomanić, Milena / Ilić, Branislav / Vlaisavljević, Željko

Noise & health

2023 Volume 25, Issue 118, Page(s) 176–182

Abstract: Background: High levels of environmental noise may lead to psychological symptoms. The present study has hypothesized that personal listening device (PLD) use and a negative attitude to noise are significantly related to anxiety and/or depression.: ... ...

Abstract	Background: High levels of environmental noise may lead to psychological symptoms. The present study has hypothesized that personal listening device (PLD) use and a negative attitude to noise are significantly related to anxiety and/or depression. Methods: This is a cross-sectional study conducted on 431 six-grade students (35% male) at the Faculty of Medicine, University of Belgrade. All students completed the questionnaires related to socio-demographic data, noise/music exposure habits, behaviors related to PLD use, tinnitus, headaches, consumption of alcohol, coffee, energy drinks and cigarettes, YANS (Youth Attitude to Noise Scale), CES-D (The Center for Epidemiologic Studies Depression), and GAD-7 (Generalised Anxiety Disorder Assessment - 7 item scale) questionnaires. Results: There were 396 (91.9%) of investigated students who used PLD, with more frequent use among girls compared to boys (95.0% and 86.8%, respectively; p = 0.002). We found no significant relationship between the frequency of PLD use and depression and anxiety. However, continuous daily PLD use longer than 1 hour was significantly and positively related to depression (p = 0.006). Students with depression had a lower total YANS score compared to those without depression, indicating a more negative attitude toward noise (p = 0.042). Students with no difficulties to concentrate in noise and with a positive attitude to daily noises had about 37% lower chance to suffer from depression and anxiety, respectively. Conclusions: PLD use is common among medical students and may be associated with their mental health. Longer than 1 hour of continuous daily use of PLD may be positively related to depression. We also found a significant relationship between difficulties concentrating in noisy environments and depression, and between negative attitudes to daily noises and anxiety.
MeSH term(s)	Female ; Adolescent ; Humans ; Male ; Students, Medical ; Cross-Sectional Studies ; Depression/epidemiology ; Depression/etiology ; Anxiety/epidemiology ; Anxiety/etiology ; Anxiety Disorders
Language	English
Publishing date	2023-10-10
Publishing country	India
Document type	Journal Article
ZDB-ID	1482372-x
ISSN	1998-4030 ; 1463-1741
ISSN (online)	1998-4030
ISSN	1463-1741
DOI	10.4103/nah.nah_27_23
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Zs.A 6638: Show issues

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Article ; Online: Antibiotic-induced degradation of antitoxin enhances the transcription of acetyltransferase-type toxin-antitoxin operon.

Li, Peifei / Goh, Ying-Xian / Ilic, Bojana / Tai, Cui / Deng, Zixin / Chen, Zhaoyan / Djordjevic, Marko / Ou, Hong-Yu

The Journal of antimicrobial chemotherapy

2023 Volume 78, Issue 4, Page(s) 1066–1075

Abstract: Background: Bacterial toxin-antitoxin (TA) modules respond to various stressful conditions. The Gcn5-related N-acetyltransferase-type toxin (GNAT) protein encoded by the GNAT-RHH TA locus is involved in the antibiotic tolerance of Klebsiella pneumoniae.! ...

