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  1. Book: Humanbiobanken

    Lanzerath, Dirk / Illig, Thomas / Bernemann, Inga / Hoppe, Nils / Robienski, Jürgen

    (Ethik in den Biowissenschaften ; 19)

    2019  

    Abstract: Biobanken im Humanbereich sind Sammlungen von Proben menschlicher Körpersubstanzen (etwa Gewebe, Blut, genetisches Material), die mit sensiblen personenbezogenen Daten und insbesondere gesundheitsbezogenen Informationen über die Spender digital verknüpft ...

    Author's details Dirk Lanzerath, PD Dr. phil., Geschäftsführer des Deutschen Referenzzentrums für Ethik in den Biowissenschaften und Privatdozent am Institut für Philosophie der Universität Bonn.§Thomas Illig, Professor Dr. rer. nat., Leiter der zentralen Biobank der Medizinischen Hochschule Hannover und Stellvertretender Direktor des Instituts für Humangenetik.§Nils Hoppe, Professor Dr. iur., Direktor des Centre for Ethics and Law in the Life Sciences an der Universität Hannover
    Series title Ethik in den Biowissenschaften ; 19
    Abstract Biobanken im Humanbereich sind Sammlungen von Proben menschlicher Körpersubstanzen (etwa Gewebe, Blut, genetisches Material), die mit sensiblen personenbezogenen Daten und insbesondere gesundheitsbezogenen Informationen über die Spender digital verknüpft sind. Sie stellen eine bedeutende Ressource für die biomedizinische Forschung dar, um Ursachen und Mechanismen zahlreicher Erkrankungen besser zu verstehen und deren Diagnose und Behandlung weiterzuentwickeln. Bei der Errichtung und Handhabun...
    Keywords HPHP025 ; NBIA023 ; MHMA035 ; LLWOG40 ; Humanbiologie ; Biomedizin ; Bioethik ; Forschung
    Language German
    Size 144 p.
    Edition 1
    Publisher Alber Verlag
    Document type Book
    Note PDA Manuell_3
    Format 214 x 134
    ISBN 9783495490372 ; 349549037X
    Database PDA

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  2. Book ; Thesis: Inzidenz und Pathomechanismen von Schädigungen des Nervus peronaeus nach Tibiakopfosteotomie

    Illig, Thomas

    1997  

    Author's details vorgelegt von Thomas Illig
    Language German
    Size 135 S. : Ill., graph. Darst.
    Document type Book ; Thesis
    Thesis / German Habilitation thesis Heidelberg, Univ., Diss., 1997
    HBZ-ID HT008168264
    Database Catalogue ZB MED Medicine, Health

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    In stock of ZB MED Cologne/Königswinter

    Shelf markLoan statusLocation
    98 E 237 order for loan Magazin

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  3. Book ; Conference proceedings: Biobanken als Bindeglied zwischen Versorgung und Forschung

    Illig, Thomas / Hummel, Michael / Jahns, Roland / Kiehntopf, Michael / Lieb, Wolfgang / Nauck, Matthias / Nußbeck, Sara / Prokosch, Hans-Ulrich / Schirmacher, Peter / Semler, Sebastian C. / Siddiqui, Roman A.

    Tagungsband des 5. Nationalen Biobanken-Symposiums vom 7.-8. Dezember 2016 in Berlin

    (Jahresbericht / Nationales Biobanken-Symposium ; 2016)

    2016  

    Institution Technologie- und Methodenplattform für die Vernetzte Medizinische Forschung e.V
    Event/congress Nationales Biobanken-Symposium (5., 2016, Berlin)
    Author's details TMF, Technologie- und Methodenplattform für die Vernetzte Medizinische Forschung e.V. ; Herausgeber Thomas Illig, Michael Hummel, oland Jahns, Michael Kiehntopf, Wolfgang Lieb, Matthias Nauck, Sara Nußbeck, Hans-Ulrich Prokosch, Peter Schirmacher, Sebastn C. Semler, Roman A. Siddiqui
    Series title Jahresbericht / Nationales Biobanken-Symposium ; 2016
    Collection
    Keywords Biobanken ; Biobanknetzwerke ; medizinische Forschung ; medizinische Versorgung ; Biobank
    Subject Biomaterialbank
    Subject code 362.1783
    Language German
    Size 207 Seiten, Illustrationen, 24 cm
    Edition [1. Auflage]
    Publisher Akademische Verlagsgesellschaft AKA GmbH
    Publishing place Berlin
    Publishing country Germany
    Document type Book ; Conference proceedings
    HBZ-ID HT019329050
    ISBN 978-3-89838-721-7 ; 3-89838-721-6
    Database Catalogue ZB MED Medicine, Health

