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  1. Article ; Online: The elephant in the room: Medication as confounder.

    Ilzarbe, Lidia / Vieta, Eduard

    European neuropsychopharmacology : the journal of the European College of Neuropsychopharmacology

    2023  Volume 71, Page(s) 6–8

    MeSH term(s) Humans ; Bipolar Disorder/drug therapy ; Medication Adherence
    Language English
    Publishing date 2023-03-15
    Publishing country Netherlands
    Document type Journal Article
    ZDB-ID 1082947-7
    ISSN 1873-7862 ; 0924-977X
    ISSN (online) 1873-7862
    ISSN 0924-977X
    DOI 10.1016/j.euroneuro.2023.03.001
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    Zs.A 3288: Show issues Location:
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  2. Article ; Online: Sex Differences in Serum Prolactin Levels in Children and Adolescents on Antipsychotics: A Systematic Review and Meta-Analysis.

    Ilzarbe, Lidia / Ilzarbe, Daniel / Gutiérrez-Arango, Felipe / Baeza, Inmaculada

    Current neuropharmacology

    2022  Volume 21, Issue 6, Page(s) 1319–1328

    Abstract: Background: Serum prolactin levels are influenced by sex, physical development and medications among other factors. Antipsychotics usually increase serum prolactin levels in both adults and younger patients, but no study has reviewed the potential ... ...

    Abstract Background: Serum prolactin levels are influenced by sex, physical development and medications among other factors. Antipsychotics usually increase serum prolactin levels in both adults and younger patients, but no study has reviewed the potential association between sex and vulnerability for developing hyperprolactinemia among children and adolescents.
    Objective: Systematic review and meta-analysis of serum prolactin levels in children and adolescents on antipsychotic treatment for any psychiatric diagnosis to determine the effect of sex.
    Methods: A systematic search was performed in MEDLINE/PubMed/Web of Science and Cochrane databases for randomized controlled trials of antipsychotics in children and adolescents reporting serum prolactin levels by sex.
    Results: Of 1278 identified records, seven studies were included, comparing different single antipsychotics to placebo (risperidone N=4; lurasidone N=1; olanzapine N=1; queriapine N=1). Both male and female children and adolescents on antipsychotics presented a significant increase in prolactin levels relative to subjects receiving a placebo. (Male: 16.53 with 95% CI: 6.15-26.92; Female: 26.97 with 95% CI: 9.18-44.75). The four studies using risperidone had similar findings (Male: 26.49 with 95% CI: 17.55-35.43; Female: 37.72 with 95% CI: 9.41-66.03). In the direct comparison between sexes, females showed greater increases in prolactin, but the differences were not statistically significant.
    Conclusion: Serum prolactin levels are increased in children and adolescents of both sexes on antipsychotics, with females showing a slightly greater increase than males. Further research is needed to clarify the influence of sex and pubertal status on prolactin levels in children and adolescents taking antipsychotics.
    MeSH term(s) Adult ; Female ; Humans ; Male ; Adolescent ; Child ; Antipsychotic Agents/therapeutic use ; Risperidone/therapeutic use ; Prolactin ; Sex Characteristics ; Olanzapine
    Chemical Substances Antipsychotic Agents ; Risperidone (L6UH7ZF8HC) ; Prolactin (9002-62-4) ; Olanzapine (N7U69T4SZR)
    Language English
    Publishing date 2022-10-23
    Publishing country United Arab Emirates
    Document type Meta-Analysis ; Systematic Review ; Journal Article
    ZDB-ID 2192352-8
    ISSN 1875-6190 ; 1570-159X
    ISSN (online) 1875-6190
    ISSN 1570-159X
    DOI 10.2174/1570159X21666221027143920
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  3. Article ; Online: Neuropsychiatric symptoms in a patient under cystic fibrosis transmembrane conductance regulator modulators treatment: a case report.

    Andreu, Helena / Olivier, Luis / Giménez-Palomo, Anna / Roson-Fernandez, Carmen / Bueno, Laura / de Juan, Óscar / Bartolomé, Inés / Ilzarbe, Lidia / Tardón-Senabre, Laia / Fernández-Plaza, Tabatha / Arbelo, Néstor / Valentí, Marc / Gil-Badenes, Joaquín / Macau, Elisabet / Pujol-Fontrodona, Gabriel / Colomer, Lluc / Vieta, Eduard / Pacchiarotti, Isabella

    International clinical psychopharmacology

    2023  Volume 38, Issue 6, Page(s) 402–405

    Abstract: In recent times, some research has focused on the study of potential treatments for cystic fibrosis (CF), such as cystic fibrosis transmembrane conductance regulator (CFTR) modulators. These treatments have been reported to produce neuropsychiatric ... ...

