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  1. Article ; Online: With commentary.

    Illingworth, R

    Archives of disease in childhood

    2010  Volume 58, Issue 9, Page(s) 739

    Language English
    Publishing date 2010-10-28
    Publishing country England
    Document type Journal Article
    ZDB-ID 524-1
    ISSN 1468-2044 ; 0003-9888 ; 1359-2998
    ISSN (online) 1468-2044
    ISSN 0003-9888 ; 1359-2998
    DOI 10.1136/adc.58.9.739
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  2. Article: Fraud and other misconduct in biomedical research.

    Illingworth, R

    British journal of neurosurgery

    2005  Volume 18, Issue 4, Page(s) 325–327

    MeSH term(s) Biomedical Research ; Scientific Misconduct
    Language English
    Publishing date 2005-02-02
    Publishing country England
    Document type Editorial
    ZDB-ID 639029-8
    ISSN 0268-8697
    ISSN 0268-8697
    DOI 10.1080/02688690400004795
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  3. Article: Fraud and other misconduct in biomedical research.

    Illingworth, R

    Neurocirugia (Asturias, Spain)

    2005  Volume 16, Issue 4, Page(s) 297–300

    MeSH term(s) Biomedical Research ; Publishing/ethics ; Scientific Misconduct
    Language English
    Publishing date 2005-09-01
    Publishing country Spain
    Document type Editorial
    ZDB-ID 2151282-6
    ISSN 1130-1473
    ISSN 1130-1473
    DOI 10.1016/s1130-1473(05)70394-8
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  4. Article ; Online: What does 'patient-centred' mean in relation to the consultation?

    Illingworth, Rosie

    The clinical teacher

    2010  Volume 7, Issue 2, Page(s) 116–120

    Abstract: Background: The phrase 'patient-centred' is frequently used in medical education, and yet has been identified as a 'fuzzy concept'. Focusing on the consultation, this article assists teachers by examining the evolution of the phrase, and then presenting ...

    Abstract Background: The phrase 'patient-centred' is frequently used in medical education, and yet has been identified as a 'fuzzy concept'. Focusing on the consultation, this article assists teachers by examining the evolution of the phrase, and then presenting and clarifying a definition.
    Context: Starting with what is regarded as the first use of the phrase, by Enid Balint in 1969, the evolution of the term is considered with English and North American contributions. Links are made with the development of communication as an important part of the consultation. The information in this article is distilled from a literature review undertaken as part of a qualitative research PhD examining the teaching and learning of patient-centredness.
    Innovation: Two defining strands are identified and explored in an informed and referenced discourse. The first strand involves the 'discovery of the patient's perspective', where a patient is a person whose disease is experienced individually as an illness, upon which they have thoughts, feelings and expectations of their doctors. The second concerns 'shared control' of the consultation, where a more sharing, participative and equal approach with the patient is adopted. The models of Stewart et al. and Pendleton et al. are compared, and it is shown that although there is common ground, there are different emphases.
    Implications: Teachers need to be explicit with both meanings of 'patient-centred' to assist learners' understanding and future practice. It is also important to explore the process, content and attitudinal aspects of patient-centredness.
    MeSH term(s) Communication ; Curriculum ; Education, Medical/methods ; Health Knowledge, Attitudes, Practice ; Humans ; Learning ; Patient-Centered Care/methods ; Physician-Patient Relations ; Referral and Consultation ; Students, Medical ; Teaching/methods
    Language English
    Publishing date 2010-06
    Publishing country England
    Document type Journal Article ; Review
    ZDB-ID 2151518-9
    ISSN 1743-498X ; 1743-4971
    ISSN (online) 1743-498X
    ISSN 1743-4971
    DOI 10.1111/j.1743-498X.2010.00367.x
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  5. Article: The after-history of premature infants: With Special Reference to the Effect of the Birth Weight on the Weight Chart.

    Illingworth, R S

    Archives of disease in childhood

    2010  Volume 14, Issue 78, Page(s) 121–136

    Language English
    Publishing date 2010-10-28
    Publishing country England
    Document type Journal Article
    ZDB-ID 524-1
    ISSN 1468-2044 ; 0003-9888 ; 1359-2998
    ISSN (online) 1468-2044
    ISSN 0003-9888 ; 1359-2998
    DOI 10.1136/adc.14.78.121
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  6. Article: Postscarlatinal encephalitis; report of a case.

    ILLINGWORTH, R S

    Lancet (London, England)

    2010  Volume 2, Issue 6378, Page(s) 600

    MeSH term(s) Encephalitis/etiology ; Encephalitis/pathology ; Humans ; Scarlet Fever/complications
    Language English
    Publishing date 2010-10-12
    Publishing country England
    Document type Journal Article
    ZDB-ID 3306-6
    ISSN 1474-547X ; 0140-6736 ; 0023-7507
    ISSN (online) 1474-547X
    ISSN 0140-6736 ; 0023-7507
    DOI 10.1016/s0140-6736(45)91614-x
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  7. Article: The Changing Pattern of Pædiatrics in a Children's Hospital 1876-1961.

