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  1. Article ; Online: Don't miss the chance to reap the fruits of recent advances in behavioral genetics.

    Alexander, Nina / Illius, Sabrina / Feyerabend, Dennis / Wacker, Jan / Liszkowski, Ulf

    The Behavioral and brain sciences

    2023  Volume 46, Page(s) e208

    Abstract: In her target article, Burt revives a by now ancient debate on nature and nurture, and the ways to measure, disentangle, and ultimately trust one or the other of these forces. Unfortunately, she largely dismisses recent advances in behavior genetics and ... ...

    Abstract In her target article, Burt revives a by now ancient debate on nature and nurture, and the ways to measure, disentangle, and ultimately trust one or the other of these forces. Unfortunately, she largely dismisses recent advances in behavior genetics and its huge potential in contributing to a better
    MeSH term(s) Humans ; Female ; Fruit ; Genetics, Behavioral ; Social Sciences
    Language English
    Publishing date 2023-09-11
    Publishing country England
    Document type Journal Article ; Comment
    ZDB-ID 423721-3
    ISSN 1469-1825 ; 0140-525X
    ISSN (online) 1469-1825
    ISSN 0140-525X
    DOI 10.1017/S0140525X22002497
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  2. Article ; Online: A data multiverse analysis investigating non-model based SCR quantification approaches.

    Sjouwerman, Rachel / Illius, Sabrina / Kuhn, Manuel / Lonsdorf, Tina B

    Psychophysiology

    2022  Volume 59, Issue 12, Page(s) e14130

    Abstract: Electrodermal signals are commonly used outcome measures in research on arousal, emotion, and habituation. Recently, we reported on heterogeneity in skin conductance response quantification approaches and its impact on replicability. Here we provide ... ...

    Abstract Electrodermal signals are commonly used outcome measures in research on arousal, emotion, and habituation. Recently, we reported on heterogeneity in skin conductance response quantification approaches and its impact on replicability. Here we provide complementary work focusing on within-approach heterogeneity of specifications for skin conductance response quantification. We focus on heterogeneity within the baseline-correction approach (BLC) which appeared as particularly heterogeneous-for instance with respect to the pre-CS baseline window duration, the start, and end of the peak detection window. We systematically scrutinize the robustness of results when applying different BLC approach specifications to one representative pre-existing data set (N = 118) in a (partly) pre-registered study. We report high agreement between different BLC approaches for US and CS+ trials, but moderate to poor agreement for CS- trials. Furthermore, a specification curve of the main effect of CS discrimination during fear acquisition training from all potential and reasonable combinations of specifications (N = 150) and a prototypical trough-to-peak (TTP) approach indicates that resulting effect sizes are largely comparable. A second specification curve (N = 605 specific combinations) highlights a strong impact of different transformation types. Crucially, however, we show that BLC approaches often misclassify the peak value-particularly for CS- trials, leading to stimulus-specific biases and challenges for post-processing and replicability of CS discrimination across studies applying different approaches. Lastly, we investigate how negative skin conductance values in BLC, appearing most frequently for CS- (CS- > CS+ > US), correspond to values in TTP quantification. We discuss the results considering prospects and challenges of the multiverse approach and future directions.
    MeSH term(s) Humans ; Conditioning, Classical/physiology ; Galvanic Skin Response ; Fear/physiology ; Arousal ; Extinction, Psychological/physiology
    Language English
    Publishing date 2022-07-02
    Publishing country United States
    Document type Journal Article ; Research Support, Non-U.S. Gov't
    ZDB-ID 209486-1
    ISSN 1540-5958 ; 0048-5772
    ISSN (online) 1540-5958
    ISSN 0048-5772
    DOI 10.1111/psyp.14130
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  3. Article: A data multiverse analysis investigating non-model based SCR quantification approaches

    Sjouwerman, Rachel / Illius, Sabrina / Kuhn, Manuel / Lonsdorf, Tina B.

    Psychophysiology

    2022  Volume 59, Issue 12, Page(s) No

    Abstract: Electrodermal signals are commonly used outcome measures in research on arousal, emotion, and habituation. Recently, we reported on heterogeneity in skin conductance response quantification approaches and its impact on replicability. Here we provide ... ...

    Title translation Eine Daten-Multiversum-Analyse zur Untersuchung von nicht modellbasierten SCR-Quantifizierungsansätzen (DeepL)
    Abstract Electrodermal signals are commonly used outcome measures in research on arousal, emotion, and habituation. Recently, we reported on heterogeneity in skin conductance response quantification approaches and its impact on replicability. Here we provide complementary work focusing on within-approach heterogeneity of specifications for skin conductance response quantification. We focus on heterogeneity within the baseline-correction approach (BLC) which appeared as particularly heterogeneous-for instance with respect to the pre-CS baseline window duration, the start, and end of the peak detection window. We systematically scrutinize the robustness of results when applying different BLC approach specifications to one representative pre-existing data set (N = 118) in a (partly) pre-registered study. We report high agreement between different BLC approaches for US and CS+ trials, but moderate to poor agreement for CS- trials. Furthermore, a specification curve of the main effect of CS discrimination during fear acquisition training from all potential and reasonable combinations of specifications (N = 150) and a prototypical trough-to-peak (TTP) approach indicates that resulting effect sizes are largely comparable. A second specification curve (N = 605 specific combinations) highlights a strong impact of different transformation types. Crucially, however, we show that BLC approaches often misclassify the peak value-particularly for CS- trials, leading to stimulus-specific biases and challenges for post-processing and replicability of CS discrimination across studies applying different approaches. Lastly, we investigate how negative skin conductance values in BLC, appearing most frequently for CS- (CS- > CS+ > US), correspond to values in TTP quantification. We discuss the results considering prospects and challenges of the multiverse approach and future directions.
    Keywords Classical Conditioning ; Conditioned Fear ; Conditioning ; Hautwiderstand ; Klassische Konditionierung ; Konditionierte Furcht ; Konditionierung ; Methodologie ; Methodology ; Modelle ; Models ; Skin Resistance ; Statistical Analysis ; Statistische Analyse
    Language English
    Document type Article
    ZDB-ID 209486-1
    ISSN 1540-5958 ; 0048-5772
    ISSN (online) 1540-5958
    ISSN 0048-5772
    DOI 10.1111/psyp.14130
    Database PSYNDEX