Abstract	Background: Bacterial toxin-antitoxin (TA) modules respond to various stressful conditions. The Gcn5-related N-acetyltransferase-type toxin (GNAT) protein encoded by the GNAT-RHH TA locus is involved in the antibiotic tolerance of Klebsiella pneumoniae. Objectives: To investigate the transcriptional mechanism of the GNAT-RHH operon kacAT under antibiotic stress. Methods: The transcriptional level of the kacAT operon of K. pneumoniae was measured by quantitative real-time (qRT) PCR assay. The degradation of antitoxin KacA was examined by western blot and fluorescent protein. The ratio of [KacA]:[KacT] was calculated by the fluorescence intensity of KacA-eGFP and mCherry-KacT. Mathematical modelling predicted protein and transcript synthesis dynamics. Results: A meropenem-induced increase in transcript levels of kacA and kacT resulted from the relief from transcriptional autoregulation of the kacAT operon. Meropenem induces the degradation of KacA through Lon protease, resulting in a reduction in the ratio of [KacA]:[KacT]. The decreased ratio causes the dissociation of the KacAT complex from its promoter region, which eliminates the repression of kacAT transcription. In addition, our dynamic model of kacAT expression regulation quantitatively reproduced the experimentally observed reduction of the [KacA]:[KacT] ratio and a large increase in kacAT transcript levels under the condition of strong promoter autorepression by the KacAT complex. Conclusions: Meropenem promotes the degradation of antitoxin by enhancing the expression of Lon protease. Degradation of antitoxin reduces the ratio of intracellular [antitoxin]:[toxin], leading to detachment of the TA complex from its promoter, and releasing repression of TA operon transcription. These results may provide an important insight into the transcriptional mechanism of GNAT-RHH TA modules under antibiotic stress.
MeSH term(s)	Antitoxins/genetics ; Meropenem ; Acetyltransferases ; Protease La/metabolism ; Operon ; Anti-Bacterial Agents/pharmacology ; Bacterial Proteins/genetics ; Bacterial Proteins/metabolism ; Gene Expression Regulation, Bacterial
Chemical Substances	Antitoxins ; Meropenem (FV9J3JU8B1) ; Acetyltransferases (EC 2.3.1.-) ; Protease La (EC 3.4.21.53) ; Anti-Bacterial Agents ; Bacterial Proteins
Language	English
Publishing date	2023-03-18
Publishing country	England
Document type	Journal Article ; Research Support, Non-U.S. Gov't
ZDB-ID	191709-2
ISSN	1460-2091 ; 0305-7453
ISSN (online)	1460-2091
ISSN	0305-7453
DOI	10.1093/jac/dkad048
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Zs.A 1197: Show issues			Location: Je nach Verfügbarkeit (siehe Angabe bei Bestand) bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular Jg. 1995 - 2021: Lesesall (1.OG) ab Jg. 2022: Lesesaal (EG)
Zs.MO 124: Show issues

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Article ; Online: Comparison of preemptive etoricoxib and dexamethasone in third molar surgery - a randomized controlled clinical trial of patient-reported and clinical outcomes.

Mijailovic, Iva / Janjic, Bojan / Milicic, Biljana / Todorovic, Ana / Ilic, Branislav / Misic, Tijana / Markovic, Nikola / Markovic, Aleksa

Clinical oral investigations

2023 Volume 27, Issue 9, Page(s) 5263–5273

Abstract: Objectives: To compare preemptive single-dose etoricoxib and dexamethasone on postoperative patient satisfaction (pPS) and clinical parameters following the impacted mandibular third molar (IMTM) extraction.: Materials and methods: A parallel-group, ... ...

Abstract	Objectives: To compare preemptive single-dose etoricoxib and dexamethasone on postoperative patient satisfaction (pPS) and clinical parameters following the impacted mandibular third molar (IMTM) extraction. Materials and methods: A parallel-group, triple-blinded, controlled clinical study included a total of 90 patients (n = 30), randomized to receive: etoricoxib 90 mg, dexamethasone 4 mg, or no premedication (control group) 1 h before surgery. Paracetamol 500 mg was prescribed as rescue medication (RM). Check-ups were scheduled at 24 h, 48 h, and day 7 post-surgery. At each time point, pPS was assessed using the 5-point Likert scale. RM parameters, swelling, trismus, and the occurrence of adverse events were also recorded, and patients were instructed to rate the perceived pain on Visual Analogue Scale. Results: In all the follow-up periods, data indicated significantly higher pPS scores in the preemptive medication groups when compared to the control group (p < 0.05). Both regimens delayed the first RM intake when compared to controls. In the etoricoxib group, a significantly lower total RM consumption was observed (p < 0.05). Dexamethasone significantly decreased swelling at each check-up and increased mouth opening at day 7 after the surgery (p < 0.05). Conclusions: Preemptive etoricoxib and dexamethasone elevate pPS after IMTM surgery. Etoricoxib improves RM parameters, while dexamethasone ameliorates the patient's postoperative functional ability. Clinical relevance: Preemptive etoricoxib and dexamethasone use may decrease patients' discomfort following the impacted mandibular third molar extraction. Trial registration: ClinicalTrials.gov Identifier: NCT05791721. Date of Registration: 28/03/2023 (retrospectively registered).
MeSH term(s)	Humans ; Etoricoxib/therapeutic use ; Molar, Third/surgery ; Pain, Postoperative/drug therapy ; Pain, Postoperative/prevention & control ; Dexamethasone ; Patient Reported Outcome Measures ; Tooth Extraction/adverse effects ; Tooth, Impacted/surgery ; Double-Blind Method ; Edema/drug therapy ; Trismus/etiology
Chemical Substances	Etoricoxib (WRX4NFY03R) ; Dexamethasone (7S5I7G3JQL)
Language	English
Publishing date	2023-07-14
Publishing country	Germany
Document type	Randomized Controlled Trial ; Journal Article
ZDB-ID	1364490-7
ISSN	1436-3771 ; 1432-6981
ISSN (online)	1436-3771
ISSN	1432-6981
DOI	10.1007/s00784-023-05146-4
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Zs.A 4788: Show issues