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    In stock of ZB MED Cologne/Königswinter

    Shelf markLoan statusLocation
    2017 A 960 available for loan (reading room) Lesesaal EG

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  4. Article ; Online: Population-Based Biobanking.

    Lieb, Wolfgang / Strathmann, Eike A / Röder, Christian / Jacobs, Gunnar / Gaede, Karoline I / Richter, Gesine / Illig, Thomas / Krawczak, Michael

    Genes

    2024  Volume 15, Issue 1

    Abstract: Population-based biobanking is an essential element of medical research that has grown substantially over the last two decades, and many countries are currently pursuing large national biobanking initiatives. The rise of individual biobanks is paralleled ...

    Abstract Population-based biobanking is an essential element of medical research that has grown substantially over the last two decades, and many countries are currently pursuing large national biobanking initiatives. The rise of individual biobanks is paralleled by various networking activities in the field at both the national and international level, such as BBMRI-ERIC in the EU. A significant contribution to population-based biobanking comes from large cohort studies and national repositories, including the United Kingdom Biobank (UKBB), the CONSTANCES project in France, the German National Cohort (NAKO), LifeLines in the Netherlands, FinnGen in Finland, and the All of Us project in the U.S. At the same time, hospital-based biobanking has also gained importance in medical research. We describe some of the scientific questions that can be addressed particularly well by the use of population-based biobanks, including the discovery and calibration of biomarkers and the identification of molecular correlates of health parameters and disease states. Despite the tremendous progress made so far, some major challenges to population-based biobanking still remain, including the need to develop strategies for the long-term sustainability of biobanks, the handling of incidental findings, and the linkage of sample-related and sample-derived data to other relevant resources.
    MeSH term(s) Humans ; Biological Specimen Banks ; Population Health ; Biomedical Research ; Calibration ; Finland
    Language English
    Publishing date 2024-01-03
    Publishing country Switzerland
    Document type Journal Article ; Review
    ZDB-ID 2527218-4
    ISSN 2073-4425 ; 2073-4425
    ISSN (online) 2073-4425
    ISSN 2073-4425
    DOI 10.3390/genes15010066
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  5. Article: Metabolomics analysis reveals novel serum metabolite alterations in cancer cachexia.

    More, Tushar H / Hiller, Karsten / Seifert, Martin / Illig, Thomas / Schmidt, Rudi / Gronauer, Raphael / von Hahn, Thomas / Weilert, Hauke / Stang, Axel

    Frontiers in oncology

    2024  Volume 14, Page(s) 1286896

    Abstract: Background: Cachexia is a body wasting syndrome that significantly affects well-being and prognosis of cancer patients, without effective treatment. Serum metabolites take part in pathophysiological processes of cancer cachexia, but apart from altered ... ...