    Abstract In recent times, some research has focused on the study of potential treatments for cystic fibrosis (CF), such as cystic fibrosis transmembrane conductance regulator (CFTR) modulators. These treatments have been reported to produce neuropsychiatric symptoms in a few patients, even though there is still no clear correlation nor underlying mechanism proposed. We present the case of a 23-year-old woman with CF and no previous psychiatric history who was admitted to our inpatient psychiatric unit presenting a wide range of neuropsychiatric symptoms, such as disorganized speech, bizarre poses or persecutory delusional ideation, after going under CFTR modulators treatment. After several diagnostic tests, other possible organic causes were ruled out. Multiple antipsychotic treatments were tested during her admission, with poor tolerance and scarce response. Finally, symptomatic remission was only observed after electroconvulsive therapy was initiated. The final diagnostic hypothesis was unspecified psychosis. This case highlights the relevance of considering the possibility of neuropsychiatric symptoms appearing in patients under CFTR modulators treatment.
    MeSH term(s) Female ; Humans ; Young Adult ; Antipsychotic Agents/therapeutic use ; Cystic Fibrosis Transmembrane Conductance Regulator/genetics ; Delusions ; Inpatients ; Psychotic Disorders/diagnosis ; Psychotic Disorders/drug therapy
    Chemical Substances Antipsychotic Agents ; Cystic Fibrosis Transmembrane Conductance Regulator (126880-72-6)
    Language English
    Publishing date 2023-09-27
    Publishing country England
    Document type Case Reports ; Journal Article ; Research Support, Non-U.S. Gov't
    ZDB-ID 632837-4
    ISSN 1473-5857 ; 0268-1315
    ISSN (online) 1473-5857
    ISSN 0268-1315
    DOI 10.1097/YIC.0000000000000475
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  4. Article ; Online: Catatonic postpartum paternal depression as a first debut of a bipolar disorder: a case report.

    de Juan, Oscar / Mas, Albert / Giménez-Palomo, Anna / Gil-Badenes, Joaquín / Ilzarbe, Lídia / Colomer, Lluc / Andreu, Helena / Bueno, Laura / Olivier, Luis / Estévez, Beatriz / Fernández-Plaza, Tábatha / Tardón-Senabre, Laia / Arbelo, Néstor / Valentí, Marc / Gomes da Costa, Susana / Pujol-Fontrodona, Gabriel / Vieta, Eduard / Pacchiarotti, Isabella

    International clinical psychopharmacology

    2023  Volume 39, Issue 2, Page(s) 113–116

    Abstract: Paternal postpartum depression (PD) is considered an affective disorder that affects fathers during the months following childbirth. Interestingly, it has been observed that during these months the chances of a male parent suffering from depression are ... ...

    Abstract Paternal postpartum depression (PD) is considered an affective disorder that affects fathers during the months following childbirth. Interestingly, it has been observed that during these months the chances of a male parent suffering from depression are double that for a non-parent male counterpart. We present the case of a 34-year-old man with no relevant medical history in who, overlapping her daughter's birth, several depressive symptoms emerged, such as fatigue, lack of concentration, sleeping disturbances and abandonment of care of the newborn. Prior to consultation, patient refused to eat and open his eyes, and his speech became progressively more parsimonious until reaching mutism. The patient was diagnosed with a severe depressive disorder with catatonia. Given the lack of improvement with pharmacological treatment and due to the evidence of electroconvulsive therapy (ECT)'s effectiveness on patients with catatonia, acute ECT treatment was indicated and started. It should be noted that PD is an important entity to consider in our differential diagnosis of young parents who present a depressive episode. Few cases of relatively young patients presenting with such clinical presentation have been described and, although this case presents some of the characteristics described in the epidemiology of PD, other clinical aspects are not typical of this entity. Informed consent was obtained from the patient for the purpose of publication.
    MeSH term(s) Female ; Infant, Newborn ; Humans ; Male ; Adult ; Bipolar Disorder/diagnosis ; Bipolar Disorder/therapy ; Bipolar Disorder/psychology ; Catatonia/therapy ; Catatonia/drug therapy ; Depression/diagnosis ; Depression/therapy ; Depression, Postpartum/diagnosis ; Depression, Postpartum/therapy ; Depression, Postpartum/complications ; Fathers ; Postpartum Period ; Electroconvulsive Therapy
    Language English
    Publishing date 2023-09-20
    Publishing country England
    Document type Case Reports ; Journal Article
    ZDB-ID 632837-4
    ISSN 1473-5857 ; 0268-1315
    ISSN (online) 1473-5857
    ISSN 0268-1315
    DOI 10.1097/YIC.0000000000000480
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  5. Article ; Online: Psychiatric Clinical Profiles and Pharmacological Interactions in COVID-19 Inpatients Referred to a Consultation Liaison Psychiatry Unit: a Cross-Sectional Study.

    Arbelo, Nestor / López-Pelayo, Hugo / Sagué, María / Madero, Santiago / Pinzón-Espinosa, Justo / Gomes-da-Costa, Susana / Ilzarbe, Lidia / Anmella, Gerard / Llach, Cristian-Daniel / Imaz, María-Luisa / Cámara, María-Mercé / Pintor, Luis

    The Psychiatric quarterly

    2021  Volume 92, Issue 3, Page(s) 1021–1033

    Abstract: The Coronavirus Disease 2019 (COVID-19) can affect mental health in different ways. There is little research about psychiatric complications in hospitalized patients with COVID-19. The aim of the study was to describe the psychiatric clinical profile and ...