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Article ; Online: Oxidative stress and inflammation parameters-novel biomarkers for idiopathic pulmonary fibrosis.

Roksandic Milenkovic, M / Klisic, A / Ceriman, V / Kotur Stevuljevic, J / Savic Vujovic, K / Mirkov, D / Gajic, M / Ilic, B / Dimic, N / Samardzic, N / Jovanovic, D

European review for medical and pharmacological sciences

2022 Volume 26, Issue 3, Page(s) 927–934

Abstract: Objective: The pathophysiological mechanisms of idiopathic pulmonary fibrosis (IPF) are not well elucidated. It is assumed that oxidative stress and inflammation are the key underlying culprits for its onset and progression. To gain deeper insight into ... ...

Abstract	Objective: The pathophysiological mechanisms of idiopathic pulmonary fibrosis (IPF) are not well elucidated. It is assumed that oxidative stress and inflammation are the key underlying culprits for its onset and progression. To gain deeper insight into these processes, we have evaluated several oxidative stress parameters, inflammation markers [i.e., high sensitivity C-reactive protein (hsCRP), serum amyloid A1 (SAA1)], soluble programmed cell death-ligand 1 (sPD-L1), and 25-hydroxyvitamin D [25(OH)D] in IPF patients. Patients and methods: Biochemistry analyses were done in 30 consecutive IPF patients and 30 age and gender-matched healthy control group (CG). Results: IPF patients had significantly higher advanced oxidation protein products (p<0.001), pro-oxidant-antioxidant balance (p=0.010), total oxidative status (p<0.001), and ischemia modified albumin (p<0.001) compared to CG. Lower total antioxidant status and total sulfhydryl groups (tSGH) and significantly higher sPD-L1, hsCRP (p<0.001 for all), SAA1 proteins (p=0.014) and [25(OH)D] severe deficiency [11.0 (9.6-15.1) nmol/L] in IPF patients compared to CG were observed. Paraoxonase 1 activity and hsCRP level were lower, while tSHG and sPD-L1 were higher in IPF patients with more severe disease (i.e., II+III stage compared to I stage, p<0.05 for all). Conclusions: IPF patients are in a state of profound oxidative stress compared to healthy people. The inflammatory component of the disease was confirmed by higher hsCRP and SAA1, but lower [25(OH)D] in IPF than in healthy people. Also, higher levels of sPD-L1 in patients with IPF compared to healthy individuals suggest that sPD-L1 may have a significant role in immune response in IPF.
MeSH term(s)	Biomarkers ; Humans ; Idiopathic Pulmonary Fibrosis/diagnosis ; Idiopathic Pulmonary Fibrosis/metabolism ; Inflammation ; Oxidative Stress ; Serum Albumin/metabolism
Chemical Substances	Biomarkers ; Serum Albumin
Language	English
Publishing date	2022-02-18
Publishing country	Italy
Document type	Journal Article
ZDB-ID	605550-3
ISSN	2284-0729 ; 1128-3602 ; 0392-291X
ISSN (online)	2284-0729
ISSN	1128-3602 ; 0392-291X
DOI	10.26355/eurrev_202202_28002
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Zs.A 1887: Show issues

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Article ; Online: A randomized, double-blind, placebo-controlled study evaluating the efficacy of propolis and N-acetylcysteine in exacerbations of chronic obstructive pulmonary disease.