    Abstract Background: Cachexia is a body wasting syndrome that significantly affects well-being and prognosis of cancer patients, without effective treatment. Serum metabolites take part in pathophysiological processes of cancer cachexia, but apart from altered levels of select serum metabolites, little is known on the global changes of the overall serum metabolome, which represents a functional readout of the whole-body metabolic state. Here, we aimed to comprehensively characterize serum metabolite alterations and analyze associated pathways in cachectic cancer patients to gain new insights that could help instruct strategies for novel interventions of greater clinical benefit.
    Methods: Serum was sampled from 120 metastatic cancer patients (stage UICC IV). Patients were grouped as cachectic or non-cachectic according to the criteria for cancer cachexia agreed upon international consensus (main criterium: weight loss adjusted to body mass index). Samples were pooled by cachexia phenotype and assayed using non-targeted gas chromatography-mass spectrometry (GC-MS). Normalized metabolite levels were compared using
    Results: Comparative analyses included 78 cachectic and 42 non-cachectic patients. Cachectic patients exhibited 19 annotable, significantly elevated (including glucose and fructose) or decreased (mostly amino acids) metabolites associating with aminoacyl-tRNA, glutathione and amino acid metabolism pathways. PLS-DA showed distinct clusters (accuracy: 85.6%), and machine-learning models identified metabolic signatures for separating cachectic states (accuracy: 83.2%; area under ROC: 88.0%). We newly identified altered blood levels of erythronic acid and glucuronic acid in human cancer cachexia, potentially linked to pentose-phosphate and detoxification pathways.
    Conclusion: We found both known and yet unknown serum metabolite and metabolic pathway alterations in cachectic cancer patients that collectively support a whole-body metabolic state with impaired detoxification capability, altered glucose and fructose metabolism, and substrate supply for increased and/or distinct metabolic needs of cachexia-associated tumors. These findings together imply vulnerabilities, dependencies and targets for novel interventions that have potential to make a significant impact on future research in an important field of cancer patient care.
    Language English
    Publishing date 2024-02-20
    Publishing country Switzerland
    Document type Journal Article
    ZDB-ID 2649216-7
    ISSN 2234-943X
    ISSN 2234-943X
    DOI 10.3389/fonc.2024.1286896
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  6. Book ; Online ; Thesis: Development and validation of transcriptome data interpretation strategies and their implementation in pulmonary biomedical research

    Liu, Bin [Verfasser] / Illig, Thomas [Akademischer Betreuer] / Rosenhahn, Bodo [Akademischer Betreuer]

    2023  

    Author's details Bin Liu ; Akademische Betreuer: Thomas Illig, Bodo Rosenhahn ; Hannover Unified Biobank (HUB)
    Keywords Medizin, Gesundheit ; Medicine, Health
    Subject code sg610
    Language German
    Publisher Bibliothek der Medizinischen Hochschule Hannover
    Publishing place Hannover
    Document type Book ; Online ; Thesis
    Database Digital theses on the web

    Full text online

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  7. Article ; Online: Effects of Repeated Freeze and Thaw Cycles on the Genome-Wide DNA Methylation Profile of Isolated Genomic DNA.

    Kopfnagel, Verena / Klopp, Norman / Bernemann, Inga / Nizhegorodtseva, Nataliia / Wilson, Rory / Gronauer, Raphael / Seifert, Martin / Illig, Thomas

    Biopreservation and biobanking

    2023  Volume 22, Issue 2, Page(s) 110–114

    Abstract: The characterization of DNA methylation patterns to identify epigenetic markers for complex human diseases is an important and rapidly evolving part in biomedical research. DNA samples collected and stored in clinical biobanks over the past years are an ... ...

    Abstract The characterization of DNA methylation patterns to identify epigenetic markers for complex human diseases is an important and rapidly evolving part in biomedical research. DNA samples collected and stored in clinical biobanks over the past years are an important source for future epigenetic studies. Isolated gDNA is considered stable when stored at low temperatures for several years. However, the effect of multiple use and the associated repeated thawing of long-term stored DNA samples on DNA methylation patterns has not yet been investigated. In this study, we examined the influence of up to 10 freeze and thaw cycles on global DNA methylation by comparing genome-wide methylation profiles. DNA samples from 19 healthy volunteers were either frozen at -80°C or subjected to up to 10 freeze and thaw cycles. Genome-wide DNA methylation was analyzed after 0, 1, 3, 5, or 10 thaw cycles using the Illumina Infinium MethylationEPIC BeadChip. Evaluation of the global DNA methylation profile by beta-value density plots and multidimensional scaling plots revealed an expected clear participant-dependent variability, but a very low variability depending on the freeze and thaw cycles. In accordance, no significant difference in any of the methylated cytosine/guanine sites studied could be detected in the performed statistical analyses. Our results suggest that long-term frozen DNA samples are still suitable for epigenetic studies after multiple thaw cycles.
    MeSH term(s) Humans ; DNA Methylation ; Freezing ; DNA/genetics ; Healthy Volunteers ; Genomics
    Chemical Substances DNA (9007-49-2)
    Language English
    Publishing date 2023-04-18
    Publishing country United States
    Document type Journal Article
    ZDB-ID 2593993-2
    ISSN 1947-5543 ; 1947-5535
    ISSN (online) 1947-5543
    ISSN 1947-5535
    DOI 10.1089/bio.2022.0045
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  8. Article ; Online: Supplemental Human Genetics Point of View.