    Illingworth, R S

    Proceedings of the Royal Society of Medicine

    2009  Volume 54, Issue 11, Page(s) 1011–1013

    Language English
    Publishing date 2009-11-24
    Publishing country England
    Document type Journal Article
    ZDB-ID 209243-8
    ISSN 0035-9157
    ISSN 0035-9157
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  8. Article: Carcinogenicity of lipid-lowering drugs.

    Illingworth, R

    JAMA

    1996  Volume 275, Issue 19, Page(s) 1479–80; author reply 1481–2

    MeSH term(s) Acyl Coenzyme A/antagonists & inhibitors ; Gemfibrozil/adverse effects ; Gemfibrozil/pharmacology ; Humans ; Hypolipidemic Agents/adverse effects ; Hypolipidemic Agents/pharmacology ; Liver/drug effects ; Liver Neoplasms/chemically induced ; Lovastatin/adverse effects ; Lovastatin/pharmacology
    Chemical Substances Acyl Coenzyme A ; Hypolipidemic Agents ; 3-hydroxy-3-methylglutaryl-coenzyme A (1553-55-5) ; Lovastatin (9LHU78OQFD) ; Gemfibrozil (Q8X02027X3)
    Language English
    Publishing date 1996-05-15
    Publishing country United States
    Document type Comment ; Letter
    ZDB-ID 2958-0
    ISSN 1538-3598 ; 0098-7484 ; 0254-9077 ; 0002-9955
    ISSN (online) 1538-3598
    ISSN 0098-7484 ; 0254-9077 ; 0002-9955
    DOI 10.1001/jama.1996.03530430023026
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  9. Article ; Online: DAXX safeguards heterochromatin formation in embryonic stem cells.

    Canat, Antoine / Veillet, Adeline / Batrin, Renaud / Dubourg, Clara / Lhoumaud, Priscillia / Arnau-Romero, Pol / Greenberg, Maxim V C / Bonhomme, Frédéric / Arimondo, Paola B / Illingworth, Robert / Fabre, Emmanuelle / Therizols, Pierre

    Journal of cell science

    2023  Volume 136, Issue 19

    Abstract: Genomes comprise a large fraction of repetitive sequences folded into constitutive heterochromatin, which protect genome integrity and cell identity. De novo formation of heterochromatin during preimplantation development is an essential step for ... ...

    Abstract Genomes comprise a large fraction of repetitive sequences folded into constitutive heterochromatin, which protect genome integrity and cell identity. De novo formation of heterochromatin during preimplantation development is an essential step for preserving the ground-state of pluripotency and the self-renewal capacity of embryonic stem cells (ESCs). However, the molecular mechanisms responsible for the remodeling of constitutive heterochromatin are largely unknown. Here, we identify that DAXX, an H3.3 chaperone essential for the maintenance of mouse ESCs in the ground state, accumulates in pericentromeric regions independently of DNA methylation. DAXX recruits PML and SETDB1 to promote the formation of heterochromatin, forming foci that are hallmarks of ground-state ESCs. In the absence of DAXX or PML, the three-dimensional (3D) architecture and physical properties of pericentric and peripheral heterochromatin are disrupted, resulting in de-repression of major satellite DNA, transposable elements and genes associated with the nuclear lamina. Using epigenome editing tools, we observe that H3.3, and specifically H3.3K9 modification, directly contribute to maintaining pericentromeric chromatin conformation. Altogether, our data reveal that DAXX is crucial for the maintenance and 3D organization of the heterochromatin compartment and protects ESC viability.
    MeSH term(s) Animals ; Mice ; Histones/genetics ; Heterochromatin/genetics ; Nuclear Proteins/genetics ; Nuclear Proteins/metabolism ; Chromatin ; Embryonic Stem Cells/metabolism
    Chemical Substances Histones ; Heterochromatin ; Nuclear Proteins ; Chromatin
    Language English
    Publishing date 2023-10-11
    Publishing country England
    Document type Journal Article ; Research Support, Non-U.S. Gov't
    ZDB-ID 2993-2
    ISSN 1477-9137 ; 0021-9533
    ISSN (online) 1477-9137
    ISSN 0021-9533
    DOI 10.1242/jcs.261092
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  10. Article: Prevention of death and disease in children.

    ILLINGWORTH, R S

    Health education journal

    2008  Volume 6, Issue 3, Page(s) 113–116

    MeSH term(s) Biomedical Research ; Child ; Death/prevention & control ; Delivery of Health Care ; Disease/prevention & control ; Humans ; Preventive Medicine
    Language English
    Publishing date 2008-10-01
    Publishing country United States
    Document type Journal Article
    ZDB-ID 604601-0
    ISSN 0017-8969
    ISSN 0017-8969
    DOI 10.1177/001789694800600306
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