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  4. Article ; Online: Serotonin transporter gene methylation predicts long-term cortisol concentrations in hair.

    Alexander, Nina / Illius, Sabrina / Stalder, Tobias / Wankerl, Matthis / Muehlhan, Markus / Kirschbaum, Clemens

    Psychoneuroendocrinology

    2019  Volume 106, Page(s) 179–182

    Abstract: Epigenetic signatures, such as DNA methylation ( ... ...

    Abstract Epigenetic signatures, such as DNA methylation (DNA
    MeSH term(s) Adolescent ; Adult ; Alleles ; CpG Islands/genetics ; DNA Methylation/genetics ; Epigenesis, Genetic/genetics ; Female ; Hair/chemistry ; Humans ; Hydrocortisone/genetics ; Hydrocortisone/metabolism ; Hypothalamo-Hypophyseal System/metabolism ; Male ; Pituitary-Adrenal System/metabolism ; Polymorphism, Single Nucleotide/genetics ; Promoter Regions, Genetic/genetics ; Serotonin Plasma Membrane Transport Proteins/genetics ; Serotonin Plasma Membrane Transport Proteins/metabolism ; Stress, Psychological/genetics
    Chemical Substances SLC6A4 protein, human ; Serotonin Plasma Membrane Transport Proteins ; Hydrocortisone (WI4X0X7BPJ)
    Language English
    Publishing date 2019-03-29
    Publishing country England
    Document type Journal Article ; Research Support, Non-U.S. Gov't
    ZDB-ID 197636-9
    ISSN 1873-3360 ; 0306-4530
    ISSN (online) 1873-3360
    ISSN 0306-4530
    DOI 10.1016/j.psyneuen.2019.03.033
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  5. Article ; Online: Eleven strategies for making reproducible research and open science training the norm at research institutions.

    Kohrs, Friederike E / Auer, Susann / Bannach-Brown, Alexandra / Fiedler, Susann / Haven, Tamarinde Laura / Heise, Verena / Holman, Constance / Azevedo, Flavio / Bernard, René / Bleier, Arnim / Bössel, Nicole / Cahill, Brian Patrick / Castro, Leyla Jael / Ehrenhofer, Adrian / Eichel, Kristina / Frank, Maximillian / Frick, Claudia / Friese, Malte / Gärtner, Anne /
    Gierend, Kerstin / Grüning, David Joachim / Hahn, Lena / Hülsemann, Maren / Ihle, Malika / Illius, Sabrina / König, Laura / König, Matthias / Kulke, Louisa / Kutlin, Anton / Lammers, Fritjof / Mehler, David M A / Miehl, Christoph / Müller-Alcazar, Anett / Neuendorf, Claudia / Niemeyer, Helen / Pargent, Florian / Peikert, Aaron / Pfeuffer, Christina U / Reinecke, Robert / Röer, Jan Philipp / Rohmann, Jessica L / Sánchez-Tójar, Alfredo / Scherbaum, Stefan / Sixtus, Elena / Spitzer, Lisa / Straßburger, Vera Maren / Weber, Marcel / Whitmire, Clarissa J / Zerna, Josephine / Zorbek, Dilara / Zumstein, Philipp / Weissgerber, Tracey L

    eLife

    2023  Volume 12

    Abstract: Reproducible research and open science practices have the potential to accelerate scientific progress by allowing others to reuse research outputs, and by promoting rigorous research that is more likely to yield trustworthy results. However, these ... ...

    Abstract Reproducible research and open science practices have the potential to accelerate scientific progress by allowing others to reuse research outputs, and by promoting rigorous research that is more likely to yield trustworthy results. However, these practices are uncommon in many fields, so there is a clear need for training that helps and encourages researchers to integrate reproducible research and open science practices into their daily work. Here, we outline eleven strategies for making training in these practices the norm at research institutions. The strategies, which emerged from a virtual brainstorming event organized in collaboration with the German Reproducibility Network, are concentrated in three areas: (i) adapting research assessment criteria and program requirements; (ii) training; (iii) building communities. We provide a brief overview of each strategy, offer tips for implementation, and provide links to resources. We also highlight the importance of allocating resources and monitoring impact. Our goal is to encourage researchers - in their roles as scientists, supervisors, mentors, instructors, and members of curriculum, hiring or evaluation committees - to think creatively about the many ways they can promote reproducible research and open science practices in their institutions.
    MeSH term(s) Humans ; Reproducibility of Results ; Mentors ; Personnel Selection ; Physicians ; Research Personnel
    Language English
    Publishing date 2023-11-23
    Publishing country England
    Document type Journal Article
    ZDB-ID 2687154-3
    ISSN 2050-084X ; 2050-084X
    ISSN (online) 2050-084X
    ISSN 2050-084X
    DOI 10.7554/eLife.89736
    Database MEDical Literature Analysis and Retrieval System OnLINE

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