LIVIVO - Das Suchportal für Lebenswissenschaften

switch to English language
Zurück zur letzten Suche Suchhistorie
Erweiterte Suche

Ihre letzten Suchen

  1. AU="Ilse A. Thompson"
  2. AU="Jazia Sriti"
  3. AU="Schaaf, L van der"
  4. AU="Ginocchi, Laura"
  5. AU="Vassilopoulos, Stéphane"
  6. AU="Rosendahl Huber, Axel"
  7. AU="Andreotti, Renato"
  8. AU="So, J B Y"
  9. AU="Masamizu Oyama"
  10. AU=Crick James M.
  11. AU="Geiger, Jennifer M"
  12. AU=Massaro Donald
  13. AU="Mao Wen"
  14. AU="Clark, Audra T"
  15. AU="Robello, Carlos"
  16. AU="Hiemstra, P S"
  17. AU="Mubin, Omar"
  18. AU="Dong, Ze-Han"
  19. AU="Küfner, Laura"
  20. AU="Iwao, Masao"
  21. AU="Suárez, Alírica Isabel"

Suchergebnis

Treffer 1 - 2 von insgesamt 2

Suchoptionen

  1. Artikel ; Online: Altered effective connectivity within an oculomotor control network in individuals with schizophrenia

    Matthew Lehet / Ivy F. Tso / Sebastiaan F.W. Neggers / Ilse A. Thompson / Beier Yao / René S. Kahn / Katharine N. Thakkar

    NeuroImage: Clinical, Vol 31, Iss , Pp 102764- (2021)

    2021  

    Abstract: Rapid inhibition or modification of actions is a crucial cognitive ability, which is impaired in persons with schizophrenia (SZP). Primate neurophysiology studies have identified a network of brain regions that subserves control over gaze. Here, we ... ...

    Abstract Rapid inhibition or modification of actions is a crucial cognitive ability, which is impaired in persons with schizophrenia (SZP). Primate neurophysiology studies have identified a network of brain regions that subserves control over gaze. Here, we examine effective connectivity within this oculomotor control network in SZP and healthy controls (HC). During fMRI, participants performed a stop-signal task variant in which they were instructed to saccade to a visual target (no-step trials) unless a second target appeared (redirect trials); on redirect trials, participants were instructed to inhibit the planned saccade and redirect to the new target. We compared functional responses on redirect trials to no-step trials and used dynamic causal modelling (DCM) to examine group differences in network effective connectivity. Behaviorally, SZP were less efficient at inhibiting, which was related to their employment status. Compared to HC, they showed a smaller difference in activity between redirect trials and no-step trials in frontal eye fields (FEF), supplementary eye fields (SEF), inferior frontal cortex (IFC), thalamus, and caudate. DCM analyses revealed widespread group differences in effective connectivity across the task, including different patterns of self-inhibition in many nodes in SZP. Group differences in how effective connectivity was modulated on redirect trials revealed differences between the FEF and SEF, between the SEF and IFC, between the superior colliculus and the thalamus, and self-inhibition within the FEF and caudate. These results provide insight into the neural mechanisms of inefficient inhibitory control in individuals with schizophrenia.
    Schlagwörter Schizophrenia ; Dynamic causal modeling ; Response inhibition ; Eye movements ; Effective connectivity ; Stop-signal task ; Computer applications to medicine. Medical informatics ; R858-859.7 ; Neurology. Diseases of the nervous system ; RC346-429
    Thema/Rubrik (Code) 150
    Sprache Englisch
    Erscheinungsdatum 2021-01-01T00:00:00Z
    Verlag Elsevier
    Dokumenttyp Artikel ; Online
    Datenquelle BASE - Bielefeld Academic Search Engine (Lebenswissenschaftliche Auswahl)

    Volltext online

    Zusatzmaterialien

    Kategorien

    Fernleihe an ZB MED

    Sie können sich den gewünschten Titel als lokale Nutzerin oder lokaler Nutzer von ZB MED direkt an den Standort Köln schicken lassen.