Buha, I / Mirić, M / Agić, A / Simić, M / Stjepanović, M / Milenković, B / Nagorni-Obradović, L / Škodrić-Trifunović, V / Ilić, B / Popević, S / Dimic-Janjic, S / Ilić, A

European review for medical and pharmacological sciences

2022 Volume 26, Issue 13, Page(s) 4809–4815

Abstract: Objective: Acute exacerbations of chronic obstructive pulmonary disease (AECOPDs) accelerate the progressive impairment of lung function and general health. Together with maintenance therapy for chronic obstructive pulmonary disease (COPD), N- ... ...

Abstract	Objective: Acute exacerbations of chronic obstructive pulmonary disease (AECOPDs) accelerate the progressive impairment of lung function and general health. Together with maintenance therapy for chronic obstructive pulmonary disease (COPD), N-acetylcysteine (NAC) and natural propolis have demonstrated pharmacological properties that address crucial pathophysiological processes underlying COPD and may prevent AECOPDs. This study aims at responding to dose-dependent efficacy and safety concerns regarding a propolis-NAC combination for the reduction of COPD exacerbation rates. Patients and methods: This was a single-center, randomized, double-blind, phase IV trial with three treatment arms: Placebo and two active substance groups, one (AS-600) received 600 mg of NAC + 80 mg of propolis while the other (AS-1,200) received 1,200 mg of NAC + 160 mg of propolis. Following an AECOPD, frequent-exacerbation phenotype patients (n=46) were assigned a once-daily three-month therapy with the study drug and one year follow-up. The primary endpoint was the COPD exacerbation incidence rate during the follow-up period as a measure of dose-dependent efficacy of NAC-propolis combination compared to placebo. Results: There was a statistically significant difference in the AECOPD incidence rate: 52.6% in patients that received placebo, 15.4% that received AS-600 and only 7.1% that received AS-1,200 (Fisher's exact test, p = 0.013). Compared to placebo, AECOPD frequency was significantly lower only in AS-1,200 (p=0.009). Compared to placebo, the relative risk for exacerbation was 0.29 in AS-600 and 0.13 in AS-1,200. No adverse events related to the treatment were reported. Conclusions: Oral combination of natural propolis with NAC confirmed formulation efficiency with a favorable safety profile. Our results need to be confirmed by larger clinical trials.
MeSH term(s)	Acetylcysteine/adverse effects ; Disease Progression ; Double-Blind Method ; Humans ; Propolis/therapeutic use ; Pulmonary Disease, Chronic Obstructive
Chemical Substances	Propolis (9009-62-5) ; Acetylcysteine (WYQ7N0BPYC)
Language	English
Publishing date	2022-07-20
Publishing country	Italy
Document type	Clinical Trial, Phase IV ; Journal Article ; Randomized Controlled Trial
ZDB-ID	605550-3
ISSN	2284-0729 ; 1128-3602 ; 0392-291X
ISSN (online)	2284-0729
ISSN	1128-3602 ; 0392-291X
DOI	10.26355/eurrev_202207_29206
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Article ; Online: Two-Directional Operation of Bistable Latchable Micro Switch Actuated by a Single Electrode.

Medina, Lior / Gilat, Rivka / Ilic, Bojan / Krylov, Slava

Proceedings (MDPI)

2019 Volume 1

Abstract: Curved micromechanical beams are a versatile platform for exploring multistable behavior, with potential applications in mechanical based logic elements and electrical and optical switches. Here we demonstrate bidirectional electrostatic actuation of a ... ...

Abstract	Curved micromechanical beams are a versatile platform for exploring multistable behavior, with potential applications in mechanical based logic elements and electrical and optical switches. Here we demonstrate bidirectional electrostatic actuation of a bistable, latched, micromechanical beam by the same electrode, which was used for the snap-through switching of the device. The release of the mechanically-latched beam is achieved by pre-loading the structure using a rising voltage applied to the electrode, followed by a sudden decrease of the voltage. This abrupt removal of the loading results in a transient response and dynamic snap-back of the beam.
Language	English
Publishing date	2019-03-30
Publishing country	Switzerland
Document type	Journal Article
ZDB-ID	2904077-2
ISSN	2504-3900 ; 2504-3900
ISSN (online)	2504-3900
ISSN	2504-3900
DOI	10.3390/proceedings1040277
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