    Abstract The Coronavirus Disease 2019 (COVID-19) can affect mental health in different ways. There is little research about psychiatric complications in hospitalized patients with COVID-19. The aim of the study was to describe the psychiatric clinical profile and pharmacological interactions in COVID-19 inpatients referred to a Consultation-Liaison Psychiatry (CLP) unit. This is a cross-sectional study, carried out at a tertiary hospital in Spain, in inpatients admitted because of COVID-19 and referred to our CLP Unit from March 17,2020 to April 28,2020. Clinical data were extracted from electronic medical records. The patients were divided in three groups depending on psychiatric diagnosis: delirium, severe mental illness (SMI) and non-severe mental illness (NSMI). Of 71 patients included (median [ICR] age 64 [54-73] years; 70.4% male), 35.2% had a delirium, 18.3% had a SMI, and 46.5% had a NSMI. Compared to patients with delirium and NSMI, patients with SMI were younger, more likely to be institutionalized and were administered less anti-COVID19 drugs. Mortality was higher among patients with delirium (21.7%) than those with SMI (0%) or NSMI (9.45%). The rate of side effects due to interactions between anti-COVID19 and psychiatric drugs was low, mainly drowsiness (4.3%) and borderline QTc prolongation (1.5%). Patients affected by SMI were more often undertreated for COVID-19. However, the rate of interactions was very low, and avoidable with a proper evaluation and drug-dose adjustment. Half of the patients with SMI were institutionalized, suggesting that living conditions in residential facilities could make them more vulnerable to infection.
    MeSH term(s) Aged ; COVID-19/drug therapy ; COVID-19/psychology ; Cross-Sectional Studies ; Female ; Humans ; Inpatients/psychology ; Male ; Mental Disorders/drug therapy ; Mental Disorders/psychology ; Middle Aged ; Psychiatry ; Referral and Consultation ; SARS-CoV-2 ; Spain
    Language English
    Publishing date 2021-01-07
    Publishing country United States
    Document type Journal Article ; Research Support, Non-U.S. Gov't
    ZDB-ID 207521-0
    ISSN 1573-6709 ; 0033-2720
    ISSN (online) 1573-6709
    ISSN 0033-2720
    DOI 10.1007/s11126-020-09868-6
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  6. Article ; Online: Perampanel-Induced Psychosis in a Young Woman: A Case Report.

    Pujal Rodríguez, Ester / Pons-Cabrera, María Teresa / Giménez, Anna / Colomer, Lluc / Baldaqui, Núria / Gutiérrez, Felipe / Anmella, Gerard / Ilzarbe, Lidia / Madero, Santiago / Sagué-Vilavella, Maria / Olivera, Marta / Santana, Daniel / Verdolini, Norma / Bioque, Miquel / Vieta, Eduard / Pacchiarotti, Isabella

    Clinical neuropharmacology

    2021  Volume 44, Issue 6, Page(s) 240–242

    Abstract: Objectives: A case of perampanel-induced psychosis in a young woman is reported, a side effect that has only rarely been reported in the literature.: Methods: We describe a case of a young woman with epilepsy and no psychiatric history with ... ...

    Abstract Objectives: A case of perampanel-induced psychosis in a young woman is reported, a side effect that has only rarely been reported in the literature.
    Methods: We describe a case of a young woman with epilepsy and no psychiatric history with perampanel-associated altered behavior and psychotic symptoms, requiring hospitalization in an acute psychiatry ward. We also provide a literature review on the possible neurobiological pathways implicated.
    Results: Perampanel is believed to block a small proportion of the α-amino-3-hydroxy-5-methyl-4-isoxazolepropionic acid receptor current, retarding epileptiform discharges while sparing most normal synaptic transmission. Most common adverse events are related to central nervous system (including dizziness, drowsiness, blurred vision and imbalance) and psychiatric symptoms have been reported.
    Conclusions: The biological vulnerability to psychiatric and behavioral adverse reactions of antiepileptic drugs is multifactorial and different mechanisms and clinical predisposing factors may interact. For this reason, patients starting these antiseizure drugs need long-term and comprehensive clinical monitoring.
    MeSH term(s) Anticonvulsants/adverse effects ; Female ; Humans ; Nitriles ; Psychotic Disorders/drug therapy ; Pyridones/adverse effects ; Treatment Outcome
    Chemical Substances Anticonvulsants ; Nitriles ; Pyridones ; perampanel (H821664NPK)
    Language English
    Publishing date 2021-11-12
    Publishing country United States
    Document type Case Reports ; Journal Article
    ZDB-ID 199293-4
    ISSN 1537-162X ; 0362-5664
    ISSN (online) 1537-162X
    ISSN 0362-5664
    DOI 10.1097/WNF.0000000000000479
    Database MEDical Literature Analysis and Retrieval System OnLINE

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