  2. Artikel ; Online: To continue or not to continue? Antipsychotic medication maintenance versus dose-reduction/discontinuation in first episode psychosis

    Marieke J. H. Begemann / Ilse A. Thompson / Wim Veling / Shiral S. Gangadin / Chris N. W. Geraets / Erna van ‘t Hag / Sanne J. Müller-Kuperus / Priscilla P. Oomen / Alban E. Voppel / Mark van der Gaag / Martijn J. Kikkert / Jim Van Os / H. Filip E. Smit / Rikus H. Knegtering / Sybren Wiersma / Luyken H. Stouten / Harm J. Gijsman / Lex Wunderink / Anton B. P. Staring /
    Selene R. T. Veerman / Amrita G. S. Mahabir / Jörg Kurkamp / Gerdina H. M. Pijnenborg / Natalie D. Veen / Machteld Marcelis / Koen P. Grootens / Gunnar Faber / Nico J. van Beveren / Agaath Been / Truus van den Brink / Maarten Bak / Therese A. M. J. van Amelsvoort / Andrea Ruissen / Christine Blanke / Karin Groen / Lieuwe de Haan / Iris E. C. Sommer

    Trials, Vol 21, Iss 1, Pp 1-

    HAMLETT, a pragmatic multicenter single-blind randomized controlled trial

    2020  Band 19

    Abstract: Abstract Background Antipsychotic medication is effective for symptomatic treatment in schizophrenia-spectrum disorders. After symptom remission, continuation of antipsychotic treatment is associated with lower relapse rates and lower symptom severity ... ...

    Abstract Abstract Background Antipsychotic medication is effective for symptomatic treatment in schizophrenia-spectrum disorders. After symptom remission, continuation of antipsychotic treatment is associated with lower relapse rates and lower symptom severity compared to dose reduction/discontinuation. Therefore, most guidelines recommend continuation of treatment with antipsychotic medication for at least 1 year. Recently, however, these guidelines have been questioned as one study has shown that more patients achieved long-term functional remission in an early discontinuation condition—a finding that was not replicated in another recently published long-term study. Methods/design The HAMLETT (Handling Antipsychotic Medication Long-term Evaluation of Targeted Treatment) study is a multicenter pragmatic single-blind randomized controlled trial in two parallel conditions (1:1) investigating the effects of continuation versus dose-reduction/discontinuation of antipsychotic medication after remission of a first episode of psychosis (FEP) on personal and social functioning, psychotic symptom severity, and health-related quality of life. In total 512 participants will be included, aged between 16 and 60 years, in symptomatic remission from a FEP for 3–6 months, and for whom psychosis was not associated with severe or life-threatening self-harm or violence. Recruitment will take place at 24 Dutch sites. Patients are randomized (1:1) to: continuation of antipsychotic medication until at least 1 year after remission (original dose allowing a maximum reduction of 25%, or another antipsychotic drug in similar dose range); or gradual dose reduction till eventual discontinuation of antipsychotics according to a tapering schedule. If signs of relapse occur in this arm, medication dose can be increased again. Measurements are conducted at baseline, at 3, and 6 months post-baseline, and yearly during a follow-up period of 4 years. Discussion The HAMLETT study will offer evidence to guide patients and clinicians regarding questions ...
    Schlagwörter Antipsychotic medication ; first episode psychosis ; Maintenance ; Treatment ; Discontinuation ; Tapering ; global functioning ; Randomized controlled trial ; Medicine (General) ; R5-920
    Thema/Rubrik (Code) 150
    Sprache Englisch
    Erscheinungsdatum 2020-02-01T00:00:00Z
    Verlag BMC
    Dokumenttyp Artikel ; Online
    Datenquelle BASE - Bielefeld Academic Search Engine (Lebenswissenschaftliche Auswahl)

    Volltext online

    Zusatzmaterialien

    Kategorien

    Fernleihe an ZB MED

    Sie können sich den gewünschten Titel als lokale Nutzerin oder lokaler Nutzer von ZB MED direkt an den Standort Köln schicken lassen.

Zum Seitenanfang