    Ripperger, Tim / Illig, Thomas / Schlegelberger, Brigitte

    Deutsches Arzteblatt international

    2019  Volume 116, Issue 14, Page(s) 251

    MeSH term(s) Hematologic Neoplasms ; Human Genetics ; Humans
    Language English
    Publishing date 2019-05-15
    Publishing country Germany
    Document type Letter ; Comment
    ZDB-ID 2406159-1
    ISSN 1866-0452 ; 1866-0452
    ISSN (online) 1866-0452
    ISSN 1866-0452
    DOI 10.3238/arztebl.2019.0251a
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  9. Article ; Online: Synergistic effect of genetic polymorphisms in

    Varzari, Alexander / Deyneko, Igor V / Tudor, Elena / Grallert, Harald / Illig, Thomas

    Innate immunity

    2021  Volume 27, Issue 5, Page(s) 365–376

    Abstract: Polymorphisms in genes that control immune function and regulation may influence susceptibility to pulmonary tuberculosis (TB). In this study, 14 polymorphisms in 12 key genes involved in the immune response ( ...

    Abstract Polymorphisms in genes that control immune function and regulation may influence susceptibility to pulmonary tuberculosis (TB). In this study, 14 polymorphisms in 12 key genes involved in the immune response (
    MeSH term(s) Adult ; Female ; Gene Frequency ; Genetic Association Studies ; Genetic Loci ; Genetic Predisposition to Disease ; Genotype ; Humans ; Male ; Middle Aged ; Moldova ; Mycobacterium tuberculosis/physiology ; Polymorphism, Single Nucleotide ; Population Groups ; Risk ; Toll-Like Receptor 10/genetics ; Toll-Like Receptor 6/genetics ; Tuberculosis, Pulmonary/genetics
    Chemical Substances TLR10 protein, human ; TLR6 protein, human ; Toll-Like Receptor 10 ; Toll-Like Receptor 6
    Language English
    Publishing date 2021-07-18
    Publishing country United States
    Document type Journal Article ; Research Support, Non-U.S. Gov't
    ZDB-ID 2381250-3
    ISSN 1753-4267 ; 1753-4259
    ISSN (online) 1753-4267
    ISSN 1753-4259
    DOI 10.1177/17534259211029996
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  10. Book: NGFN2-Neuronetzwerk "Adipositas und assoziierte Störungen", Teilprojekt 15 "Identifizierung von Kandidatengenen für Adipositas beim Menschen"

    Illig, Thomas

    Schlussbericht über den Projektverlauf vom 01.09.2004 bis 31.05.2008

    2008  

    Title variant Identifizierung von Kandidatengenen für Adipositas beim Menschen
    Institution HelmholtzZentrum München
    Author's details Helmholtz Zentrum München, Deutsches Forschungszentrum für Gesundheit und Umwelt (GmbH). Teilprojektleiter: Thomas Illig
    Language German
    Size [25] Bl., graph. Darst.
    Publishing place Neuherberg
    Document type Book
    Note Förderkennzeichen BMBF 01GS0485. - Verbund-Nr. 01033279 ; Unterschiede zwischen dem gedruckten Dokument und der elektronischen Ressource können nicht ausgeschlossen werden
    Database Library catalogue of the German National Library of Science and Technology (TIB), Hannover

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